Groothuis, Geny M. M.

Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction

Martignoni, M., Groothuis, G. M. M., & de Kanter, R. (2006) · Expert Opinion on Drug Metabolism & Toxicology

Pharmacogenetics and Drug MetabolismDrug-Induced Hepatotoxicity and Protection

Cited by 1,478

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

Godoy, P., Hewitt, N. J., Albrecht, U., Andersen, M. E., Ansari, N., Bhattacharya, S., Bode, J. G., Bolleyn, J., Borner, C., Böttger, J., et al. (2013) · Archives of Toxicology

Drug-Induced Hepatotoxicity and ProtectionLiver physiology and pathology

Cited by 1,280

Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies

Hewitt, N. J., Gómez Lechón, M. J., Houston, J. B., Hallifax, D., Brown, H. S., Maurel, P., Kenna, J. G., Gustavsson, L., Lohmann, C., Skonberg, C., et al. (2007) · Drug Metabolism Reviews

Pharmacogenetics and Drug MetabolismDrug-Induced Hepatotoxicity and Protection

Cited by 735

A microfluidic approach for in vitro assessment of interorgan interactions in drug metabolism using intestinal and liver slices

van Midwoud, P. M., Merema, M. T., Verpoorte, E., & Groothuis, G. M. M. (2010) · Lab on a Chip

Pharmacogenetics and Drug MetabolismDrug Transport and Resistance Mechanisms

Cited by 203

Microfluidic devices for in vitro studies on liver drug metabolism and toxicity

van Midwoud, P. M., Verpoorte, E., & Groothuis, G. M. M. (2011) · Integrative Biology

3D Printing in Biomedical ResearchMicrofluidic and Capillary Electrophoresis Applications

Cited by 115

Targeting dexamethasone to Kupffer cells: Effects on liver inflammation and fibrosis in rats

Melgert, B. N., Olinga, P., Van Der Laan, J. M. S., Weert, B., Cho, J., Schuppan, D., Groothuis, G. M. M., Meijer, D. K. F., & Poelstra, K. (2001) · Hepatology

Liver physiology and pathologyNanoparticle-Based Drug Delivery

Cited by 115

COMPARISON OF MOUSE AND RAT CYTOCHROME P450-MEDIATED METABOLISM IN LIVER AND INTESTINE

Martignoni, M., Groothuis, G., & de Kanter, R. (2006) · Drug Metabolism and Disposition

Pharmacogenetics and Drug MetabolismDrug Transport and Resistance Mechanisms

Cited by 101

Precision-cut fibrotic rat liver slices as a new model to test the effects of anti-fibrotic drugs in vitro

van de Bovenkamp, M., Groothuis, G. M. M., Meijer, D. K. F., & Olinga, P. (2006) · Journal of Hepatology

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 43