Karsdal, Morten

The good and the bad collagens of fibrosis – Their role in signaling and organ function

Karsdal, M. A., Nielsen, S. H., Leeming, D. J., Langholm, L. L., Nielsen, M. J., Manon-Jensen, T., Siebuhr, A., Gudmann, N. S., Rønnow, S., Sand, J. M., et al. (2017) · Advanced Drug Delivery Reviews

Liver physiology and pathologyCollagen: Extraction and Characterization

Cited by 509

Diagnostic accuracy of elastography and magnetic resonance imaging in patients with NAFLD: a systematic review and meta-analysis

Selvaraj, E. A., Mózes, F. E., Jayaswal, A. N. A., Zafarmand, M. H., Vali, Y., Lee, J. A., Levick, C. K., Young, L. A. J., Palaniyappan, N., Liu, C.-H., et al. (2021) · Journal of Hepatology

Liver Disease Diagnosis and TreatmentUltrasound Imaging and Elastography

Cited by 376

Value of biomarkers in osteoarthritis: current status and perspectives

Lotz, M., Martel-Pelletier, J., Christiansen, C., Brandi, M.-L., Bruyère, O., Chapurlat, R., Collette, J., Cooper, C., Giacovelli, G., Kanis, J. A., et al. (2013) · Annals of the Rheumatic Diseases

Osteoarthritis Treatment and MechanismsProteoglycans and glycosaminoglycans research

Cited by 328

Longitudinal change in collagen degradation biomarkers in idiopathic pulmonary fibrosis: an analysis from the prospective, multicentre PROFILE study

Jenkins, R. G., Simpson, J. K., Saini, G., Bentley, J. H., Russell, A.-M., Braybrooke, R., Molyneaux, P. L., McKeever, T. M., Wells, A. U., Flynn, A., et al. (2015) · The Lancet Respiratory Medicine

Interstitial Lung Diseases and Idiopathic Pulmonary FibrosisOccupational and environmental lung diseases

Cited by 314

ADAPT: an algorithm incorporating PRO-C3 accurately identifies patients with NAFLD and advanced fibrosis

Daniels, S. J., Leeming, D. J., Eslam, M., Hashem, A. M., Nielsen, M. J., Krag, A., Karsdal, M. A., Grove, J. I., Neil Guha, I., Kawaguchi, T., et al. (2019) · Hepatology

Liver Disease Diagnosis and TreatmentLiver Disease and Transplantation

Cited by 273

An unbiased ranking of murine dietary models based on their proximity to human metabolic dysfunction-associated steatotic liver disease (MASLD)

Vacca, M., Kamzolas, I., Harder, L. M., Oakley, F., Trautwein, C., Hatting, M., Ross, T., Bernardo, B., Oldenburger, A., Hjuler, S. T., et al. (2024) · Nature Metabolism

Liver Disease Diagnosis and TreatmentDiet, Metabolism, and Disease

Cited by 262

Proteinases in bone resorption: obvious and less obvious roles

Delaissé, J.-M., Engsig, M. T., Everts, V., del Carmen Ovejero, M., Ferreras, M., Lund, L., Vu, T. H., Werb, Z., Winding, B., Lochter, A., et al. (2000) · Clinica Chimica Acta

Bone Metabolism and DiseasesProtease and Inhibitor Mechanisms

Cited by 227

The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis

Woodcock, H. V., Eley, J. D., Guillotin, D., Platé, M., Nanthakumar, C. B., Martufi, M., Peace, S., Joberty, G., Poeckel, D., Good, R. B., et al. (2019) · Nature Communications

Interstitial Lung Diseases and Idiopathic Pulmonary FibrosisPI3K/AKT/mTOR signaling in cancer

Cited by 224

Biomarkers for staging fibrosis and non-alcoholic steatohepatitis in non-alcoholic fatty liver disease (the LITMUS project): a comparative diagnostic accuracy study

Vali, Y., Lee, J., Boursier, J., Petta, S., Wonders, K., Tiniakos, D., Bedossa, P., Geier, A., Francque, S., Allison, M., et al. (2023) · The Lancet Gastroenterology & Hepatology

Liver Disease Diagnosis and TreatmentLiver Diseases and Immunity

Cited by 224

Performance of non-invasive tests and histology for the prediction of clinical outcomes in patients with non-alcoholic fatty liver disease: an individual participant data meta-analysis

Mózes, F. E., Lee, J. A., Vali, Y., Alzoubi, O., Staufer, K., Trauner, M., Paternostro, R., Stauber, R. E., Holleboom, A. G., van Dijk, A.-M., et al. (2023) · The Lancet Gastroenterology & Hepatology

Liver Disease Diagnosis and TreatmentLiver Disease and Transplantation

Cited by 214

Effect of NGM282, an FGF19 analogue, in primary sclerosing cholangitis: a multicenter, randomized, double-blind, placebo-controlled phase II trial

Hirschfield, G. M., Chazouillères, O., Drenth, J. P., Thorburn, D., Harrison, S. A., Landis, C. S., Mayo, M. J., Muir, A. J., Trotter, J. F., Leeming, D. J., et al. (2019) · Journal of Hepatology

Liver Diseases and ImmunityDrug Transport and Resistance Mechanisms

Cited by 187

Characterization of osteoclasts derived from CD14+ monocytes isolated from peripheral blood

Sørensen, M. G., Henriksen, K., Schaller, S., Henriksen, D. B., Nielsen, F. C., Dziegiel, M. H., & Karsdal, M. A. (2006) · Journal of Bone and Mineral Metabolism

Bone Metabolism and DiseasesRheumatoid Arthritis Research and Therapies

Cited by 143

Performance of the PRO-C3 collagen neo-epitope biomarker in non-alcoholic fatty liver disease

Boyle, M., Tiniakos, D., Schattenberg, J. M., Ratziu, V., Bugianessi, E., Petta, S., Oliveira, C. P., Govaere, O., Younes, R., McPherson, S., et al. (2019) · JHEP Reports

Liver Disease Diagnosis and TreatmentLiver Diseases and Immunity

Cited by 140

Biomarkers of collagen synthesis predict progression in the PROFILE idiopathic pulmonary fibrosis cohort

Organ, L. A., Duggan, A.-M. R., Oballa, E., Taggart, S. C., Simpson, J. K., Kang’ombe, A. R., Braybrooke, R., Molyneaux, P. L., North, B., Karkera, Y., et al. (2019) · Respiratory Research

Interstitial Lung Diseases and Idiopathic Pulmonary FibrosisChronic Obstructive Pulmonary Disease (COPD) Research

Cited by 139

Calcitonin impairs the anabolic effect of PTH in young rats and stimulates expression of sclerostin by osteocytes

Gooi, J. H., Pompolo, S., Karsdal, M. A., Kulkarni, N. H., Kalajzic, I., McAhren, S. H. M., Han, B., Onyia, J. E., Ho, P. W. M., Gillespie, M. T., et al. (2010) · Bone

Bone Metabolism and DiseasesBone health and osteoporosis research

Cited by 117

Osteoclasts secrete non-bone derived signals that induce bone formation

Karsdal, M. A., Neutzsky-Wulff, A. V., Dziegiel, M. H., Christiansen, C., & Henriksen, K. (2008) · Biochemical and Biophysical Research Communications

Bone Metabolism and DiseasesBone health and osteoporosis research

Cited by 112

Oral salmon calcitonin induced suppression of urinary collagen type II degradation in postmenopausal women: A new potential treatment of osteoarthritis

Bagger, Y. Z., Tankó, L. B., Alexandersen, P., Karsdal, M. A., Olson, M., Mindeholm, L., Azria, M., & Christiansen, C. (2005) · Bone

Osteoarthritis Treatment and MechanismsBone health and osteoporosis research

Cited by 109

BMS-986263 in patients with advanced hepatic fibrosis: 36-week results from a randomized, placebo-controlled phase 2 trial

Lawitz, E. J., Shevell, D. E., Tirucherai, G. S., Du, S., Chen, W., Kavita, U., Coste, A., Poordad, F., Karsdal, M., Nielsen, M., et al. (2022) · Hepatology

Liver physiology and pathologyHepatitis C virus research

Cited by 107

Prolonged Calcitonin Receptor Signaling by Salmon, but Not Human Calcitonin, Reveals Ligand Bias

Andreassen, K. V., Hjuler, S. T., Furness, S. G., Sexton, P. M., Christopoulos, A., Nosjean, O., Karsdal, M. A., & Henriksen, K. (2014) · PLoS ONE

Receptor Mechanisms and SignalingNeuropeptides and Animal Physiology

Cited by 89

Calcitonin directly attenuates collagen type II degradation by inhibition of matrix metalloproteinase expression and activity in articular chondrocytes

Sondergaard, B. C., Wulf, H., Henriksen, K., Schaller, S., Oestergaard, S., Qvist, P., Tankó, L. B., Bagger, Y. Z., Christiansen, C., & Karsdal, M. A. (2006) · Osteoarthritis and Cartilage

Osteoarthritis Treatment and MechanismsProtease and Inhibitor Mechanisms

Cited by 88

Transforming Growth Factor-β-induced Osteoblast Elongation Regulates Osteoclastic Bone Resorption through a p38 Mitogen-activated Protein Kinase- and Matrix Metalloproteinase-dependent Pathway

Karsdal, M. A., Fjording, M. S., Foged, N. T., Delaissé, J.-M., & Lochter, A. (2001) · Journal of Biological Chemistry

Bone Metabolism and DiseasesTGF-β signaling in diseases

Cited by 81

A randomized, double-blind, multicenter, placebo-controlled study to evaluate the efficacy and safety of oral salmon calcitonin in the treatment of osteoporosis in postmenopausal women taking calcium and vitamin D

Henriksen, K., Byrjalsen, I., Andersen, J. R., Bihlet, A. R., Russo, L. A., Alexandersen, P., Valter, I., Qvist, P., Lau, E., Riis, B. J., et al. (2016) · Bone

Bone health and osteoporosis researchMenopause: Health Impacts and Treatments

Cited by 78

Dissociation of Bone Resorption and Bone Formation in Adult Mice with a Non-Functional V-ATPase in Osteoclasts Leads to Increased Bone Strength

Henriksen, K., Flores, C., Thomsen, J. S., Brüel, A.-M., Thudium, C. S., Neutzsky-Wulff, A. V., Langenbach, G. E. J., Sims, N., Askmyr, M., Martin, T. J., et al. (2011) · PLoS ONE

Bone Metabolism and DiseasesBone health and osteoporosis research

Cited by 77

Measurement of MMP‐9 and ‐12 degraded elastin (ELM) provides unique information on lung tissue degradation

Skjøt-Arkil, H., Clausen, R. E., Nguyen, Q. H. T., Wang, Y., Zheng, Q., Martinez, F. J., Hogaboam, C. M., Han, M., Klickstein, L. B., Larsen, M. R., et al. (2012) · BMC Pulmonary Medicine

Protease and Inhibitor MechanismsInterstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

Cited by 65