Proteinases in bone resorption: obvious and less obvious roles

A matrix metalloproteinase expressed on the surface of invasive tumour cells

Sato, H., Takino, T., Okada, Y., Cao, J. P., Shinagawa, A., Yamamoto, E., & Seiki, M. (1994) · Nature · doi:10.1038/370061a0 · Cited by 2,534 · see citing works

VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation

Gerber, H. P., Vu, T. H., Ryan, A. M., Kowalski, J., Werb, Z., & Ferrara, N. (1999) · Nature Medicine · doi:10.1038/9467 · Cited by 2,089 · see citing works

MMP-9/Gelatinase B Is a Key Regulator of Growth Plate Angiogenesis and Apoptosis of Hypertrophic Chondrocytes

Vu, T. H., Shipley, J. M., Bergers, G., Berger, J. E., Helms, J. A., Hanahan, D., Shapiro, S. D., Senior, R. M., & Werb, Z. (1998) · Cell · doi:10.1016/s0092-8674(00)81169-1 · Cited by 1,737 · see citing works

Principles of Bone Biology

Compston, J. E. (1997) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1997.2431019.x · Cited by 1,383 · see citing works

ECM and Cell Surface Proteolysis: Regulating Cellular Ecology

Werb, Z. (1997) · Cell · doi:10.1016/s0092-8674(00)80429-8 · Cited by 1,307 · see citing works

MT1-MMP-Deficient Mice Develop Dwarfism, Osteopenia, Arthritis, and Connective Tissue Disease due to Inadequate Collagen Turnover

Holmbeck, K., Bianco, P., Caterina, J., Yamada, S., Kromer, M., Kuznetsov, S. A., Mankani, M., Gehron Robey, P., Poole, A. R., Pidoux, I., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80064-1 · Cited by 1,298 · see citing works

c-Fos: a Key Regulator of Osteoclast-Macrophage Lineage Determination and Bone Remodeling

Grigoriadis, A. E., Wang, Z., Cecchini, M. G., Hofstetter, W., Felix, R., Fleisch, H. A., & Wagner, E. F. (1994) · Science · doi:10.1126/science.7939685 · Cited by 1,260 · see citing works

Pycnodysostosis, a Lysosomal Disease Caused by Cathepsin K Deficiency

Gelb, B. D., Shi, G., Chapman, H. A., & Desnick, R. J. (1996) · Science · doi:10.1126/science.273.5279.1236 · Cited by 1,022 · see citing works

Role of osteoblasts in hormonal control of bone resorption—A hypothesis

Rodan, G. A., & Martin, T. J. (1981) · Calcified Tissue International · doi:10.1007/bf02409454 · Cited by 982 · see citing works

Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice

Säftig, P., Hunziker, E. B., Wehmeyer, O., Jones, S. J., BOYDE, A., Rommerskirch, W., Moritz, J. D., Schu, P. V., & FIGURA, K. V. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.23.13453 · Cited by 909 · see citing works

Cathepsin K, but Not Cathepsins B, L, or S, Is Abundantly Expressed in Human Osteoclasts

Drake, F. H., Dodds, R. A., James, I. E., Connor, J. R., Debouck, C. M., Richardson, S. B., Lee-Rykaczewski, E., Coleman, L., Rieman, D. J., Barthlow, R., et al. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.21.12511 · Cited by 721 · see citing works

Tetracyclines Inhibit Connective Tissue Breakdown by Multiple Non-Antimicrobial Mechanisms

Golub, L. M., Lee, H. M., RYAN, M. E., Giannobile, W. V., Payne, J. B., & Sorsa, T. A. (1998) · Advances in Dental Research · doi:10.1177/08959374980120010501 · Cited by 689 · see citing works

Role of Matrix Metalloproteinases in Human Periodontal Diseases

Birkedal‐Hansen, H. (1993) · Journal of Periodontology · doi:10.1902/jop.1993.64.5s.474 · Cited by 670 · see citing works

The Collagenolytic Activity of Cathepsin K Is Unique among Mammalian Proteinases

Garnero, P., Borel, O., Byrjalsen, I., Ferreras, M., Drake, F. H., McQueney, M. S., Foged, N. T., Delmas, P. D., & Delaissé, J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.48.32347 · Cited by 647 · see citing works

Degradation of decorin by matrix metalloproteinases: identification of the cleavage sites, kinetic analyses and transforming growth factor-β1 release

Imai, K., HIRAMATSU, A., Fukushima, D., Pierschbacher, M. D., & Okada, Y. (1997) · Biochemical Journal · doi:10.1042/bj3220809 · Cited by 445 · see citing works

Human Cathepsin O2, a Matrix Protein-degrading Cysteine Protease Expressed in Osteoclasts

Brömme, D., Okamoto, K., Wang, B., & Biroc, S. L. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.4.2126 · Cited by 428 · see citing works

Regulation of Matrix Metalloproteinases (MMP-2, -3, -9, and -13) by Interleukin-1 and Interleukin-6 in Mouse Calvaria: Association of MMP Induction with Bone Resorption

Kusano, K., Miyaura, C., Inada, M., Tamura, T., Itô, A., Nagase, H., Kamoi, K., & Suda, T. (1998) · Endocrinology · doi:10.1210/endo.139.3.5818 · Cited by 385 · see citing works

Molecular Cloning of Human cDNA for Cathepsin K: Novel Cysteine Proteinase Predominantly Expressed in Bone

Inaoka, T., Bilbe, G., Ishibashi, O., Tezuka, K., Kumegawa, M., & Kokubo, T. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.1013 · Cited by 352 · see citing works

Cellular biology and biochemical mechanism of bone resorption. A review of recent developments on the formation, activation, and mode of action of osteoclasts.

Vaes, G. (1988) · PubMed · Cited by 346 · see citing works

Molecular cloning of a possible cysteine proteinase predominantly expressed in osteoclasts.

Tezuka, K., Tezuka, Y., Maejima, A., Sato, T., Nemoto, K., Kamioka, H., Hakeda, Y., & Kumegawa, M. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)42227-7 · Cited by 342 · see citing works

Localization of matrix metalloproteinase 9 (92-kilodalton gelatinase/type IV collagenase = gelatinase B) in osteoclasts: implications for bone resorption.

Okada, Y., Naka, K., Kawamura, K., Matsumoto, T., Nakanishi, I., Fujimoto, N., Sato, H., & Seiki, M. (1995) · PubMed · Cited by 303 · see citing works

Biology and Physiology of the Osteoclast

Rifkin, B. R. (1992) · Cited by 293 · see citing works

Degradation of collagen in the bone‐resorbing compartment underlying the osteoclast involves both cysteine‐proteinases and matrix metalloproteinases

Everts, V. E., Delaissé, J., Korper, W., Niehof, A., Vaes, G., & Beertsen, W. (1992) · Journal of Cellular Physiology · doi:10.1002/jcp.1041500202 · Cited by 286 · see citing works

High expression of 92-kD type IV collagenase (gelatinase B) in the osteoclast lineage during mouse development

Reponen, P., Sahlberg, C., Munaut, C., Thesleff, I., & Tryggvason, K. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.124.6.1091 · Cited by 279 · see citing works

Initiation of Osteoclast Bone Resorption by Interstitial Collagenase

Holliday, L. S., Welgus, H. G., Fliszar, C. J., Veith, G. M., Jeffrey, J. J., & Gluck, S. L. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.35.22053 · Cited by 249 · see citing works

Inhibition of osteolytic bone metastasis of breast cancer by combined treatment with the bisphosphonate ibandronate and tissue inhibitor of the matrix metalloproteinase-2.

Yoneda, T., Sasaki, A., Dunstan, C. R., Williams, P. J., Bauss, F., DeClerck, Y. A., & Mundy, G. R. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119435 · Cited by 247 · see citing works

Collagenase-3 (MMP-13) is expressed during human fetal ossification and re-expressed in postnatal bone remodeling and in rheumatoid arthritis.

Ståhle‐Bäckdahl, M., Sandstedt, B., Bruce, K., Lindahl, A. H., Jiménez, M., Vega, J. A., & López-Otı́n, C. (1997) · PubMed · Cited by 234 · see citing works

Bone cells predispose bone surfaces to resorption by exposure of mineral to osteoclastic contact

Chambers, T. J., & Fuller, K. (1985) · Journal of Cell Science · doi:10.1242/jcs.76.1.155 · Cited by 234 · see citing works

In vivo and in vitro evidence for the involvement of cysteine proteinases in bone resorption

Delaissé, J., Eeckhout, Y., & Vaes, G. (1984) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(84)90560-6 · Cited by 228 · see citing works

Dissociation between bone resorption and bone formation in osteopenic transgenic mice

Corral, D. A., Amling, M., Priemel, M., Loyer, E. M., Fuchs, S., Ducy, P. F., Baron, R., & Karsenty, G. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.23.13835 · Cited by 227 · see citing works

Matrix metalloproteinases are obligatory for the migration of preosteoclasts to the developing marrow cavity of primitive long bones

Blavier, L., & Delaissé, J. M. (1995) · Journal of Cell Science · doi:10.1242/jcs.108.12.3649 · Cited by 221 · see citing works

Identification of the membrane-type matrix metalloproteinase MT1-MMP in osteoclasts

Sato, T., Ovejero, M. D. C., Hou, P., Heegaard, A.-M., Kumegawa, M., Tækker Foged, N., & Delaissé, J.-M. (1997) · Journal of Cell Science · doi:10.1242/jcs.110.5.589 · Cited by 214 · see citing works

Bone resorption induced by parathyroid hormone is strikingly diminished in collagenase-resistant mutant mice

Zhao, W., Byrne, M. H., Boyce, B. F., & Krane, S. M. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5481 · Cited by 212 · see citing works

Localization of cathepsin K in human osteoclasts by in situ hybridization and immunohistochemistry

Littlewood-Evans, A. J., Kokubo, T., Ishibashi, O., Inaoka, T., Wlodarski, B., Gallagher, J. A., & Bilbe, G. (1997) · Bone · doi:10.1016/s8756-3282(96)00351-1 · Cited by 190 · see citing works

Peptide Aldehyde Inhibitors of Cathepsin K Inhibit Bone Resorption Both In Vitro and In Vivo

Votta, B. J., Levy, M. A., Badger, A. M., Bradbeer, J. N., Dodds, R. A., James, I. E., Thompson, S. K., Bossard, M. J., Carr, T. J., Connor, J. R., et al. (1997) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1997.12.9.1396 · Cited by 185 · see citing works

Hormonal Regulation of the Production of Collagenase and a Collagenase Inhibitor Activity by Rat Osteogenic Sarcoma Cells*

Partridge, N. C., Jeffrey, J. J., Ehlich, L. S., Teitelbaum, S. L., Fliszar, C. J., Welgus, H. G., & Kahn, A. J. (1987) · Endocrinology · doi:10.1210/endo-120-5-1956 · Cited by 184 · see citing works

Functional heterogeneity of osteoclasts: matrix metalloproteinases participate in osteoclastic resorption of calvarial bone but not in resorption of long bone

Everts, V. E., Korper, W., Jansen, D. C., Steinfort, J., Lammerse, I., Heera, S., Docherty, A. J. P., & Beertsen, W. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.10.1219 · Cited by 174 · see citing works

Matrix metalloproteinases and their inhibition in periodontal treatment.

RYAN, M. E., Ramamurthy, S., & Golub, L. M. (1996) · PubMed · Cited by 167 · see citing works

Identification of matrix metalloproteinase 9 in rabbit osteoclasts.

Tezuka, K., Nemoto, K., Tezuka, Y., Sato, T., Ikeda, Y., Kobori, M., Kawashima, H., Eguchi, H., Hakeda, Y., & Kumegawa, M. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36566-3 · Cited by 167 · see citing works

The effects of selective inhibitors of matrix metalloproteinases (MMPs) on bone resorption and the identification of MMPs and TIMP-1 in isolated osteoclasts

Hill, P. A., Murphy, G., Docherty, A., Hembry, R. M., Millican, T. A., Reynolds, J. J., & Meikle, M. C. (1994) · Journal of Cell Science · doi:10.1242/jcs.107.11.3055 · Cited by 164 · see citing works

Human osteoblasts in culture synthesize collagenase and other matrix metalloproteinases in response to osteotropic hormones and cytokines

Meikle, M. C., Bord, S., Hembry, R. M., Compston, J. E., Croucher, P. I., & Reynolds, J. J. (1992) · Journal of Cell Science · doi:10.1242/jcs.103.4.1093 · Cited by 155 · see citing works

Cathepsin K Antisense Oligodeoxynucleotide Inhibits Osteoclastic Bone Resorption

Inui, T., Ishibashi, O., Inaoka, T., Origane, Y., Kumegawa, M., Kokubo, T., & Yamamura, T. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.13.8109 · Cited by 151 · see citing works

Expression of interstitial collagenase during skeletal development of the mouse is restricted to osteoblast-like cells and hypertrophic chondrocytes.

Gack, S., Vallon, R., Schmidt, J., Grigoriadis, A. E., Tuckermann, J. P., Schenkel, J., Weiher, H., Wagner, E. F., & Angel, P. E. (1995) · PubMed · Cited by 150 · see citing works

Characterization of novel cathepsin K mutations in the pro and mature polypeptide regions causing pycnodysostosis

Hou, W.-S., Brömme, D., Zhao, Y., Mehler, E. L., Dushey, C., Weinstein, H., Sá-Miranda, C., Fraga, C., Greig, F., Carey, J. C., et al. (1999) · Journal of Clinical Investigation · doi:10.1172/jci653 · Cited by 149 · see citing works

Expression of 92 kD type IV collagenase/gelatinase B in human osteoclasts

Wucherpfennig, A. L., Li, Y.-P., Stetler‐Stevenson, W. G., Rosenberg, A. E., & Stashenko, P. (1994) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650090415 · Cited by 141 · see citing works

(Pro)collagenase (matrix metalloproteinase-1) is present in rodent osteoclasts and in the underlying bone-resorbing compartment

Delaissé, J., Eeckhout, Y., Neff, L., François-Gillet, C., Henriet, P., Su, Y., Vaes, G., & Baron, R. (1993) · Journal of Cell Science · doi:10.1242/jcs.106.4.1071 · Cited by 140 · see citing works

Phagocytosis of bone collagen by osteoclasts in two cases of pycnodysostosis

Everts, V. E., Aronson, D. C., & Beertsen, W. (1985) · Calcified Tissue International · doi:10.1007/bf02557674 · Cited by 136 · see citing works

Ricinoleic acid-based biopolymers

Teomim, D., Nyska, A., & Domb, A. J. (1999) · Journal of Biomedical Materials Research · doi:10.1002/(sici)1097-4636(19990605)45:3 · Cited by 135 · see citing works

Cysteine Proteinases and Matrix Metalloproteinases Play Distinct Roles in the Subosteoclastic Resorption Zone

Everts, V. E., Delaissé, J., Korper, W., & Beertsen, W. (1998) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1998.13.9.1420 · Cited by 134 · see citing works

Synthesis of collagenase and collagenase inhibitors by osteoblast-like cells in culture

Otsuka, K., Sodek, J., & Limeback, H. (1984) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1984.tb08530.x · Cited by 124 · see citing works

Design of potent and selective human cathepsin K inhibitors that span the active site

Thompson, S. K., Halbert, S. M., Bossard, M. J., Tomaszek, T. A., Levy, M. A., Zhao, B., Smith, W. W., Abdel‐Meguid, S. S., Janson, C. A., D'Alessio, K. J., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.26.14249 · Cited by 121 · see citing works

Inhibition of bone resorption in culture by inhibitors of thiol proteinases

Delaissé, J., Eeckhout, Y., & Vaes, G. (1980) · Biochemical Journal · doi:10.1042/bj1920365 · Cited by 119 · see citing works

Expression of metalloproteinases and tissue inhibitors of metalloproteinases in human osteoblast-like cells: differentiation is associated with repression of metalloproteinase biosynthesis

Rifas, L., Fausto, A., Scott, M. J., Avioli, L. V., & Welgus, H. G. (1994) · Endocrinology · doi:10.1210/endo.134.1.8275936 · Cited by 119 · see citing works

Inhibition of bone resrption by selctive inactivators of cysteine proteinases

Hill, P. A., Buttle, D. J., Jones, S. J., BOYDE, A., Murata, M., Reynolds, J. J., & Meikle, M. C. (1994) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240560116 · Cited by 115 · see citing works

Mouse cathepsin K: cDNA cloning and predominant expression of the gene in osteoclasts, and in some hypertrophying chondrocytes during mouse development

Rantakokko, J., Aro, H. T., Savontaus, M., & VUORIO, E. I. (1996) · FEBS Letters · doi:10.1016/0014-5793(96)00907-6 · Cited by 115 · see citing works

Bone-Resorbing Agents Affect the Production and Distribution of Procollagenase as well as the Activity of Collagenase in Bone Tissue*

Delaissé, J., Eeckhout, Y., & Vaes, G. (1988) · Endocrinology · doi:10.1210/endo-123-1-264 · Cited by 114 · see citing works

Treatment of lymphoid malignancies in patients with ataxia-telangiectasia

Sandoval, C., & Swift, M. (1998) · Medical and Pediatric Oncology · doi:10.1002/(sici)1096-911x(199812)31:6 · Cited by 109 · see citing works

Expression of membrane-type 1 matrix metalloproteinase and activation of progelatinase A in human osteoarthritic cartilage.

Imai, K., Ohta, S., Matsumoto, T., Fujimoto, N., Sato, H., Seiki, M., & Okada, Y. (1997) · Europe PMC (PubMed Central) · Cited by 107 · see citing works

Fluorescence Microscopic Demonstration of Cathepsin K Activity as the Major Lysosomal Cysteine Proteinase in Osteoclasts

Kamiya, T., Kobayashi, Y., Kanaoka, K., Nakashima, T., Kato, Y., Mizuno, A., & Sakai, H. (1998) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a022001 · Cited by 105 · see citing works

Retinoic acid directly stimulates osteoclastic bone resorption and gene expression of cathepsin K/OC-2

Saneshige, S., Mano, H., Tezuka, K., Kakudo, S., Mori, Y., Honda, Y., Itabashi, A., Yamada, T., Miyata, K., Hakeda, Y., et al. (1995) · Biochemical Journal · doi:10.1042/bj3090721 · Cited by 102 · see citing works

A new synthetic inhibitor of mammalian tissue collagenase inhibits bone resorption in culture

Delaissé, J., Eeckhout, Y., Sear, C. H. J., Galloway, A., McCullagh, K. G., & Vaes, G. (1985) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(85)90932-5 · Cited by 98 · see citing works

Effects of the proteinase inhibitors leupeptin and E-64 on osteoclastic bone resorption

Everts, V. E., Beertsen, W., & Schröder, R. (1988) · Calcified Tissue International · doi:10.1007/bf02571316 · Cited by 98 · see citing works

Mammalian Mature Osteoclasts as Estrogen Target Cells

Mano, H., Yuasa, T., Kameda, T., Miyazawa, K., Nakamaru, Y., Shiokawa, M., Mori, Y., Yamada, T., Miyata, K., Shindo, H., et al. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.0947 · Cited by 97 · see citing works

Localisation of mRNA for collagenase in osteocytic, bone surface and chondrocytic cells but not osteoclasts

Fuller, K., & Chambers, T. J. (1995) · Journal of Cell Science · doi:10.1242/jcs.108.6.2221 · Cited by 95 · see citing works

Multiple forms of gelatinases/type IV collagenases in saliva and gingival crevicular fluid of periodontitis patients

Ingman, T., Sorsa, T., Lindy, O., Koski, H., & Konttinen, Y. T. (1994) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.1994.tb00272.x · Cited by 93 · see citing works

Factors related to degradation of articular cartilagein osteoarthritis: a review

Tanaka, S., Hamanishi, C., Kikuchi, H., & Fukuda, K. (1998) · Seminars in Arthritis and Rheumatism · doi:10.1016/s0049-0172(98)80019-x · Cited by 93 · see citing works

Minocycline prevents the decrease in bone mineral density and trabecular bone in ovariectomized aged rats

Williams, S., Wakisaka, A., Zeng, Q., Barnes, J., Martin, G. R., Wechter, W. J., & Liang, C. T. (1996) · Bone · doi:10.1016/s8756-3282(96)00302-x · Cited by 91 · see citing works

Expression of matrix metalloproteinase 7 (matrilysin) in human osteoarthritic cartilage.

Ohta, S., Imai, K., Yamashita, K., Matsumoto, T., Azumano, I., & Okada, Y. (1998) · PubMed · Cited by 85 · see citing works

Matrix metalloproteinase 9 (gelatinase B) is expressed in multinucleated giant cells of human giant cell tumor of bone and is associated with vascular invasion.

Ueda, Y., Imai, K., Tsuchiya, H., Fujimoto, N., Nakanishi, I., Katsuda, S., Seiki, M., & Okada, Y. (1996) · Europe PMC (PubMed Central) · Cited by 84 · see citing works

Detection of gelatinase B expression reveals osteoclastic bone resorption as a feature of early calvarial bone development

Rice, D. P. C., Kim, H.-J., & Thesleff, I. (1997) · Bone · doi:10.1016/s8756-3282(97)00182-8 · Cited by 73 · see citing works

Anti-collagenolytic mechanism of action of doxycycline treatment in rheumatoid arthritis

Nordström, D., Lindy, O., Lauhio, A., Sorsa, T. A., Santavirta, S. S., & Konttinen, Y. T. (1998) · Rheumatology International · doi:10.1007/s002960050030 · Cited by 72 · see citing works

Active gelatinase B is identified by histozymography in the cartilage resorption sites of developing long bones

Lee, E. R., Murphy, G., Elalfy, M., Davoli, M. A., Lamplugh, L., Docherty, A., & Leblond, C. P. (1999) · Developmental Dynamics · doi:10.1002/(sici)1097-0177(199907)215:3 · Cited by 47 · see citing works

Production of matrix metalloproteinases 2 and 3 (stromelysin) by stromal cells of giant cell tumor of bone.

Sasaguri, Y., Komiya, S., Sugama, K., Suzuki, K., Inoue, A., Morimatsu, M., & Nagase, H. (1992) · PubMed Central · Cited by 47 · see citing works

Alendronate blocks metalloproteinase secretion and bone collagen I release by PC-3 ML cells in SCID mice

Stearns, M. E., & Wang, M. (1998) · Clinical & Experimental Metastasis · doi:10.1023/a:1006524610591 · Cited by 43 · see citing works

Effect of an Inhibitor of Matrix Metalloproteinases on Spontaneous Osteoarthritis in Guinea Pigs

de Bri, E., Lei, W., Svensson, O., Chowdhury, M. H., Moak, S. A., & Greenwald, R. A. (1998) · Advances in Dental Research · doi:10.1177/08959374980120012601 · Cited by 43 · see citing works

H-31 human breast cancer cells stimulate type I collagenase production in osteoblast-like cells and induce bone resorption

Ohishi, K., Fujita, N., Morinaga, Y., & Tsuruo, T. (1995) · Clinical & Experimental Metastasis · doi:10.1007/bf00133484 · Cited by 36 · see citing works

Membrane-type-1 matrix metalloproteinase is abundantly expressed in fibroblasts and osteoclasts at the bone-implant interface of aseptically loosened joint arthroplasties in situ.

Pap, T., Pap, G., Hummel, K. M., Franz, J. K., Jeisy, E., Sainsbury, I., Gay, R. E., Billingham, M., Neumann, W., & Gay, S. (1999) · PubMed · Cited by 36 · see citing works

Heterogeneity Among Cells That Express Osteoclast-Associated Genes in Developing Bone

Jemtland, R., Lee, K., & Segre, G. V. (1998) · Endocrinology · doi:10.1210/endo.139.1.5664 · Cited by 32 · see citing works

High levels of expression of collagenase-3 (MMP-13) in pathological conditions associated with a foreign-body reaction

Imai, S., Konttinen, Y. T., Jumppanen, M., Lindy, O., Čeponis, A., Kemppinen, P., Sorsa, T. A., Santavirta, S. S., Xu, J., & López-Otı́n, C. (1998) · Journal of Bone and Joint Surgery - British Volume · doi:10.1302/0301-620x.80b4.7952 · Cited by 32 · see citing works

Expression of Gelatinase A and Its Activator MT1-MMP in the Inflammatory Periprosthetic Response to Polyethylene

Nawrocki‐Raby, B., Polette, M., Burlet, H., Birembaut, P. L., & Adnet, J. (1999) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1999.14.2.288 · Cited by 30 · see citing works

Expression of metalloproteinases and tissue inhibitors of metalloproteinases in giant cell tumor of bone: An immunohistochemical study with clinical correlation

Schoedel, K. E., GRECO, M. A., Stetler‐Stevenson, W. G., Ohori, N. P., Goswami, S., Present, D. A., & Steiner, G. C. (1996) · Human Pathology · doi:10.1016/s0046-8177(96)90306-8 · Cited by 30 · see citing works

The membrane-type-matrix metalloproteinase/matrix metalloproteinase-2/tissue inhibitor of metalloproteinase-2 system in periprosthetic connective-tissue remodeling in loose total-hip prostheses.

Takagi, M., Santavirta, S. S., Ida, H., Ishii, M., Akimoto, K., Saotome, K., & Konttinen, Y. T. (1998) · PubMed · Cited by 28 · see citing works

Immunolocalization of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human chondrosarcomas.

Kawashima, A., Okada, Y., Nakanishi, I., Ueda, Y., Iwata, K., & Roessner, A. (1997) · PubMed · Cited by 25 · see citing works

Concanavalin A Directly Stimulates Bone-Resorbing Activity of Osteoclasts and Their Gene Expression of Cathepsin K/OC-2

Kakudo, S., Mano, H., Shiokawa, M., Mori, Y., Kumegawa, M., & Hakeda, Y. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6594 · Cited by 11 · see citing works

10. A collagenase inhibitor inhibits bone resorption in vivo, as evaluated by 3H-tetracycline retention in bones of prelabelled mice

Delaissé, J., Terlain, B. L., Cartwright, T., Lefebvre, V., & Vaes, G. (1991) · Bone · doi:10.1016/8756-3282(91)90087-y · Cited by 5 · see citing works

Untitled work

(1999) · doi:10.1002/1529-0131(199901)42:1

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Bolamperti, S., Villa, I., & Rubinacci, A. (2022) · Bone Research · doi:10.1038/s41413-022-00219-8 · Cited by 482 · see citing works

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Garnero, P., Ferreras, M., Karsdal, M. A., NicAmhlaoibh, R., Risteli, J., Borel, O., Qvist, P., Delmas, P. D., Foged, N., & Delaissé, J. (2003) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2003.18.5.859 · Cited by 472 · see citing works

Current developments in salivary diagnostics

Miller, C., Foley, J. D., Bailey, A., Campell, C. L., Humphries, R., Christodoulides, N., Floriano, P., Simmons, G. W., Bhagwandin, B., Jacobson, J. W., et al. (2010) · Biomarkers in Medicine · doi:10.2217/bmm.09.68 · Cited by 387 · see citing works

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Chen, W., Hoffmann, A. D., Liu, H., & Liu, X. (2018) · npj Precision Oncology · doi:10.1038/s41698-018-0047-0 · Cited by 393 · see citing works

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Linder, S., Wiesner, C., & Himmel, M. (2011) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-092910-154216 · Cited by 363 · see citing works

Salivary biomarkers of existing periodontal disease

Miller, C. S., King, C. P., Langub, M. C., Kryscio, R. J., & Thomas, M. V. (2006) · The Journal of the American Dental Association · doi:10.14219/jada.archive.2006.0181 · Cited by 362 · see citing works

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Delaissé, J., Andersen, T. L., Engsig, M. T., Henriksen, K., Troen, T., & Blavier, L. (2003) · Microscopy Research and Technique · doi:10.1002/jemt.10374 · Cited by 341 · see citing works

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YASUDA, Y., KALETA, J., & Brömme, D. (2005) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2004.12.013 · Cited by 301 · see citing works

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Gene expression profiling of plasma cells and plasmablasts: toward a better understanding of the late stages of B-cell differentiation

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Wu, X., Gan, B., Yoo, Y., & Guan, J. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.06.006 · Cited by 195 · see citing works

Cysteine proteases as disease markers

Berdowska, I. (2004) · Clinica Chimica Acta · doi:10.1016/j.cccn.2003.12.016 · Cited by 193 · see citing works

Biomarkers of periodontitis in oral fluids

Rai, B., Kharb, S., Jain, R., & Suresh, A. (2008) · Journal of Oral Science · doi:10.2334/josnusd.50.53 · Cited by 183 · see citing works

Invadosomes at a glance

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The molecular mechanism behind bone remodelling: a review

Proff, P., & Römer, P. (2009) · Clinical Oral Investigations · doi:10.1007/s00784-009-0268-2 · Cited by 172 · see citing works

A signalling cascade involving PKC, Src and Cdc42 regulates podosome assembly in cultured endothelial cells in response to phorbol ester

Tatin, F., Varon, C., Genot, E. M., & Moreau, V. (2006) · Journal of Cell Science · doi:10.1242/jcs.02787 · Cited by 172 · see citing works

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Transforming Growth Factor β Induces Rosettes of Podosomes in Primary Aortic Endothelial Cells

Varon, C., Tatin, F., Moreau, V., Obberghen‐Schilling, E. V., Fernandez-Sauze, S., Reuzeau, E., Kramer, I. M., & Genot, E. M. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.9.3582-3594.2006 · Cited by 162 · see citing works

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Stoch, S. A., Zajic, S. C., Stone, J. A., Miller, D., Dyck, K. V., Gutierrez, M. J., Decker, M., Liu, L., Liu, Q., Scott, B., et al. (2009) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2009.60 · Cited by 157 · see citing works

Tea Polyphenols Inhibit Rat Osteoclast Formation and Differentiation

Oka, Y., Iwai, S., Amano, H., Irie, Y., Yatomi, K., Ryu, K., Yamada, S., Inagaki, K., & Oguchi, K. (2011) · Journal of Pharmacological Sciences · doi:10.1254/jphs.11082fp · Cited by 153 · see citing works

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Logar, D. B., Komadina, R., Preželj, J., Ostanek, B., Trošt, Z., & Marc, J. (2007) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-007-0753-0 · Cited by 148 · see citing works

Formation and function of the ruffled border in osteoclasts

Stenbeck, G. (2002) · Seminars in Cell and Developmental Biology · doi:10.1016/s1084952102000587 · Cited by 133 · see citing works

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Fruits and dietary phytochemicals in bone protection

Shen, C., von Bergen, V., Chyu, M., Jenkins, M., Mo, H., Chen, C., & Kwun, I. (2012) · Nutrition Research · doi:10.1016/j.nutres.2012.09.018 · Cited by 119 · see citing works

X-ray Structure of Human proMMP-1

Jozic, D., Bourenkov, G. P., Lim, N. H., Visse, R., Nagase, H., Bode, W., & Maskos, K. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m411084200 · Cited by 117 · see citing works

Local invasiveness of ameloblastoma. Role played by matrix metalloproteinases and proliferative activity

Pinheiro, J. D. J. V., Freitas, V. M., Moretti, A. I. S., Jorge, A. G., & Jaeger, R. G. (2004) · Histopathology · doi:10.1111/j.1365-2559.2004.01902.x · Cited by 113 · see citing works

Podosomes in adhesion, migration, mechanosensing and matrix remodeling

Schachtner, H., Calaminus, S. D. J., Thomas, S. G., & Machesky, L. M. (2013) · Cytoskeleton · doi:10.1002/cm.21119 · Cited by 112 · see citing works

Podosomes in space

Wiesner, C., Cabec, V. L., Azzouzi, K. E., Maridonneau‐Parini, I., & Linder, S. (2014) · Cell Adhesion & Migration · doi:10.4161/cam.28116 · Cited by 102 · see citing works

Matrix metalloproteinases as master regulators of the vicious cycle of bone metastasis

Lynch, C. C. (2010) · Bone · doi:10.1016/j.bone.2010.06.007 · Cited by 99 · see citing works

MMP9 protects against LPS-induced inflammation in osteoblasts

Zhang, H., Liu, L., Jiang, C., Pan, K., Deng, J., & Wan, C. (2019) · Innate Immunity · doi:10.1177/1753425919887236 · Cited by 97 · see citing works

Erythropoietin Promotes Bone Formation through EphrinB2/EphB4 Signaling

Li, C., Shi, C., Kim, J., Chen, Y., Ni, S., Jiang, L., Zheng, C., Li, D., Hou, J., Taichman, R. S., et al. (2015) · Journal of Dental Research · doi:10.1177/0022034514566431 · Cited by 95 · see citing works

Evidence-based recommendations for monitoring bone disease and the response to enzyme replacement therapy in Gaucher patients

Dahl, S. V., Poll, L. W., Rocco, M. D., Ciana, G., Denes, C. L., Mariani, G., & Maas, M. M. (2006) · Current Medical Research and Opinion · doi:10.1185/030079906x104623 · Cited by 86 · see citing works

Matrix Metalloproteinases (MMPs) Safeguard Osteoblasts from Apoptosis during Transdifferentiation into Osteocytes: MT1-MMP Maintains Osteocyte Viability

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pH regulators in invadosomal functioning: Proton delivery for matrix tasting

Brisson, L., Reshkin, S. J., Goré, J., & Roger, S. (2012) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2012.04.004 · Cited by 82 · see citing works

Bone Metastasis of Breast Cancer: Molecular Mechanisms and Therapeutic Strategies

Pang, L., Chen, G., Xu, J. Y., Jia, Y., Chai, J., Huang, R., Li, A., Ge, H., Yu, S., & Cheng, H. (2022) · Cancers · doi:10.3390/cancers14235727 · Cited by 89 · see citing works

Anti–IL-20 Monoclonal Antibody Suppresses Breast Cancer Progression and Bone Osteolysis in Murine Models

Hsu, Y., Hsing, C., Li, C., Chan, C.-H., Chang, M.-C., Yan, J.-J., & Chang, M. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1102843 · Cited by 81 · see citing works

Increased cathepsin K and tartrate-resistant acid phosphatase expression in bone of streptozotocin-induced diabetic rats

Hie, M., Shimono, M., Fujii, K., & Tsukamoto, I. (2007) · Bone · doi:10.1016/j.bone.2007.08.030 · Cited by 79 · see citing works

Odanacatib, a selective cathepsin K inhibitor to treat osteoporosis: safety, tolerability, pharmacokinetics and pharmacodynamics – results from single oral dose studies in healthy volunteers

Stoch, S. A., Zajic, S. C., Stone, J. A., Miller, D. L., Bortel, L. V., Lasseter, K. C., Pramanik, B., Cilissen, C., Liu, Q., Liu, L., et al. (2012) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2012.04471.x · Cited by 78 · see citing works

Upregulation of matrix metalloproteinases (MMPs) in breast cancer xenografts: A major induction of stromal MMP‐13

Lafleur, M. A., Drew, A. F., de Sousa, E. L., Blick, T., Bills, M. M., Walker, E. C., Williams, E. D., Waltham, M. C., & Thompson, E. W. (2004) · International Journal of Cancer · doi:10.1002/ijc.20763 · Cited by 77 · see citing works

Thermo‐Reversible Green Tea Catechin Gel for Local Application in Chronic Periodontitis: A 4‐Week Clinical Trial

Chava, V. K., & Vedula, B. D. (2012) · Journal of Periodontology · doi:10.1902/jop.2012.120425 · Cited by 74 · see citing works

Actin polymerization modulates CD44 surface expression, MMP‐9 activation, and osteoclast function

Samanna, V., Ma, T., Mak, T. W., Rogers, M. J., & Chellaiah, M. A. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21137 · Cited by 71 · see citing works

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Liu, X., Wei, D., Zhong, J. Q., Ma, M., Zhou, J., Peng, X., Ye, Y., Sun, G., & He, D. (2015) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5b04868 · Cited by 69 · see citing works

Synthetic matrix metalloproteinase inhibitors inhibit growth of established breast cancer osteolytic lesions and prolong survival in mice.

Winding, B., NicAmhlaoibh, R., Misander, H., Høegh-Andersen, P., Andersen, T. L., Holst‐Hansen, C., Heegaard, A., Foged, N. T., Brünner, N., & Delaissé, J. (2002) · PubMed · Cited by 67 · see citing works

Effects of Matrix Metalloproteinase Inhibitors on Bone Resorption and Orthodontic Tooth Movement

Holliday, L. S., Vakani, A., Archer, L., & Dolce, C. (2003) · Journal of Dental Research · doi:10.1177/154405910308200906 · Cited by 63 · see citing works

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Geoffroy, V., Morieux, C., Legoupil, N., Clement-Lacroix, P., Terraz, C., Frain, M., Roux, S., Rossert, J., & de Vernejoul, M. C. (2004) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.040119 · Cited by 63 · see citing works

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Chellaiah, M. A. (2006) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2006.01.008 · Cited by 62 · see citing works

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Ishikawa, T., Nishigaki, F., Miyata, S., Hirayama, Y., Minoura, K., Imanishi, J., Neya, M., Mizutani, T., Imamura, Y., Naritomi, Y., et al. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706054 · Cited by 61 · see citing works

Cathepsin D is up-regulated in inflammatory bowel disease macrophages

Hausmann, M., Obermeier, F., Schreiter, K., Spöttl, T., Falk, W., Schölmerich, J., HERFARTH, H., Säftig, P., & Rogler, G. (2004) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2004.02420.x · Cited by 61 · see citing works

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Onodera, S., Sasaki, S., Ohshima, S., Amizuka, N., Li, M., Udagawa, N., Irie, K., Nishihira, J., Koyama, Y., Shiraishi, A., et al. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.060310 · Cited by 61 · see citing works

Osteoprotegerin differentially regulates protease expression in osteoclast cultures

Wittrant, Y., Couillaud, S., Théoleyre, S., Dunstan, C. R., Heymann, D., & Rédiní, F. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)00179-1 · Cited by 61 · see citing works

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Tsuboi, H., Matsui, Y., Hayashida, K., Yamane, S., Maeda-Tanimura, M., Nampei, A., Hashimoto, J., Suzuki, R., Yoshikawa, H., & Ochi, T. (2003) · Annals of the Rheumatic Diseases · doi:10.1136/ard.62.3.196 · Cited by 60 · see citing works

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Wittrant, Y., Théoleyre, S., Couillaud, S., Dunstan, C. R., Heymann, D., & Rédiní, F. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.09.084 · Cited by 59 · see citing works

Upregulation of matrix metalloproteinase (MMP)‐1 and its activator MMP‐3 of human osteoblast by uniaxial cyclic stimulation

Sasaki, K., Takagi, M., Konttinen, Y. T., Sasaki, A., Tamaki, Y., Ogino, T., Santavirta, S. S., & Salo, J. (2006) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.30622 · Cited by 59 · see citing works

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Thiolloy, S., Halpern, J. L., Holt, G. E., Schwartz, H. S., Mundy, G. R., Matrisian, L. M., & Lynch, C. C. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-3949 · Cited by 60 · see citing works

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Salari, P., Abdollahi, M. R., & Larijani, B. A. (2010) · Rheumatology International · doi:10.1007/s00296-010-1586-z · Cited by 55 · see citing works

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Tang, Q. O., Tran, G. T., Gamie, Z., Graham, S. M., Tsialogiannis, E., Tsiridis, E., Linder, T., & Tsiridis, E. E. (2008) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.17.10.1435 · Cited by 51 · see citing works

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Accorsi-Mendonça, T., Paiva, K. B. S., Zambuzzi, W. F., Cestari, T. M., Lara, V. S., Sogayar, M. C., Taga, R., & Granjeiro, J. M. (2007) · Journal of Molecular Histology · doi:10.1007/s10735-007-9152-z · Cited by 50 · see citing works

Simvastatin, an HMG-CoA Reductase Inhibitor, Reduced the Expression of Matrix Metalloproteinase-9 (Gelatinase B) in Osteoblastic Cells and HT1080 Fibrosarcoma Cells

Thunyakitpisal, P., & Chaisuparat, R. (2004) · Journal of Pharmacological Sciences · doi:10.1254/jphs.94.403 · Cited by 49 · see citing works

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MMP9 Deficiency Increased the Size of Experimentally Induced Apical Periodontitis

Wan, C., Yuan, G., Yang, J., Sun, Q., Zhang, L., Zhang, J., Zhang, L., & Chen, Z. (2014) · Journal of Endodontics · doi:10.1016/j.joen.2014.01.003 · Cited by 47 · see citing works

Characterization of the Bone Phenotype in ClC-7-Deficient Mice

Neutzsky-Wulff, A. V., Karsdal, M. A., & Henriksen, K. (2008) · Calcified Tissue International · doi:10.1007/s00223-008-9185-7 · Cited by 47 · see citing works

Cause and effect of microenvironmental acidosis on bone metastases

Avnet, S., Pompo, G. D., Lemma, S., & Baldini, N. (2019) · Cancer and Metastasis Reviews · doi:10.1007/s10555-019-09790-9 · Cited by 46 · see citing works

Significance of Circulating and Crevicular Matrix Metalloproteinase-9 in Rheumatoid Arthritis-Chronic Periodontitis Association

Siloşi, I., Cojocaru, M., Foia, L. G., Boldeanu, M. V., Petrescu, F., Șurlin, P., & Biciuşcă, V. (2015) · Journal of Immunology Research · doi:10.1155/2015/218060 · Cited by 45 · see citing works

Saurolactam inhibits osteoclast differentiation and stimulates apoptosis of mature osteoclasts

Kim, M. H., Ryu, S. Y., Choi, J. S., Min, Y. K., & Kim, S. H. (2009) · Journal of Cellular Physiology · doi:10.1002/jcp.21892 · Cited by 45 · see citing works

Expression analysis of matrix metalloproteinase-9 in epithelialized and nonepithelialized apical periodontitis lesions

Carneiro, E., Menezes, R., Garlet, G. P., Garcia, R. B., Bramante, C. M., Figueira, R., Sogayar, M. C., & Granjeiro, J. M. (2008) · Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology · doi:10.1016/j.tripleo.2008.07.030 · Cited by 45 · see citing works

Expression of Genes Associated with Bone Resorption is Increased and Bone Formation is Decreased in Mice Fed a High‐Fat Diet

Xiao, Y., Cui, J., Li, Y., Shi, Y., & Le, G. (2010) · Lipids · doi:10.1007/s11745-010-3397-0 · Cited by 44 · see citing works

MMP-9 and CD68+ cells are required for tissue remodeling in response to natural hydroxyapatite

Zambuzzi, W. F., Paiva, K. B. S., Menezes, R., de Oliveira, R. C., Taga, R., & Granjeiro, J. M. (2009) · Journal of Molecular Histology · doi:10.1007/s10735-009-9241-2 · Cited by 44 · see citing works

Morphologic evaluation and expression of matrix metalloproteinases-2 and 9 and nitric oxide during experimental periodontal disease in rat

Rodini, C. O., Batista, A. C., Dionísio, T. J., Santos, C. F., Cunha, F. Q., & Lara, V. S. (2008) · Journal of Molecular Histology · doi:10.1007/s10735-008-9163-4 · Cited by 43 · see citing works

Transmigration: A New Property of Mature Multinucleated Osteoclasts

Saltel, F., Chabadel, A., Zhao, Y., Lafage-Proust, M.-H., Clézardin, P., Jurdic, P., & Bonnelye, E. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.060821 · Cited by 41 · see citing works

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Everts, V. E., Jansen, I. D. C., & de Vries, T. J. (2022) · Bone · doi:10.1016/j.bone.2022.116499 · Cited by 46 · see citing works

Gelatinase B is associated with peri‐implant bone loss

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Levels of gingival crevicular metalloproteinases-8 and -9 in periodontitis

Rai, B., Kaur, J., Jain, R., & Suresh, A. (2010) · The Saudi Dental Journal · doi:10.1016/j.sdentj.2010.04.006 · Cited by 40 · see citing works

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Fuller, K., Kirstein, B., & Chambers, T. J. (2007) · Clinical Science · doi:10.1042/cs20060274 · Cited by 40 · see citing works

Family C1 Cysteine Proteases: Biological Diversity or Redundancy?

Nägler, D. K., & Menard, R. (2003) · Biological Chemistry · doi:10.1515/bc.2003.094 · Cited by 40 · see citing works

An Osteoblast-Derived Proteinase Controls Tumor Cell Survival via TGF-beta Activation in the Bone Microenvironment

Thiolloy, S., Edwards, J., Fingleton, B., Rifkin, D. B., Matrisian, L. M., & Lynch, C. C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0029862 · Cited by 39 · see citing works

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Amiable, N., Tat, S. K., Lajeunesse, D., Duval, N., Pelletier, J., Martel‐Pelletier, J., & Boileau, C. (2009) · Bone · doi:10.1016/j.bone.2009.02.015 · Cited by 39 · see citing works

Association between bacteria occurring in the apical canal system and expression of bone‐resorbing mediators and matrix metalloproteinases in apical periodontitis

Takahama, A., Rôças, I. N., Faustino, I. S. P., Alves, F. R. F., Azevedo, R. S., Gomes, C. C., Araújo‐Filho, W. R., & Siqueira, J. F., Jr. (2018) · International Endodontic Journal · doi:10.1111/iej.12895 · Cited by 38 · see citing works

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Bañón‐Rodríguez, I., Monypenny, J., Ragazzini, C., Franco, A. C. G., Calle, Y., Jones, G. E., & Anton, I. M. (2010) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2010.09.001 · Cited by 38 · see citing works

Interactions of myeloma cells with osteoclasts promote tumour expansion and bone degradation through activation of a complex signalling network and upregulation of cathepsin K, matrix metalloproteinases (MMPs) and urokinase plasminogen activator (uPA)

Hecht, M., von Metzler, I., Sack, K., Kaiser, M., & Sezer, O. (2007) · Experimental Cell Research · doi:10.1016/j.yexcr.2007.10.021 · Cited by 38 · see citing works

Immunohistochemical expression of MMPs 1, 7, and 26 in syndrome and nonsyndrome odontogenic keratocysts

Cavalcante, R. B., Pereira, K. M. A., Nonaka, C. F. W., Nogueira, R. L. M., & de Souza, L. B. (2008) · Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology · doi:10.1016/j.tripleo.2007.12.028 · Cited by 38 · see citing works

Focal Adhesion Kinases in Adhesion Structures and Disease

Eleniste, P. P., & Bruzzaniti, A. (2012) · Journal of Signal Transduction · doi:10.1155/2012/296450 · Cited by 37 · see citing works

Effect of a Cleavage-Resistant Collagen Mutation on Left Ventricular Remodeling

Lindsey, M. L., Yoshioka, J., MacGillivray, C., Muangman, S., Gannon, J., Verghese, A., Aikawa, M., Libby, P., Krane, S. M., & Lee, R. T. (2003) · Circulation Research · doi:10.1161/01.res.0000085580.45279.60 · Cited by 36 · see citing works

DNA Methylation of MMP9 Is Associated with High Levels of MMP-9 Messenger RNA in Periapical Inflammatory Lesions

Campos, K., Gomes, C. C., Farias, L. C., Silva, R. M., Letra, A., & Gomez, R. S. (2015) · Journal of Endodontics · doi:10.1016/j.joen.2015.10.002 · Cited by 35 · see citing works

MMP2 and MMP9 are Associated with Apical Periodontitis Progression and Might be Modulated by TLR2 and MyD88

Barreiros, D., Nelson‐Filho, P., Paula‐Silva, F. W. G., de Oliveira, K. M. H., Lucisano, M. P., ROSSI, A. D., da Silva, L. A. B., Küchler, É. C., & da Silva, R. A. B. (2017) · Brazilian Dental Journal · doi:10.1590/0103-6440201801731 · Cited by 35 · see citing works

Low-molecular weight fucoidan inhibits the differentiation of osteoclasts and reduces osteoporosis in ovariectomized rats

Jin, X., Zhu, L., Li, X., Jia, J., Zhang, Y., Sun, X., Ma, J., Liu, Z., & Ma, X. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.6062 · Cited by 34 · see citing works

Rosmarinic acid and arbutin suppress osteoclast differentiation by inhibiting superoxide and NFATc1 downregulation in RAW 264.7 cells

Omori, A., Yoshimura, Y., Deyama, Y., & Suzuki, K. (2015) · Biomedical Reports · doi:10.3892/br.2015.452 · Cited by 31 · see citing works

Prostate cancer mediates osteoclastogenesis through two different pathways

Inoue, H., Nishimura, K., Oka, D., Nakai, Y., Shiba, M., Tokizane, T., Arai, Y., Nakayama, M., Shimizu, K., Takaha, N., et al. (2004) · Cancer Letters · doi:10.1016/j.canlet.2004.09.053 · Cited by 31 · see citing works

Intracellular co-localization of trypsin-2 and matrix metalloprotease-9: Possible proteolytic cascade of trypsin-2, MMP-9 and enterokinase in carcinoma

Vilén, S., Nyberg, P., Hukkanen, M., Sutinen, M., Ylipalosaari, M., Bjartell, A. S., Paju, A., Haaparanta, V., Stenman, U., Sorsa, T. A., et al. (2007) · Experimental Cell Research · doi:10.1016/j.yexcr.2007.10.025 · Cited by 30 · see citing works

Expression of matrix metalloproteinase-9 mRNA and protein during deciduous tooth resorption in bovine odontoclasts

Linsuwanont, B., Takagi, Y., Ohya, K., & Shimokawa, H. (2002) · Bone · doi:10.1016/s8756-3282(02)00856-6 · Cited by 30 · see citing works

Kinsenoside prevents ovariectomy-induced bone loss and suppresses osteoclastogenesis by regulating classical NF-κB pathways

Hsiao, H.-B., Lin, H., Wu, J.-B., & Lin, W. (2012) · Osteoporosis International · doi:10.1007/s00198-012-2199-z · Cited by 29 · see citing works

The zymographic evaluation of gelatinase (MMP-2 and -9) levels in acute and chronic periapical abscesses

Buzoğlu, H. D., Ünal, H., Ülger, C., Mert, S., Küçükyıldırım, S., & Er, N. (2009) · Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology · doi:10.1016/j.tripleo.2009.07.014 · Cited by 29 · see citing works

The influence of surface modified poly( l -lactic acid) films on the differentiation of human monocytes into macrophages

Correia, C. R., Gaifem, J., Oliveira, M. B., Silvestre, R., & Mano, J. F. (2017) · Biomaterials Science · doi:10.1039/c6bm00920d · Cited by 28 · see citing works

Matrix Degradation in Osteoclastic Bone Resorption Under Pathological Conditions

Okada, Y. (1999) · Springer eBooks · doi:10.1007/978-4-431-68529-6_2

The Collagenolytic Activity of Cathepsin K Is Unique among Mammalian Proteinases

Garnero, P., Borel, O., Byrjalsen, I., Ferreras, M., Drake, F. H., McQueney, M. S., Foged, N. T., Delmas, P. D., & Delaissé, J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.48.32347 · Cited by 647 · see citing works

Osteoclastic Bone Degradation and the Role of Different Cysteine Proteinases and Matrix Metalloproteinases: Differences Between Calvaria and Long Bone

Everts, V. E., Korper, W., Hoeben, K. A., Jansen, I. D. C., Brömme, D., Cleutjens, K. B. J. M., Heeneman, S., Peters, C., Reinheckel, T., Säftig, P., et al. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.060614 · Cited by 183 · see citing works

Recent Insights into Mechanism of Bone Remodeling : Crucial Involvement of Cathepsin K in Bone Resorption

山村, 堯. (1999)

Matrix metalloproteinases (MMP) and cathepsin K contribute differently to osteoclastic activities

Delaissé, J., Andersen, T. L., Engsig, M. T., Henriksen, K., Troen, T., & Blavier, L. (2003) · Microscopy Research and Technique · doi:10.1002/jemt.10374 · Cited by 341 · see citing works