Dissociation of Bone Resorption and Bone Formation in Adult Mice with a Non-Functional V-ATPase in Osteoclasts Leads to Increased Bone Strength
Open accessAbstract
Osteopetrosis caused by defective acid secretion by the osteoclast, is characterized by defective bone resorption, increased osteoclast numbers, while bone formation is normal or increased. In contrast the bones are of poor quality, despite this uncoupling of formation from resorption.To shed light on the effect of uncoupling in adult mice with respect to bone strength, we transplanted irradiated three-month old normal mice with hematopoietic stem cells from control or oc/oc mice, which have defective acid secretion, and followed them for 12 to 28 weeks.Engraftment levels were assessed by flow cytometry of peripheral blood. Serum samples were collected every six weeks for measurement of bone turnover markers. At termination bones were collected for µCT and mechanical testing. An engraftment level of 98% was obtained. From week 6 until termination bone resorption was significantly reduced, while the osteoclast number was increased when comparing oc/oc to controls. Bone formation was elevated at week 6, normalized at week 12, and reduced onwards. µCT and mechanical analyses of femurs and vertebrae showed increased bone volume and bone strength of cortical and trabecular bone.In conclusion, these data show that attenuation of acid secretion in adult mice leads to uncoupling and improves bone strength.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In models of osteoclast-rich osteopetrosis, bone formation is maintained or enhanced despite impairment of resorption activity, providing evidence that nonresorbing osteoclasts promote or maintain bone formation.
“In fact, in models of osteoclast-rich OPT, bone formation is maintained or enhanced despite the impairment of resorption activity,224 thus providing evidence that nonresorbing osteoclasts promote/maintain bone formation.”
From Bone remodeling: an operational process ensuring survival and bone mechanical competence (2022) · cites this paper as [224]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
PARFITT, A. M., Drezner, M. K., Glorieux, F. H., Kanis, J. А., Malluche, H. H., Meunier, P. J., Ott, S. M., & Recker, R. R. (1987) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650020617 · Cited by 5,015 · see citing works
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph node organogenesis.
Kong, Y.-Y., Yoshida, H., Sarosi, I., Tan, H.-L., Timms, E., Capparelli, C., Morony, S., Oliveira-dos-Santos, A. J., Van, G., Itie, A., et al. (1999) · Nature · doi:10.1038/16852 · Cited by 3,351 · see citing works
Bone Histomorphometry : Standardization of Nomenclature, Symbols, and Units
PARFITT, A. M., Drezner, M. K., Glorieux, F. H., Kanis, J. А., Malluche, H. H., Meunier, P. J., Ott, S. M., & Recker, R. R. (1987) · Journal of Bone and Mineral Research · Cited by 3,258 · see citing works
Bone Quality — The Material and Structural Basis of Bone Strength and Fragility
Seeman, E., & Delmas, P. D. (2006) · New England Journal of Medicine · doi:10.1056/nejmra053077 · Cited by 2,108 · see citing works
Li, J., Sarosi, I., Yan, X.-Q., Morony, S., Capparelli, C., Tan, H.-L., McCabe, S., Elliott, R., Scully, S., Van, G., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.4.1566 · Cited by 1,119 · see citing works
Loss of the ClC-7 Chloride Channel Leads to Osteopetrosis in Mice and Man
Kornak, U., Kasper, D., Bösl, M. R., Kaiser, E., Schweizer, M., Schulz, A., Friedrich, W., Delling, G., & Jentsch, T. J. (2001) · Cell · doi:10.1016/s0092-8674(01)00206-9 · Cited by 995 · see citing works
Bidirectional ephrinB2-EphB4 signaling controls bone homeostasis
Zhao, C., Irie, N., Takada, Y., Shimoda, K., Miyamoto, T., Nishiwaki, T., Suda, T., & Matsuo, K. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.05.012 · Cited by 777 · see citing works
Osteoclasts: What Do They Do and How Do They Do It?
Teitelbaum, S. L. (2007) · The American Journal of Pathology · doi:10.2353/ajpath.2007.060834 · Cited by 730 · see citing works
Frattini, A., Orchard, P. J., Sobacchi, C., Giliani, S. C., Abinun, M., Mattsson, J. P., Keeling, D. J., Andersson, A., Wallbrandt, P., Zecca, L., et al. (2000) · Nature Genetics · doi:10.1038/77131 · Cited by 669 · see citing works
Osteoclast-derived activity in the coupling of bone formation to resorption
Martin, T. J., & Sims, N. A. (2005) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2004.12.004 · Cited by 659 · see citing works
Self-citationPederson, L., Ruan, M., Westendorf, J. J., Khosla, S., & Oursler, M. J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805133106 · Cited by 556 · see citing works
Tolar, J., Teitelbaum, S. L., & Orchard, P. J. (2004) · New England Journal of Medicine · doi:10.1056/nejmra040952 · Cited by 496 · see citing works
Gowen, M., Lazner, F., Dodds, R. A., Kapadia, R. D., Feild, J. A., Tavaria, M. D., Bertoncello, I., Drake, F. H., Zavarselk, S., Tellis, I., et al. (1999) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1999.14.10.1654 · Cited by 491 · see citing works
Li, Y., Chen, W., Liang, Y., Li, E., & Stashenko, P. (1999) · Nature Genetics · doi:10.1038/70563 · Cited by 467 · see citing works
The Cl-/H+ antiporter ClC-7 is the primary chloride permeation pathway in lysosomes
Graves, A. R., Curran, P. K., Smith, C. L., & Mindell, J. A. (2008) · Nature · doi:10.1038/nature06907 · Cited by 399 · see citing works
Osteoclast-poor human osteopetrosis due to mutations in the gene encoding RANKL
Sobacchi, C., Frattini, A., Guerrini, M. M., Abinun, M., Pangrazio, A., Susani, L., Bredius, R. G. M., Mancini, G. M. S., Cant, A. J., Bishop, N. J., et al. (2007) · Nature Genetics · doi:10.1038/ng2076 · Cited by 389 · see citing works
Bone Resorption Restored in Osteopetrotic Mice by Transplants of Normal Bone Marrow and Spleen Cells
Walker, D. G. (1975) · Science · doi:10.1126/science.1105786 · Cited by 346 · see citing works
Mutations in the a3 subunit of the vacuolar H+-ATPase cause infantile malignant osteopetrosis
Kornak, U. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.13.2059 · Cited by 343 · see citing works
Human Osteoclast-Poor Osteopetrosis with Hypogammaglobulinemia due to TNFRSF11A (RANK) Mutations
Guerrini, M. M., Sobacchi, C., Cassani, B., Abinun, M., Kilic, S. S., Pangrazio, A., Moratto, D., Mazzolari, E., Clayton-Smith, J., Orchard, P., et al. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2008.06.015 · Cited by 309 · see citing works
Genetics, pathogenesis and complications of osteopetrosis
Fattore, A. D., Cappariello, A., & Teti, A. M. (2007) · Bone · doi:10.1016/j.bone.2007.08.029 · Cited by 284 · see citing works
Local communication on and within bone controls bone remodeling
Henriksen, K., Neutzsky-Wulff, A. V., Bonewald, L. F., & Karsdal, M. A. (2009) · Bone · doi:10.1016/j.bone.2009.03.671 · Cited by 284 · see citing works
Self-citationHoward, G. A., Bottemiller, B. L., Turner, R. T., Rader, J. I., & Baylink, D. J. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.5.3204 · Cited by 266 · see citing works
Bone homeostasis in growth hormone receptor–null mice is restored by IGF-I but independent of Stat5
Sims, N. A., Clément-Lacroix, P., Ponte, F. D., Bouali, Y., Binart, N., Moriggl, R., Goffin, V., Coschigano, K. T., Gaillard-Kelly, M., Kopchick, J. J., et al. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10753 · Cited by 249 · see citing works
Self-citationAre Nonresorbing Osteoclasts Sources of Bone Anabolic Activity?
Karsdal, M. A., Martin, T. J., Bollerslev, J., Christiansen, C., & Henriksen, K. (2007) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.070109 · Cited by 242 · see citing works
Self-citationWalker, D. G. (1975) · The Journal of Experimental Medicine · doi:10.1084/jem.142.3.651 · Cited by 241 · see citing works
Henriksen, K., Bollerslev, J., Everts, V. E., & Karsdal, M. A. (2011) · Endocrine Reviews · doi:10.1210/er.2010-0006 · Cited by 230 · see citing works
Self-citationChavassieux, P., Seeman, E., & Delmas, P. D. (2006) · Endocrine Reviews · doi:10.1210/er.2006-0029 · Cited by 217 · see citing works
Scimeca, J., Franchi, A. J., Trojani, C., Parrinello, H., Grosgeorge, J., Robert, C., Jaillon, O., Poirier, C., Gaudray, P., & Carle, G. F. (2000) · Bone · doi:10.1016/s8756-3282(99)00278-1 · Cited by 204 · see citing works
Impaired gastric acidification negatively affects calcium homeostasis and bone mass
Schinke, T., Schilling, A. F., Baranowsky, A., Seitz, S. A., Marshall, R. P., Linn, T., Blaeker, M., Huebner, A. K., Schulz, A., Simon, R., et al. (2009) · Nature Medicine · doi:10.1038/nm.1963 · Cited by 203 · see citing works
Fattore, A. D., Peruzzi, B., Rucci, N., Recchia, I., Cappariello, A., Longo, M., Fortunati, D., Ballanti, P., Iacobini, M., Luciani, M., et al. (2005) · Journal of Medical Genetics · doi:10.1136/jmg.2005.036673 · Cited by 181 · see citing works
Kiviranta, R., Morko, J. P., Alatalo, S. L., NicAmhlaoibh, R., Risteli, J., Laitala‐Leinonen, T., & VUORIO, E. I. (2004) · Bone · doi:10.1016/j.bone.2004.09.020 · Cited by 169 · see citing works
Karsdal, M. A., Henriksen, K., Sørensen, M. G., Gram, J., Schaller, S., Dziegiel, M. H., Heegaard, A., Christophersen, P., Martin, T. J., Christiansen, C., et al. (2005) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)62269-9 · Cited by 155 · see citing works
Self-citationWaguespack, S. G., Hui, S. L., DiMeglio, L. A., & Econs, M. J. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1986 · Cited by 154 · see citing works
Schaller, S., Henriksen, K., Sveigaard, C., Heegaard, A., Hélix, N., Stahlhut, M., Ovejero, M. D. C., Johansen, J. V., Solberg, H., Andersen, T. L., et al. (2004) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.040302 · Cited by 147 · see citing works
Self-citationRissanen, J. P., Suominen, M. I., Peng, Z., & Halleen, J. M. (2007) · Calcified Tissue International · doi:10.1007/s00223-007-9091-4 · Cited by 147 · see citing works
Bone density, strength, and formation in adult cathepsin K (−/−) mice
Pennypacker, B. L., Shea, M., Liu, Q., Masarachia, P. J., Säftig, P., Rodan, S. B., Rodan, G. A., & Kimmel, D. B. (2008) · Bone · doi:10.1016/j.bone.2008.08.130 · Cited by 146 · see citing works
Henriksen, K., Tankó, L. B., Qvist, P., Delmas, P. D., Christiansen, C., & Karsdal, M. A. (2006) · Osteoporosis International · doi:10.1007/s00198-006-0286-8 · Cited by 138 · see citing works
Self-citationSpleen Cells Transmit Osteopetrosis in Mice
Walker, D. G. (1975) · Science · doi:10.1126/science.1198094 · Cited by 129 · see citing works
Advances in osteoclast biology resulting from the study of osteopetrotic mutations
Segovia‐Silvestre, T., Neutzsky-Wulff, A. V., Sørensen, M. G., Christiansen, C., Bollerslev, J., Karsdal, M. A., & Henriksen, K. (2008) · Human Genetics · doi:10.1007/s00439-008-0583-8 · Cited by 127 · see citing works
Self-citationHenriksen, K., Gram, J., Schaller, S., Dahl, B. H., Dziegiel, M. H., Bollerslev, J., & Karsdal, M. A. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63712-1 · Cited by 124 · see citing works
Self-citationAlatalo, S. L., Ivaska, K. K., Waguespack, S. G., Econs, M. J., Väänänen, H. K., & Halleen, J. M. (2004) · Clinical Chemistry · doi:10.1373/clinchem.2003.029355 · Cited by 118 · see citing works
Sørensen, M. G., Henriksen, K., Neutzsky-Wulff, A. V., Dziegiel, M. H., & Karsdal, M. A. (2007) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.070613 · Cited by 118 · see citing works
Self-citationCathepsin K inhibitors prevent matrix-derived growth factor degradation by human osteoclasts
Fuller, K., Lawrence, K. M., Ross, J. L., Grabowska, U. B., Shiroo, M., Samuelsson, B., & Chambers, T. J. (2007) · Bone · doi:10.1016/j.bone.2007.09.044 · Cited by 115 · see citing works
Cells of the Osteoclast Lineage as Mediators of the Anabolic Actions of Parathyroid Hormone in Bone
Koh, A. J., Demiralp, B., Neiva, K. G., Hooten, J. N., Nohutçu, R. M., Shim, H., Datta, N. S., Taichman, R. S., & McCauley, L. K. (2005) · Endocrinology · doi:10.1210/en.2005-0333 · Cited by 114 · see citing works
Osteoclasts secrete non-bone derived signals that induce bone formation
Karsdal, M. A., Neutzsky-Wulff, A. V., Dziegiel, M. H., Christiansen, C., & Henriksen, K. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.11.168 · Cited by 112 · see citing works
Self-citationBollerslev, J. (1989) · Endocrine Reviews · doi:10.1210/edrv-10-1-45 · Cited by 112 · see citing works
Anabolic Actions of Parathyroid Hormone during Bone Growth Are Dependent on c-fos
Demiralp, B., Chen, H.-L., Koh, A. J., Keller, E. T., & McCauley, L. K. (2002) · Endocrinology · doi:10.1210/en.2002-220221 · Cited by 112 · see citing works
Genotype-Phenotype Relationship in Human ATP6i-Dependent Autosomal Recessive Osteopetrosis
Taranta, A., Migliaccio, S., Recchia, I., Caniglia, M., Luciani, M., Rossi, G., Dionisi‐Vici, C., Pinto, R. M., Francalanci, P., Boldrini, R., et al. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63798-4 · Cited by 106 · see citing works
Dai, X.-M., Zong, X.-H., Akhter, M. P., & Stanley, E. R. (2004) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.040514 · Cited by 105 · see citing works
Effects of tissue preservation on murine bone mechanical properties
Nazarian, A., Hermannsson, B. J., Muller, J. A., Zurakowski, D., & Snyder, B. D. (2008) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2008.09.037 · Cited by 89 · see citing works
Bollerslev, J., Marks, S. C., Pockwinse, S. M., Kassem, M. S., Brixen, K., Steiniche, T., & Mosekilde, L. (1993) · Bone · doi:10.1016/8756-3282(93)90316-3 · Cited by 72 · see citing works
Hematological defects in the oc/oc mouse, a model of infantile malignant osteopetrosis
Blin‐Wakkach, C., Wakkach, A., Sexton, P. M., Rochet, N., & Carle, G. F. (2004) · Leukemia · doi:10.1038/sj.leu.2403449 · Cited by 71 · see citing works
Is bone quality associated with collagen age?
Leeming, D. J., Henriksen, K., Byrjalsen, I., Qvist, P., Madsen, S. H., Garnero, P., & Karsdal, M. A. (2009) · Osteoporosis International · doi:10.1007/s00198-009-0904-3 · Cited by 68 · see citing works
Self-citationAe2 a,b ‐Deficient mice exhibit osteopetrosis of long bones but not of calvaria
Jansen, I. D. C., Mardones, P., Lecanda, F., de Vries, T. J., Recalde, S., Hoeben, K. A., Schoenmaker, T., Ravesloot, J., van Borren, M. M. G. J., van Eijden, T. M. G. J., et al. (2009) · The FASEB Journal · doi:10.1096/fj.08-122598 · Cited by 66 · see citing works
Self-citationXu, J., Cheng, T., Feng, H., Pavlos, N. J., & Zheng, M. (2007) · PubMed · doi:10.14670/hh-22.443 · Cited by 65 · see citing works
Mosekilde, L., Thomsen, J. S., Orhii, P. B., McCarter, R., Mejía, W., & Kalu, D. N. (1999) · Bone · doi:10.1016/s8756-3282(98)00169-0 · Cited by 62 · see citing works
Self-citationJohansson, M. K., de Vries, T. J., Schoenmaker, T., Ehinger, M., Brun, A. C. M., Fasth, A. L., Karlsson, S., Everts, V. E., & Richter, J. (2007) · Blood · doi:10.1182/blood-2006-12-061382 · Cited by 49 · see citing works
Self-citationCharacterization of the Bone Phenotype in ClC-7-Deficient Mice
Neutzsky-Wulff, A. V., Karsdal, M. A., & Henriksen, K. (2008) · Calcified Tissue International · doi:10.1007/s00223-008-9185-7 · Cited by 47 · see citing works
Self-citationSamadfam, R., Xia, Q., & Goltzman, D. (2007) · Endocrinology · doi:10.1210/en.2006-1475 · Cited by 43 · see citing works
Waguespack, S. G., Hui, S. L., White, K. E., Buckwalter, K. A., & Econs, M. J. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.5.8497 · Cited by 43 · see citing works
Severe developmental bone phenotype in ClC-7 deficient mice
Neutzsky-Wulff, A. V., Sims, N. A., Supanchart, C., Kornak, U., Felsenberg, D., Poulton, I. J., Martin, T. J., Karsdal, M. A., & Henriksen, K. (2010) · Developmental Biology · doi:10.1016/j.ydbio.2010.06.018 · Cited by 39 · see citing works
Self-citationRESORPTION PRECEDES FORMATIVE ACTIVITY.
Takahashi, H., Epker, B. N., & Frost, H. M. (1964) · PubMed · Cited by 37 · see citing works
The vacuolar ATPase in bone cells: a potential therapeutic target in osteoporosis
Yuan, F., Li, X., Lü, W., Li, C.-W., Li, J.-P., & Wang, Y. (2010) · Molecular Biology Reports · doi:10.1007/s11033-010-0004-7 · Cited by 32 · see citing works
Nielsen, R. H., Karsdal, M. A., Sørensen, M. G., Dziegiel, M. H., & Henriksen, K. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.06.145 · Cited by 29 · see citing works
Self-citationElevated serum levels of creatine kinase BB in autosomal dominant osteopetrosis type II
Gram, J., Antonsen, S., Hørder, M., & Bollerslev, J. (1991) · Calcified Tissue International · doi:10.1007/bf02556458 · Cited by 25 · see citing works
Fetal Liver Cells Transplanted in Utero Rescue the Osteopetrotic Phenotype in the oc/oc Mouse
Tondelli, B., Blair, H. C., Guerrini, M. M., Patrene, K. D., Cassani, B., Vezzoni, P., & Lucchini, F. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.080688 · Cited by 24 · see citing works
Askmyr, M., Holmberg, J., Flores, C., Ehinger, M., Hjalt, T. Å. H., & Richter, J. (2008) · Experimental Hematology · doi:10.1016/j.exphem.2008.10.010 · Cited by 13 · see citing works
Self-citationWiktor-Jędrzejczak, W., Szczylik, C. A., Ratajczak, M. Z., & Ahmed, A. A. (1986) · PubMed · Cited by 8 · see citing works
Scott, K. R., Pennypacker, B. L., Cusick, T. E., Duong⁎, L. T., & Kimmel, D. B. (2009) · Bone · doi:10.1016/j.bone.2009.03.386 · Cited by 7 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [51]Neutzsky-Wulff AV Karsdal MA Henriksen K 2008 Characterization of the bone phenotype in ClC-7-deficient mice. Calcif Tissue Int 83 425 437 18958510
Cited by
Sorted by citations
Osteopetrosis: genetics, treatment and new insights into osteoclast function
Sobacchi, C., Schulz, A., Coxon, F. P., Villa, A., & Helfrich, M. H. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.137 · Cited by 580 · see citing works
Bone remodeling: an operational process ensuring survival and bone mechanical competence
Bolamperti, S., Villa, I., & Rubinacci, A. (2022) · Bone Research · doi:10.1038/s41413-022-00219-8 · Cited by 482 · see citing works
Osteoclasts Provide Coupling Signals to Osteoblast Lineage Cells Through Multiple Mechanisms
Sims, N. A., & Martin, T. J. (2020) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021119-034425 · Cited by 286 · see citing works
Self-citationRani, A., Devi, P., Jha, U. C., Sharma, K. D., Siddique, K. H. M., & Nayyar, H. (2020) · Frontiers in Plant Science · doi:10.3389/fpls.2019.01759 · Cited by 232 · see citing works
Karsdal, M. A., Bay‐Jensen, A., Lories, R. J. U., Abramson, S. B., Spector, T. D., Pastoureau, P., Christiansen, C., Attur, M. G., Henriksen, K., Goldring, S. R., et al. (2013) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2013-204111 · Cited by 202 · see citing works
Self-citationOsteoclast-Derived Coupling Factors in Bone Remodeling
Henriksen, K., Karsdal, M. A., & Martin, T. J. (2013) · Calcified Tissue International · doi:10.1007/s00223-013-9741-7 · Cited by 145 · see citing works
Self-citationAquatic Ecotoxicity of Microplastics and Nanoplastics: Lessons Learned from Engineered Nanomaterials
Rist, S., & Hartmann, N. B. (2017) · The handbook of environmental chemistry · doi:10.1007/978-3-319-61615-5_2 · Cited by 131 · see citing works
Sims, N. A., & Vrahnas, C. (2014) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2014.05.015 · Cited by 123 · see citing works
Self-citationWeivoda, M. M., Ruan, M. M., Pederson, L. G., Hachfeld, C. M., Davey, R. A., Zajac, J. D., Westendorf, J. J., Khosla, S., & Oursler, M. J. (2015) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2586 · Cited by 83 · see citing works
Genetics in Endocrinology: Autosomal dominant osteopetrosis revisited: lessons from recent studies
Bollerslev, J., Henriksen, K., Nielsen, M. F., Brixen, K., & Hul, W. V. (2013) · European Journal of Endocrinology · doi:10.1530/eje-13-0136 · Cited by 69 · see citing works
Self-citationNovel insights into the coupling of osteoclasts and resorption to bone formation
Durdan, M., Azaria, R. D., & Weivoda, M. M. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2021.10.008 · Cited by 65 · see citing works
Sims, N. A., & Ng, K. W. (2014) · Current Osteoporosis Reports · doi:10.1007/s11914-014-0196-1 · Cited by 61 · see citing works
Self-citationKasonga, A. E., Deepak, V., Kruger, M. C., & Coetzee, M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0125145 · Cited by 59 · see citing works
Ouattara, Z. A., Boti, J. B., Ahibo, A. C., Sutour, S., Casanova, J., Tomi, F., & Bighelli, A. (2014) · Flavour and Fragrance Journal · doi:10.1002/ffj.3215 · Cited by 56 · see citing works
Lichius, A., Yáñez-Gutiérrez, M. E., Read, N. D., & Castro‐Longoria, E. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030372 · Cited by 48 · see citing works
Kartner, N., & Manolson, M. F. (2014) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2014.902155 · Cited by 42 · see citing works
Enoxacin Directly Inhibits Osteoclastogenesis without Inducing Apoptosis
Toro, E. J., Zuo, J., Ostrov, D. A., Catalfamo, D. L., Bradaschia-Corrêa, V., Arana-Chavez, V. E., Caridad, A. R., Neubert, J. K., Wronski, T. J., Wallet, S. M., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.280511 · Cited by 41 · see citing works
Low-Pathogenic Avian Influenza Viruses in Wild House Mice
Shriner, S. A., VanDalen, K. K., Mooers, N. L., Ellis, J. W., Sullivan, H. J., Root, J. J., Pelzel‐McCluskey, A. M., & Franklin, A. B. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039206 · Cited by 41 · see citing works
A specific subtype of osteoclasts secretes factors inducing nodule formation by osteoblasts
Henriksen, K., Andreassen, K. V., Thudium, C. S., Gudmann, K. N. S., Moscatelli, I., Crüger-Hansen, C., Schulz, A., Dziegiel, M. H., Richter, J., Karsdal, M. A., et al. (2012) · Bone · doi:10.1016/j.bone.2012.06.007 · Cited by 40 · see citing works
Self-citationMcMichael, L., Edson, D., McLaughlin, A. B., Mayer, D. G., Kopp, S. R., Meers, J., & Field, H. E. (2015) · PLoS ONE · doi:10.1371/journal.pone.0125741 · Cited by 39 · see citing works
Park, S., Woodhall, J. W., Ma, G., Veinot, J. G. C., Cresser, M. S., & Boxall, A. B. A. (2013) · Nanotoxicology · doi:10.3109/17435390.2013.818173 · Cited by 39 · see citing works
Yamamoto, T., Ugawa, Y., Kawamura, M., Yamashiro, K., Kochi, S., Ideguchi, H., & Takashiba, S. (2017) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-017-0425-3 · Cited by 39 · see citing works
A review for clinicians: Prostate cancer and the antineoplastic properties of metformin
Hankinson, S. J., Fam, M. M., & Patel, N. N. (2016) · Urologic Oncology Seminars and Original Investigations · doi:10.1016/j.urolonc.2016.10.009 · Cited by 39 · see citing works
Sciarrone, D., Pantò, S., Rotondo, A., Tedone, L., Tranchida, P. Q., Dugo, P., & Mondello, L. (2013) · Analytica Chimica Acta · doi:10.1016/j.aca.2013.04.069 · Cited by 38 · see citing works
Thudium, C. S., Moscatelli, I., Flores, C., Thomsen, J. S., Brüel, A., Gudmann, N. S., Hauge, E.-M., Karsdal, M. A., Richter, J., & Henriksen, K. (2014) · Calcified Tissue International · doi:10.1007/s00223-014-9865-4 · Cited by 36 · see citing works
Self-citationSouza, B. K., Lopez, P. L. D. C., Menegotto, P. R., Vieira, I. A., Kersting, N., Abujamra, A. L., Brunetto, A. T., Brunetto, A. L., Gregianin, L. J., de Farias, C. B., et al. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-0874-6 · Cited by 36 · see citing works
Pantò, S., Sciarrone, D., Maimone, M., Ragonese, C., Giofrè, S. V., Donato, P., Farnetti, S., & Mondello, L. (2015) · Journal of Chromatography A · doi:10.1016/j.chroma.2015.09.039 · Cited by 32 · see citing works
Physiological stress and Hendra virus in flying-foxes (Pteropus spp.), Australia
McMichael, L., Edson, D., Smith, C. S., Mayer, D. G., Smith, I., Kopp, S. R., Meers, J., & Field, H. E. (2017) · PLoS ONE · doi:10.1371/journal.pone.0182171 · Cited by 32 · see citing works
Bone phenotypes in rheumatology – there is more to bone than just bone
Thudium, C. S., Nielsen, S. H., Sardar, S., Mobasheri, A., van Spil, W. E., Lories, R. J. U., Henriksen, K., Bay‐Jensen, A., & Karsdal, M. A. (2020) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-020-03804-2 · Cited by 33 · see citing works
Self-citationLau, P., Vico, L., & Rittweger, J. (2022) · Biomedicines · doi:10.3390/biomedicines10020342 · Cited by 32 · see citing works
A novel osteoporosis model with ascorbic acid deficiency in Akr1A1 gene knockout mice
Lai, C.-W., Chen, H., Tu, M., Lin, W.-Y., Röhrig, T., Yang, S., Lan, Y., Chong, K., & Chen, C. (2017) · Oncotarget · doi:10.18632/oncotarget.14458 · Cited by 29 · see citing works
Burroughs, A. L., Durr, P. A., Boyd, V., Graham, K., White, J. R., Todd, S., Barr, J. A., Smith, I., Baverstock, G., Meers, J., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0155252 · Cited by 28 · see citing works
Evolution and status of preparative gas chromatography as a green sample-preparation technique
Sciarrone, D., Pantò, S., Ragonese, C., Dugo, P., & Mondello, L. (2015) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2015.02.024 · Cited by 28 · see citing works
Liu, W., & Ji, R. (2019) · Information Resources Management Journal · doi:10.4018/irmj.2019070104 · Cited by 26 · see citing works
Early Silurian chondrichthyans from the Tarim Basin (Xinjiang, China)
Andreev, P. S., Zhao, W., Wang, N.-Z., Smith, M. M., Li, Q., Cui, X., Zhu, M., & Sansom, I. J. (2020) · PLoS ONE · doi:10.1371/journal.pone.0228589 · Cited by 25 · see citing works
Malayanines A and B, two novel limonoids from Chisocheton erythrocarpus Hiern
Chong, S., Awang, K., Martin, M. T., Mokhtar, M. R., Chan, G., Litaudon, M., Guéritte, F., & Mohamad, K. (2012) · Tetrahedron Letters · doi:10.1016/j.tetlet.2012.07.067 · Cited by 23 · see citing works
Role of miR-199a-5p in osteoblast differentiation by targeting TET2
Qi, X., Jia, B., Wang, W., Xu, G., Guo, J., Li, X., & Liu, J. (2019) · Gene · doi:10.1016/j.gene.2019.144193 · Cited by 23 · see citing works
Liu, L., Fan, W., Lu, H., & Xiao, W. (2015) · Scientific Reports · doi:10.1038/srep11121 · Cited by 22 · see citing works
Vacuolar H+-ATPases (V-ATPases) as therapeutic targets: a brief review and recent developments
Holliday, L. S. (2017) · Biotarget · doi:10.21037/biotarget.2017.12.01 · Cited by 21 · see citing works
Temporal Variation in Physiological Biomarkers in Black Flying-Foxes (Pteropus alecto), Australia
McMichael, L., Edson, D., Mayer, D. G., McLaughlin, A. B., Goldspink, L. K., Vidgen, M. E., Kopp, S. R., Meers, J., & Field, H. E. (2016) · EcoHealth · doi:10.1007/s10393-016-1113-0 · Cited by 19 · see citing works
Effects of hypothalamic leptin gene therapy on osteopetrosis in leptin-deficient mice
Philbrick, K. A., Martin, S. A., Colagiovanni, A. R., Branscum, A. J., Turner, R. T., & Iwaniec, U. T. (2017) · Journal of Endocrinology · doi:10.1530/joe-17-0524 · Cited by 17 · see citing works
Sommer, C., Rumpel, S., Roy, S., Farès, C., Artero, V., Fontecave, M., Reijerse, E. J., & Lubitz, W. (2018) · JBIC Journal of Biological Inorganic Chemistry · doi:10.1007/s00775-018-1558-4 · Cited by 17 · see citing works
Shen, G., Liu, X., Lei, W., Duan, R., & Yao, Z. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.101767 · Cited by 19 · see citing works
Wendelboe, M. H., Thomsen, J. S., Henriksen, K., Vegger, J. B., & Brüel, A. (2016) · Bone · doi:10.1016/j.bone.2016.03.012 · Cited by 15 · see citing works
Self-citationSciarrone, D., Pantò, S., Donato, P., & Mondello, L. (2016) · Journal of Chromatography A · doi:10.1016/j.chroma.2016.11.013 · Cited by 15 · see citing works
Brent, M. B., Thomsen, J. S., & Brüel, A. (2017) · Bone Reports · doi:10.1016/j.bonr.2017.12.001 · Cited by 15 · see citing works
Self-citationMarachlian, E., Klappenbach, M., & Locatelli, F. F. (2021) · Cell and Tissue Research · doi:10.1007/s00441-020-03396-2 · Cited by 15 · see citing works
Islas-Weinstein, L., Marquina‐Castillo, B., Mata‐Espinosa, D., Paredes-González, I. S., Chávez, J., Balboa, L., Franco, J. L. M., Guerrero-Romero, D., Barrios‐Payán, J., & Hernández‐Pando, R. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.581911 · Cited by 13 · see citing works
Short‐distance migration of W rynecks J ynx torquilla from C entral E uropean populations
van Wijk, R. E., Schaub, M., Tolkmitt, D., Becker, D., & Hahn, S. (2013) · Ibis · doi:10.1111/ibi.12083 · Cited by 12 · see citing works
Sun, S., Karsdal, M. A., Bay‐Jensen, A., Sørensen, M. G., Zheng, Q., Dziegiel, M. H., Maksymowych, W. P., & Henriksen, K. (2013) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2013.04.012 · Cited by 12 · see citing works
Self-citationOsteoclasts are not crucial for hematopoietic stem cell maintenance in adult mice
Flores, C., Moscatelli, I., Thudium, C. S., Gudmann, N. S., Thomsen, J. S., Brüel, A., Karsdal, M. A., Henriksen, K., & Richter, J. (2013) · Haematologica · doi:10.3324/haematol.2013.089466 · Cited by 12 · see citing works
Self-citationScreening and function discussion of a hereditary renal tubular acidosis family pathogenic gene
Chen, L., Wang, H., Zhu, Y., Jin, Z., Huang, J., Lin, X.-F., Luo, J.-W., & Fang, Z.-T. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-2354-y · Cited by 12 · see citing works
Thomsen, J. S., Straarup, T., Danielsen, C. C., Oxlund, H., & Brüel, A. (2013) · Scandinavian Journal of Rheumatology · doi:10.3109/03009742.2013.774046 · Cited by 12 · see citing works
Self-citationKottmann, V., Nienhaus, M., Drees, P., Gercek, E., & Ritz, U. (2026) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2026.189551 · Cited by 14 · see citing works
S-Adenosyl Homocysteine Hydrolase (SAHH) Accelerates Flagellar Regeneration in Dunaliella salina
Li, Q., Zhu, L., Yan, Y., Chai, D., Li, J., & Xue, L. (2013) · Current Microbiology · doi:10.1007/s00284-013-0357-y · Cited by 11 · see citing works
Bittencourt-Silva, G. B., Lawson, L. P., Tolley, K. A., Portik, D. M., Barratt, C. D., Nagel, P., & Loader, S. P. (2017) · Molecular Phylogenetics and Evolution · doi:10.1016/j.ympev.2017.06.022 · Cited by 10 · see citing works
Barbosa-Filho, M. L. V., Tavares, D. C., Siciliano, S. J., de Moura, J. F., Neto, E. M. C., Motta, F. S., & Koike, C. D. V. (2016) · Marine Policy · doi:10.1016/j.marpol.2016.08.007 · Cited by 9 · see citing works
Coupling of bone formation and resorption
Sims, N. A., & Martin, T. J. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814841-9.00010-5 · Cited by 9 · see citing works
Self-citationCoupling: The Influences of Immune and Bone Cells
Sims, N. A., Martin, T. J., & Quinn, J. M. W. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-800571-2.00010-4 · Cited by 9 · see citing works
Self-citationEmergency Centre care for sexual assault victims
Krolikowski, A. M., & Koyfman, A. (2012) · African Journal of Emergency Medicine · doi:10.1016/j.afjem.2011.12.005 · Cited by 8 · see citing works
Bauer, T. O., Graf, D., Lamparter, T., & Schünemann, V. (2013) · Hyperfine Interactions · doi:10.1007/s10751-013-0969-4 · Cited by 8 · see citing works
Sørensen, T. G., Brent, M. B., Thomsen, J. S., & Brüel, A. (2019) · Bone · doi:10.1016/j.bone.2019.115183 · Cited by 8 · see citing works
Self-citationEwanchuk, B. W., Arnold, C. R., Balce, D. R., Premnath, P., Orsetti, T. L., Warren, A. L., Olsen, A., Krawetz, R. J., & Yates, R. M. (2021) · Science Advances · doi:10.1126/sciadv.abd3684 · Cited by 7 · see citing works
Guo, J., Bervoets, T. J. M., Henriksen, K., Everts, V. E., & Bronckers, A. L. J. J. (2015) · Cell and Tissue Research · doi:10.1007/s00441-015-2263-z · Cited by 6 · see citing works
Self-citationHoneybee workers with higher reproductive potential have a greater learning ability
Kuszewska, K., & Rojek, W. (2021) · Apidologie · doi:10.1007/s13592-021-00847-9 · Cited by 5 · see citing works
A Framework of Algorithms: Computing the Bias and Prestige of Nodes in Trust Networks
Li, R.-H., Yu, J. X., Huang, X., & Cheng, H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050843 · Cited by 4 · see citing works
Vidhya, V. M., Lakshmi, B. S., & Ponnuraj, K. (2020) · Journal of Molecular Modeling · doi:10.1007/s00894-019-4284-0 · Cited by 4 · see citing works
Computational Design of Multinuclear Metalloproteins Using Unnatural Amino Acids
Hansen, W. A., Mills, J. H., & Khare, S. D. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-3569-7_10 · Cited by 3 · see citing works
Umweltauswirkungen künstlich hergestellter Nanomaterialien
Greßler, S., & Nentwich, M. (2014) · Springer eBooks · doi:10.1007/978-3-7091-1405-6_2 · Cited by 3 · see citing works
Brent, M. B., Brüel, A., & Thomsen, J. S. (2021) · Endocrine and Metabolic Science · doi:10.1016/j.endmts.2021.100114 · Cited by 3 · see citing works
Self-citationAnterior cruciate ligament rupture in a patient with Albers-Schonberg disease
Lü, K., Cheng, B., Shi, Q., Gao, X.-J., & Li, C. (2022) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-022-05687-x · Cited by 2 · see citing works
Slavensky, O. L., Bromer, F. D., Thomsen, J. S., & Brüel, A. (2025) · Scientific Reports · doi:10.1038/s41598-025-29729-1 · Cited by 1 · see citing works
Self-citationAlMuraikhi, N. A., Alkhamees, L., Tareen, S., & Manikandan, M. (2026) · Current Issues in Molecular Biology · doi:10.3390/cimb48030316 · Cited by 1 · see citing works
Holliday, L. S., Huynh, Zuo, & Törö (2013) · Research and Reports in Biochemistry · doi:10.2147/rrbc.s28414 · Cited by 1 · see citing works
An Improved Community Detection Method in Bipartite Networks
Chunlong, F., Song, Y., Huimin, S., & Guohui, D. (2016) · Lecture notes in computer science · doi:10.1007/978-3-319-47121-1_22 · Cited by 1 · see citing works
Adaptation of Candida albicans for Growth Within the Host
Zakaria, Z., Basma, A. A., & Ganeshan, S. (2013) · Springer eBooks · doi:10.1007/978-94-007-5931-2_17
Abdi, F. S., Jamshidi, S., Moosakhani, F., & Sasani, F. (2016) · Diagnostic Pathology · doi:10.1186/s13000-016-0572-5
Retracted
- Authors
- Henriksen, K., Flores, C., Thomsen, J. S., Brüel, A.-M., Thudium, C. S., Neutzsky-Wulff, A. V., Langenbach, G. E. J., Sims, N., Askmyr, M., Martin, T. J., Everts, V., Karsdal, M. A., & Richter, J.
- Affiliations
- Nordic Bioscience (Denmark) (DK)
- Lund University (SE)
- Aarhus University (DK)
- Academic Center for Dentistry Amsterdam (NL)
- Corresponding author
- Henriksen, Kim
- ORCID
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2011-11-07
- Volume
- 6
- Issue
- 11
- Pages
- e27482
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3210177
- OpenAlex
- W2111252052
- Cited by
- 77
- References
- 69
- Citations by year
- 2026: 2 · 2025: 1 · 2022: 4 · 2021: 6 · 2020: 5 · 2019: 5 · 2018: 2 · 2017: 8 · 2016: 9 · 2015: 8 · 2014: 6 · 2013: 14 · 2012: 7
- FWCI
- 3.51
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- VU Research Portal (publishedVersion, other-oa)
- UvA-DARE (University of Amsterdam) (submittedVersion, other-oa)
- Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Minerva Access (University of Melbourne) (submittedVersion, cc-by)
- Lund University Publications (Lund University) (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Funders
- Stiftelsen för Strategisk Forskning
- Lunds Universitet
- NordForsk
- Barncancerfonden
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Rheumatology › Osteomyelitis and Bone Disorders Research
- Keywords
- osteopetrosis, bone resorption, bone formation, bone strength, hematopoietic stem cell transplantation, bone turnover markers, cortical and trabecular bone, bone volume
- MeSH terms
- Animals, Bone Resorption, Graft Survival, Osteoclasts, Osteogenesis, Osteopetrosis, Bone Density, Hematopoietic Stem Cell Transplantation, Vacuolar Proton-Translocating ATPases, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review