Grinstein, Sergio

Antimicrobial mechanisms of phagocytes and bacterial evasion strategies

Flannagan, R. S., Cosío, G., & Grinstein, S. (2009) · Nature Reviews Microbiology

Tuberculosis Research and EpidemiologyImmune Response and Inflammation

Cited by 947

Scavenger receptors in homeostasis and immunity

Canton, J., Neculai, D., & Grinstein, S. (2013) · Nature Reviews Immunology

Phagocytosis and Immune RegulationAtherosclerosis and Cardiovascular Diseases

Cited by 838

The position of lysosomes within the cell determines their luminal pH

Johnson, D. E., Ostrowski, P., Jaumouillé, V., & Grinstein, S. (2016) · Journal of Cell Biology

Cellular transport and secretionAutophagy in Disease and Therapy

Cited by 590

Activation of antibacterial autophagy by NADPH oxidases

Huang, J., Canadien, V., Lam, G. Y., Steinberg, B. E., Dinauer, M. C., Magalhaes, M. A. O., Glogauer, M., Grinstein, S., & Brumell, J. H. (2009) · Proceedings of the National Academy of Sciences

Autophagy in Disease and TherapyNeutrophil, Myeloperoxidase and Oxidative Mechanisms

Cited by 556

Phagocytosis: Receptors, signal integration, and the cytoskeleton

Freeman, S. A., & Grinstein, S. (2014) · Immunological Reviews

Phagocytosis and Immune RegulationCellular transport and secretion

Cited by 548

Localized Biphasic Changes in Phosphatidylinositol-4,5-Bisphosphate at Sites of Phagocytosis

Botelho, R. J., Teruel, M., Dierckman, R., Anderson, R., Wells, A., York, J. D., Meyer, T., & Grinstein, S. (2000) · The Journal of Cell Biology

Cellular transport and secretionProtein Kinase Regulation and GTPase Signaling

Cited by 539

In vivo requirement for Atg5 in antigen presentation by dendritic cells

Lee, H. K., Mattei, L. M., Steinberg, B. E., Alberts, P., Lee, Y. H., Chervonsky, A., Mizushima, N., Grinstein, S., & Iwasaki, A. (2010) · Immunity

Autophagy in Disease and TherapyImmunotherapy and Immune Responses

Cited by 506

The delta F508 mutation decreases the stability of cystic fibrosis transmembrane conductance regulator in the plasma membrane. Determination of functional half-lives on transfected cells.

Lukacs, G. L., Chang, X. B., Bear, C., Kartner, N., Mohamed, A., Riordan, J. R., & Grinstein, S. (1993) · Journal of Biological Chemistry

Cystic Fibrosis Research AdvancesIon Transport and Channel Regulation

Cited by 387

The Syk protein tyrosine kinase is essential for Fcγ receptor signaling in macrophages and neutrophils

Kiefer, F., Brumell, J., Al-Alawi, N., Latour, S., Cheng, A., Veillette, A., Grinstein, S., & Pawson, T. (1998) · Molecular and Cellular Biology

Monoclonal and Polyclonal Antibodies ResearchNeutrophil, Myeloperoxidase and Oxidative Mechanisms

Cited by 376

Natural Resistance to Intracellular Infections

Jabado, N., Jankowski, A., Dougaparsad, S., Picard, V., Grinstein, S., & Gros, P. (2000) · The Journal of Experimental Medicine

Immune Response and InflammationImmune responses and vaccinations

Cited by 372

Receptor Activation Alters Inner Surface Potential During Phagocytosis

Yeung, T., Terebiznik, M., Yu, L., Silvius, J., Abidi, W. M., Philips, M., Levine, T., Kapus, A., & Grinstein, S. (2006) · Science

Lipid Membrane Structure and BehaviorCellular transport and secretion

Cited by 329

The cytoskeleton in phagocytosis and macropinocytosis

Mylvaganam, S., Freeman, S. A., & Grinstein, S. (2021) · Current Biology

Cellular Mechanics and InteractionsCellular transport and secretion

Cited by 263

Contrasting phagosome pH regulation and Maturation in Human M1 and M2 macrophages

Canton, J., Khezri, R., Glogauer, M., & Grinstein, S. (2014) · Molecular Biology of the Cell

Cellular transport and secretionPhagocytosis and Immune Regulation

Cited by 221

Lysosomal calcium homeostasis defects, not proton pump defects, cause endo-lysosomal dysfunction in PSEN-deficient cells

Coen, K., Flannagan, R. S., Baron, S., Carraro-Lacroix, L. R., Wang, D., Vermeire, W., Michiels, C., Munck, S., Baert, V., Sugita, S., et al. (2012) · Journal of Cell Biology

Cellular transport and secretionCalcium signaling and nucleotide metabolism

Cited by 208

Host Resistance to Intracellular Infection: Mutation of Natural Resistance-associated Macrophage Protein 1 (Nramp1) Impairs Phagosomal Acidification

Hackam, D. J., Rotstein, O. D., Zhang, W.-J., Gruenheid, S., Gros, P., & Grinstein, S. (1998) · The Journal of Experimental Medicine

Tuberculosis Research and EpidemiologyImmune responses and vaccinations

Cited by 202

Rho is required for the initiation of calcium signaling and phagocytosis by Fcγ receptors in macrophages

Hackam, D. J., Rotstein, O. D., Schreiber, A., Zhang, W.-J., & Grinstein, S. (1997) · The Journal of Experimental Medicine

Protein Kinase Regulation and GTPase SignalingPhagocytosis and Immune Regulation

Cited by 166

Differential Role of Actin, Clathrin, and Dynamin in Fcγ Receptor-mediated Endocytosis and Phagocytosis

Tse, S. M. L., Furuya, W., Gold, E., Schreiber, A. D., Sandvig, K., Inman, R. D., & Grinstein, S. (2003) · Journal of Biological Chemistry

Cellular transport and secretionPhagocytosis and Immune Regulation

Cited by 124

Fusion, fission, and secretion during phagocytosis

Huynh, K. K., Kay, J. G., Stow, J. L., & Grinstein, S. (2007) · Physiology

Cellular transport and secretionPhagocytosis and Immune Regulation

Cited by 105

Activation of P2X7 Receptor by ATP Plays an Important Role in Regulating Inflammatory Responses during Acute Viral Infection

Lee, B. H., Hwang, D. M., Palaniyar, N., Grinstein, S., Philpott, D. J., & Hu, J. (2012) · PLoS ONE

Adenosine and Purinergic SignalingInflammasome and immune disorders

Cited by 102

Nramp1 modifies the fusion of Salmonella typhimurium-containing vacuoles with cellular endomembranes in macrophages

Cuellar-Mata, P., Jabado, N., Liu, J., Furuya, W., Finlay, B. B., Gros, P., & Grinstein, S. (2002) · Journal of Biological Chemistry

Cellular transport and secretionSalmonella and Campylobacter epidemiology

Cited by 79

Differential ability of proinflammatory and anti-inflammatory macrophages to perform macropinocytosis

Redka, D. S., Gütschow, M., Grinstein, S., & Canton, J. (2018) · Molecular Biology of the Cell

Cellular transport and secretionImmune cells in cancer

Cited by 58

Expression of the Protein Kinase C Substrate Pleckstrin in Macrophages: Association with Phagosomal Membranes

Brumell, J. H., Howard, J. C., Craig, K., Grinstein, S., Schreiber, A. D., & Tyers, M. (1999) · The Journal of Immunology

Phagocytosis and Immune RegulationCellular transport and secretion

Cited by 54

Carboxyl-terminus determinants of the iron transporter DMT1/SLC11A2 isoform II (-IRE/1B) mediate internalization from the plasma membrane into recycling endosomes.

Lam-Yuk-Tseung, S., Touret, N., Grinstein, S., & Gros, P. (2005) · Biochemistry

Iron Metabolism and DisordersCellular transport and secretion

Cited by 35