Antimicrobial mechanisms of phagocytes and bacterial evasion strategies

Flannagan, Ronald S.; Cosío, Gabriela; Grinstein, Sergio

doi:10.1038/nrmicro2128

Cited by 947Tuberculosis Research and EpidemiologyImmune Response and InflammationImmune responses and vaccinations

Antimicrobial mechanisms of phagocytes and bacterial evasion strategies

Flannagan, Ronald S., Cosío, Gabriela, Grinstein, Sergio·2009·Nature Reviews Microbiology

DOI 10.1038/nrmicro2128

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Abstract

Professional phagocytes have a vast and sophisticated arsenal of microbicidal features. They are capable of ingesting and destroying invading organisms, and can present microbial antigens on their surface, eliciting acquired immune responses. To survive this hostile response, certain bacterial species have developed evasive strategies that often involve the secretion of effectors to co-opt the cellular machinery of the host. In this Review, we present an overview of the antimicrobial defences of the host cell, with emphasis on macrophages, for which phagocytosis has been studied most extensively. In addition, using Mycobacterium tuberculosis, Listeria monocytogenes, Legionella pneumophila and Coxiella burnetii as examples, we describe some of the evasive strategies used by bacteria.

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“Both intracellular and extracellular parasites have evolved mechanisms to not only avoid or survive the immune response, but also to use it for their own benefit (93, 94).”
From Macrophage Cytokines: Involvement in Immunity and Infectious Diseases (2014) · cites this paper as [94]
The maturing phagosome acquires and loses molecules that function at and characterize individual maturation stages and diversion routes.
“During this process, the maturing phagosome acquires and loses molecules functioning at but also characterizing individual maturation stages and diversion routes (7).”
From Macrophage defense mechanisms against intracellular bacteria (2015) · cites this paper as [7]

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Reconstitution of recycling from the phagosomal compartment in streptolysin O-permeabilized macrophages: Role of Rab11
Leiva, N., Pavarotti, M. A., Colombo, M. I., et al. (2006) · Experimental Cell Research · doi:10.1016/j.yexcr.2006.02.015 · Cited by 21 · see citing works

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Macrophage Cytokines: Involvement in Immunity and Infectious Diseases
Arango Duque, G., & Descoteaux, A. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00491 · Cited by 2,708 · see citing works
“Both intracellular and extracellular parasites have evolved mechanisms to not only avoid or survive the immune response, but also to use it for their own benefit (93, 94).”
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“Phagocytosis of bacterial or apoptotic cells by professional macrophages occurs by a complex mechanism that requires a diverse set of components (28) (FIGURE 4).”
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Copper Homeostasis at the Host-Pathogen Interface
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Iron and Immunity: Immunological Consequences of Iron Deficiency and Overload
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Characterisation of Innate Fungal Recognition in the Lung
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Authors: Flannagan, R. S., Cosío, G., & Grinstein, S.
Affiliations: Hospital for Sick Children (CA)
Corresponding author: Grinstein, Sergio
ORCID: Flannagan, Ronald S.
Grinstein, Sergio
Venue: Nature Reviews Microbiology
Publisher: Springer Science and Business Media LLC
Published: 2009-05
Volume: 7
Issue: 5
Pages: 355-366
ISSN: 1740-1526 (ISSN-L)
1740-1534
DOI: 10.1038/nrmicro2128
OpenAlex: W2002047195
Cited by: 947
References: 178
Citations by year: 2026: 36 · 2025: 38 · 2024: 47 · 2023: 41 · 2022: 47 · 2021: 55 · 2020: 64 · 2019: 59 · 2018: 62 · 2017: 59 · 2016: 63 · 2015: 55 · 2014: 65 · 2013: 52 · 2012: 74
FWCI: 7.53
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Microbiology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Keywords: phagocytes, antimicrobial mechanisms, phagocytosis, macrophages, intracellular pathogens, host-pathogen interaction, bacterial effector proteins, Mycobacterium tuberculosis, Listeria monocytogenes, Legionella pneumophila, Coxiella burnetii, antigen presentation
MeSH terms: Animals, Bacteria, Humans, Phagocytes, Phagosomes

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Antimicrobial mechanisms of phagocytes and bacterial evasion strategies

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