Eizirik, Decio L.

Mechanisms of Pancreatic β-Cell Death in Type 1 and Type 2 Diabetes

Cnop, M., Welsh, N., Jonas, J.-C., Jörns, A., Lenzen, S., & Eizirik, D. L. (2005) · Diabetes

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 1,491

DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients

Volkmar, M., Dedeurwaerder, S., Cunha, D. A., Ndlovu, M. N., Defrance, M., Deplus, R., Calonne, E., Volkmar, U., Igoillo‐Esteve, M., Naamane, N., et al. (2012) · The EMBO Journal

Epigenetics and DNA MethylationPancreatic function and diabetes

Cited by 420

The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients

Marchetti, P., Bugliani, M., Lupi, R., Marselli, L., Masini, M., Boggi, U., Filipponi, F., Weir, G. C., Eizirik, D. L., & Cnop, M. (2007) · Diabetologia

Endoplasmic Reticulum Stress and DiseasePancreatic function and diabetes

Cited by 413

Long-Term GABA Administration Induces Alpha Cell-Mediated Beta-like Cell Neogenesis

Ben-Othman, N., Vieira, A., Courtney, M., Record, F., Gjernes, E., Avolio, F., Hadzic, B., Druelle, N., Napolitano, T., Navarro-Sanz, S., et al. (2017) · Cell

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 322

Viral infections in type 1 diabetes mellitus — why the β cells?

Op de Beeck, A., & Eizirik, D. L. (2016) · Nature Reviews Endocrinology

Diabetes and associated disordersPancreatic function and diabetes

Cited by 291

Interferon-α mediates human beta cell HLA class I overexpression, endoplasmic reticulum stress and apoptosis, three hallmarks of early human type 1 diabetes

Marroqui, L., Dos Santos, R. S., Op de beeck, A., Coomans de Brachène, A., Marselli, L., Marchetti, P., & Eizirik, D. L. (2017) · Diabetologia

Diabetes and associated disordersEndoplasmic Reticulum Stress and Disease

Cited by 203

Pro-inflammatory cytokines induce cell death, inflammatory responses, and endoplasmic reticulum stress in human iPSC-derived beta cells

Demine, S., Schiavo, A. A., Marín-Cañas, S., Marchetti, P., Cnop, M., & Eizirik, D. L. (2020) · Stem Cell Research & Therapy

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 107

CTSH regulates β-cell function and disease progression in newly diagnosed type 1 diabetes patients

Fløyel, T., Brorsson, C., Nielsen, L. B., Miani, M., Bang-Berthelsen, C. H., Friedrichsen, M., Overgaard, A. J., Berchtold, L. A., Wiberg, A., Poulsen, P., et al. (2014) · Proceedings of the National Academy of Sciences

Diabetes and associated disordersPancreatic function and diabetes

Cited by 104

IFN-α induces a preferential long-lasting expression of MHC class I in human pancreatic beta cells

Coomans de Brachène, A., Dos Santos, R. S., Marroqui, L., Colli, M. L., Marselli, L., Mirmira, R. G., Marchetti, P., & Eizirik, D. L. (2018) · Diabetologia

Diabetes and associated disordersPancreatic function and diabetes

Cited by 81

Human pancreatic beta-cell deoxyribonucleic acid-synthesis in islet grafts decreases with increasing organ donor age but increases in response to glucose stimulation in vitro

Tyrberg, B., Eizirik, D. L., Hellerström, C., Pipeleers, D. G., & Andersson, A. (1996) · Endocrinology

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 62

Redox regulation of m6A methyltransferase METTL3 in β-cells controls the innate immune response in type 1 diabetes

De Jesus, D. F., Zhang, Z., Brown, N. K., Li, X., Xiao, L., Hu, J., Gaffrey, M. J., Fogarty, G., Kahraman, S., Wei, J., et al. (2024) · Nature Cell Biology

Diabetes and associated disordersRNA modifications and cancer

Cited by 56

Redox Regulation of m 6 A Methyltransferase METTL3 in Human β-cells Controls the Innate Immune Response in Type 1 Diabetes

De Jesus, D. F., Zhang, Z., Brown, N. K., Li, X., Gaffrey, M. J., Kahraman, S., Wei, J., Hu, J., Basile, G., Xiao, L., et al. (2023) · Nature Cell Biology

Diabetes and associated disordersRNA modifications and cancer

Cited by 56

Exercise as a non-pharmacological intervention to protect pancreatic beta cells in individuals with type 1 and type 2 diabetes

Coomans de Brachène, A., Scoubeau, C., Musuaya, A. E., Costa-Junior, J. M., Castela, A., Carpentier, J., Faoro, V., Klass, M., Cnop, M., & Eizirik, D. L. (2023) · Diabetologia

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 44

Regulation of β-cell death by ADP-ribosylhydrolase ARH3 via lipid signaling in insulitis

Sarkar, S., Deiter, C., Kyle, J. E., Guney, M. A., Sarbaugh, D., Yin, R., Li, X., Cui, Y., Ramos-Rodriguez, M., Nicora, C. D., et al. (2023) · Cell Communication and Signaling

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 6

Regulation of β-cell death by ADP-ribosylhydrolase ARH3 via lipid signaling in insulitis

Sarkar, S., Deiter, C., Kyle, J. E., Guney, M. A., Sarbaugh, D., Yin, R., Li, X., Cui, Y., Ramos-Rodriguez, M., Nicora, C. D., et al. (2024) · Cell Communication and Signaling

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 6