Exercise as a non-pharmacological intervention to protect pancreatic beta cells in individuals with type 1 and type 2 diabetes
Open accessAbstract
Aims/hypothesis Diabetes is characterised by progressive loss of functional pancreatic beta cells. None of the therapeutic agents used to treat diabetes arrest this process; preventing beta cell loss remains a major unmet need. We have previously shown that serum from eight young healthy male participants who exercised for 8 weeks protected human islets and insulin-producing EndoC-βH1 cells from apoptosis induced by proinflammatory cytokines or the endoplasmic reticulum (ER) stressor thapsigargin. Whether this protective effect is influenced by sex, age, training modality, ancestry or diabetes is unknown.Methods We enrolled 82 individuals, male or female, non-diabetic or diabetic, from different origins, in different supervised training protocols for 8-12 weeks (including training at home during the COVID-19 pandemic). EndoC-βH1 cells were treated with 'exercised' serum or with the exerkine clusterin to ascertain cytoprotection from ER stress.Results The exercise interventions were effective and improved [Formula: see text] values in both younger and older, non-obese and obese, non-diabetic and diabetic participants. Serum obtained after training conferred significant beta cell protection (28% to 35% protection after 4 and 8 weeks of training, respectively) from severe ER stress-induced apoptosis. Cytoprotection was not affected by the type of exercise training or participant age, sex, BMI or ancestry, and persisted for up to 2 months after the end of the training programme. Serum from exercised participants with type 1 or type 2 diabetes was similarly protective. Clusterin reproduced the beneficial effects of exercised sera.Conclusions/interpretation These data uncover the unexpected potential to preserve beta cell health by exercise training, opening a new avenue to prevent or slow diabetes progression through humoral muscle-beta cell crosstalk.
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Serum from people with type 1 or type 2 diabetes who completed an exercise training programme benefits a human beta-cell line.
“Serum from participants with type 1 diabetes and T2DM who underwent an exercise training programme was shown to benefit a human β-cell line20.”
From Exercise activates AMPK in mouse and human pancreatic islets to decrease senescence (2024) · cites this paper as [20]
The beneficial effects of exercise on β-cells are relevant to both type 1 diabetes and type 2 diabetes.
“The beneficial effects of exercise on β-cells apply to both type 1 diabetes and T2DM20 and should be considered an additional therapeutic pathway.”
From Exercise activates AMPK in mouse and human pancreatic islets to decrease senescence (2024) · cites this paper as [20]
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Low to High Intensity Exercise dalam Menurunkan Kadar Gula Darah pada Pasien DM Tipe 2
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“Bulan 1 BEBG 71.0 PEBG 54.8 EIGR 34.0 Bulan 2 BEBG 60.1 PEBG 41.1 EIGR 35.1 Bulan 3 BEBG 54.8 PEBG 31.5 EIGR 35.3 (Coomans de Brachène et al., 2023).”
InfluentialAdvances in Exercise and Nutrition as Therapy in Diabetes
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Kommentar zu: Diabetes mellitus: Schutz von Betazellen durch körperliches Training
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Diabetes mellitus: Schutz von Betazellen durch körperliches Training
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- Authors
- Coomans de Brachène, A., Scoubeau, C., Musuaya, A. E., Costa-Junior, J. M., Castela, A., Carpentier, J., Faoro, V., Klass, M., Cnop, M., & Eizirik, D. L.
- Affiliations
- Université Libre de Bruxelles (BE)
- ORCID
- Venue
- Diabetologia
- Published
- 2022-11-19
- Volume
- 66
- Issue
- 3
- Pages
- 450-460
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- PMC
- PMC9676790
- OpenAlex
- W4309668129
- Cited by
- 44
- References
- 43
- Citations by year
- 2026: 9 · 2025: 11 · 2024: 12 · 2023: 12
- FWCI
- 8.35
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Diabetologia (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion, other-oa)
- Funders
- Innovative Medicines Initiative 2 Joint Undertaking (INNODIA HARVEST)
- European Foundation for the Study of Diabetes (Multi-System Challenges in Diabetes)
- Dutch Diabetes Research Foundation (2018.10.002)
- Walloon Region SPW-EERWin2Wal (BetaSource)
- JDRF and The Leona M. and Harry B. Helmsley Charitable Trust
- INNOVIRIS BRIDGE (DiaType)
- Francophone Foundation for Diabetes Research
- Fonds De La Recherche Scientifique - FNRS
- Welbio/FRFS (WELBIO-CR-(2019-CGR-X400120F))
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Endoplasmic Reticulum Stress and Disease
- Keywords
- exercise training, pancreatic beta cells, beta-cell protection, type 1 diabetes, type 2 diabetes, endoplasmic reticulum stress, thapsigargin, apoptosis, clusterin, exerkines, EndoC-βH1 cells
- MeSH terms
- COVID-19, Diabetes Mellitus, Type 2, Female, Humans, Infant, Male, Apoptosis, Insulin-Secreting Cells, Clusterin, Pandemics, Endoplasmic Reticulum Stress
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