Liu, David R.

Continuous evolution of base editors with expanded target compatibility and improved activity

Thuronyi, B. W., Koblan, L. W., Levy, J. M., Yeh, W.-H., Zheng, C., Newby, G. A., Wilson, C., Bhaumik, M., Shubina-Oleinik, O., Holt, J. R., et al. (2019) · Nature Biotechnology

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 347

How pathogenic bacteria evade mammalian sabotage in the battle for iron

Fischbach, M. A., Lin, H., Liu, D. R., & Walsh, C. T. (2006) · Nature Chemical Biology

Escherichia coli research studiesBacterial Genetics and Biotechnology

Cited by 321

The pathogen-associated iroA gene cluster mediates bacterial evasion of lipocalin 2

Fischbach, M. A., Lin, H., Zhou, L., Yu, Y., Abergel, R. J., Liu, D. R., Raymond, K. N., Wanner, B. L., Strong, R. K., Walsh, C. T., et al. (2006) · Proceedings of the National Academy of Sciences

Escherichia coli research studiesBacterial Genetics and Biotechnology

Cited by 319

Massively parallel assessment of human variants with base editor screens

Hanna, R. E., Hegde, M., Fagre, C. R., DeWeirdt, P. C., Sangree, A. K., Szegletes, Z., Griffith, A., Feeley, M. N., Sanson, K. R., Baidi, Y., et al. (2021) · Cell

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 316

Massively parallel assessment of human variants with base editor screens

Hanna, R. E., Hegde, M., Fagre, C. R., DeWeirdt, P. C., Sangree, A. K., Szegletes, Z., Griffith, A., Feeley, M. N., Sanson, K. R., Baidi, Y., et al. (2020) · Cell

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 314

Determinants of Base Editing Outcomes from Target Library Analysis and Machine Learning

Arbab, M., Shen, M. W., Mok, B., Wilson, C., Matuszek, Ż., Cassa, C. A., & Liu, D. R. (2020) · Cell

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 294

In vivo base editing of post-mitotic sensory cells

Yeh, W.-H., Chiang, H., Rees, H. A., Edge, A. S. B., & Liu, D. R. (2018) · Nature Communications

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 225

Adenine base editing in an adult mouse model of tyrosinaemia

Song, C.-Q., Jiang, T., Richter, M., Rhym, L. H., Koblan, L. W., Zafra, M. P., Schatoff, E. M., Doman, J. L., Cao, Y., Dow, L. E., et al. (2019) · Nature Biomedical Engineering

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 200

Precision genome editing using cytosine and adenine base editors in mammalian cells

Huang, T. P., Newby, G. A., & Liu, D. R. (2021) · Nature Protocols

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 175

Designing and executing prime editing experiments in mammalian cells

Doman, J. L., Sousa, A. A., Randolph, P. B., Chen, P. J., & Liu, D. R. (2022) · Nature Protocols

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 172

In vitro characterization of IroB, a pathogen-associated C -glycosyltransferase

Fischbach, M. A., Lin, H., Liu, D. R., & Walsh, C. T. (2005) · Proceedings of the National Academy of Sciences

Escherichia coli research studiesBacterial Genetics and Biotechnology

Cited by 169

High-throughput analysis of the activities of xCas9, SpCas9-NG and SpCas9 at matched and mismatched target sequences in human cells

Kim, H. K., Lee, S., Kim, Y., Park, J., Min, S., Choi, J. W., Huang, T. P., Yoon, S., Liu, D. R., & Kim, H. H. (2020) · Nature Biomedical Engineering

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 145

Enhanced functional potential of nucleic acid aptamer libraries patterned to increase secondary structure

Ruff, K. M., Snyder, T. M., & Liu, D. R. (2010) · Journal of the American Chemical Society

Advanced biosensing and bioanalysis techniquesRNA and protein synthesis mechanisms

Cited by 86

Phage-assisted evolution of highly active cytosine base editors with enhanced selectivity and minimal sequence context preference

Zhang, E., Neugebauer, M. E., Krasnow, N. A., & Liu, D. R. (2024) · Nature Communications

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 68

Assigning functionality to cysteines by base editing of cancer dependency genes

Li, H., Ma, T., Remsberg, J. R., Won, S. J., DeMeester, K. E., Njomen, E., Ogasawara, D., Zhao, K. T., Huang, T. P., Lu, B., et al. (2023) · Nature Chemical Biology

Click Chemistry and ApplicationsProtein Degradation and Inhibitors

Cited by 62

Small-molecule binding and sensing with a designed protein family

Lee, G. R., Pellock, S. J., Norn, C., Tischer, D., Dauparas, J., Anischenko, I., Mercer, J. A. M., Kang, A., Bera, A., Nguyen, H., et al. (2023) · Nature Communications

Protein Structure and DynamicsBiochemical and Structural Characterization

Cited by 41

In vivo photoreceptor base editing ameliorates rhodopsin-E150K autosomal-recessive retinitis pigmentosa in mice

Du, S. W., Newby, G. A., Salom, D., Gao, F., Menezes, C. R., Suh, S., Choi, E. H., Chen, P. Z., Liu, D. R., & Palczewski, K. (2024) · Proceedings of the National Academy of Sciences

Retinal Development and DisordersCRISPR and Genetic Engineering

Cited by 20