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Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance

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CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions

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Discovery of a Potent and Selective BCL-X L Inhibitor with in Vivo Activity

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Functional Genetic Variants Revealed by Massively Parallel Precise Genome Editing

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In vivo base editing of post-mitotic sensory cells

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A framework for exhaustively mapping functional missense variants

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Sequence-specific prediction of the efficiencies of adenine and cytosine base editors

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Hypomyelination with atrophy of the basal ganglia and cerebellum: further delineation of the phenotype and genotype–phenotype correlation

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Target identification of small molecules using large-scale CRISPR-Cas mutagenesis scanning of essential genes

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Efficient, continuous mutagenesis in human cells using a pseudo-random DNA editor

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Predicting base editing outcomes with an attention-based deep learning algorithm trained on high-throughput target library screens

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CRISPR-suppressor scanning reveals a nonenzymatic role of LSD1 in AML

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A CRISPR-based base-editing screen for the functional assessment of BRCA1 variants

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miR-103/107 prolong Wnt/β-catenin signaling and colorectal cancer stemness by targeting Axin2

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