Markesbery, William R.

Defective DNA base excision repair in brain from individuals with Alzheimer's disease and amnestic mild cognitive impairment

Weissman, L., Jo, D.-G., Sorensen, M. M., de Souza-Pinto, N. C., Markesbery, W. R., Mattson, M. P., & Bohr, V. A. (2007) · Nucleic Acids Research

Alzheimer's disease research and treatmentsDNA Repair Mechanisms

Cited by 299

Decreased levels of proteasome activity and proteasome expression in aging spinal cord

Keller, J. N., Huang, F. F., & Markesbery, W. R. (2000) · Neuroscience

Ubiquitin and proteasome pathwaysGenetics, Aging, and Longevity in Model Organisms

Cited by 297

Clinicopathologic Correlations in a Large Alzheimer Disease Center Autopsy Cohort: Neuritic Plaques and Neurofibrillary Tangles "Do Count" When Staging Disease Severity

Nelson, P. T., Jicha, G. A., Schmitt, F. A., Liu, H., Davis, D. G., Mendiondo, M. S., Abner, E. L., & Markesbery, W. R. (2007) · Journal of Neuropathology and Experimental Neurology

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 292

Increased oxidative damage in nuclear and mitochondrial DNA in mild cognitive impairment

Wang, J., Markesbery, W. R., & Lovell, M. A. (2006) · Journal of Neurochemistry

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 260

Redox proteomic identification of 4-Hydroxy-2-nonenal-modified brain proteins in amnestic mild cognitive impairment: Insight into the role of lipid peroxidation in the progression and pathogenesis of Alzheimer's disease

Reed, T., Perluigi, M., Sultana, R., Pierce, W. M., Klein, J. B., Turner, D. M., Coccia, R., Markesbery, W. R., & Butterfield, D. A. (2008) · Neurobiology of Disease

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 257

Modeling the Association between 43 Different Clinical and Pathological Variables and the Severity of Cognitive Impairment in a Large Autopsy Cohort of Elderly Persons

Nelson, P. T., Abner, E. L., Schmitt, F. A., Kryscio, R. J., Jicha, G. A., Smith, C. D., Davis, D. G., Poduska, J. W., Patel, E., Mendiondo, M. S., et al. (2010) · Brain Pathology

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 239

Neuropathologic Alterations in Mild Cognitive Impairment: A Review

Markesbery, W. R. (2010) · Journal of Alzheimer's Disease

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 236

Toll-like receptor-4 mediates neuronal apoptosis induced by amyloid β-peptide and the membrane lipid peroxidation product 4-hydroxynonenal

Tang, S.-C., Lathia, J. D., Selvaraj, P. K., Jo, D.-G., Mughal, M. R., Cheng, A., Siler, D. A., Markesbery, W. R., Arumugam, T. V., & Mattson, M. P. (2008) · Experimental Neurology

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 232

AD lesions and infarcts in demented and non‐demented Japanese‐American men

Petrovitch, H., Ross, G. W., Steinhorn, S. C., Abbott, R. D., Markesbery, W., Davis, D., Nelson, J., Hardman, J., Masaki, K., Vogt, M. R., et al. (2005) · Annals of Neurology

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 230

Lewy Body Pathology in Normal Elderly Subjects

Markesbery, W. R., Jicha, G. A., Liu, H., & Schmitt, F. A. (2009) · Journal of Neuropathology & Experimental Neurology

Parkinson's Disease Mechanisms and TreatmentsDementia and Cognitive Impairment Research

Cited by 210

Increased levels of 4-hydroxynonenal and acrolein in the brain in preclinical Alzheimer disease

Bradley, M. A., Markesbery, W. R., & Lovell, M. A. (2010) · Free Radical Biology and Medicine

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 193

Proteomic identification of HNE-bound proteins in early Alzheimer disease: Insights into the role of lipid peroxidation in the progression of AD

Reed, T. T., Pierce, W. M., Markesbery, W. R., & Butterfield, D. A. (2009) · Brain Research

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 190

Brain structural alterations before mild cognitive impairment

Smith, C. D., Chebrolu, H., Wekstein, D. R., Schmitt, F. A., Jicha, G. A., Cooper, G., & Markesbery, W. R. (2007) · Neurology

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 161

Recent Clinical-Pathologic Research on the Causes of Dementia in Late Life: Update From the Honolulu-Asia Aging Study

White, L., Small, B. J., Petrovitch, H., Ross, G. W., Masaki, K., Abbott, R. D., Hardman, J., Davis, D., Nelson, J., & Markesbery, W. (2005) · Journal of Geriatric Psychiatry and Neurology

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 155

Decreased RNA, and Increased RNA Oxidation, in Ribosomes from Early Alzheimer’s Disease

Ding, Q., Markesbery, W. R., Cecarini, V., & Keller, J. N. (2006) · Neurochemical Research

Alzheimer's disease research and treatmentsRNA and protein synthesis mechanisms

Cited by 140

Proteomic identification of nitrated brain proteins in early Alzheimer’s disease inferior parietal lobule

Reed, T. T., Pierce Jr., W. M., Turner, D. M., Markesbery, W. R., & Allan Butterfield, D. (2009) · Journal of Cellular and Molecular Medicine

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 135

Association between male gender and cortical Lewy body pathology in large autopsy series

Nelson, P. T., Schmitt, F. A., Jicha, G. A., Kryscio, R. J., Abner, E. L., Smith, C. D., Van Eldik, L. J., & Markesbery, W. R. (2010) · Journal of Neurology

Parkinson's Disease Mechanisms and TreatmentsDementia and Cognitive Impairment Research

Cited by 131

AD brain pathology: Vascular origins?

Launer, L. J., Petrovitch, H., Ross, G. W., Markesbery, W., & White, L. R. (2008) · Neurobiology of Aging

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 117

Brains With Medial Temporal Lobe Neurofibrillary Tangles But No Neuritic Amyloid Plaques Are a Diagnostic Dilemma But May Have Pathogenetic Aspects Distinct From Alzheimer Disease

Nelson, P. T., Abner, E. L., Schmitt, F. A., Kryscio, R. J., Jicha, G. A., Santacruz, K., Smith, C. D., Patel, E., & Markesbery, W. R. (2009) · Journal of Neuropathology & Experimental Neurology

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 115

Altered 8-oxoguanine glycosylase in mild cognitive impairment and late-stage Alzheimer’s disease brain

Shao, C., Xiong, S., Li, G.-M., Gu, L., Mao, G., Markesbery, W. R., & Lovell, M. A. (2008) · Free Radical Biology and Medicine

Alzheimer's disease research and treatmentsDNA Repair Mechanisms

Cited by 114

Oxidative stress in head trauma in aging

Shao, C., Roberts, K. N., Markesbery, W. R., Scheff, S. W., & Lovell, M. A. (2006) · Free Radical Biology and Medicine

Traumatic Brain Injury and Neurovascular DisturbancesTraumatic Brain Injury Research

Cited by 111

Prodromal clinical manifestations of neuropathologically confirmed Lewy body disease

Jicha, G. A., Schmitt, F. A., Abner, E., Nelson, P. T., Cooper, G. E., Smith, C. D., & Markesbery, W. R. (2010) · Neurobiology of Aging

Dementia and Cognitive Impairment ResearchParkinson's Disease Mechanisms and Treatments

Cited by 111

Alzheimer disease pathology in cognitively healthy elderly: A genome-wide study

Kramer, P. L., Xu, H., Woltjer, R. L., Westaway, S. K., Clark, D., Erten-Lyons, D., Kaye, J. A., Welsh-Bohmer, K. A., Troncoso, J. C., Markesbery, W. R., et al. (2011) · Neurobiology of Aging

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 108

Comparison of neuropathologic criteria for the diagnosis of Alzheimer's disease

Geddes, J. W., Tekirian, T. L., Soultanian, N. S., Ashford, J. W., Davis, D. G., & Markesbery, W. R. (1997) · Neurobiology of Aging

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 101