Saretzki, Gabriele

A DNA damage checkpoint response in telomere-initiated senescence

Fagagna, F. D. D., Reaper, P. M., Clay-Farrace, L., Fiegler, H., Carr, P., von Zglinicki, T., Saretzki, G., Carter, N. P., & Jackson, S. P. (2003) · Nature

Telomeres, Telomerase, and SenescenceDNA Repair Mechanisms

Cited by 2,917

Feedback between p21 and reactive oxygen production is necessary for cell senescence

Passos, J. F., Nelson, G., Wang, C., Richter, T., Simillion, C., Proctor, C. J., Miwa, S., Olijslagers, S., Hallinan, J., Wipat, A., et al. (2010) · Molecular Systems Biology

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 1,019

Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: a model for senescence?

von Zglinicki, T., Saretzki, G., Döcke, W., & Lotze, C. (1995) · Experimental Cell Research

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 856

Chronic inflammation induces telomere dysfunction and accelerates ageing in mice

Jurk, D., Wilson, C., Passos, J. F., Oakley, F., Correia-Melo, C., Greaves, L., Saretzki, G., Fox, C., Lawless, C., Anderson, R., et al. (2014) · Nature Communications

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 819

Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence

Passos, J. F., Saretzki, G., Ahmed, S., Nelson, G., Richter, T., Peters, H., Wappler, I., Birket, M. J., Harold, G., Schaeuble, K., et al. (2007) · PLoS Biology

Telomeres, Telomerase, and SenescenceMitochondrial Function and Pathology

Cited by 796

Mitochondria are required for pro-ageing features of the senescent phenotype

Correia‐Melo, C., Marques, F. D., Anderson, R., Hewitt, G., Hewitt, R., Cole, J., Carroll, B. M., Miwa, S., Birch, J., Merz, A., et al. (2016) · The EMBO Journal

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 796

Preferential Accumulation of Single-Stranded Regions in Telomeres of Human Fibroblasts

Petersen, S., Saretzki, G., & Zglinicki, T. V. (1998) · Experimental Cell Research

Telomeres, Telomerase, and SenescenceDNA Repair Mechanisms

Cited by 427

Human cell senescence as a DNA damage response

Zglinicki, T. V., Saretzki, G., Ladhoff, J., Fagagna, F. D. D., & Jackson, S. P. (2005) · Mechanisms of Ageing and Development

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 419

DNA damage in telomeres and mitochondria during cellular senescence: is there a connection?

Passos, J. F., Saretzki, G., & von Zglinicki, T. (2007) · Nucleic Acids Research

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 344

Extracellular superoxide dismutase is a major antioxidant in human fibroblasts and slows telomere shortening

Serra, V., von Zglinicki, T., Lorenz, M., & Saretzki, G. (2003) · Journal of Biological Chemistry

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 278

The bystander effect contributes to the accumulation of senescent cells in vivo

da Silva, P. F. L., Ogrodnik, M., Kucheryavenko, O., Glibert, J., Miwa, S., Cameron, K., Ishaq, A., Saretzki, G., Nagaraja‐Grellscheid, S., Nelson, G., et al. (2019) · Aging Cell

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 247

Neutrophils induce paracrine telomere dysfunction and senescence in ROS‐dependent manner

Lagnado, A., Leslie, J., Ruchaud‐Sparagano, M., Victorelli, S., Hirsova, P., Ogrodnik, M., Collins, A. L., Vizioli, M. G., Habiballa, L., Saretzki, G., et al. (2021) · The EMBO Journal

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 211

MitoQ counteracts telomere shortening and elongates lifespan of fibroblasts under mild oxidative stress

Saretzki, G., Murphy, M. P., & Von Zglinicki, T. (2003) · Aging Cell

Telomeres, Telomerase, and SenescenceMitochondrial Function and Pathology

Cited by 203

Overexpression of Telomerase Confers Growth Advantage, Stress Resistance, and Enhanced Differentiation of ESCs Toward the Hematopoietic Lineage

Armstrong, L., Saretzki, G., Peters, H., Wappler, I., Evans, J., Hole, N., von Zglinicki, T., & Lako, M. (2005) · Stem Cells

Telomeres, Telomerase, and SenescencePluripotent Stem Cells Research

Cited by 153

Adult-onset, short-term dietary restriction reduces cell senescence in mice

Wang, C., Maddick, M., Miwa, S., Jurk, D., Czapiewski, R., Saretzki, G., Langie, S. A. S., Godschalk, R. W. L., Cameron, K., & von Zglinicki, T. (2010) · Aging

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 142

The Role of Telomerase Protein TERT in Alzheimer's Disease and in Tau-Related Pathology In Vitro

Spilsbury, A., Miwa, S., Attems, J., & Saretzki, G. (2015) · The Journal of Neuroscience

Alzheimer's disease research and treatmentsTelomeres, Telomerase, and Senescence

Cited by 140

A Key Role for Telomerase Reverse Transcriptase Unit in Modulating Human Embryonic Stem Cell Proliferation, Cell Cycle Dynamics, and In Vitro Differentiation

Yang, C., Przyborski, S., Cooke, M. J., Zhang, X., Stewart, R., Anyfantis, G., Atkinson, S. P., Saretzki, G., Armstrong, L., & Lako, M. (2008) · Stem Cells

Telomeres, Telomerase, and SenescencePluripotent Stem Cells Research

Cited by 136

An Induced Pluripotent Stem Cell Patient Specific Model of Complement Factor H (Y402H) Polymorphism Displays Characteristic Features of Age-Related Macular Degeneration and Indicates a Beneficial Role for UV Light Exposure

Hallam, D., Collin, J., Bojic, S., Chichagova, V., Buskin, A., Xu, Y., Lafage, L., Otten, E. G., Anyfantis, G., Mellough, C., et al. (2017) · Stem Cells

Retinal Diseases and TreatmentsRetinal Development and Disorders

Cited by 75

Derivation and functional analysis of patient-specific induced pluripotent stem cells as an in vitro model of chronic granulomatous disease

Jiang, Y., Cowley, S. A., Siler, U., Melguizo, D., Tilgner, K., Browne, C., Dewilton, A., Przyborski, S., Saretzki, G., James, W. S., et al. (2012) · Stem Cells

Pluripotent Stem Cells ResearchImmunodeficiency and Autoimmune Disorders

Cited by 71

A stochastic step model of replicative senescence explains ROS production rate in ageing cell populations

Lawless, C., Jurk, D., Gillespie, C. S., Shanley, D., Saretzki, G., von Zglinicki, T., & Passos, J. F. (2012) · PLoS ONE

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 62

Increased telomerase improves motor function and alpha-synuclein pathology in a transgenic mouse model of Parkinson’s disease associated with enhanced autophagy

Wan, T., Weir, E. J., Johnson, M., Korolchuk, V. I., & Saretzki, G. C. (2021) · Progress in Neurobiology

Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and Signaling

Cited by 52

Atorvastatin induces T cell proliferation by a telomerase reverse transcriptase (TERT) mediated mechanism

Bennaceur, K., Atwill, M., Al Zhrany, N., Hoffmann, J., Keavney, B., Breault, D., Richardson, G., von Zglinicki, T., Saretzki, G., & Spyridopoulos, I. (2014) · Atherosclerosis

Telomeres, Telomerase, and SenescenceAtherosclerosis and Cardiovascular Diseases

Cited by 51