Mucke, Lennart

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

Games, D., Adams, D., Alessandrini, R., Barbour, R., Borthelette, P., Blackwell, C., Carr, T., Clemens, J., Donaldson, T., Gillespie, F., et al. (1995) · Nature

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 2,516

Reducing Endogenous Tau Ameliorates Amyloid ß-Induced Deficits in an Alzheimer's Disease Mouse Model

Roberson, E. D., Scearce-Levie, K., Palop, J. J., Yan, F., Cheng, I. H., Wu, T., Gerstein, H., Yu, G.-Q., & Mucke, L. (2007) · Science

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 1,892

High-Level Neuronal Expression of Aβ1–42in Wild-Type Human Amyloid Protein Precursor Transgenic Mice: Synaptotoxicity without Plaque Formation

Mucke, L., Masliah, E., Yu, G.-Q., Mallory, M., Rockenstein, E. M., Tatsuno, G., Hu, K., Kholodenko, D., Johnson-Wood, K., & McConlogue, L. (2000) · The Journal of Neuroscience

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 1,856

Alzheimer Mechanisms and Therapeutic Strategies

Huang, Y., & Mucke, L. (2012) · Cell

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 1,758

Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of alzheimer’s disease.

Palop, J. J., Chin, J., Roberson, E. D., Wang, J., Thwin, M. T., Bien-Ly, N., Yoo, J., Ho, K. O., Yu, G.-Q., Kreitzer, A., et al. (2007) · Neuron

Alzheimer's disease research and treatmentsNeuroscience and Neuropharmacology Research

Cited by 1,653

Amyloid-β–induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks

Palop, J. J., & Mucke, L. (2010) · Nature Neuroscience

Alzheimer's disease research and treatmentsNeuroscience and Neuropharmacology Research

Cited by 1,651

Inflammation in Neurodegenerative Disease—A Double-Edged Sword

Wyss-Coray, T., & Mucke, L. (2002) · Neuron

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 1,235

Inhibitory Interneuron Deficit Links Altered Network Activity and Cognitive Dysfunction in Alzheimer Model

Verret, L., Mann, E. O., Hang, G. B., Barth, A. M. I., Cobos, I., Ho, K., Devidze, N., Masliah, E., Kreitzer, A. C., Mody, I., et al. (2012) · Cell

Alzheimer's disease research and treatmentsNeuroscience and Neuropharmacology Research

Cited by 1,216

Plaque-independent disruption of neural circuits in Alzheimer’s disease mouse models

Hsia, A. Y., Masliah, E., McConlogue, L., Yu, G.-Q., Tatsuno, G., Hu, K., Kholodenko, D., Malenka, R. C., Nicoll, R. A., & Mucke, L. (1999) · Proceedings of the National Academy of Sciences

Alzheimer's disease research and treatmentsNeuroscience and Neuropharmacology Research

Cited by 1,123

Leukocyte Infiltration, Neuronal Degeneration, and Neurite Outgrowth after Ablation of Scar-Forming, Reactive Astrocytes in Adult Transgenic Mice

Bush, T. G., Puvanachandra, N., Horner, C. H., Polito, A., Ostenfeld, T., Svendsen, C. N., Mucke, L., Johnson, M. H., & Sofroniew, M. V. (1999) · Neuron

Traumatic Brain Injury and Neurovascular DisturbancesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 1,116

Network abnormalities and interneuron dysfunction in Alzheimer disease

Palop, J. J., & Mucke, L. (2016) · Nature reviews. Neuroscience

Alzheimer's disease research and treatmentsNeural dynamics and brain function

Cited by 1,022

Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6.

Campbell, I. L., Abraham, C. R., Masliah, E., Kemper, P., Inglis, J. D., Oldstone, M. B., & Mucke, L. (1993) · Proceedings of the National Academy of Sciences

Neuroinflammation and Neurodegeneration MechanismsTryptophan and brain disorders

Cited by 1,006

Neurotoxicity of Amyloid -Protein: Synaptic and Network Dysfunction

Mucke, L., & Selkoe, D. J. (2012) · Cold Spring Harbor Perspectives in Medicine

Alzheimer's disease research and treatmentsNeuroscience and Neuropharmacology Research

Cited by 1,000

The many faces of tau

Morris, M., Maeda, S., Vossel, K., & Mucke, L. (2011) · Neuron

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 899

SIRT1 Protects against Microglia-dependent Amyloid-β Toxicity through Inhibiting NF-κB Signaling

Chen, J., Zhou, Y., Mueller-Steiner, S., Chen, L.-F., Kwon, H., Yi, S., Mucke, L., & Gan, L. (2005) · Journal of Biological Chemistry

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 740

Amyloid-β/Fyn–Induced Synaptic, Network, and Cognitive Impairments Depend on Tau Levels in Multiple Mouse Models of Alzheimer's Disease

Roberson, E. D., Halabisky, B., Yoo, J. W., Yao, J., Chin, J., Yan, F., Wu, T., Hamto, P., Devidze, N., Yu, G.-Q., et al. (2011) · The Journal of Neuroscience

Alzheimer's disease research and treatmentsNeuroscience and Neuropharmacology Research

Cited by 654

Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer’s disease model

Sanchez, P. E., Zhu, L., Verret, L., Vossel, K. A., Orr, A. G., Cirrito, J. R., Devidze, N., Ho, K., Yu, G.-Q., Palop, J. J., et al. (2012) · Proceedings of the National Academy of Sciences

Alzheimer's disease research and treatmentsNeuroscience and Neuropharmacology Research

Cited by 638

β-Amyloid peptides enhance α-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease

Masliah, E., Rockenstein, E., Veinbergs, I., Sagara, Y., Mallory, M., Hashimoto, M., & Mucke, L. (2001) · Proceedings of the National Academy of Sciences

Alzheimer's disease research and treatmentsParkinson's Disease Mechanisms and Treatments

Cited by 607

TGF-β1 promotes microglial amyloid-β clearance and reduces plaque burden in transgenic mice

Wyss-Coray, T., Lin, C., Yan, F., Yu, G.-Q., Rohde, M., McConlogue, L., Masliah, E., & Mucke, L. (2001) · Nature Medicine

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 587

Incidence and impact of subclinical epileptiform activity in Alzheimer’s disease.

Vossel, K. A., Ranasinghe, K. G., Beagle, A. J., Mizuiri, D., Honma, S. M., Dowling, A. F., Darwish, S. M., Van Berlo, V., Barnes, D. E., Mantle, M., et al. (2016) · Annals of Neurology

Dementia and Cognitive Impairment ResearchEpilepsy research and treatment

Cited by 557

Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-β

Suberbielle, E., Sanchez, P. E., Kravitz, A. V., Wang, X., Ho, K., Eilertson, K., Devidze, N., Kreitzer, A. C., & Mucke, L. (2013) · Nature Neuroscience

DNA Repair MechanismsAlzheimer's disease research and treatments

Cited by 487

Tau Reduction Prevents Aβ-Induced Defects in Axonal Transport

Vossel, K. A., Zhang, K., Brodbeck, J., Daub, A. C., Sharma, P., Finkbeiner, S., Cui, B., & Mucke, L. (2010) · Science

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 486

Tau post-translational modifications in wild-type and human amyloid precursor protein transgenic mice

Morris, M., Knudsen, G. M., Maeda, S., Trinidad, J. C., Ioanoviciu, A., Burlingame, A. L., & Mucke, L. (2015) · Nature Neuroscience

Alzheimer's disease research and treatmentsAdvanced Proteomics Techniques and Applications

Cited by 472

Alzheimer's disease

Mucke, L. (2009) · Nature

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 456