Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-β
Open accessAbstract
We show that a natural behavior, exploration of a novel environment, causes DNA double-strand breaks (DSBs) in neurons of young adult wild-type mice. DSBs occurred in multiple brain regions, were most abundant in the dentate gyrus, which is involved in learning and memory, and were repaired within 24 h. Increasing neuronal activity by sensory or optogenetic stimulation increased neuronal DSBs in relevant but not irrelevant networks. Mice transgenic for human amyloid precursor protein (hAPP), which simulate key aspects of Alzheimer's disease, had increased neuronal DSBs at baseline and more severe and prolonged DSBs after exploration. Interventions that suppress aberrant neuronal activity and improve learning and memory in hAPP mice normalized their levels of DSBs. Blocking extrasynaptic NMDA-type glutamate receptors prevented amyloid-β (Aβ)-induced DSBs in neuronal cultures. Thus, transient increases in neuronal DSBs occur as a result of physiological brain activity, and Aβ exacerbates DNA damage, most likely by eliciting synaptic dysfunction.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Aβ induces oxidative DNA damage.
“With the recognized knowledge that Aβ induces oxidative DNA damage (Suberbielle et al., 2013; Wu et al., 2014; Yan et al., 2014)”
From CIP2A Causes Tau/APP Phosphorylation, Synaptopathy, and Memory Deficits in Alzheimer’s Disease (2018) · cites this paper as Suberbielle et al., 2013
Neurons actively induce both DSBs and single-stranded breaks as part of their normal physiology.
“neurons also actively induce both DSBs and single-stranded breaks as part of their normal physiology”
From Neuronal DNA double-strand breaks lead to genome structural variations and 3D genome disruption in neurodegeneration (2023) · cites this paper as [11]
DSBs play important roles in cell physiology, including T-cell receptor and antibody diversity, chromosomal recombination during meiosis, and immediate early gene expression in neurons.
“DSBs are required for T‐cell receptor and antibody diversity, chromosomal recombination during meiosis, and in the case of neurons, assist in the expression of immediate early genes”
From Mechanisms of DNA damage-mediated neurotoxicity in neurodegenerative disease (2022) · cites this paper as Suberbielle et al, 2013
Some data suggest that Aβ toxicity is partially mediated through tau, as tau knockout mice are protected against Aβ-induced insults including cognitive effects, seizures, survival, axonal transport, and DNA double-stranded breaks.
“Some data suggest that Aβ toxicity is partially mediated through tau (50–52) as the tau knockout mouse has proven to be protected against a growing number of Aβ-induced insults, including those affecting cognition (50, 53), seizures (14, 50, 51, 54, 55), survival (50, 51, 54), axonal transport (52), and double-stranded breaks in DNA (55).”
From Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy (2017) · cites this paper as [55]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
nlme : Linear and nonlinear mixed effects models
DebRoy, S. (2006) · Medical Entomology and Zoology · Cited by 10,009 · see citing works
Reducing Endogenous Tau Ameliorates Amyloid ß-Induced Deficits in an Alzheimer's Disease Mouse Model
Roberson, E. D., Scearce-Levie, K., Palop, J. J., Yan, F., Cheng, I. H., Wu, T., Gerstein, H., Yu, G.-Q., & Mucke, L. (2007) · Science · doi:10.1126/science.1141736 · Cited by 1,892 · see citing works
Self-citationRegulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry
Kravitz, A. V., Freeze, B. S., Parker, P. R. L., Kay, K., Thwin, M. T., Deisseroth, K., & Kreitzer, A. C. (2010) · Nature · doi:10.1038/nature09159 · Cited by 1,885 · see citing works
Self-citationGene regulation and DNA damage in the ageing human brain
Lu, T., Pan, Y., Kao, S.-Y., Li, C., Kohane, I., Chan, J., & Yankner, B. A. (2004) · Nature · doi:10.1038/nature02661 · Cited by 1,874 · see citing works
The comet assay: a method to measure DNA damage in individual cells
Olive, P. L., & Banáth, J. P. (2006) · Nature Protocols · doi:10.1038/nprot.2006.5 · Cited by 1,845 · see citing works
Palop, J. J., Chin, J., Roberson, E. D., Wang, J., Thwin, M. T., Bien-Ly, N., Yoo, J., Ho, K. O., Yu, G.-Q., Kreitzer, A., et al. (2007) · Neuron · doi:10.1016/j.neuron.2007.07.025 · Cited by 1,653 · see citing works
Self-citationAmyloid-β–induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks
Palop, J. J., & Mucke, L. (2010) · Nature Neuroscience · doi:10.1038/nn.2583 · Cited by 1,651 · see citing works
Self-citationSynaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders
Hardingham, G. E., & Bading, H. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2911 · Cited by 1,644 · see citing works
Bonner, W. M., Redon, C. E., Dickey, J. S., Nakamura, A. J., Sedelnikova, O. A., Solier, S., & Pommier, Y. (2008) · Nature reviews. Cancer · doi:10.1038/nrc2523 · Cited by 1,623 · see citing works
Verret, L., Mann, E. O., Hang, G. B., Barth, A. M. I., Cobos, I., Ho, K., Devidze, N., Masliah, E., Kreitzer, A. C., Mody, I., et al. (2012) · Cell · doi:10.1016/j.cell.2012.02.046 · Cited by 1,216 · see citing works
Self-citationLi, S., Hong, S., Shepardson, N. E., Walsh, D. M., Shankar, G. M., & Selkoe, D. (2009) · Neuron · doi:10.1016/j.neuron.2009.05.012 · Cited by 972 · see citing works
Morris, M., Maeda, S., Vossel, K., & Mucke, L. (2011) · Neuron · doi:10.1016/j.neuron.2011.04.009 · Cited by 899 · see citing works
Self-citationEpilepsy and Cognitive Impairments in Alzheimer Disease
Palop, J. J. (2009) · Archives of Neurology · doi:10.1001/archneurol.2009.15 · Cited by 684 · see citing works
Animal models of Alzheimer's disease and frontotemporal dementia
Götz, J., & Ittner, L. M. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2420 · Cited by 676 · see citing works
Li, S., Jin, M., Koeglsperger, T., Shepardson, N. E., Shankar, G. M., & Selkoe, D. J. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0203-11.2011 · Cited by 664 · see citing works
Roberson, E. D., Halabisky, B., Yoo, J. W., Yao, J., Chin, J., Yan, F., Wu, T., Hamto, P., Devidze, N., Yu, G.-Q., et al. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.4152-10.2011 · Cited by 654 · see citing works
Self-citationSanchez, P. E., Zhu, L., Verret, L., Vossel, K. A., Orr, A. G., Cirrito, J. R., Devidze, N., Ho, K., Yu, G.-Q., Palop, J. J., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1121081109 · Cited by 638 · see citing works
Self-citationH2AX Is Required for Chromatin Remodeling and Inactivation of Sex Chromosomes in Male Mouse Meiosis
Fernández-Capetillo, Ó., Mahadevaiah, S. K., Celeste, A., Romanienko, P. J., Camerini‐Otero, R. D., Bonner, W. M., Manova, K., Burgoyne, P. S., & Nussenzweig, A. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00093-5 · Cited by 598 · see citing works
Epigenetic mechanisms in cognition
Day, J. J., & Sweatt, J. D. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.019 · Cited by 510 · see citing works
Reversing EphB2 depletion rescues cognitive functions in Alzheimer model
Cissé, M., Halabisky, B., Harris, J., Devidze, N., Dubal, D. B., Sun, B., Orr, A., Lotz, G., Kim, D. H., Hamto, P., et al. (2011) · Nature · doi:10.1038/nature09635 · Cited by 433 · see citing works
Self-citationCheng, I. H.-J., Scearce-Levie, K. A., Legleiter, J. A., Palop, J. J., Gerstein, H., Bien‐Ly, N., Puolivaöli, J., Lesné, S., Ashe, K. H., Muchowski, P. J., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m701078200 · Cited by 403 · see citing works
Self-citationPalop, J. J., Jones, B., Kekonius, L., Chin, J., Yu, G.-Q., Raber, J., Masliah, E., & Mucke, L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1133381100 · Cited by 402 · see citing works
Self-citationEpigenetic regulation of gene expression in physiological and pathological brain processes
Gräff, J., Kim, D., Dobbin, M. M., & Tsai, L.-H. (2011) · Physiological Reviews · doi:10.1152/physrev.00012.2010 · Cited by 373 · see citing works
Phosphorylation and rapid relocalization of 53BP1 to nuclear foci upon DNA damage
Anderson, L., Henderson, C., & Adachi, Y. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.5.1719-1729.2001 · Cited by 367 · see citing works
Ward, I. M., Minn, K. T., Jorda, K. G., & Chen, J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.c300117200 · Cited by 361 · see citing works
Harris, J. A., Devidze, N., Verret, L., Ho, K., Halabisky, B., Thwin, M. T., Kim, D., Hamto, P., Lo, I., Yu, G.-Q., et al. (2010) · Neuron · doi:10.1016/j.neuron.2010.10.020 · Cited by 319 · see citing works
Self-citationDeregulation of HDAC1 by p25/Cdk5 in Neurotoxicity
Kim, D., Frank, C. L., Dobbin, M. M., Tsunemoto, R. K., Tu, W., Peng, P. L., Guan, J.-S., Lee, B.-H., Moy, L. Y., Giusti, P., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.10.015 · Cited by 286 · see citing works
The EthoVision video tracking system—A tool for behavioral phenotyping of transgenic mice
Spink, A., Tegelenbosch, R. A. J., Buma, M., & Noldus, L. P. J. J. (2001) · Physiology & Behavior · doi:10.1016/s0031-9384(01)00530-3 · Cited by 271 · see citing works
Rong, Y., Doctrow, S. R., Tocco, G., & Baudry, M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.17.9897 · Cited by 264 · see citing works
Esposito, L., Raber, J., Kekonius, L., Yan, F., Yu, G.-Q., Bien-Ly, N., Puoliväli, J., Scearce-Levie, K., Masliah, E., & Mucke, L. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.0482-06.2006 · Cited by 254 · see citing works
ATM controls meiotic double-strand-break formation
Lange, J., Pan, J., Cole, F., Thelen, M. P., Jasin, M., & Keeney, S. (2011) · Nature · doi:10.1038/nature10508 · Cited by 249 · see citing works
Vazdarjanova, A. I., Ramı́rez-Amaya, V., Insel, N., Plummer, T. K., Rosi, S., Chowdhury, S., Mikhael, D. M., Worley, P. F., Guzowski, J. F., & Barnes, C. A. (2006) · The Journal of Comparative Neurology · doi:10.1002/cne.21003 · Cited by 233 · see citing works
Induction of DNA damage, alteration of DNA repair and transcriptional activation by stress hormones
Flint, M. S., Baum, A. E., Chambers, W. H., & Jenkins, F. J. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.02.013 · Cited by 224 · see citing works
Nucleic acid oxidation in Alzheimer disease
Moreira, P. I., Nunomura, A., Nakamura, M., Takeda, A., Shenk, J. C., Aliev, G., Smith, M. A., & Perry, G. L. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.01.002 · Cited by 206 · see citing works
Fillingham, J., Keogh, M., & Krogan, N. J. (2006) · Biochemistry and Cell Biology · doi:10.1139/o06-072 · Cited by 190 · see citing works
Behavioral phenotypes of amyloid‐based genetically modified mouse models of Alzheimer's disease
Kobayashi, D. T., & Chen, K. S. (2005) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2005.00124.x · Cited by 175 · see citing works
Inducible response required for repair of low-dose radiation damage in human fibroblasts
Grudzenski, S., Raths, A., Conrad, S., Rübe, C. E., & Löbrich, M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002213107 · Cited by 161 · see citing works
Palop, J. J., Chin, J., Bien‐Ly, N., Massaro, C. M., Yeung, B. Z., Yu, G.-Q., & Mucke, L. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.2829-05.2005 · Cited by 144 · see citing works
Self-citationCell cycle restriction by histone H2AX limits proliferation of adult neural stem cells
Fernando, R. N., Eleuteri, B., Abdelhady, S., Nussenzweig, A., Andäng, M., & Ernfors, P. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1014993108 · Cited by 138 · see citing works
Collagen VI protects neurons against Aβ toxicity
Cheng, J. S., Dubal, D. B., Kim, D. H., Legleiter, J. A., Cheng, I. H.-J., Yu, G.-Q., Tesseur, I. C., Wyss‐Coray, T., Bonaldo, P., & Mucke, L. (2009) · Nature Neuroscience · doi:10.1038/nn.2240 · Cited by 134 · see citing works
Self-citationMarchetti, C., & Marie, H. (2011) · Reviews in the Neurosciences · doi:10.1515/rns.2011.035 · Cited by 133 · see citing works
Lee, H., Casadesús, G., Zhu, X., Castellani, R. J., McShea, A., Perry, G. L., Petersen, R. B., Bajić, V., & Smith, M. A. (2008) · Neurochemistry International · doi:10.1016/j.neuint.2008.10.013 · Cited by 132 · see citing works
Zhang, Y., Goodyer, C. G., & LeBlanc, A. C. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-22-08384.2000 · Cited by 130 · see citing works
Age-appropriate cognition and subtle dopamine-independent motor deficits in aged Tau knockout mice
Morris, M., Hamto, P., Adame, A., Devidze, N., Masliah, E., & Mucke, L. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.12.003 · Cited by 117 · see citing works
Self-citationThe γ‐H2A.X: Is it just a surrogate marker of double‐strand breaks or much more?
Ismail, I. H., & Hendzel, M. J. (2007) · Environmental and Molecular Mutagenesis · doi:10.1002/em.20358 · Cited by 107 · see citing works
Differential DNA damage signaling accounts for distinct neural apoptotic responses in ATLD and NBSPreprint
Shull, E. R. P., Lee, Y., Nakane, H., Stracker, T. H., Zhao, J., Russell, H. R., Petrini, J. H. J., & McKinnon, P. J. (2009) · Genes & Development · doi:10.1101/gad.1746609 · Cited by 104 · see citing works
Yang, J., Tadokoro, T., Keijzers, G., Mattson, M. P., & Bohr, V. A. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.082883 · Cited by 94 · see citing works
Pong, K., Doctrow, S. R., Huffman, K. D., Adinolfi, C. A., & Baudry, M. (2001) · Experimental Neurology · doi:10.1006/exnr.2001.7747 · Cited by 91 · see citing works
Rapid phosphorylation of histone H2A.X following ionotropic glutamate receptor activation
Crowe, S. L., Movsesyan, V. A., Jorgensen, T. J., & Kondratyev, A. D. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04768.x · Cited by 87 · see citing works
Brasnjevic, I., Hof, P. R., Steinbusch, H. W. M., & Schmitz, C. (2008) · DNA repair · doi:10.1016/j.dnarep.2008.03.010 · Cited by 86 · see citing works
Canugovi, C., Yoon, J. S., Feldman, N. H., Croteau, D. L., Mattson, M. P., & Bohr, V. A. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1204156109 · Cited by 81 · see citing works
Microscopic imaging of DNA repair foci in irradiated normal tissues
Bhogal, N., Jalali, F., & Bristow, R. G. (2009) · International Journal of Radiation Biology · doi:10.1080/09553000902785791 · Cited by 61 · see citing works
Tau Reduction Does Not Prevent Motor Deficits in Two Mouse Models of Parkinson's Disease
Morris, M., Koyama, A., Masliah, E., & Mucke, L. (2011) · PLoS ONE · doi:10.1371/journal.pone.0029257 · Cited by 56 · see citing works
Self-citationYin, B., Savic, V., Juntilla, M. M., Bredemeyer, A. L., Yang-Iott, K. S., Helmink, B. A., Koretzky, G. A., Sleckman, B. P., & Bassing, C. H. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20091320 · Cited by 53 · see citing works
Li, L., Cheung, T., Chen, J., & Herrup, K. (2011) · International Journal of Alzheimer s Disease · doi:10.4061/2011/171464 · Cited by 47 · see citing works
Crowe, S. L., Tsukerman, S., Gale, K., Jorgensen, T. J., & Kondratyev, A. D. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0092-11.2011 · Cited by 43 · see citing works
Histone XH2AX Is Required for Xenopus Anterior Neural Development
Lee, S., Lau, A. T. Y., Jeong, C., Shim, J., Kim, H.-G., Kim, J., Bode, A. M., & Dong, Z. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.127233 · Cited by 11 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Synergy between amyloid-β and tau in Alzheimer’s disease
Busche, M. A., & Hyman, B. T. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-0687-6 · Cited by 1,242 · see citing works
Network abnormalities and interneuron dysfunction in Alzheimer disease
Palop, J. J., & Mucke, L. (2016) · Nature reviews. Neuroscience · doi:10.1038/nrn.2016.141 · Cited by 1,022 · see citing works
Self-citationEmerging roles of oxidative stress in brain aging and Alzheimer's disease
Ionescu-Tucker, A., & Cotman, C. W. (2021) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2021.07.014 · Cited by 737 · see citing works
Activity-Induced DNA Breaks Govern the Expression of Neuronal Early-Response Genes
Madabhushi, R., Gao, F., Pfenning, A. R., Pan, L., Yamakawa, S., Seo, J., Rueda, R., Phan, T. X., Yamakawa, H., Pao, P.-C., et al. (2015) · Cell · doi:10.1016/j.cell.2015.05.032 · Cited by 700 · see citing works
DNA damage and its links to neurodegeneration
Madabhushi, R., Pan, L., & Tsai, L.-H. (2014) · Neuron · doi:10.1016/j.neuron.2014.06.034 · Cited by 654 · see citing works
The road to restoring neural circuits for the treatment of Alzheimer's disease
Canter, R. G., Penney, J., & Tsai, L.-H. (2016) · Nature · doi:10.1038/nature20412 · Cited by 565 · see citing works
Mosaic Copy Number Variation in Human Neurons
McConnell, M. J., Lindberg, M. R., Brennand, K. J., Piper, J. C., Voet, T., Cowing-Zitron, C., Shumilina, S., Lasken, R. S., Vermeesch, J. R., Hall, I. M., et al. (2013) · Science · doi:10.1126/science.1243472 · Cited by 551 · see citing works
DeVos, S. L., Miller, R. L., Schoch, K. M., Holmes, B. B., Kebodeaux, C. S., Wegener, A. J., Chen, G., Shen, T., Tran, H., Nichols, B., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aag0481 · Cited by 516 · see citing works
Morris, M., Knudsen, G. M., Maeda, S., Trinidad, J. C., Ioanoviciu, A., Burlingame, A. L., & Mucke, L. (2015) · Nature Neuroscience · doi:10.1038/nn.4067 · Cited by 472 · see citing works
Self-citationAntisense Reduction of Tau in Adult Mice Protects against Seizures
DeVos, S. L., Goncharoff, D. K., Chen, G., Kebodeaux, C. S., Yamada, K., Stewart, F. R., Schuler, D. R., Maloney, S. E., Wozniak, D. F., Rigo, F., et al. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2107-13.2013 · Cited by 311 · see citing works
Activation of innate immune cGAS-STING pathway contributes to Alzheimer’s pathogenesis in 5×FAD mice
Xie, X., Ma, G., Li, X., Zhao, J., Zhao, Z., & Zeng, J. (2023) · Nature Aging · doi:10.1038/s43587-022-00337-2 · Cited by 292 · see citing works
Maintaining genome stability in the nervous system
McKinnon, P. J. (2013) · Nature Neuroscience · doi:10.1038/nn.3537 · Cited by 229 · see citing works
Early neuronal accumulation of DNA double strand breaks in Alzheimer’s disease
Shanbhag, N. M., Evans, M. D., Mao, W., Nana, A. L., Seeley, W. W., Adame, A., Rissman, R. A., Masliah, E., & Mucke, L. (2019) · Acta Neuropathologica Communications · doi:10.1186/s40478-019-0723-5 · Cited by 214 · see citing works
Self-citationNeuronal enhancers are hotspots for DNA single-strand break repair
Wu, W., Kargbo-Hill, S. E., Nathan, W. J., Paiano, J., Callen, E., Wang, D., Shinoda, K., van Wietmarschen, N., Colón-Mercado, J. M., Zong, D., et al. (2021) · Nature · doi:10.1038/s41586-021-03468-5 · Cited by 223 · see citing works
Somatic APP gene recombination in Alzheimer’s disease and normal neurons
Lee, M.-H., Siddoway, B., Kaeser, G. E., Segota, I., Rivera, R., Romanow, W. J., Liu, C. S., Park, C., Kennedy, G., Long, T., et al. (2018) · Nature · doi:10.1038/s41586-018-0718-6 · Cited by 210 · see citing works
APOE2 enhances neuroprotection against Alzheimer’s disease through multiple molecular mechanisms
Conejero-Goldberg, C., Gomar, J. J., Bobes-Bascaran, T., Hyde, T. M., Kleinman, J. E., Herman, M. M., Chen, S., Davies, P., & Goldberg, T. E. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.194 · Cited by 199 · see citing works
Zalocusky, K. A., Najm, R., Taubes, A. L., Hao, Y., Yoon, S. Y., Koutsodendris, N., Nelson, M. R., Rao, A., Bennett, D. A., Bant, J., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-021-00851-3 · Cited by 189 · see citing works
Genomic integrity and the ageing brain
Chow, H.-M., & Herrup, K. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn4020 · Cited by 174 · see citing works
Tau reduction prevents Aβ-induced axonal transport deficits by blocking activation of GSK3β
Vossel, K. A., Xu, J. C., Fomenko, V., Miyamoto, T., Suberbielle, E., Knox, J. A., Ho, K., Kim, D. H., Yu, G.-Q., & Mucke, L. (2015) · Journal of Cell Biology · doi:10.1083/jcb.201407065 · Cited by 167 · see citing works
Self-citationSong, X., Ma, F., & Herrup, K. (2019) · The Journal of Neuroscience · doi:10.1523/jneurosci.0774-19.2019 · Cited by 133 · see citing works
Bushman, D. M., Kaeser, G. E., Siddoway, B., Westra, J. W., Rivera, R. R., Rehen, S. K., Yung, Y. C., & Chun, J. (2015) · eLife · doi:10.7554/elife.05116 · Cited by 136 · see citing works
Dileep, V., Boix, C. A., Mathys, H., Marco, A., Welch, G. M., Meharena, H. S., Loon, A., Jeloka, R., Peng, Z., Bennett, D. A., et al. (2023) · Cell · doi:10.1016/j.cell.2023.08.038 · Cited by 130 · see citing works
Mechanisms of DNA damage-mediated neurotoxicity in neurodegenerative disease
Welch, G., & Tsai, L. (2022) · The EMBO Reports · doi:10.15252/embr.202154217 · Cited by 129 · see citing works
A NPAS4–NuA4 complex couples synaptic activity to DNA repair
Pollina, E. A., Gilliam, D. T., Landau, A. T., Lin, C., Pajarillo, N., Davis, C. P., Harmin, D. A., Yap, E.-L., Vogel, I. R., Griffith, E. C., et al. (2023) · Nature · doi:10.1038/s41586-023-05711-7 · Cited by 125 · see citing works
Genome instability in Alzheimer disease
Hou, Y., Song, H., Croteau, D. L., Akbari, M., & Bohr, V. A. (2017) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.04.005 · Cited by 120 · see citing works
Incorporation of a nucleoside analog maps genome repair sites in postmitotic human neurons
Reid, D. A., Reed, P. J., Schlachetzki, J. C. M., Nitulescu, I. I., Chou, G., Tsui, E. C., Jones, J. R., Chandran, S., Lu, A. T., McClain, C. A., et al. (2021) · Science · doi:10.1126/science.abb9032 · Cited by 121 · see citing works
The dendritic hypothesis for Alzheimer's disease pathophysiology
Cochran, J. N., Hall, A. M., & Roberson, E. D. (2014) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2013.12.004 · Cited by 114 · see citing works
Contributions of DNA Damage to Alzheimer’s Disease
Lin, X., Kapoor, A., Gu, Y., Chow, M. J., Peng, J., Zhao, K., & Tang, D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21051666 · Cited by 117 · see citing works
DNA double-strand breaks as drivers of neural genomic change, function, and disease
Alt, F. W., & Schwer, B. (2018) · DNA Repair · doi:10.1016/j.dnarep.2018.08.019 · Cited by 110 · see citing works
Epigenetic memory: The Lamarckian brain
Fischer, A. (2014) · The EMBO Journal · doi:10.1002/embj.201387637 · Cited by 107 · see citing works
Tau reduction in the presence of amyloid-β prevents tau pathology and neuronal death in vivo
DeVos, S. L., Corjuc, B. T., Commins, C., Dujardin, S., Bannon, R. N., Corjuc, D., Moore, B. D., Bennett, R. E., Jorfi, M., Gonzales, J. A., et al. (2018) · Brain · doi:10.1093/brain/awy117 · Cited by 106 · see citing works
Thadathil, N., Delotterie, D. F., Xiao, J., Hori, R., McDonald, M. P., & Khan, M. M. (2021) · Molecular Neurobiology · doi:10.1007/s12035-020-02109-8 · Cited by 94 · see citing works
CIP2A Causes Tau/APP Phosphorylation, Synaptopathy, and Memory Deficits in Alzheimer’s Disease
Shentu, Y.-P., Huo, Y., Feng, X.-L., Gilbert, J., Zhang, Q., Liuyang, Z.-Y., Wang, X.-L., Wang, G., Zhou, H., Wang, X.-C., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.06.009 · Cited by 90 · see citing works
“In AD neurons, oxidative DNA damage signaling is induced by exposure of cells to Aβ (Suberbielle et al., 2013; Wu et al., 2014; Yan et al., 2014).”
BackgroundSelf-citationWei, Z., Chen, X.-C., Song, Y., Pan, X.-D., Dai, X.-M., Zhang, J., Cui, X.-L., Wu, X.-L., & Zhu, Y.-G. (2016) · Chinese Medical Journal · doi:10.4103/0366-6999.186646 · Cited by 89 · see citing works
Welch, G. M., Boix, C. A., Schmauch, E., Davila-Velderrain, J., Victor, M. B., Dileep, V., Bozzelli, P. L., Su, Q., Cheng, J. D., Lee, A., et al. (2022) · Science Advances · doi:10.1126/sciadv.abo4662 · Cited by 84 · see citing works
Profiling DNA break sites and transcriptional changes in response to contextual fear learning
Stott, R. T., Kritsky, O., & Tsai, L.-H. (2021) · PLOS ONE · doi:10.1371/journal.pone.0249691 · Cited by 62 · see citing works
Miyamoto, T., Kim, D., Knox, J. A., Johnson, E., & Mucke, L. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.666529 · Cited by 33 · see citing works
Self-citationTranscription Blockage by DNA Damage in Nucleotide Excision Repair-Related Neurological Dysfunctions
Kajitani, G. S., Nascimento, L. L. D. S., Neves, M. R. D. C., Leandro, G. D. S., Garcia, C. C. M., & Menck, C. F. M. (2021) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2020.10.009 · Cited by 22 · see citing works
Three-dimensional chromatin organization in brain function and dysfunction
Dileep, V., & Tsai, L.-H. (2021) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2021.04.006 · Cited by 14 · see citing works
- Authors
- Suberbielle, E., Sanchez, P. E., Kravitz, A. V., Wang, X., Ho, K., Eilertson, K., Devidze, N., Kreitzer, A. C., & Mucke, L.
- Affiliations
- Gladstone Institutes (US)
- Corresponding author
- Mucke, Lennart
- ORCID
- Venue
- Nature Neuroscience
- Published
- 2013-03-24
- Volume
- 16
- Issue
- 5
- Pages
- 613-621
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC3637871
- OpenAlex
- W2056079743
- Cited by
- 487
- References
- 57
- Citations by year
- 2026: 26 · 2025: 31 · 2024: 48 · 2023: 33 · 2022: 47 · 2021: 41 · 2020: 31 · 2019: 32 · 2018: 40 · 2017: 33 · 2016: 38 · 2015: 33 · 2014: 36 · 2013: 18
- FWCI
- 18.65
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute on Aging (AG011385, R37AG011385, AG022074, P01AG022074, R01AG011385)
- National Institute of Neurological Disorders and Stroke (NS065780, P30NS065780)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- DNA double-strand breaks, neuronal activity, amyloid-beta, amyloid precursor protein, extrasynaptic NMDA receptors, optogenetic stimulation, novel environment exploration, dentate gyrus, DNA repair, Alzheimer's disease, synaptic dysfunction, learning and memory
- MeSH terms
- Channelrhodopsins, Animals, Animals, Newborn, Cells, Cultured, Cerebral Cortex, Corpus Striatum, Corticosterone, Disease Models, Animal, Exploratory Behavior, Gene Expression Regulation, Hippocampus, Histones, Humans, Mice, Inbred C57BL, Mice, Transgenic, Neurons, Photic Stimulation, Quinoxalines, Stress, Physiological, Valine, Amyloid beta-Peptides, Amyloid beta-Protein Precursor, tau Proteins, Reactive Oxygen Species, Excitatory Amino Acid Antagonists, Mice, DNA Breaks, Double-Stranded
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
