Savvides, Savvas N.

Design of protein-binding proteins from the target structure alone

Cao, L., Coventry, B., Goreshnik, I., Huang, B., Sheffler, W., Park, J. S., Jude, K. M., Marković, I., Kadam, R. U., Verschueren, K. H. G., et al. (2022) · Nature

Protein Structure and DynamicsChemical Synthesis and Analysis

Cited by 577

Improving de novo protein binder design with deep learning

Bennett, N. R., Coventry, B., Goreshnik, I., Huang, B., Allen, A., Vafeados, D., Peng, Y. P., Dauparas, J., Baek, M., Stewart, L., et al. (2023) · Nature Communications

Protein Structure and Dynamicsvaccines and immunoinformatics approaches

Cited by 402

Alzheimer’s-Causing Mutations Shift Aβ Length by Destabilizing γ-Secretase-Aβn Interactions

Szaruga, M., Munteanu, B., Lismont, S., Veugelen, S., Horré, K., Mercken, M., Saido, T. C., Ryan, N. S., De Vos, T., Savvides, S. N., et al. (2017) · Cell

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 248

Crystal Structure of the Antioxidant Enzyme Glutathione Reductase Inactivated by Peroxynitrite

Savvides, S. N., Scheiwein, M., Böhme, C. C., Arteel, G. E., Karplus, P. A., Becker, K., & Schirmer, R. H. (2002) · Journal of Biological Chemistry

Redox biology and oxidative stressGlutathione Transferases and Polymorphisms

Cited by 127

Modulation of Signaling Mediated by TSLP and IL-7 in Inflammation, Autoimmune Diseases, and Cancer

Marković, I., & Savvides, S. N. (2020) · Frontiers in Immunology

Cytokine Signaling Pathways and InteractionsT-cell and B-cell Immunology

Cited by 86

Unexpected Complexity of the Ammonia Monooxygenase in Archaea

Hodgskiss, L. H., Melcher, M., Kerou, M., Chen, W., Ponce-Toledo, R. I., Savvides, S. N., Wienkoop, S., Hartl, M., & Schleper, C. (2022) · The ISME Journal

Microbial metabolism and enzyme functionWastewater Treatment and Nitrogen Removal

Cited by 58

The Fab region of IgG impairs the internalization pathway of FcRn upon Fc engagement

Brinkhaus, M., Pannecoucke, E., van der Kooi, E. J., Bentlage, A. E. H., Derksen, N. I. L., Andries, J., Balbino, B., Sips, M., Ulrichts, P., Verheesen, P., et al. (2022) · Nature Communications

Monoclonal and Polyclonal Antibodies ResearchDrug Transport and Resistance Mechanisms

Cited by 51

Activation of goblet-cell stress sensor IRE1β is controlled by the mucin chaperone AGR2

Cloots, E., Guilbert, P., Provost, M., Neidhardt, L., Van de Velde, E., Fayazpour, F., De Sutter, D., Savvides, S. N., Eyckerman, S., & Janssens, S. (2023) · The EMBO Journal

Endoplasmic Reticulum Stress and DiseaseCellular transport and secretion

Cited by 31

Activation of goblet cell stress sensor IRE1β is controlled by the mucin chaperone AGR2

Cloots, E., Guilbert, P., Provost, M., Neidhardt, L., Van de Velde, E., Fayazpour, F., Sutter, D. D., Savvides, S. N., Eyckerman, S., & Janssens, S. (2023) · The EMBO Journal

Endoplasmic Reticulum Stress and DiseaseCellular transport and secretion

Cited by 31

Mechanism of receptor assembly via the pleiotropic adipokine Leptin

Tsirigotaki, A., Dansercoer, A., Verschueren, K. H. G., Marković, I., Pollmann, C., Hafer, M., Felix, J., Birck, C., Van Putte, W., Catteeuw, D., et al. (2023) · Nature Structural & Molecular Biology

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 29

EGOC inhibits TOROID polymerization by structurally activating TORC1

Prouteau, M., Bourgoint, C., Felix, J., Bonadei, L., Sadian, Y., Gabus, C., Savvides, S. N., Gutsche, I., Desfosses, A., & Loewith, R. (2023) · Nature Structural & Molecular Biology

PI3K/AKT/mTOR signaling in cancerFungal and yeast genetics research

Cited by 15

EGOC inhibits TOROID polymerization by structurally activating TORC1

Prouteau, M., Bourgoint, C., Felix, J., Bonadei, L., Sadian, Y., Gabus, C., Savvides, S., Gutsche, I., Desfosses, A., & Loewith, R. (2022) · Nature Structural & Molecular Biology

PI3K/AKT/mTOR signaling in cancerFungal and yeast genetics research

Cited by 15

Mechanism of receptor assembly via the pleiotropic adipokine Leptin

Tsirigotaki, A., Dansercoer, A., Verschueren, K. H. G., Marković, I., Pollmann, C., Hafer, M., Felix, J., Birck, C., Van Putte, W., Catteeuw, D., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory)

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 2

Structural and mechanistic insights into the constitutive Themis–Grb2 complex in T cell signalling

Clancy, D. M., Sanz-Sanjuan, A., Gilis, E., Tougaard, P., Velghe, I., Van Droogenbroeck, Y., Felix, J., Bloch, Y., Cuadrado, Á. F., Merceron, R., et al. (2026) · Nature Communications

T-cell and B-cell ImmunologyProtein Tyrosine Phosphatases

Cited by 0

Themis and Grb2 form a constitutive structural hub in T cell receptor signalling

Savvides, S., Clancy, D., Sanjuan, A. S., Gillis, E., Velghe, I., Droogenbroeck, Y. V., Felix, J., Bloch, Y., Cuadrado, A. F., Merceron, R., et al. (2025) · Nature Communications

T-cell and B-cell ImmunologyProtein Tyrosine Phosphatases

Cited by 0