Modulation of Signaling Mediated by TSLP and IL-7 in Inflammation, Autoimmune Diseases, and Cancer

Human epithelial cells trigger dendritic cell–mediated allergic inflammation by producing TSLP

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Two Phase 3 Trials of Dupilumab versus Placebo in Atopic Dermatitis

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Dupilumab Efficacy and Safety in Moderate-to-Severe Uncontrolled Asthma

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Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes

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Therapeutic antibodies: successes, limitations and hopes for the future

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Small molecules, big targets: drug discovery faces the protein–protein interaction challenge

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The role of JAK/STAT signaling pathway and its inhibitors in diseases.

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The Epithelial Cell-Derived Atopic Dermatitis Cytokine TSLP Activates Neurons to Induce Itch

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Tezepelumab in Adults with Uncontrolled Asthma

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Therapeutic antibodies for autoimmunity and inflammation

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Effects of an Anti-TSLP Antibody on Allergen-Induced Asthmatic Responses

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Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells

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Next generation antibody drugs: pursuit of the 'high-hanging fruit'

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Intratumor T helper type 2 cell infiltrate correlates with cancer-associated fibroblast thymic stromal lymphopoietin production and reduced survival in pancreatic cancer

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Interleukin 7 receptor α chain ( IL7R ) shows allelic and functional association with multiple sclerosis

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Interleukin-7 receptor expression: intelligent design

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Harnessing the biology of IL-7 for therapeutic application

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Rearrangement of CRLF2 is associated with mutation of JAK kinases, alteration of IKZF1, Hispanic/Latino ethnicity, and a poor outcome in pediatric B-progenitor acute lymphoblastic leukemia

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Sensing the outside world: TSLP regulates barrier immunity

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Exploiting a natural conformational switch to engineer an interleukin-2 ‘superkine’

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Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis

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TSLP promotes interleukin-3-independent basophil haematopoiesis and type 2 inflammation

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De novo design of potent and selective mimics of IL-2 and IL-15

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Molecular and Structural Basis of Cytokine Receptor Pleiotropy in the Interleukin-4/13 System

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TLR3- and Th2 Cytokine-Dependent Production of Thymic Stromal Lymphopoietin in Human Airway Epithelial Cells

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Variation in interleukin 7 receptor α chain (IL7R) influences risk of multiple sclerosis

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Cloning of a receptor subunit required for signaling by thymic stromal lymphopoietin

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IL-7 administration to humans leads to expansion of CD8+ and CD4+ cells but a relative decrease of CD4+ T-regulatory cells

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Interleukin-7 restores lymphocytes in septic shock: the IRIS-7 randomized clinical trial

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Cloning of the Murine Thymic Stromal Lymphopoietin (Tslp) Receptor

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Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia

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Human Monocytes Undergo Functional Re-programming during Sepsis Mediated by Hypoxia-Inducible Factor-1α

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The Interleukin-2 Receptor γ Chain: Its Role in the Multiple Cytokine Receptor Complexes and T Cell Development in XSCID

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Human Thymic Stromal Lymphopoietin Preferentially Stimulates Myeloid Cells

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Human intestinal epithelial cells promote the differentiation of tolerogenic dendritic cells

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The pharmacology and therapeutic applications of monoclonal antibodies

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Cytokine traps: multi-component, high-affinity blockers of cytokine action

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Gain-of-function mutations in interleukin-7 receptor-α ( IL7R ) in childhood acute lymphoblastic leukemias

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IL-7 administration drives T cell–cycle entry and expansion in HIV-1 infection

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Cell biology of IL-7, a key lymphotrophin

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Orchestrating B cell lymphopoiesis through interplay of IL-7 receptor and pre-B cell receptor signalling

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Functional screening identifies CRLF2 in precursor B-cell acute lymphoblastic leukemia

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Increased expression of immunoreactive thymic stromal lymphopoietin in patients with severe asthma

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Tezepelumab, an anti–thymic stromal lymphopoietin monoclonal antibody, in the treatment of moderate to severe atopic dermatitis: A randomized phase 2a clinical trial

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Insights into Cytokine–Receptor Interactions from Cytokine Engineering

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Interleukin-7 is necessary to maintain the B cell potential in common lymphoid progenitors

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Thymic stromal lymphopoietin fosters human breast tumor growth by promoting type 2 inflammation

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Thymic stromal lymphopoietin and allergic disease

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Phase I Study of Recombinant Human Interleukin-7 Administration in Subjects with Refractory Malignancy

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Biologics for targeting inflammatory cytokines, clinical uses, and limitations

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Interleukin 7 signaling in dendritic cells regulates the homeostatic proliferation and niche size of CD4+ T cells

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Recombinant human interleukin-7 (CYT107) promotes T-cell recovery after allogeneic stem cell transplantation

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Thymic Stromal Lymphopoietin-Activated Plasmacytoid Dendritic Cells Induce the Generation of FOXP3+ Regulatory T Cells in Human Thymus

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Hepatic interleukin-7 expression regulates T cell responses.

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Structure, binding, and antagonists in the IL-4/IL-13 receptor system

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Respiratory syncytial virus infection activates IL-13–producing group 2 innate lymphoid cells through thymic stromal lymphopoietin

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Cloning of human thymic stromal lymphopoietin (TSLP) and signaling mechanisms leading to proliferation

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Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma

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TSLP: from allergy to cancer

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Staphylococcus aureus membrane and diacylated lipopeptide induce thymic stromal lymphopoietin in keratinocytes through the Toll-like receptor 2–Toll-like receptor 6 pathway

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Interleukin-9 Is Required for Allergic Airway Inflammation Mediated by the Cytokine TSLP

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Requirement for Stat5 in Thymic Stromal Lymphopoietin-Mediated Signal Transduction

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Functional Analysis of the Thymic Stromal Lymphopoietin Variants in Human Bronchial Epithelial Cells

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Peptide-based inhibitors of protein–protein interactions

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Interleukin-2 Activity Can Be Fine Tuned with Engineered Receptor Signaling Clamps

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Evolutionary Origin of a Secondary Structure: π-Helices as Cryptic but Widespread Insertional Variations of α-Helices That Enhance Protein Functionality

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Conversion of human interleukin‐4 into a high affinity antagonist by a single amino acid replacement.

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Interleukin-7 promotes survival and cell cycle progression of T-cell acute lymphoblastic leukemia cells by down-regulating the cyclin-dependent kinase inhibitor p27kip1

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TSLP-activated dendritic cells induce human T follicular helper cell differentiation through OX40-ligand

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CSL–MAML-dependent Notch1 signaling controls T lineage–specific IL-7Rα gene expression in early human thymopoiesis and leukemia

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IL-7–producing stromal cells are critical for lymph node remodeling

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Constitutive and inducible thymic stromal lymphopoietin expression in human airway smooth muscle cells: role in chronic obstructive pulmonary disease

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Interleukin-7 is a growth factor of precursor B and T acute lymphoblastic leukemia

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IL-7 receptor blockade reverses autoimmune diabetes by promoting inhibition of effector/memory T cells

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IL-7 Contributes to the Progression of Human T-cell Acute Lymphoblastic Leukemias

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Biancheri, P., Sabatino, A. D., Rescigno, M., Giuffrida, P., Fornasa, G., Tsilingiri, K., Pender, S. L. F., Papadia, C., Wood, E., Pasini, A., et al. (2015) · Gut · doi:10.1136/gutjnl-2014-308876 · Cited by 38 · see citing works

Evaluation of thymic stromal lymphopoietin (TSLP) and its correlation with lymphatic metastasis in human gastric cancer

Barooei, R., Mahmoudian, R. A., Abbaszadegan, M. R., Mansouri, A., & Gholamin, M. (2015) · Medical Oncology · doi:10.1007/s12032-015-0653-4 · Cited by 38 · see citing works

New anti-IL-7Rα monoclonal antibodies show efficacy against T cell acute lymphoblastic leukemia in pre-clinical models

Hixon, J. A., Andrews, C., Kashi, L., Kohnhorst, C. L., Senkevitch, E., Czarra, K., Barata, J. T., Li, W., Schneider, J. P., Walsh, S. T. R., et al. (2019) · Leukemia · doi:10.1038/s41375-019-0531-8 · Cited by 37 · see citing works

The Long-Term Survival Potential of Mature T Lymphocytes Is Programmed During Development in the Thymus

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Structure-Activity Relationships of Baicalein and its Analogs as Novel TSLP Inhibitors

Park, B. B., Choi, J. W., Park, D., Choi, D., Paek, J., Kim, H. J., Son, S.-Y., Mushtaq, A. U., Shin, H., Kim, S. H., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-44853-5 · Cited by 34 · see citing works

Expression analysis and specific blockade of the receptor for human thymic stromal lymphopoietin (TSLP) by novel antibodies to the human TSLPRα receptor chain

Borowski, A., Vetter, T., Kuepper, M., Wohlmann, A., Krause, S., Lorenzen, T., Virchow, J. C., Jr., Luttmann, W., & Friedrich, K. (2012) · Cytokine · doi:10.1016/j.cyto.2012.10.025 · Cited by 32 · see citing works

Disulfide Bond Assignment in Human Interleukin-7 by Matrix-assisted Laser Desorption/Ionization Mass Spectroscopy and Site-directed Cysteine to Serine Mutational Analysis

Cosenza, L., Sweeney, É., & Murphy, J. R. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.52.32995 · Cited by 31 · see citing works

Thymic stromal lymphopoietin (TSLP)-induced polyclonal B-cell activation and autoimmunity are mediated by CD4+ T cells and IL-4

Iseki, M., Omori‐Miyake, M., Xu, W., Sun, X., Takaki, S., Rawlings, D. J., & Ziegler, S. F. (2012) · International Immunology · doi:10.1093/intimm/dxr113 · Cited by 29 · see citing works

Identification of small molecule inhibitors of Interleukin-18

Krumm, B., Meng, X., Xiang, Y., & Deng, J. (2017) · Scientific Reports · doi:10.1038/s41598-017-00532-x · Cited by 29 · see citing works

Intranasal Introduction of Fc-Fused Interleukin-7 Provides Long-Lasting Prophylaxis against Lethal Influenza Virus Infection

Kang, M. C., Choi, D., Choi, Y. W., Park, S. J., Namkoong, H., Park, K. S., Ahn, S.-S., Surh, C. D., Yoon, S., Kim, D., et al. (2015) · Journal of Virology · doi:10.1128/jvi.02768-15 · Cited by 28 · see citing works

ZEB2 and LMO2 drive immature T-cell lymphoblastic leukemia via distinct oncogenic mechanisms

Goossens, S., Wang, J., Tremblay, C. S., Medts, J. D., T’Sas, S., Nguyen, T. M., Saw, J., Haigh, K., Curtis, D. J., Vlierberghe, P. V., et al. (2019) · Haematologica · doi:10.3324/haematol.2018.207837 · Cited by 26 · see citing works

Skin tissue expression and serum level of thymic stromal lymphopoietin in patients with psoriasis vulgaris

Suwarsa, O., Dharmadji, H. P., Sutedja, E., Herlina, L., Sori, P. R., Hindritiani, R., Dwiyana, R. F., & Gunawan, H. (2019) · Dermatology Reports · doi:10.4081/dr.2019.8006 · Cited by 26 · see citing works

Comparative model building of interleukin‐7 using interleukin‐4 as a template: A structural hypothesis that displays atypical surface chemistry in helix D important for receptor activation

Cosenza, L., Murphy, J. R., Smith, T. F., Rosenbach, A., & White, J. V. (2000) · Protein Science · doi:10.1110/ps.9.5.916 · Cited by 22 · see citing works

Codelivery of IL-7 Augments Multigenic HCV DNA Vaccine-induced Antibody as well as Broad T Cell Responses in Cynomolgus Monkeys

Park, S., Song, M.-Y., Nam, H. J., Im, S. J., & Sung, Y. (2010) · Immune Network · doi:10.4110/in.2010.10.6.198 · Cited by 22 · see citing works

Interleukin-31 and thymic stromal lymphopoietin expression in plasma and lymph node from Hodgkin lymphoma patients

Ferretti, E., Hohaus, S., Napoli, A. D., Belmonte, B., Cuccaro, A., Cupelli, E., Galli, E., Rufini, V., Tripodi, G., Orcioni, G. F., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.19665 · Cited by 22 · see citing works

Blockade of thymic stromal lymphopoietin (TSLP) receptor inhibits TSLP-driven proliferation and signalling in lymphoblasts from a subset of B-precursor ALL patients

Vetter, T., Borowski, A., Wohlmann, A., Ranjan, N., Kuepper, M., Badura, S., Ottmann, O. G., & Friedrich, K. (2015) · Leukemia Research · doi:10.1016/j.leukres.2015.10.003 · Cited by 21 · see citing works

High soluble IL-7 receptor expression in Sjögren's syndrome identifies patients with increased immunopathology and dryness

Hillen, M. R., Blokland, S. L. M., Risselada, A. P., Bikker, A., Lauwerys, B. R., Kruize, A. A., Radstake, T. R. D. J., & van Roon, J. A. G. (2016) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2016-209236 · Cited by 21 · see citing works

Serum TSLP is a potential biomarker of psoriasis vulgaris activity

El-Ghareeb, M. I., Ghanem, A. H., Kazzaz, S. A., & Samir, H. (2019) · Psoriasis Targets and Therapy · doi:10.2147/ptt.s212774 · Cited by 21 · see citing works

TSLP Expression and High Serum TSLP Level Indicate a Poor Prognosis in Gastric Cancer Patients.

Watanabe, J., Saito, H., Miyatani, K., Ikeguchi, M., & Umekita, Y. (2015) · Europe PMC (PubMed Central) · Cited by 19 · see citing works

Receptor occupancy and blocking of STAT5 signaling by an anti‐ IL ‐7 receptor α antibody in cynomolgus monkeys

Kern, B., Li, W., Bono, C. P., Lee, L., & Kraynov, E. A. (2015) · Cytometry Part B Clinical Cytometry · doi:10.1002/cyto.b.21247 · Cited by 18 · see citing works

Thymic stromal lymphopoietin regulates eosinophil migration via phosphorylation of l ‐plastin in atopic dermatitis

Noh, J. Y., Shin, J. U., Park, C. O., Lee, N., Jin, S., Kim, S. H., Kim, J. H., Min, A., Shin, M. H., & Lee, K. H. (2016) · Experimental Dermatology · doi:10.1111/exd.13111 · Cited by 18 · see citing works

Overexpression of thymic stromal lymphopoietin is correlated with poor prognosis in epithelial ovarian carcinoma

Xu, L., Guo, Y.-C., Xu, N., Chen, L., Zhu, J., Liu, N., & Zhang, Z. (2019) · Bioscience Reports · doi:10.1042/bsr20190116 · Cited by 18 · see citing works

Synthesis and biological evaluation of peptide-derived TSLP inhibitors

Park, S., Park, Y., Son, S., Lee, K., Jung, Y. W., Lee, K. Y., Jeon, Y. H., & Byun, Y. (2017) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2017.09.010 · Cited by 17 · see citing works

Human thymic stromal lymphopoietin promotes the proliferation and invasion of cervical cancer cells by downregulating microRNA‑132 expression

Zhou, W., Yang, H., Chang, K., Meng, Y., Wang, M., Yuan, M., Li, M., & Xie, F. (2017) · Oncology Letters · doi:10.3892/ol.2017.7260 · Cited by 17 · see citing works

Cardioprotective activity of chalcones in ischemia/reperfusion-induced myocardial infarction in albino rats.

Annapurna, A., Mudagal, M. P., Ansari, A., & Srinivasa Rao, A. (2012) · Europe PMC (PubMed Central) · Cited by 15 · see citing works

Thymic stromal lymphopoietin expression from benign lymphoproliferation to malignant B-cell lymphoma in primary Sjögren's syndrome.

Gandolfo, S., Bulfoni, M., Fabro, C., Russi, S., Sansonno, D. E., Loreto, C. D., Cesselli, D., & Vita, S. D. (2019) · PubMed · Cited by 15 · see citing works

Model-Based Characterization of the Pharmacokinetics, Target Engagement Biomarkers, and Immunomodulatory Activity of PF-06342674, a Humanized mAb Against IL-7 Receptor-α, in Adults with Type 1 Diabetes

Williams, J. H., Udata, C., Ganguly, B. J., Bucktrout, S. L., Joh, T., Shannon, M., Wong, G. Y., Levisetti, M. G., Garzone, P. D., & Xu, M. J. (2020) · The AAPS Journal · doi:10.1208/s12248-019-0401-3 · Cited by 14 · see citing works

Thymic stromal lymphopoietin deficiency attenuates experimental autoimmune encephalomyelitis

Eckhardt, J., Döbbeler, M., Koenig, C., Kuczera, K., Kuhnt, C., Ostalecki, C., Zinser, E., Mak, T. W., Steinkasserer, A., & Lechmann, M. (2015) · Clinical & Experimental Immunology · doi:10.1111/cei.12621 · Cited by 13 · see citing works

Nonlytic Fc-fused IL-7 synergizes with Mtb32 DNA vaccine to enhance antigen-specific T cell responses in a therapeutic model of tuberculosis

Ahn, S.-S., Jeon, B., Park, S.-J., Choi, D.-H., Ku, S.-H., Cho, S.-N., & Sung, Y. (2013) · Vaccine · doi:10.1016/j.vaccine.2013.04.029 · Cited by 11 · see citing works

Effects of rhIL-7 on leukocyte subsets in mice: implications for antitumor activity.

Komschlies, K. L., Back, T. T., Ta, G., Gruys, M. E., Damia, G. L. M., Wiltrout, R., & Cr, F. (1994) · PubMed · Cited by 11 · see citing works

Virtual screening for inhibitors of the human TSLP:TSLPR interaction

Rompaey, D. V., Verstraete, K., Peelman, F., Savvides, S. N., Augustyns, K., der Veken, P. V., & Winter, H. L. D. (2017) · Scientific Reports · doi:10.1038/s41598-017-17620-7 · Cited by 11 · see citing works

STRUCTURE FUNCTION ANALYSIS OF INTERLEUKIN 7: REQUIREMENT FOR AN AROMATIC RING AT POSITION 143 OF HELIX D

vanderSpek, J. C., Sutherland, J. A., Gill, B. M., Görgün, G., Foss, F. M., & Murphy, J. R. (2002) · Cytokine · doi:10.1006/cyto.2002.1004 · Cited by 9 · see citing works

Expression and allele frequencies of Thymic stromal lymphopoietin are a key factor of breast cancer risk

Semlali, A., Almutairi, M. H., Parine, N. R., Amri, A. A., Almeer, R., Alanazi, M. S., & Rouabhia, M. (2019) · Molecular Genetics & Genomic Medicine · doi:10.1002/mgg3.813 · Cited by 9 · see citing works

IL‐7R gene polymorphisms among patients with rheumatoid arthritis: A case–control study

Bai, M., He, X., He, Y., Yuan, D., Jin, T., & Wang, L. (2019) · Molecular Genetics & Genomic Medicine · doi:10.1002/mgg3.738 · Cited by 8 · see citing works

Small-molecule inhibitors get pro-inflammatory TNF into shape

Savvides, S. N., & Elewaut, D. S. (2020) · Nature Reviews Rheumatology · doi:10.1038/s41584-020-0388-2 · Cited by 8 · see citing works

Anti-TSLPR Antibody RG7258 Blocks Dendritic Cell Activation, Mast Cell Cytokine Release And Reduces Th2 Inflammation In A Non-Human Primate Model Of Allergic Lung Inflammation

Fuentes, M. E., Ma, X., Zhang, J., Pashine, A., Apparsundaram, S., Wilson, S., & Niewoehner, J. (2011) · doi:10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a2767 · Cited by 6 · see citing works

The Additive Inflammatory In Vivo and In Vitro Effects of IL-7 and TSLP in Arthritis Underscore the Therapeutic Rationale for Dual Blockade

Hillen, M. R., Hartgring, S. A. Y., Willis, C. R., Radstake, T. R. D. J., Hack, C. E., Lafeber, F. P. J. G., & van Roon, J. A. G. (2015) · PLoS ONE · doi:10.1371/journal.pone.0130830 · Cited by 6 · see citing works

Development and identification of a fully human single‐chain variable fragment 29 against TSLP

Nian, S., Zhu, J., Yu, H. Z., Chen, Q., Ye, Y., Cao, X., & Yuan, Q. (2019) · Biotechnology and Applied Biochemistry · doi:10.1002/bab.1747 · Cited by 6 · see citing works

Human interleukin-7 induces proliferation of neoplastic cells from chronic lymphocytic leukemia and acute leukemias

Digel, W., Schmid, M., Heil, G., et al. (1991) · Blood · doi:10.1182/blood.v78.3.753.bloodjournal783753 · Cited by 6 · see citing works

ASP7266, a novel antibody against human TSLPR, in the treatment of allergic disease

Numazaki, M., Hanaoka, K., Imamura, E., Maeda, M., Arai, K., Saito, T., Takamura, F., Suzuki, H., Kubo, S., & Furukawa, S. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.12.042 · Cited by 4 · see citing works

Abstract 727: TSLP expression and high serum TSLP level indicate a poor prognosis in gastric cancer patients

Watanabe, J., Saito, H., Miyatani, K., Ikeguchi, M., Umekita, Y., Otani, S., & Tsujitani, S. (2016) · Cancer Research · doi:10.1158/1538-7445.am2016-727 · Cited by 3 · see citing works

Abstract 4991: Hyleukin-7, the Fc-fused interleukin-7, generates anti-tumor activity by modulating both adaptive and innate immune cells in the tumor microenvironment

Kim, J., Hong, S., Kim, Y., Jo, S.-B., Ji, M. K., Oh, Y. K., Park, H. W., Kim, S., Choi, D., Lee, B. H., et al. (2019) · Cancer Research · doi:10.1158/1538-7445.am2019-4991 · Cited by 2 · see citing works

Engineering of an IL-2 immunocytokine with very low toxicity that retains potent anti-tumor activity in immune competent and immune deficient mouse tumor models

Gillies, S. D., Yan, L., Lauder, S., Brunkhorst, B. A., Sun, Y., & Lo, K.-M. (2004) · Cancer Research · Cited by 2 · see citing works

A versatile platform for activity determination of cytokines and growth factors based on the human TSLP (thymic stromal lymphopoietin) receptor

Marković, I., Barthel, T., Schirmer, M., Delgado, A. G., Wilhelm, S., Krause, S., Friedrich, K., & Wohlmann, A. (2018) · Cytokine · doi:10.1016/j.cyto.2018.07.010 · Cited by 1 · see citing works

Design of protein-binding proteins from the target structure alone

Cao, L., Coventry, B., Goreshnik, I., Huang, B., Sheffler, W., Park, J. S., Jude, K. M., Marković, I., Kadam, R. U., Verschueren, K. H. G., et al. (2022) · Nature · doi:10.1038/s41586-022-04654-9 · Cited by 577 · see citing works

The role of inflammation in autoimmune disease: a therapeutic target

Xiang, Y., Zhang, M., Jiang, D., Su, Q., & Shi, J. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1267091 · Cited by 205 · see citing works

Targeting lymphoid-derived IL-17 signaling to delay skin aging

Solá, P., Mereu, E., Bonjoch, J., Casado-Peláez, M., Prats, N., Aguilera, M., Reina, Ó., Blanco, E., Esteller, M., Croce, L. D., et al. (2023) · Nature Aging · doi:10.1038/s43587-023-00431-z · Cited by 86 · see citing works

Tezepelumab: A Potential New Biological Therapy for Severe Refractory Asthma

Pelaia, C., Pelaia, G., Crimi, C., Maglio, A., Gallelli, L., Terracciano, R., & Vatrella, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094369 · Cited by 76 · see citing works

Targeting alarmins in asthma: From bench to clinic

Akenroye, A. T., Boyce, J. A., & Kita, H. (2025) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2025.01.017 · Cited by 60 · see citing works

Thymic Stromal Lymphopoietin (TSLP), Its Isoforms and the Interplay with the Epithelium in Allergy and Asthma

Smolińska, S., Antolín‐Amérigo, D., Popescu, F., & Jutel, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241612725 · Cited by 59 · see citing works

Monoclonal Antibodies Targeting Alarmins: A New Perspective for Biological Therapies of Severe Asthma

Pelaia, C., Pelaia, G., Longhini, F., Crimi, C., Calabrese, C., Gallelli, L., Sciacqua, A., & Vatrella, A. (2021) · Biomedicines · doi:10.3390/biomedicines9091108 · Cited by 45 · see citing works

The application of Interleukin-2 family cytokines in tumor immunotherapy research

Zhou, Y., Quan, G., Liu, Y., Shi, N., Wu, Y., Zhang, R., Gao, X., & Luo, L. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1090311 · Cited by 41 · see citing works

JAK2 Alterations in Acute Lymphoblastic Leukemia: Molecular Insights for Superior Precision Medicine Strategies

Downes, C. E. J., McClure, B. J., McDougal, D. P., Heatley, S. L., Bruning, J. B., Thomas, D., Yeung, D. T. O., & White, D. L. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.942053 · Cited by 38 · see citing works

Skin microbe-dependent TSLP-ILC2 priming axis in early life is co-opted in allergic inflammation

Cha, J., Kim, T., Bhae, E., Gwak, H., Ju, Y., Choe, Y. H., Jang, I.-H., Jung, Y., Moon, S., Kim, T. H., et al. (2024) · Cell Host & Microbe · doi:10.1016/j.chom.2023.12.006 · Cited by 35 · see citing works

Novel Biological Therapies for Severe Asthma Endotypes

Pelaia, C., Pelaia, G., Crimi, C., Maglio, A., Stanziola, A. A., Calabrese, C., Terracciano, R., Longhini, F., & Vatrella, A. (2022) · Biomedicines · doi:10.3390/biomedicines10051064 · Cited by 35 · see citing works

The Role of Cytokines in Cholesterol Accumulation in Cells and Atherosclerosis Progression

Markin, A. M., Markina, Y. V., Bogatyreva, A. I., Tolstik, T. V., Chakal, D. A., Геннадьевич, Б. Д., & Charchyan, E. R. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076426 · Cited by 34 · see citing works

TSLP in DRG neurons causes the development of neuropathic pain through T cells

Ino, Y., Maruyama, M., Shimizu, M., Morita, R., Sakamoto, A., Suzuki, H., & Sakai, A. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02882-y · Cited by 30 · see citing works

Critical influence of cytokines and immune cells in autoimmune gastritis

Zhang, Z., Zhu, T., Zhang, L., Xing, Y., Yan, Z., & Li, Q. (2023) · Autoimmunity · doi:10.1080/08916934.2023.2174531 · Cited by 26 · see citing works

Inflammation-mediated fibroblast activation and immune dysregulation in collagen VII-deficient skin

Anderson-Crannage, M., Ascensión, A., Ibáñez-Solé, O., Zhu, H.-W., Schaefer, E., Ottomanelli, D., Hochberg, B., Pan, J., Luo, W., Tian, M., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1211505 · Cited by 24 · see citing works

Heterogeneity of ILC2s in the Intestine; Homeostasis and Pathology

Sunaga, S., Tsunoda, J., Teratani, T., Mikami, Y., & Kanai∥, T. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.867351 · Cited by 26 · see citing works

The Salivary Microbiota, Cytokines, and Metabolome in Patients with Ankylosing Spondylitis Are Altered and More Proinflammatory than Those in Healthy Controls

Lv, L., Jiang, H., Ren, Y., Xu, D., Wang, K., Wang, Q., Chen, X., & Li, L. (2021) · mSystems · doi:10.1128/msystems.01173-20 · Cited by 19 · see citing works

Development of a Novel Immune-Related Gene Prognostic Index for Breast Cancer

Yao, Y., Kong, X., Liu, R., Xu, F., Liu, G., & Sun, C. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.845093 · Cited by 18 · see citing works

Systematic single-cell dissecting reveals heterogeneous oncofetal reprogramming in the tumor microenvironment of gastric cancer

Mo, S., Shen, X., Wang, Y., Liu, Y., Sugasawa, T., Yang, Z., Gu, W., & Nakajima, T. (2023) · Human Cell · doi:10.1007/s13577-023-00856-z · Cited by 18 · see citing works

Interstitial Deletions Generating Fusion Genes

Panagopoulos, I., & Heim, S. (2021) · Cancer Genomics & Proteomics · doi:10.21873/cgp.20251 · Cited by 17 · see citing works

New scaffolds for type II JAK2 inhibitors overcome the acquired G993A resistance mutation

Arwood, M. L., Liu, Y., Harkins, S. K., Weinstock, D. M., Yang, L., Stevenson, K. E., Plana, O. D., Dong, J., Cirka, H., Jones, K. L., et al. (2023) · Cell chemical biology · doi:10.1016/j.chembiol.2023.05.007 · Cited by 16 · see citing works

Single-cell dissection reveals the role of aggrephagy patterns in tumor microenvironment components aiding predicting prognosis and immunotherapy on lung adenocarcinoma

Sun, X., Meng, F., Nong, M.-Y., Fang, H., Lu, C., Wang, Y., & Zhang, P. (2023) · Aging · doi:10.18632/aging.205306 · Cited by 15 · see citing works

Association between IL-7 and primary Sjögren's syndrome: A single-center study and a systematic scoping review

Liang, Y., Zhang, Z., Li, J., Luo, W., Jiang, T., & Yang, Z. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.108758 · Cited by 14 · see citing works

From gene identifications to therapeutic targets for asthma: Focus on great potentials of TSLP, ORMDL3, and GSDMB

Zhang, Y. (2023) · Chinese Medical Journal - Pulmonary and Critical Care Medicine · doi:10.1016/j.pccm.2023.08.001 · Cited by 13 · see citing works

Robust de novo design of protein binding proteins from target structural information alonePreprint

Cao, L., Coventry, B., Goreshnik, I., Huang, B., Park, J. S., Jude, K. M., Marković, I., Kadam, R. U., Verschueren, K. H. G., Verstraete, K., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.09.04.459002 · Cited by 12 · see citing works

A novel monoclonal antibody against human thymic stromal lymphopoietin for the treatment of TSLP-mediated diseases

Shi, L., Yu, M., Jin, Y., Chen, P., Mu, G., Tam, S. H., Cho, M., Tornetta, M. A., Han, C., Fung, M., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1442588 · Cited by 10 · see citing works

TSLP and TSLPR Expression Levels in Peripheral Blood as Potential Biomarkers in Patients with Chronic Rhinosinusitis with Nasal Polyps

Moreno‐Jimenez, E., Morgado, N., Gómez-García, M., Sanz, C., Gil‐Melcón, M., Isidoro‐García, M., Davila, I. J., & Garcı́a-Sánchez, A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26031227 · Cited by 10 · see citing works

Construction of an oxidative stress-related lncRNAs signature to predict prognosis and the immune response in gastric cancer

Zhang, H., Feng, H., Yu, T., Zhang, M., Liu, Z., Ma, L., & Liu, H. (2023) · Scientific Reports · doi:10.1038/s41598-023-35167-8 · Cited by 9 · see citing works

Phase 1 Safety and Pharmacokinetics Study of TAVO101, an Anti‐Human Thymic Stromal Lymphopoietin Antibody for the Treatment of Allergic Inflammatory Conditions

Han, C., Fung, I., Zhang, D., Jin, Y., Chen, P., Tam, S. H., Chiu, M. L., & Fung, M. (2024) · The Journal of Clinical Pharmacology · doi:10.1002/jcph.6115 · Cited by 8 · see citing works

Nuclear PLD1 combined with NPM1 induces gemcitabine resistance through tumorigenic IL7R in pancreatic adenocarcinoma

Fu, D., Yan, J., Zhang, Z., Liu, Y., Ma, X., Ding, J., Yang, S., Zhao, R., Chang, A., Gao, C., et al. (2023) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2023.0039 · Cited by 8 · see citing works

Integration of biobank-scale genetics and plasma proteomics reveals evidence for causal processes in asthma risk and heterogeneity

Donoghue, L. J., Benner, C., Chang, D., Irudayanathan, F. J., Pendergrass, R. K., Yaspan, B. L., Mahajan, A., & McCarthy, M. I. (2025) · Cell Genomics · doi:10.1016/j.xgen.2025.100840 · Cited by 8 · see citing works

Lymphomagenesis predictors and related pathogenesis

Ruíz-Ordóñez, I., Piedrahita, J.-M., Arévalo, J.-A., Agualimpia, A., & Tobón, G. J. (2021) · Journal of Translational Autoimmunity · doi:10.1016/j.jtauto.2021.100098 · Cited by 8 · see citing works

A Bispecific Antibody Blocking Both TSLP and IL-4Rα for the Treatment of Allergic Inflammatory Diseases

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Thymic Stromal Lymphopoietin Activates Mouse Dendritic Cells Through the JAK/SYK Pathway in Promoting Th17 Response in Psoriasis

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Key role of thymic stromal lymphopoietin as a molecular target for biologic treatment of severe asthma

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Downregulation of deubiquitinating enzyme USP25 promotes the development of allergic rhinitis by enhancing TSLP signaling in the nasal epithelium

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Ruyong formula improves thymus function of CUMS-stimulated breast cancer mice

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TSLP pretreatment inhibits M1 macrophage polarization and attenuates LPS-induced iNKT cell-dependent acute lung injury

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A Complementarity‐Based Approach to De Novo Binder Design

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Type 2 immunity plays an essential role for murine model of allergic contact dermatitis with mixed type 1/type 2 immune response

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Thymic stromal lymphopoietin improves protective immunity of the SARS-CoV-2 subunit vaccine by inducing dendritic cell-dependent germinal center response

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TSLP mitigates post-infarction myocardial remodeling by promoting eosinophil recruitment and inhibiting JAK1–STAT5-mediated ferroptosis

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Prevalence of Selected Polymorphisms of Il7R, CD226, CAPSL, and CLEC16A Genes in Children and Adolescents with Autoimmune Thyroid Diseases

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Circulating immunome fingerprint in eosinophilic esophagitis is associated with clinical response to proton pump inhibitor treatment

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Off-target reactivity in clinical monoclonal antibodies

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Structure-based design and disulfide stapling of interfacial cyclic peptidic inhibitors from thymic stromal lymphopoietin (TSLP) receptor to competitively target TSLP

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Longitudinal transcriptome analysis of cattle infected with Theileria parva

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Type III interferon exerts thymic stromal lymphopoietin in mediating adaptive antiviral immune response

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Analysis of genetic variant associated with heart failure mortality implicates thymic stromal lymphopoietin as mediator of strain‐induced myocardial fibroblast‐mast cell crosstalk and fibrosis

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Anti-Inflammatory Control of Human Skin Keratinocytes by Targeting Nuclear Transport Checkpoint

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Tezepelumab: patient selection and place in therapy in severe asthma

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Exploring thymic stromal lymphopoietin in the breast cancer microenvironment: A preliminary study

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Seasonal Proteomic Variations and Biomarkers in Seasonal Allergic Rhinitis: Insights from Olink Inflammation Profiling

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Evaluation of ocular surface inflammation and systemic conditions in patients with systemic lupus erythematosus: a cross-sectional study

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Increased expression of long-isoform thymic stromal lymphopoietin is associated with rheumatoid arthritis and fosters inflammatory responses

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Progressive multifocal leukoencephalopathy treated with interleukin-7

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Geometric Tuning of Cytokine Receptor Association Modulates Synthetic Agonist SignalingPreprint

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Single-cell RNA sequencing of cerebrospinal fluid immune cells in relapsing–remitting multiple sclerosis: insights into cellular composition and immune dynamics

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The Interleukin-7 Receptor Signaling Pathway and Its Perturbation in Immunodeficiency, Autoimmune Disease and Lymphoid Malignancy

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Identification of new IL-7Rα small-molecule agonists: a multi-computational approach

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Functional characterisation of two receptor interaction determinants in human thymic stromal lymphopoietin

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Biological and immunosuppressive therapies for lung disease: a potential reciprocal influence between their use and malignancy

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Computational studies reveal co-occurrence of two mutations in IL7R gene of high-grade serous carcinoma patients

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Title-Inflammatory Signaling Pathways in Allergic and Infection-Associated Lung Diseases

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Thymic stromal lymphopoietin in leukemia: A double-edged sword?

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Overexpression of IL7R Attenuates Cerebral Ischemia–Reperfusion Injury by Inhibiting Apoptosis

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The Relationship Between Human Cerebrospinal Fluid Proteins and the Risk of Delirium: A Study Based on Genetic Data

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Mechanism of “Fructus Arctii–licorice” herb pair in treating oral-mucosa diseases based on bioinformatics–network pharmacology–molecular dockingPreprint

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New Drug for Management of Severe Uncontrolled Asthma: Tezepelumab

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Density of lymphocytes in cortex and medulla substance of thymus particles of white rats in normal conditions and under influence of heavy metal salts during three months

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An In Silico Analysis Integrating Bulk and Single-Cells RNA Sequencing to Study the Mechanistic Effects of Umbelliferone in COPD

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Crosstalk between T cell gene regulation and intestinal epithelial cells: Insights into mucosal immunity

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Role of interleukin-7 in acute large vessel occlusion stroke

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The Dual Role of Thymic Stromal Lymphopoietin in the Tumor Microenvironment

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Additional file 1 of TSLP in DRG neurons causes the development of neuropathic pain through T cells

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Alopecia Areata and Atopic Dermatitis: Common Mechanisms and Emerging Therapeutics

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From Resistance to Vulnerability: Therapy-Induced Surface Receptor Plasticity in ALL as an Immunotherapeutic Opportunity

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Targeting Interleukin-7 Signalling in Ulcerative Colitis: Rationale and Emerging Clinical Evidence

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Parasite‐Derived IL‐33 Inhibitors Prevent Bleomycin‐Induced Lung Fibrosis

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Structural basis of the proinflammatory signaling complex mediated by TSLP

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Flip the coin: IL-7 and IL-7R in health and disease

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Research progress in thymic stromal lymphopoietin

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