Challen, Grant A.

Dnmt3a is essential for hematopoietic stem cell differentiation

Challen, G. A., Sun, D., Jeong, M., Luo, M., Jelinek, J., Berg, J. S., Bock, C., Vasanthakumar, A., Gu, H., Xi, Y., et al. (2012) · Nature Genetics

Hematopoietic Stem Cell TransplantationEpigenetics and DNA Methylation

Cited by 1,122

Clonal haematopoiesis harbouring AML-associated mutations is ubiquitous in healthy adults

Young, A. L., Challen, G. A., Birmann, B. M., & Druley, T. E. (2016) · Nature Communications

Acute Myeloid Leukemia ResearchCancer Genomics and Diagnostics

Cited by 692

A side order of stem cells: the SP phenotype

Challen, G. A., & Little, M. H. (2006) · Stem Cells

Hematopoietic Stem Cell TransplantationCancer Cells and Metastasis

Cited by 475

Dnmt3a and Dnmt3b have overlapping and distinct functions in hematopoietic stem cells

Challen, G. A., Sun, D., Mayle, A., Jeong, M., Luo, M., Rodriguez, B., Mallaney, C., Celik, H., Yang, L., Xia, Z., et al. (2014) · Cell Stem Cell

Hematopoietic Stem Cell TransplantationEpigenetics and DNA Methylation

Cited by 354

Chronic infection drives Dnmt3a-loss-of-function clonal hematopoiesis via IFNγ signaling

Hormaechea-Agulla, D., Matatall, K. A., Le, D. T., Kain, B., Long, X., Kus, P., Jaksik, R., Challen, G. A., Kimmel, M., & King, K. Y. (2021) · Cell Stem Cell

Acute Myeloid Leukemia ResearchHematopoietic Stem Cell Transplantation

Cited by 329

Large conserved domains of low DNA methylation maintained by Dnmt3a

Jeong, M., Sun, D., Luo, M., Huang, Y., Challen, G. A., Rodriguez, B., Zhang, X., Chavez, L., Wang, H., Hannah, R., et al. (2014) · Nature Genetics

Epigenetics and DNA MethylationGenomics and Chromatin Dynamics

Cited by 324

Loss of Dnmt3a Immortalizes Hematopoietic Stem Cells In Vivo

Jeong, M., Park, H. J., Celik, H., Ostrander, E. L., Reyes, J. M., Guzman, A., Rodriguez, B., Lei, Y., Lee, Y., Ding, L., et al. (2018) · Cell Reports

Acute Myeloid Leukemia ResearchHematopoietic Stem Cell Transplantation

Cited by 243

Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation

Mayle, A., Yang, L., Rodriguez, B., Zhou, T., Chang, E., Curry, C. V., Challen, G. A., Li, W., Wheeler, D., Rebel, V. I., et al. (2015) · Blood

Acute Myeloid Leukemia ResearchHematopoietic Stem Cell Transplantation

Cited by 235

Inflammatory cytokines promote clonal hematopoiesis with specific mutations in ulcerative colitis patients

Zhang, C. R. C., Nix, D., Gregory, M., Ciorba, M. A., Ostrander, E. L., Newberry, R. D., Spencer, D. H., & Challen, G. A. (2019) · Experimental Hematology

Acute Myeloid Leukemia ResearchCancer Genomics and Diagnostics

Cited by 137

Clonal Hematopoiesis: Mechanisms Driving Dominance of Stem Cell Clones

Challen, G., & Goodell, M. A. (2020) · Blood

Acute Myeloid Leukemia ResearchHematopoietic Stem Cell Transplantation

Cited by 131

Enforced differentiation of Dnmt3a-null bone marrow leads to failure with c-Kit mutations driving leukemic transformation

Celik, H., Mallaney, C., Kothari, A., Ostrander, E. L., Eultgen, E., Martens, A., Miller, C. A., Hundal, J., Klco, J. M., & Challen, G. A. (2015) · Blood

Acute Myeloid Leukemia ResearchHematopoietic Stem Cell Transplantation

Cited by 95

Kdm6b regulates context-dependent hematopoietic stem cell self-renewal and leukemogenesis

Mallaney, C., Ostrander, E. L., Celik, H., Kramer, A. C., Martens, A., Kothari, A., Koh, W. K., Haussler, E., Iwamori, N., Gontarz, P., et al. (2019) · Leukemia

Hematopoietic Stem Cell TransplantationAcute Myeloid Leukemia Research

Cited by 63

Dnmt3a regulates T-cell development and suppresses T-ALL transformation

Kramer, A. C., Kothari, A., Wilson, W. C., Celik, H., Nikitas, J., Mallaney, C., Ostrander, E. L., Eultgen, E., Martens, A., Valentine, M. C., et al. (2017) · Leukemia

Acute Lymphoblastic Leukemia researchAcute Myeloid Leukemia Research

Cited by 53

Txnip Enhances Fitness of Dnmt3a -Mutant Hematopoietic Stem Cells via p21

Zhang, C. R., Ostrander, E. L., Kukhar, O., Mallaney, C., Sun, J., Haussler, E., Celik, H., Koh, W. K., King, K. Y., Gontarz, P., et al. (2022) · Blood Cancer Discovery

Acute Myeloid Leukemia ResearchHematopoietic Stem Cell Transplantation

Cited by 23