Ferbeyre, Gerardo

Cellular Senescence: Defining a Path Forward

Gorgoulis, V., Adams, P. D., Alimonti, A., Bennett, D. C., Bischof, O., Bishop, C., Campisi, J., Collado, M., Evangelou, K., Ferbeyre, G., et al. (2019) · Cell

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 3,225

Metformin inhibits the senescence‐associated secretory phenotype by interfering with IKK/NF‐κ B activation

Moiseeva, O., Deschênes‐Simard, X., St‐Germain, E., Igelmann, S., Huot, G., Cadar, A. E., Bourdeau, V., Pollak, M. N., & Ferbeyre, G. (2013) · Aging Cell

Metabolism, Diabetes, and CancerNF-κB Signaling Pathways

Cited by 654

The senescence-associated secretory phenotype and its regulation

Lopes-Paciencia, S., Saint-Germain, E., Rowell, M.-C., Ruiz, A. F., Kalegari, P., & Ferbeyre, G. (2019) · Cytokine

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 601

PML is induced by oncogenic ras and promotes premature senescence

Ferbeyre, G., de Stanchina, E., Querido, E., Baptiste, N., Prives, C., & Lowe, S. W. (2000) · Genes & Development

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

Cited by 536

Mitochondrial Dysfunction Contributes to Oncogene-Induced Senescence

Moiseeva, O., Bourdeau, V., Roux, A., Deschênes-Simard, X., & Ferbeyre, G. (2009) · Molecular and Cellular Biology

Telomeres, Telomerase, and SenescenceMitochondrial Function and Pathology

Cited by 408

The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence

Mallette, F. A., Gaumont-Leclerc, M.-F., & Ferbeyre, G. (2007) · Genes & Development

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

Cited by 406

Metformin reduces endogenous reactive oxygen species and associated DNA damage

Algire, C., Moiseeva, O., Deschênes-Simard, X., Amrein, L., Petruccelli, L., Birman, E., Viollet, B., Ferbeyre, G., & Pollak, M. N. (2012) · Cancer Prevention Research

Metabolism, Diabetes, and CancerParaquat toxicity studies and treatments

Cited by 372

PML Is a Direct p53 Target that Modulates p53 Effector Functions

de Stanchina, E., Querido, E., Narita, M., Davuluri, R. V., Pandolfi, P. P., Ferbeyre, G., & Lowe, S. W. (2004) · Molecular Cell

Cancer-related Molecular PathwaysCell death mechanisms and regulation

Cited by 312

Oncogenic ras and p53 Cooperate To Induce Cellular Senescence

Ferbeyre, G., de Stanchina, E., Lin, A. W., Querido, E., McCurrach, M. E., Hannon, G. J., & Lowe, S. W. (2002) · Molecular and Cellular Biology

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

Cited by 290

DNA Damage Signaling and p53-dependent Senescence after Prolonged β-Interferon Stimulation

Moiseeva, O., Mallette, F. A., Mukhopadhyay, U. K., Moores, A., & Ferbeyre, G. (2006) · Molecular Biology of the Cell

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

Cited by 252

Tumor suppressor activity of the ERK/MAPK pathway by promoting selective protein degradation

Deschênes-Simard, X., Gaumont-Leclerc, M.-F., Bourdeau, V., Lessard, F., Moiseeva, O., Forest, V., Igelmann, S., Mallette, F. A., Saba-El-Leil, M. K., Meloche, S., et al. (2013) · Genes & Development

Telomeres, Telomerase, and SenescenceMelanoma and MAPK Pathways

Cited by 194

Regulation of E2Fs and senescence by PML nuclear bodies

Vernier, M., Bourdeau, V., Gaumont-Leclerc, M.-F., Moiseeva, O., Bégin, V., Saad, F., Mes-Masson, A.-M., & Ferbeyre, G. (2011) · Genes & Development

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

Cited by 177

Senescence-associated ribosome biogenesis defects contributes to cell cycle arrest through the Rb pathway

Lessard, F., Igelmann, S., Trahan, C., Huot, G., Saint-Germain, E., Mignacca, L., Del Toro, N., Lopes-Paciencia, S., Le Calvé, B., Montero, M., et al. (2018) · Nature Cell Biology

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 174

The DNA Damage Signaling Pathway Connects Oncogenic Stress to Cellular Senescence

Mallette, F. A., & Ferbeyre, G. (2007) · Cell Cycle

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

Cited by 125

Osteoclasts protect bone blood vessels against senescence through the angiogenin/plexin-B2 axis

Liu, X., Chai, Y., Liu, G., Su, W., Guo, Q., Lv, X., Gao, P., Yu, B., Ferbeyre, G., Cao, X., et al. (2021) · Nature Communications

Bone Metabolism and DiseasesTelomeres, Telomerase, and Senescence

Cited by 116

ARF1 controls proliferation of breast cancer cells by regulating the retinoblastoma protein

Boulay, P.-L., Schlienger, S., Lewis-Saravalli, S., Vitale, N., Ferbeyre, G., & Claing, A. (2011) · Oncogene

Cancer-related Molecular PathwaysCellular transport and secretion

Cited by 61

A hydride transfer complex reprograms NAD metabolism and bypasses senescence

Igelmann, S., Lessard, F., Uchenunu, O., Bouchard, J., Fernandez-Ruiz, A., Rowell, M.-C., Lopes-Paciencia, S., Papadopoli, D., Fouillen, A., Ponce, K. J., et al. (2021) · Molecular Cell

Telomeres, Telomerase, and SenescenceSirtuins and Resveratrol in Medicine

Cited by 60

Myc Down-regulation as a Mechanism to Activate the Rb Pathway in STAT5A-induced Senescence

Mallette, F. A., Gaumont-Leclerc, M.-F., Huot, G., & Ferbeyre, G. (2007) · Journal of Biological Chemistry

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

Cited by 51

Circumventing senescence is associated with stem cell properties and metformin sensitivity

Deschênes‐Simard, X., Parisotto, M., Rowell, M., Le Calvé, B., Igelmann, S., Moineau‐Vallée, K., Saint‐Germain, E., Kalegari, P., Bourdeau, V., Kottakis, F., et al. (2019) · Aging Cell

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 45

Senescence: A program in the road to cell elimination and cancer

Moiseeva, O., Guillon, J., & Ferbeyre, G. (2022) · Seminars in Cancer Biology

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

Cited by 25