Ernst, Matthias

Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system

Stumhofer, J. S., Laurence, A., Wilson, E. H., Huang, E., Tato, C. M., Johnson, L. M., Villarino, A. V., Huang, Q., Yoshimura, A., Sehy, D., et al. (2006) · Nature Immunology

Psoriasis: Treatment and PathogenesisT-cell and B-cell Immunology

Cited by 955

gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis

Bollrath, J., Phesse, T. J., von Burstin, V. A., Putoczki, T., Bennecke, M., Bateman, T., Nebelsiek, T., Lundgren-May, T., Canli, Ö., Schwitalla, S., et al. (2009) · Cancer Cell

Cytokine Signaling Pathways and InteractionsNF-κB Signaling Pathways

Cited by 946

Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice

Tebbutt, N. C., Giraud, A. S., Inglese, M., Jenkins, B., Waring, P., Clay, F. J., Malki, S., Alderman, B. M., Grail, D., Hollande, F., et al. (2002) · Nature Medicine

Cytokine Signaling Pathways and InteractionsProtein Tyrosine Phosphatases

Cited by 474

STAT3 Is Required for IL-6-gp130–Dependent Activation of Hepcidin In Vivo

Pietrangelo, A., Dierssen, U., Valli, L., Garuti, C., Rump, A., Corradini, E., Ernst, M., Klein, C., & Trautwein, C. (2007) · Gastroenterology

Iron Metabolism and DisordersCytokine Signaling Pathways and Interactions

Cited by 315

Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-β signaling

Jenkins, B. J., Grail, D., Nheu, T., Najdovska, M., Wang, B., Waring, P., Inglese, M., McLoughlin, R. M., Jones, S. A., Topley, N., et al. (2005) · Nature Medicine

Cytokine Signaling Pathways and InteractionsTGF-β signaling in diseases

Cited by 308

IL-6 Trans-Signaling Modulates TLR4-Dependent Inflammatory Responses via STAT3

Greenhill, C. J., Rose-John, S., Lissilaa, R., Ferlin, W., Ernst, M., Hertzog, P. J., Mansell, A., & Jenkins, B. J. (2011) · The Journal of Immunology

Cytokine Signaling Pathways and InteractionsImmune Response and Inflammation

Cited by 264

Defective gp130-mediated signal transducer and activator of transcription (STAT) signaling results in degenerative joint disease, gastrointestinal ulceration, and failure of uterine implantation

Ernst, M., Inglese, M., Waring, P., Campbell, I. K., Bao, S., Clay, F. J., Alexander, W. S., Wicks, I. P., Tarlinton, D. M., Novak, U., et al. (2001) · The Journal of Experimental Medicine

Cytokine Signaling Pathways and InteractionsRheumatoid Arthritis Research and Therapies

Cited by 227

General nature of the STAT3-activated anti-inflammatory response.

El Kasmi, K. C., Holst, J., Coffre, M., Mielke, L., de Pauw, A., Lhocine, N., Smith, A. M., Rutschman, R., Kaushal, D., Shen, Y., et al. (2006) · The Journal of Immunology

Cytokine Signaling Pathways and InteractionsPsoriasis: Treatment and Pathogenesis

Cited by 225

Therapeutic Targeting of IL-6 Trans Signaling Counteracts STAT3 Control of Experimental Inflammatory Arthritis

Nowell, M. A., Williams, A. S., Carty, S. A., Scheller, J., Hayes, A. J., Jones, G. W., Richards, P. J., Slinn, S., Ernst, M., Jenkins, B. J., et al. (2009) · The Journal of Immunology

Cytokine Signaling Pathways and InteractionsRheumatoid Arthritis Research and Therapies

Cited by 215

Continuous glycoprotein-130-mediated signal transducer and activator of transcription-3 activation promotes inflammation, left ventricular rupture, and adverse outcome in subacute myocardial infarction

Hilfiker-Kleiner, D., Shukla, P., Klein, G., Schaefer, A., Stapel, B., Hoch, M., Müller, W., Scherr, M., Theilmeier, G., Ernst, M., et al. (2010) · Circulation

Cardiac Fibrosis and RemodelingCytokine Signaling Pathways and Interactions

Cited by 167

Genetic partitioning of interleukin-6 signalling in mice dissociates Stat3 from Smad3-mediated lung fibrosis

O'Donoghue, R. J. J., Knight, D. A., Richards, C. D., Prêle, C. M., Lau, H. L., Jarnicki, A. G., Jones, J., Bozinovski, S., Vlahos, R., Thiem, S., et al. (2012) · EMBO Molecular Medicine

Interstitial Lung Diseases and Idiopathic Pulmonary FibrosisTGF-β signaling in diseases

Cited by 152

Tumor-associated macrophages in pancreatic ductal adenocarcinoma: therapeutic opportunities and clinical challenges

Poh, A. R., & Ernst, M. (2021) · Cancers

Immune cells in cancerPancreatic and Hepatic Oncology Research

Cited by 106

Scrib heterozygosity predisposes to lung cancer and cooperates with KRas hyperactivation to accelerate lung cancer progression in vivo

Elsum, I. A., Yates, L. L., Pearson, H. B., Phesse, T. J., Long, F., O'Donoghue, R., Ernst, M., Cullinane, C., & Humbert, P. O. (2014) · Oncogene

Protein Kinase Regulation and GTPase SignalingLung Cancer Treatments and Mutations

Cited by 60

Targeting triple-negative breast cancers with the Smac-mimetic birinapant

Lalaoui, N., Merino, D., Giner, G., Vaillant, F., Chau, D., Liu, L., Kratina, T., Pal, B., Whittle, J. R., Etemadi, N., et al. (2020) · Cell Death & Differentiation

Cell death mechanisms and regulationHistone Deacetylase Inhibitors Research

Cited by 51

Molecular dissection of gp130-dependent pathways in hepatocytes during liver regeneration

Dierssen, U., Beraza, N., Lutz, H. H., Liedtke, C., Ernst, M., Wasmuth, H. E., & Trautwein, C. (2008) · Journal of Biological Chemistry

Liver physiology and pathologyCytokine Signaling Pathways and Interactions

Cited by 48

Imbalanced gp130-Dependent Signaling in Macrophages Alters Macrophage Colony-Stimulating Factor Responsiveness via Regulation of c-fms Expression

Jenkins, B. J., Grail, D., Inglese, M., Quilici, C., Bozinovski, S., Wong, P., & Ernst, M. (2004) · Molecular and Cellular Biology

Cytokine Signaling Pathways and InteractionsImmune cells in cancer

Cited by 43

The polarity protein Scrib mediates epidermal development and exerts a tumor suppressive function during skin carcinogenesis

Pearson, H. B., McGlinn, E., Phesse, T. J., Schlüter, H., Srikumar, A., Gödde, N. J., Woelwer, C. B., Ryan, A., Phillips, W. A., Ernst, M., et al. (2015) · Molecular Cancer

Skin and Cellular Biology ResearchDevelopmental Biology and Gene Regulation

Cited by 39

SOCS3 negatively regulates LIF signaling in neural precursor cells

Emery, B., Merson, T. D., Snell, C., Young, K. M., Ernst, M., & Kilpatrick, T. J. (2006) · Molecular and Cellular Neuroscience

Cytokine Signaling Pathways and InteractionsNeurogenesis and neuroplasticity mechanisms

Cited by 29