Molecular dissection of gp130-dependent pathways in hepatocytes during liver regeneration

STATs and Gene Regulation

Darnell, J. E. (1997) · Science · doi:10.1126/science.277.5332.1630 · Cited by 3,979 · see citing works

Liver Regeneration

Michalopoulos, G. K., & DeFrances, M. C. (1997) · Science · doi:10.1126/science.276.5309.60 · Cited by 2,828 · see citing works

Gp130 and the interleukin-6 family of cytokines.

Taga, T., & Kishimoto, T. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.797 · Cited by 1,603 · see citing works

Liver Failure and Defective Hepatocyte Regeneration in Interleukin-6-Deficient Mice

Cressman, D. E., Greenbaum, L. E., DeAngelis, R. A., Ciliberto, G., Furth, E. E., Poli, V., & Taub, R. (1996) · Science · doi:10.1126/science.274.5291.1379 · Cited by 1,536 · see citing works

STATs: Signal Transducers and Activators of Transcription

Ihle, J. N. (1996) · Cell · doi:10.1016/s0092-8674(00)81277-5 · Cited by 1,381 · see citing works

Interleukin 6 and its receptor: ten years later

Hirano, T. (1998) · International Reviews of Immunology · doi:10.3109/08830189809042997 · Cited by 788 · see citing works

Two Signals Are Necessary for Cell Proliferation Induced by a Cytokine Receptor gp130: Involvement of STAT3 in Anti-Apoptosis

Fukada, T., Hibi, M., Yamanaka, Y., Takahashi-Tezuka, M., Fujitani, Y., Yamaguchi, T., Nakajima, K., & Hirano, T. (1996) · Immunity · doi:10.1016/s1074-7613(00)80501-4 · Cited by 652 · see citing works

Liver regeneration. 2. Role of growth factors and cytokines in hepatic regeneration.

Fausto, N., Laird, A., & Webber, E. M. (1995) · The FASEB Journal · doi:10.1096/fasebj.9.15.8529831 · Cited by 620 · see citing works

Induction of Keratinocyte Migration via Transactivation of the Epidermal Growth Factor Receptor by the Antimicrobial Peptide LL-37

Tokumaru, S., Sayama, K., Shirakata, Y., Komatsuzawa, H., Ouhara, K., Hanakawa, Y., Yahata, Y., Dai, X., Tohyama, M., Nagai, H., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.7.4662 · Cited by 357 · see citing works

Differential Activation of Acute Phase Response Factor/STAT3 and STAT1 via the Cytoplasmic Domain of the Interleukin 6 Signal Transducer gp130

Gerhartz, C., Heesel, B., Sasse, J., Hemmann, U., Landgraf, C., Schneider-Mergener, J., Horn, F., Heinrich, P., & Graeve, L. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.22.12991 · Cited by 351 · see citing works

STAT3 Is Required for IL-6-gp130–Dependent Activation of Hepcidin In Vivo

Pietrangelo, A., Dierssen, U., Valli, L., Garuti, C., Rump, A., Corradini, E., Ernst, M., Klein, C., & Trautwein, C. (2007) · Gastroenterology · doi:10.1053/j.gastro.2006.10.018 · Cited by 315 · see citing works

STAT3 Contributes to the Mitogenic Response of Hepatocytes during Liver Regeneration

Li, W., Liang, X., Kellendonk, C., Poli, V., & Taub, R. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202807200 · Cited by 307 · see citing works

Acquiring signalling specificity from the cytokine receptor gp130

Ernst, M. (2003) · Trends in Genetics · doi:10.1016/j.tig.2003.11.003 · Cited by 297 · see citing works

SOCS3 Is a Critical Physiological Negative Regulator of G-CSF Signaling and Emergency Granulopoiesis

Croker, B. A., Metcalf, D., Robb, L., Wei, W., Mifsud, S., DiRago, L., Cluse, L. A., Sutherland, K. D., Hartley, L., Williams, E., et al. (2004) · Immunity · doi:10.1016/s1074-7613(04)00022-6 · Cited by 285 · see citing works

The Mitogen-Activated Protein Kinase Kinase/Extracellular Signal-Regulated Kinase Cascade Activation Is a Key Signalling Pathway Involved in the Regulation of G₁ Phase Progression in Proliferating Hepatocytes

Talarmin, H., Rescan, C., Cariou, S., Glaise, D., Zanninelli, G., Bilodeau, M., Loyer, P., Guguen-Guillouzo, C., & Baffet, G. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.9.6003 · Cited by 265 · see citing works

Interleukin 6 and liver regeneration

STREETZ, K. L., LUEDDE, T., MANNS, M. P., & TRAUTWEIN, C. (2000) · Gut · doi:10.1136/gut.47.2.309 · Cited by 238 · see citing works

Defective gp130-mediated signal transducer and activator of transcription (STAT) signaling results in degenerative joint disease, gastrointestinal ulceration, and failure of uterine implantation

Ernst, M., Inglese, M., Waring, P., Campbell, I. K., Bao, S., Clay, F. J., Alexander, W. S., Wicks, I. P., Tarlinton, D. M., Novak, U., et al. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.2.189 · Cited by 227 · see citing works

Tyrosine-phosphorylated SOCS-3 inhibits STAT activation but binds to p120 RasGAP and activates Ras

Cacalano, N. A., Sanden, D., & Johnston, J. A. (2001) · Nature Cell Biology · doi:10.1038/35074525 · Cited by 210 · see citing works

Interleukin 6 Is Important for Survival After Partial Hepatectomy in Mice

Blindenbacher, A., Wang, X., Langer, I., Savino, R., Terracciano, L., & Heim, M. H. (2003) · Hepatology · doi:10.1053/jhep.2003.50378 · Cited by 202 · see citing works

The IL-6–gp130–STAT3 pathway in hepatocytes triggers liver protection in T cell–mediated liver injury

Klein, C., Wüstefeld, T., Assmus, U., Roskams, T., Rose-John, S., Müller, M., Manns, M. P., Ernst, M., & Trautwein, C. (2005) · Journal of Clinical Investigation · doi:10.1172/jci200523640 · Cited by 200 · see citing works

Interleukin-6/Glycoprotein 130-dependent Pathways Are Protective during Liver Regeneration

Wüestefeld, T., Klein, C., Streetz, K. L., Betz, U. A. K., Lauber, J., Buer, J., Manns, M. P., Müller, W., & Trautwein, C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m208470200 · Cited by 176 · see citing works

Cyclins and Cyclin-Dependent Kinases: Theme and Variations

Pines, J. (1995) · Advances in cancer research · doi:10.1016/s0065-230x(08)60254-7 · Cited by 172 · see citing works

Hepatocyte proliferation and tissue remodeling is impaired after liver injury in oncostatin M receptor knockout mice

Nakamura, K., Nonaka, H., Saito, H., Tanaka, M., & Miyajima, A. (2004) · Hepatology · doi:10.1002/hep.20086 · Cited by 157 · see citing works

PI3K-FRAP/mTOR pathway is critical for hepatocyte proliferation whereas MEK/ERK supports both proliferation and survival

Coutant, A., Rescan, C., Gilot, D., Loyer, P., Guguen‐Guillouzo, C., & Baffet, G. (2002) · Hepatology · doi:10.1053/jhep.2002.36160 · Cited by 134 · see citing works

Interleukin-6-Induced STAT3 and AP-1 Amplify Hepatocyte Nuclear Factor 1-Mediated Transactivation of Hepatic Genes, an Adaptive Response to Liver Injury

Leu, J. I., Crissey, M. A. S., Leu, J. P., Ciliberto, G., & Taub, R. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.2.414-424.2001 · Cited by 134 · see citing works

Acute-phase response factor, increased binding, and target gene transcription during liver regeneration

Trautwein, C., Rakemann, T., Niehof, M., Rose-John, S., & Manns, M. (1996) · Gastroenterology · doi:10.1053/gast.1996.v110.pm8964411 · Cited by 131 · see citing works

Identification of Both Positive and Negative Domains within the Epidermal Growth Factor Receptor COOH-terminal Region for Signal Transducer and Activator of Transcription (STAT) Activation

Xia, L., Wang, L., Chung, A. S., Ivanov, S. S., Ling, M. Y., Dragoi, A. M., Platt, A., Gilmer, T. M., Fu, X.-Y., & Chin, Y. E. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202823200 · Cited by 126 · see citing works

Results of Split Liver Transplantation in Children

Deshpande, R., Bowles, M. J., Vilca‐Melendez, H., Srinivasan, P., Girlanda, R., Dhawan, A. K., Mieli‐Vergani, G., Muiesan, P., Heaton, N. D., & Rela, M. (2002) · Annals of Surgery · doi:10.1097/00000658-200208000-00014 · Cited by 99 · see citing works

In vivo hepatocyte proliferation is inducible through a TNF and IL-6-independent pathway

Ledda-Columbano, G. M., Curto, M., Piga, R., Zedda, A. I., Menegazzi, M., Sartori, C., Shinozuka, H., Bluethmann, H., Poli, V, Ciliberto, G., et al. (1998) · Oncogene · doi:10.1038/sj.onc.1202018 · Cited by 96 · see citing works

Expression of SOCS1 and SOCS3 genes is differentially regulated in breast cancer cells in response to proinflammatory cytokine and growth factor signals

Evans, M. K., Yu, C.-R., Lohani, A., Mahdi, R. M., Liu, X., Trzeciak, A. R., & Egwuagu, C. E. (2006) · Oncogene · doi:10.1038/sj.onc.1209993 · Cited by 82 · see citing works

ONCOSTATIN M PRODUCTION BY HUMAN DENDRITIC CELLS IN RESPONSE TO BACTERIAL PRODUCTS

Suda, T., Chida, K., Todate, A., Ide, K., Asada, K., Nakamura, Y., Suzuki, K., Kuwata, H., & Nakamura, H. (2002) · Cytokine · doi:10.1006/cyto.2002.1023 · Cited by 82 · see citing works

IL-6 modulates hepatocyte proliferation via induction of HGF/p21cip1: Regulation by SOCS3

Sun, R., Jaruga, B., Kulkarni, S., Sun, H., & Gao, B. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.10.171 · Cited by 72 · see citing works

Pediatric Transplantation: The Hamburg Experience

Kim, J., schen, R. G., Mueller, T. M., Ganschow, R., Bicak, T., Wilms, C., Müller, L. P., Helmke, K., Burdelski, M. M., Rogiers, X., et al. (2005) · Transplantation · doi:10.1097/01.tp.0000160758.13505.d2 · Cited by 51 · see citing works

Mechanisms of SOCS3 Phosphorylation upon Interleukin-6 Stimulation

Sommer, U., Schmid, C., Sobota, R. M., Lehmann, U., Stevenson, N., Johnston, J., Schaper, F., Heinrich, P., & Haan, S. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m506008200 · Cited by 49 · see citing works

Interplay among cardiotrophin‐1, prostaglandins, and vascular endothelial growth factor in rat liver regeneration

Beraza, N., Marqués, J. M., Martínez-Ansó, E., Íñiguez, M., Prieto, J., & Bustos, M. (2005) · Hepatology · doi:10.1002/hep.20590 · Cited by 47 · see citing works

Oncostatin M Receptor-mediated Signal Transduction Is Negatively Regulated by SOCS3 through a Receptor Tyrosine-independent Mechanism

Stroß, C., Radtke, S., Clahsen, T., Gerlach, C., Volkmer, R., Schaper, F., Heinrich, P. C., & Hermanns, H. M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m511212200 · Cited by 41 · see citing works

The Suppressor of Cytokine Signaling-3 Is Upregulated in Impaired Skin Repair: Implications for Keratinocyte Proliferation

Goren, I., Linke, A., Müller, E., Pfeilschifter, J. M., & Frank, S. (2005) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700063 · Cited by 40 · see citing works

Role of ERK, p38 and PI3-kinase in EGF Receptor-Mediated Mitogenic Signalling in Cultured Rat Hepatocytes: Requirement for Sustained ERK Activation

Thoresen, H. G., Guren, T. K., & Christoffersen, T. (2003) · Cellular Physiology and Biochemistry · doi:10.1159/000072426 · Cited by 37 · see citing works

SOCS3/CIS3 negative regulation of STAT3 in HGF-induced keratinocyte migration

Tokumaru, S., Sayama, K., Yamasaki, K., Shirakata, Y., Hanakawa, Y., Yahata, Y., Dai, X., Tohyama, M., Yang, L., Yoshimura, A., et al. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.11.145 · Cited by 27 · see citing works

A new player in the team: SOCS-3 socks it to cytokine signaling in the regenerating liver

Luedde, T., Wüestefeld, T., & Trautwein, C. (2001) · Hepatology · doi:10.1053/jhep.2001.0341254 · Cited by 6 · see citing works

Liver regeneration after adult living donor and deceased donor split-liver transplants

Kadry, Z., Selzner, N., Selzner, M., & Clavien, P. (2004) · Liver Transplantation · doi:10.1002/lt.20200 · Cited by 4 · see citing works

Mesenchymal stem cell-derived exosomes promote hepatic regeneration in drug-induced liver injury models

Tan, C. Y., Lai, R. C., Wong, W., Dan, Y. Y., Lim, S.-K., & Ho, H. K. (2014) · Stem Cell Research & Therapy · doi:10.1186/scrt465 · Cited by 548 · see citing works

STAT proteins – Key regulators of anti-viral responses, inflammation, and tumorigenesis in the liver

Gao, B., Wang, H., Lafdil, F., & Feng, D. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.01.029 · Cited by 179 · see citing works

New insights into IL-6 family cytokines in metabolism, hepatology and gastroenterology

Giraldez, M. D., Carneros, D., Garbers, C., Rose-John, S., & Bustos, M. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00473-x · Cited by 156 · see citing works

Continuous glycoprotein-130-mediated signal transducer and activator of transcription-3 activation promotes inflammation, left ventricular rupture, and adverse outcome in subacute myocardial infarction

Hilfiker-Kleiner, D., Shukla, P., Klein, G., Schaefer, A., Stapel, B., Hoch, M., Müller, W., Scherr, M., Theilmeier, G., Ernst, M., et al. (2010) · Circulation · doi:10.1161/circulationaha.109.933127 · Cited by 167 · see citing works

Long-term culture and expansion of primary human hepatocytes

Levy, G., Bomze, D., Heinz, S., Ramachandran, S. D., Noerenberg, A., Cohen, M., Shibolet, O., Sklan, E., Braspenning, J., & Nahmias, Y. (2015) · Nature Biotechnology · doi:10.1038/nbt.3377 · Cited by 155 · see citing works

The stat3/socs3a Pathway Is a Key Regulator of Hair Cell Regeneration in Zebrafish stat3/socs3a Pathway: Regulator of Hair Cell Regeneration

Liang, J., Wang, D., Renaud, G., Wolfsberg, T. G., Wilson, A. F., & Burgess, S. M. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.5785-10.2012 · Cited by 95 · see citing works

Hepatocyte-specific mutation of both NF-κB RelA and STAT3 abrogates the acute phase response in mice

Quinton, L. J., Blahna, M. T., Jones, M. R., Allen, E., Ferrari, J. D., Hilliard, K. L., Zhang, X., Sabharwal, V., Algül, H., Akira, S., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59408 · Cited by 84 · see citing works

Pro-apoptotic Sorafenib signaling in murine hepatocytes depends on malignancy and is associated with PUMA expression in vitro and in vivo

Sonntag, R., Gaßler, N., Bangen, J.-M., Trautwein, C., & Liedtke, C. (2014) · Cell Death and Disease · doi:10.1038/cddis.2013.557 · Cited by 75 · see citing works

Aberrant Cell Cycle Progression and Endoreplication in Regenerating Livers of Mice That Lack a Single E-Type Cyclin

Nevzorova, Y. A., Tschaharganeh, D. F., Gaßler, N., Geng, Y., Weiskirchen, R., Siciński, P., Trautwein, C., & Liedtke, C. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.05.003 · Cited by 68 · see citing works

JAK-STAT signaling in hepatic fibrosis

Mair, M. (2011) · Frontiers in bioscience · doi:10.2741/3886 · Cited by 63 · see citing works

Conditional gp130 deficient mouse mutants

Fasnacht, N., & Müller, W. (2008) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2008.07.001 · Cited by 60 · see citing works

Partial hepatectomy in mice

Nevzorova, Y. A., Tolba, R. H., Trautwein, C., & Liedtke, C. (2015) · Laboratory Animals · doi:10.1177/0023677215572000 · Cited by 63 · see citing works

Placenta extract promote liver regeneration in CCl4-injured liver rat model

Jung, J., Lee, H., Lee, J. M., Na, K.-H., Hwang, S. G., & Kim, G. J. (2011) · International Immunopharmacology · doi:10.1016/j.intimp.2011.02.012 · Cited by 61 · see citing works

Hepatitis B virus HBx protein impairs liver regeneration through enhanced expression of IL-6 in transgenic mice

Quétier, I., Brezillon, N., Duriez, M., Massinet, H., Giang, E., Ahodantin, J., Lamant, C., Brunelle-Navas, M.-N., Soussan, P., & Kremsdorf, D. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2013.03.021 · Cited by 56 · see citing works

Immune-mediated liver injury

Lohse, A. W., Weiler‐Normann, C., & Tiegs, G. (2009) · Journal of Hepatology · doi:10.1016/j.jhep.2009.10.016 · Cited by 56 · see citing works

Nuclear α1-Antichymotrypsin Promotes Chromatin Condensation and Inhibits Proliferation of Human Hepatocellular Carcinoma Cells

Santamaria, M., Pardo–Saganta, A., Alvarez–Asiain, L., Scala, M. D., Qian, C., Prìeto, J., & Avila, M. A. (2013) · Gastroenterology · doi:10.1053/j.gastro.2012.12.029 · Cited by 52 · see citing works

Pioglitazone promotes survival and prevents hepatic regeneration failure after partial hepatectomy in obese and diabetic KK-Ay mice #

Aoyama, T., Ikejima, K., Kon, K., Okumura, K., Arai, K., & Watanabe, S. (2009) · Hepatology · doi:10.1002/hep.22828 · Cited by 52 · see citing works

Lack of Glycoprotein 130/Signal Transducer and Activator of Transcription 3-Mediated Signaling in Hepatocytes Enhances Chronic Liver Injury and Fibrosis Progression in a Model of Sclerosing Cholangitis

Plum, W., Tschaharganeh, D. F., Kroy, D. C., Corsten, E., Erschfeld, S., Dierssen, U., Wasmuth, H. E., Trautwein, C., & Streetz, K. L. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.090469 · Cited by 51 · see citing works

Exogenous melatonin protects small‐for‐size liver grafts by promoting monocyte infiltration and releases interleukin‐6

Song, Z., Humar, B., Gupta, A. K., Maurizio, E., Borgeaud, N., Graf, R., Clavien, P., & Tian, Y. (2018) · Journal of Pineal Research · doi:10.1111/jpi.12486 · Cited by 45 · see citing works

Toll-like receptor 4 and myeloid differentiation factor 88 provide mechanistic insights into the cause and effects of interleukin-6 activation in mouse liver regeneration

Vaquero, J., Campbell, J. S., Haque, J. A., McMahon, R. S., Riehle, K. J., Bauer, R. L., & Fausto, N. (2011) · Hepatology · doi:10.1002/hep.24420 · Cited by 45 · see citing works

Regulation of drug transporter expression by oncostatin M in human hepatocytes

Vée, M. L., Jouan, E., Stieger, B., Lecureur, V., & Fardel, O. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.04.017 · Cited by 39 · see citing works

Hepatocyte growth control by SOCS1 and SOCS3

Khan, M. G. M., Ghosh, A., Variya, B. C., Santharam, M. A., Kandhi, R., Ramanathan, S., & Ilangumaran, S. (2019) · Cytokine · doi:10.1016/j.cyto.2019.154733 · Cited by 37 · see citing works

The Regenerative Activity of Interleukin-6

Galun, E., & Rose-John, S. (2013) · Methods in Molecular Biology · doi:10.1007/978-1-62703-308-4_4 · Cited by 34 · see citing works

Transcriptional regulation of IL-6 in bile duct epithelia by extracellular ATP

Yu, J. H., Sheung, N., Soliman, E., Spirlı̀, C., & Dranoff, J. A. (2009) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90502.2008 · Cited by 32 · see citing works

Model Based Targeting of IL-6-Induced Inflammatory Responses in Cultured Primary Hepatocytes to Improve Application of the JAK Inhibitor Ruxolitinib

Sobotta, S., Raue, A., Huang, X., Vanlier, J., Jünger, A., Bohl, S., Albrecht, U., Hahnel, M. J., Wolf, S., Mueller, N. S., et al. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00775 · Cited by 28 · see citing works

NF-κB Essential Modifier Is Required for Hepatocyte Proliferation and the Oval Cell Reaction After Partial Hepatectomy in Mice

Malato, Y., Ehedego, H., Al-Masaoudi, M., Cubero, F. J., Bornemann, J., Gaßler, N., Liedtke, C., Beraza, N., & Trautwein, C. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.08.030 · Cited by 28 · see citing works

Optimization of upcyte® human hepatocytes for the in vitro micronucleus assay

Noerenberg, A., Heinz, S., Scheller, K., Hewitt, N. J., Braspenning, J., & Ott, M. (2013) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2013.09.008 · Cited by 22 · see citing works

The epidermal growth factor receptor ligand amphiregulin is a negative regulator of hepatic acute-phase gene expression

Pardo–Saganta, A., Latasa, M. U., Castillo, J., Alvarez–Asiain, L., Perugorria, M. J., Sarobe, P., Rodríguez‐Ortigosa, C. M., Prìeto, J., Berasain, C., Santamaría, M., et al. (2009) · Journal of Hepatology · doi:10.1016/j.jhep.2009.06.030 · Cited by 22 · see citing works

Lysophosphatidic Acid Alters the Expression Profiles of Angiogenic Factors, Cytokines, and Chemokines in Mouse Liver Sinusoidal Endothelial Cells

Chou, C., Lai, S.-L., Ho, C., Lin, W.-H., Chen, C., Lee, P., Peng, F.-C., Kuo, S., Wu, S., & Lai, H. (2015) · PLoS ONE · doi:10.1371/journal.pone.0122060 · Cited by 22 · see citing works

Novel sequence-based method for identifying transcription factor binding sites in prokaryotic genomes

Sahota, G., & Stormo, G. D. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq501 · Cited by 22 · see citing works

Hepatocyte growth factor/c-Met signalling is important for the selection of transplanted hepatocytes

Kaldenbach, M., Giebeler, A., Tschaharganeh, D. F., Erschfeld, S., Wasmuth, H. E., Dollé, L., Floege, J., Trautwein, C., & Streetz, K. L. (2012) · Gut · doi:10.1136/gutjnl-2011-301345 · Cited by 20 · see citing works

Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumors #

Spannbauer, M., & Trautwein, C. (2009) · Hepatology · doi:10.1002/hep.22902 · Cited by 16 · see citing works

Role of Interleukin-6 in the Control of DNA Synthesis of Hepatocytes: Involvement of PKC, p44/42 MAPKs, and PPARδ

Suh, H. N., Lee, S. H., Lee, M. Y., Lee, Y. J., Lee, J., & Han, H. J. (2008) · Cellular Physiology and Biochemistry · doi:10.1159/000185551 · Cited by 14 · see citing works

Mechanism and Effect of HNF4α Decrease in a Rat Model of Cirrhosis and Liver Failure

Melis, M., Marino, R. B., Tian, J., Johnson, C., Sethi, R., Oertel, M., Fox, I. J., & Locker, J. D. (2023) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2023.11.009 · Cited by 12 · see citing works

Liver Regeneration after Partial Hepatectomy Is Not Impaired in Mice with Double Deficiency ofMyd88andIFNARGenes

Vaquero, J., Riehle, K. J., Fausto, N., & Campbell, J. S. (2011) · Gastroenterology Research and Practice · doi:10.1155/2011/727403 · Cited by 10 · see citing works

Hepatocyte Specific gp130 Signalling Underlies APAP Induced Liver Injury

Dong, J., Lim, W., Shekeran, S. G., Tan, J., Lim, S. Y., Goh, J. W. T., George, B. L., Schäfer, S., Cook, S. A., & Widjaja, A. A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23137089 · Cited by 9 · see citing works

Molecular dissection of human oncostatin M-mediated signal transductions through site-directed mutagenesis

Liu (1998) · International Journal of Molecular Medicine · doi:10.3892/ijmm_00000113 · Cited by 7 · see citing works

Glycoprotein 130–dependent pathways in host hepatocytes are important for liver repopulation in mice

Tschaharganeh, D. F., Kaldenbach, M., Erschfeld, S., Tischendorf, J. J. W., Trautwein, C., & Streetz, K. L. (2009) · Liver Transplantation · doi:10.1002/lt.21962 · Cited by 5 · see citing works

TNF/TNF Receptors

Schattenberg, J. M., & Czaja, M. J. (2009) · Springer eBooks · doi:10.1007/978-3-642-00150-5_10 · Cited by 5 · see citing works

Efficacy of chorionic plate-derived mesenchymal stem cells isolated from placenta in CCl4-injured rat liver depends on transplantation routes

Jung, J., Na, K.-H., Lee, M.-J., Moon, J., Kim, G. I., Jang, J.-J., Hwang, S., & Kim, G. J. (2013) · Tissue Engineering and Regenerative Medicine · doi:10.1007/s13770-013-0364-x · Cited by 3 · see citing works

Protein-protein interaction map is a key gateway into liver regeneration

Xie, C. (2010) · World Journal of Gastroenterology · doi:10.3748/wjg.v16.i28.3491 · Cited by 2 · see citing works

Developmental Pathways in Liver Regeneration-I

Nejak‐Bowen, K. N., & Monga, S. P. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-420128-6.00006-3 · Cited by 2 · see citing works

Effects of S/B Remedy Containing Scutellaria baicalensis and Bupleurum scorzonerifolfium on Hepatic Interleukin-6 Related Signal Transducer and Activator of Transcription 3 Activation in Mice through Cell-Cell Interaction

Lee, C., Wang, J., Chen, T., Jiang, J.-K., Peng, C.-H., Kuo, C., Chang, W.-C., Chiu, J., & Wu, C.-W. (2011) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.34.727 · Cited by 1 · see citing works

Liver Regeneration

Nevzorova, Y. A., & Trautwein, C. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4377-0881-3.00002-4 · Cited by 1 · see citing works

Acute Liver Failure: A Dangerous and Challenging Syndrome

Canbay, A. E., & Gerken, G. (2014) · EMJ Hematology · doi:10.33590/emjhepatol/10310152 · Cited by 1 · see citing works

Batf regulates previously unknown AP-1 target genes to control TH17 differentiation

Schraml, B. U. (2009) · Open Scholarship Institutional Repository (Washington University in St. Louis) · doi:10.7936/k7bg2m0c

Liver regeneration

Humar, B., & Humar, R. (2023) · doi:10.1093/med/9780192862457.003.0003

HGF,c-Met and IL-6,gp130 mediated signalling pathways in a model of acute and chronic cholestatic liver injury in mice

Giebeler, A., & Spehr, M. (2011) · RWTH Publications (RWTH Aachen)

Role of IL-6/gp130-dependent signalling pathways in hepatocytes during liver regeneration and inflammation

Dierssen, U., & Trautwein, C. (2008) · RWTH Publications (RWTH Aachen)

Interleukin-6/Glycoprotein 130-dependent Pathways Are Protective during Liver Regeneration

Wüestefeld, T., Klein, C., Streetz, K. L., Betz, U. A. K., Lauber, J., Buer, J., Manns, M. P., Müller, W., & Trautwein, C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m208470200 · Cited by 176 · see citing works

Die Aktivierung des IL-6-gp130-STAT Signalwegs während der Leberregeneration ist protektiv und steuert die Proliferation der Hepatozyten

Dierssen, U., Beraza, N., Ernst, M., & Trautwein, C. (2007) · Zeitschrift für Gastroenterologie · doi:10.1055/s-2007-988472

Lack of gp130 expression in hepatocytes promotes liver injury1 1K.L.S. and T.W. contributed equally to this work.

StreetZ, K. L., Wüstefeld, T., Klein, C., Kallen, K.-J., Tronche, F., Betz, U. A. K., Schütz, G., Manns, M. P., Müller, W., & Trautwein, C. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00901-6 · Cited by 94 · see citing works

Gp1 30-STAT3-dependent SOCS3 induction controls timing of hepatocyte proliferation during liver regeneration

Dierssen, U., Beraza, N., Ernst, M., & Trautwein, C. (2007) · RWTH Publications (RWTH Aachen)