Akbar, Arne N.

Fibroblasts regulate the switch from acute resolving to chronic persistent inflammation

Buckley, C. D., Pilling, D., Lord, J. M., Akbar, A. N., Scheel-Toellner, D., & Salmon, M. (2001) · Trends in Immunology

Wound Healing and TreatmentsCardiac Fibrosis and Remodeling

Cited by 796

Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition

Pereira, B. I., Devine, O. P., Vukmanovic-Stejic, M., Chambers, E. S., Subramanian, P., Patel, N., Virasami, A., Sebire, N. J., Kinsler, V., Valdovinos, A., et al. (2019) · Nature Communications

Telomeres, Telomerase, and SenescenceImmune Cell Function and Interaction

Cited by 556

Are senescence and exhaustion intertwined or unrelated processes that compromise immunity?

Akbar, A. N., & Henson, S. M. (2011) · Nature Reviews Immunology

T-cell and B-cell ImmunologyTelomeres, Telomerase, and Senescence

Cited by 474

Dietary supplementation with inulin-propionate ester or inulin improves insulin sensitivity in adults with overweight and obesity with distinct effects on the gut microbiota, plasma metabolome and systemic inflammatory responses: A randomised cross-over trial

Chambers, E. S., Byrne, C. S., Morrison, D. J., Murphy, K. G., Preston, T., Tedford, C., Garcia-Perez, I., Fountana, S., Serrano-Contreras, J. I., Holmes, E., et al. (2019) · Gut

Microbial Metabolites in Food BiotechnologyGut microbiota and health

Cited by 443

Human immunosenescence: is it infectious?

Pawelec, G., Akbar, A., Caruso, C., Solana, R., Grubeck‐Loebenstein, B., & Wikby, A. (2005) · Immunological Reviews

Cytomegalovirus and herpesvirus researchImmune responses and vaccinations

Cited by 405

p38 signaling inhibits mTORC1-independent autophagy in senescent human CD8+ T cells

Henson, S. M., Lanna, A., Riddell, N. E., Franzese, O., Macaulay, R., Griffiths, S. J., Puleston, D. J., Watson, A. S., Simon, A. K., Tooze, S. A., et al. (2014) · Journal of Clinical Investigation

Telomeres, Telomerase, and SenescenceAutophagy in Disease and Therapy

Cited by 389

The kinase p38 activated by the metabolic regulator AMPK and scaffold TAB1 drives the senescence of human T cells

Lanna, A., Henson, S. M., Escors, D., & Akbar, A. N. (2014) · Nature Immunology

Telomeres, Telomerase, and SenescenceT-cell and B-cell Immunology

Cited by 328

Cytomegalovirus-specific CD4+ T cells in healthy carriers are continuously driven to replicative exhaustion

Fletcher, J. M., Vukmanovic-Stejic, M., Dunne, P. J., Birch, K. E., Cook, J. E., Jackson, S. E., Salmon, M., Rustin, M. H., & Akbar, A. N. (2005) · The Journal of Immunology

T-cell and B-cell ImmunologyCytomegalovirus and herpesvirus research

Cited by 296

Senescence of T Lymphocytes: Implications for Enhancing Human Immunity

Akbar, A. N., Henson, S. M., & Lanna, A. (2016) · Trends in Immunology

T-cell and B-cell ImmunologyTelomeres, Telomerase, and Senescence

Cited by 285

A sestrin-dependent Erk–Jnk–p38 MAPK activation complex inhibits immunity during aging

Lanna, A., Gomes, D. C. O., Muller-Durovic, B., McDonnell, T., Escors, D., Gilroy, D. W., Lee, J. H., Karin, M., & Akbar, A. N. (2017) · Nature Immunology

T-cell and B-cell ImmunologyGenetics, Aging, and Longevity in Model Organisms

Cited by 284

KLRG1 signaling induces defective Akt (ser473) phosphorylation and proliferative dysfunction of highly differentiated CD8+ T cells

Henson, S. M., Franzese, O., Macaulay, R., Libri, V., Azevedo, R. I., Kiani-Alikhan, S., Plunkett, F. J., Masters, J. E., Jackson, S., Griffiths, S. J., et al. (2009) · Blood

T-cell and B-cell ImmunologyTelomeres, Telomerase, and Senescence

Cited by 262

Functional skewing of the global CD8 T cell population in chronic hepatitis B virus infection

Das, A., Hoare, M., Davies, N., Lopes, A. R., Dunn, C., Kennedy, P. T. F., Alexander, G., Finney, H., Lawson, A., Plunkett, F. J., et al. (2008) · The Journal of Experimental Medicine

Hepatitis B Virus StudiesT-cell and B-cell Immunology

Cited by 256

Clearance of senescent macrophages ameliorates tumorigenesis in KRAS-driven lung cancer

Haston, S., Gonzalez-Gualda, E., Morsli, S., Ge, J., Reen, V., Calderwood, A., Moutsopoulos, I., Panousopoulos, L., Deletic, P., Carreno, G., et al. (2023) · Cancer Cell

Telomeres, Telomerase, and SenescenceImmune cells in cancer

Cited by 251

Reversible Senescence in Human CD4+CD45RA+CD27− Memory T Cells

Di Mitri, D., Azevedo, R. I., Henson, S. M., Libri, V., Riddell, N. E., Macaulay, R., Kipling, D., Soares, M. V. D., Battistini, L., & Akbar, A. N. (2011) · The Journal of Immunology

Telomeres, Telomerase, and SenescenceT-cell and B-cell Immunology

Cited by 231

The loss of telomerase activity in highly differentiated CD8+CD28−CD27− T cells is associated with decreased Akt (Ser473) phosphorylation

Plunkett, F. J., Franzese, O., Finney, H. M., Fletcher, J. M., Belaramani, L. L., Salmon, M., Dokal, I., Webster, D., Lawson, A. D. G., & Akbar, A. N. (2007) · The Journal of Immunology

Telomeres, Telomerase, and SenescenceT-cell and B-cell Immunology

Cited by 222

Blocking elevated p38 MAPK restores efferocytosis and inflammatory resolution in the elderly

De Maeyer, R. P. H., van de Merwe, R. C., Louie, R., Bracken, O. V., Devine, O. P., Goldstein, D. R., Uddin, M., Akbar, A. N., & Gilroy, D. W. (2020) · Nature Immunology

Phagocytosis and Immune RegulationImmune Response and Inflammation

Cited by 182

Properties of end-stage human T cells defined by CD45RA re-expression

Henson, S. M., Riddell, N. E., & Akbar, A. N. (2012) · Current Opinion in Immunology

T-cell and B-cell ImmunologyTelomeres, Telomerase, and Senescence

Cited by 180

Memory T Cells Constitute a Subset of the Human CD8+CD45RA+ Pool with Distinct Phenotypic and Migratory Characteristics

Faint, J. M., Annels, N. E., Curnow, S. J., Shields, P., Pilling, D., Hislop, A. D., Wu, L., Akbar, A. N., Buckley, C. D., Moss, P. A. H., et al. (2001) · The Journal of Immunology

T-cell and B-cell ImmunologyImmunotherapy and Immune Responses

Cited by 171

Cytomegalovirus Infection Reduces Telomere Length of the Circulating T Cell Pool

van de Berg, P. J. E. J., Griffiths, S. J., Yong, S.-L., Macaulay, R., Bemelman, F. J., Jackson, S., Henson, S. M., ten Berge, I. J. M., Akbar, A. N., & van Lier, R. A. W. (2010) · The Journal of Immunology

Telomeres, Telomerase, and SenescenceCytomegalovirus and herpesvirus research

Cited by 157

New advances in CMV and immunosenescence

Sansoni, P., Vescovini, R., Fagnoni, F. F., Akbar, A., Arens, R., Chiu, Y.-L., Čičin-Šain, L., Dechanet-Merville, J., Derhovanessian, E., Ferrando-Martinez, S., et al. (2014) · Experimental Gerontology

Cytomegalovirus and herpesvirus researchImmune responses and vaccinations

Cited by 150

Blockade of PD‐1 or p38 MAP kinase signaling enhances senescent human CD8+ T‐cell proliferation by distinct pathways

Henson, S. M., Macaulay, R., Riddell, N. E., Nunn, C. J., & Akbar, A. N. (2015) · European Journal of Immunology

T-cell and B-cell ImmunologyTelomeres, Telomerase, and Senescence

Cited by 146

Epstein–Barr virus-specific CD8+ T cells that re-express CD45RA are apoptosis-resistant memory cells that retain replicative potential

Dunne, P. J., Faint, J. M., Gudgeon, N. H., Fletcher, J. M., Plunkett, F. J., Soares, M. V. D., Hislop, A. D., Annels, N. E., Rickinson, A. B., Salmon, M., et al. (2002) · Blood

T-cell and B-cell ImmunologyViral-associated cancers and disorders

Cited by 144

Will telomere erosion lead to a loss of T-cell memory?

Akbar, A. N., Beverley, P. C. L., & Salmon, M. (2004) · Nature Reviews Immunology

T-cell and B-cell ImmunologyTelomeres, Telomerase, and Senescence

Cited by 135

The kinetics of CD4+Foxp3+ T cell accumulation during a human cutaneous antigen-specific memory response in vivo

Vukmanovic-Stejic, M., Agius, E., Booth, N., Dunne, P. J., Lacy, K. E., Reed, J. R., Sobande, T. O., Kissane, S., Salmon, M., Rustin, M. H., et al. (2008) · Journal of Clinical Investigation

T-cell and B-cell ImmunologyPsoriasis: Treatment and Pathogenesis

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