The kinetics of CD4+Foxp3+ T cell accumulation during a human cutaneous antigen-specific memory response in vivo

Vukmanovic-Stejic, Milica; Agius, Elaine; Booth, Nicola; Dunne, Padraic J.; Lacy, Katie E.; Reed, John R.; Sobande, Toni O.; Kissane, Steven; Salmon, Mike; Rustin, Malcolm H.; Akbar, Arne N.

doi:10.1172/jci35834

Cited by 131T-cell and B-cell ImmunologyPsoriasis: Treatment and PathogenesisCancer Immunotherapy and Biomarkers

The kinetics of CD4+Foxp3+ T cell accumulation during a human cutaneous antigen-specific memory response in vivo

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Vukmanovic-Stejic, Milica, Agius, Elaine, Booth, Nicola, Dunne, Padraic J., Lacy, Katie E., Reed, John R., Sobande, Toni O., Kissane, Steven +3 more·2008·Journal of Clinical Investigation

DOI 10.1172/jci35834PMC PMC2556297

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Abstract

Naturally occurring CD4(+)CD25(hi)Foxp3(+) Tregs (nTregs) are highly proliferative in blood. However, the kinetics of their accumulation and proliferation during a localized antigen-specific T cell response is currently unknown. To explore this, we used a human experimental system whereby tuberculin purified protein derivative (PPD) was injected into the skin and the local T cell response analyzed over time. The numbers of both CD4(+)Foxp3(-) (memory) and CD4(+)Foxp3(+) (putative nTreg) T cells increased in parallel, with the 2 populations proliferating at the same relative rate. In contrast to CD4(+)Foxp3(-) T cell populations, skin CD4(+)Foxp3(+) T cells expressed typical Treg markers (i.e., they were CD25(hi), CD127(lo), CD27(+), and CD39(+)) and did not synthesize IL-2 or IFN-gamma after restimulation in vitro, indicating that they were not recently activated effector cells. To determine whether CD4(+)Foxp3(+) T cells in skin could be induced from memory CD4(+) T cells, we expanded skin-derived memory CD4(+) T cells in vitro and anergized them. These cells expressed high levels of CD25 and Foxp3 and suppressed the proliferation of skin-derived responder T cells to PPD challenge. Our data therefore demonstrate that memory and CD4(+) Treg populations are regulated in tandem during a secondary antigenic response. Furthermore, it is possible to isolate effector CD4(+) T cell populations from inflamed tissues and manipulate them to generate Tregs with the potential to suppress inflammatory responses.

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Treg cells increase in skin and possibly other compartments, where they contribute to impaired T cell responses in older individuals.
“Treg cells increase in the skin and possibly other compartments, where they contribute to impaired T cell responses in older individuals”
From Successful and Maladaptive T Cell Aging (2017) · cites this paper as Vukmanovic-Stejic et al., 2008

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Regulatory T cells (Treg) and Their Roles in Immune System with Respect to Immunopathological Disorders
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Authors: Vukmanovic-Stejic, M., Agius, E., Booth, N., Dunne, P. J., Lacy, K. E., Reed, J. R., Sobande, T. O., Kissane, S., Salmon, M., Rustin, M. H., & Akbar, A. N.
Affiliations: The Royal Free Hospital (GB)
University College London (GB)
University of Birmingham (GB)
Corresponding author: Akbar, Arne N.
ORCID: Lacy, Katie E.
Reed, John R.
Akbar, Arne N.
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 2008-11-03
Volume: 118
Issue: 11
Pages: 3639-3650
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci35834
PMC: PMC2556297
OpenAlex: W2056451142
Cited by: 131
References: 65
Citations by year: 2026: 4 · 2025: 2 · 2024: 5 · 2023: 1 · 2022: 2 · 2021: 4 · 2020: 5 · 2019: 4 · 2018: 2 · 2017: 17 · 2016: 8 · 2015: 9 · 2014: 9 · 2013: 12 · 2012: 13
FWCI: 4.69
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
Funders: British Skin Foundation
University College London
University of Oxford
Biotechnology and Biological Sciences Research Council (BB/D015251/1)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
Keywords: regulatory T cells, Foxp3, CD4+ T cells, purified protein derivative, Treg proliferation, Treg suppressive function, CD25, CD39, CD127, CD27, interleukin-2, interferon-gamma, skin inflammation
MeSH terms: Antigens, Humans, Immunologic Memory, Kinetics, Skin, CD4 Antigens, T-Lymphocytes, Regulatory, Forkhead Transcription Factors

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The kinetics of CD4+Foxp3+ T cell accumulation during a human cutaneous antigen-specific memory response in vivo

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