Dietary supplementation with inulin-propionate ester or inulin improves insulin sensitivity in adults with overweight and obesity with distinct effects on the gut microbiota, plasma metabolome and systemic inflammatory responses: a randomised cross-over trial

Chambers, Edward S; Byrne, Claire S; Morrison, Douglas J; Murphy, Kevin G; Preston, Tom; Tedford, Catriona; Garcia-Perez, Isabel; Fountana, Sofia; Serrano-Contreras, Jose Ivan; Holmes, Elaine; Reynolds, Catherine J; Roberts, Jordie F; Boyton, Rosemary J; Altmann, Daniel M; McDonald, Julie A K; Marchesi, Julian R; Akbar, Arne N; Riddell, Natalie E; Wallis, Gareth A; Frost, Gary S

doi:10.1136/gutjnl-2019-318424

Dietary supplementation with inulin-propionate ester or inulin improves insulin sensitivity in adults with overweight and obesity with distinct effects on the gut microbiota, plasma metabolome and systemic inflammatory responses: a randomised cross-over trial

Objective To investigate the underlying mechanisms behind changes in glucose homeostasis with delivery of propionate to the human colon by comprehensive and coordinated analysis of gut bacterial composition, plasma metabolome and immune responses. Design Twelve non-diabetic adults with overweight…