Soares, Miguel P.

Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway

Otterbein, L. E., Bach, F. H., Alam, J., Soares, M., Tao Lu, H., Wysk, M., Davis, R. J., Flavell, R. A., & Choi, A. M. K. (2000) · Nature Medicine

Heme Oxygenase-1 and Carbon MonoxideHemoglobin structure and function

Cited by 2,153

Disease Tolerance as a Defense Strategy

Medzhitov, R., Schneider, D. S., & Soares, M. P. (2012) · Science

Immune Response and InflammationImmune responses and vaccinations

Cited by 1,718

Mechanisms of Cell Protection by Heme Oxygenase-1

Gozzelino, R., Jeney, V., & Soares, M. P. (2010) · Annual Review of Pharmacology and Toxicology

Heme Oxygenase-1 and Carbon MonoxideHemoglobin structure and function

Cited by 1,241

Carbon Monoxide Generated by Heme Oxygenase 1 Suppresses Endothelial Cell Apoptosis

Brouard, S., Otterbein, L. E., Anrather, J., Tobiasch, E., Bach, F. H., Choi, A. M. K., & Soares, M. P. (2000) · The Journal of Experimental Medicine

Heme Oxygenase-1 and Carbon MonoxideHemoglobin structure and function

Cited by 984

Electrophilic properties of itaconate and derivatives regulate the IκBζ–ATF3 inflammatory axis

Bambouskova, M., Gorvel, L., Lampropoulou, V., Sergushichev, A., Loginicheva, E., Johnson, K., Korenfeld, D., Mathyer, M. E., Kim, H., Huang, L.-H., et al. (2018) · Nature

NF-κB Signaling PathwaysGenomics, phytochemicals, and oxidative stress

Cited by 713

Heme oxygenase-1 and carbon monoxide suppress the pathogenesis of experimental cerebral malaria

Pamplona, A., Ferreira, A., Balla, J., Jeney, V., Balla, G., Epiphanio, S., Chora, Â., Rodrigues, C. D., Gregoire, I. P., Cunha-Rodrigues, M., et al. (2007) · Nature Medicine

Heme Oxygenase-1 and Carbon MonoxideMalaria Research and Control

Cited by 560

A Central Role for Free Heme in the Pathogenesis of Severe Sepsis

Larsen, R., Gozzelino, R., Jeney, V., Tokaji, L., Bozza, F. A., Japiassú, A. M., Bonaparte, D., Cavalcante, M. M., Chora, Â., Ferreira, A., et al. (2010) · Science Translational Medicine

Sepsis Diagnosis and TreatmentHemoglobin structure and function

Cited by 483

Macrophages and Iron Metabolism

Soares, M. P., & Hamza, I. (2016) · Immunity

Iron Metabolism and DisordersImmune cells in cancer

Cited by 401

Disease tolerance and immunity in host protection against infection

Soares, M. P., Teixeira, L., & Moita, L. F. (2017) · Nature reviews. Immunology

Immune Response and InflammationImmune responses and vaccinations

Cited by 376

Sickle Hemoglobin Confers Tolerance to Plasmodium Infection

Ferreira, A., Marguti, I., Bechmann, I., Jeney, V., Chora, Â., Palha, N. R., Rebelo, S., Henri, A., Beuzard, Y., & Soares, M. P. (2011) · Cell

Malaria Research and ControlHemoglobinopathies and Related Disorders

Cited by 340

Heme Oxygenase-1-derived Carbon Monoxide Requires the Activation of Transcription Factor NF-κB to Protect Endothelial Cells from Tumor Necrosis Factor-α-mediated Apoptosis

Brouard, S., Berberat, P. O., Tobiasch, E., Seldon, M. P., Bach, F. H., & Soares, M. P. (2002) · Journal of Biological Chemistry

Heme Oxygenase-1 and Carbon MonoxideNF-κB Signaling Pathways

Cited by 306

Metabolic adaptation establishes disease tolerance to sepsis

Weis, S., Carlos, A. R., Moita, M. R., Singh, S., Blankenhaus, B., Cardoso, S., Larsen, R., Rebelo, S., Schäuble, S., Del Barrio, L., et al. (2017) · Cell

Sepsis Diagnosis and TreatmentIron Metabolism and Disorders

Cited by 284

Heme oxygenase-1 affords protection against noncerebral forms of severe malaria

Seixas, E., Gozzelino, R., Chora, Â., Ferreira, A., Silva, G., Larsen, R., Rebelo, S., Penido, C., Smith, N. R., Coutinho, A., et al. (2009) · Proceedings of the National Academy of Sciences

Heme Oxygenase-1 and Carbon MonoxideMalaria Research and Control

Cited by 275

Heme oxygenase-1: from biology to therapeutic potential

Soares, M. P., & Bach, F. H. (2009) · Trends in Molecular Medicine

Heme Oxygenase-1 and Carbon MonoxideHemoglobin structure and function

Cited by 257

The Iron age of host–microbe interactions

Soares, M. P., & Weiss, G. (2015) · The EMBO Reports

Iron Metabolism and DisordersImmune Response and Inflammation

Cited by 227

Heavy chain ferritin acts as an anti‐apoptotic gene that protects livers from ischemia‐reperfusion injury

Berberat, P. O., Katori, M., Kaczmarek, E., Anselmo, D., Lassman, C., Ke, B., Shen, X., Busuttil, R. W., Yamashita, K., Csizmadia, E., et al. (2003) · The FASEB Journal

Heme Oxygenase-1 and Carbon MonoxideOrgan Transplantation Techniques and Outcomes

Cited by 207

A central role for free heme in the pathogenesis of severe malaria: the missing link?

Ferreira, A., Balla, J., Jeney, V., Balla, G., & Soares, M. P. (2008) · Journal of Molecular Medicine

Malaria Research and ControlHeme Oxygenase-1 and Carbon Monoxide

Cited by 205

Tissue damage control in disease tolerance

Soares, M. P., Gozzelino, R., & Weis, S. (2014) · Trends in Immunology

Immune Response and InflammationImmune responses and vaccinations

Cited by 187

Biliverdin, a natural product of heme catabolism, induces tolerance to cardiac allografts

Yamashita, K., McDaid, J., Öllinger, R., Tsui, T., Berberat, P. O., Usheva, A., Csizmadia, E., Smith, R. N., Soares, M. P., & Bach, F. H. (2004) · The FASEB Journal

Heme Oxygenase-1 and Carbon MonoxideTransplantation: Methods and Outcomes

Cited by 180

Coupling Heme and Iron Metabolism via Ferritin H Chain

Gozzelino, R., & Soares, M. P. (2014) · Antioxidants & Redox Signaling

Iron Metabolism and DisordersHeme Oxygenase-1 and Carbon Monoxide

Cited by 151

Red alert: labile heme is an alarmin

Soares, M. P., & Bozza, M. T. (2016) · Current Opinion in Immunology

Immune Response and InflammationHemoglobin structure and function

Cited by 148

Oxidized Hemoglobin Is an Endogenous Proinflammatory Agonist That Targets Vascular Endothelial Cells

Silva, G., Jeney, V., Chora, Â., Larsen, R., Balla, J., & Soares, M. P. (2009) · Journal of Biological Chemistry

Hemoglobin structure and functionNitric Oxide and Endothelin Effects

Cited by 137

IL-22 controls iron-dependent nutritional immunity against systemic bacterial infections

Sakamoto, K., Kim, Y.-G., Hara, H., Kamada, N., Caballero-Flores, G., Tolosano, E., Soares, M. P., Puente, J. L., Inohara, N., & Núñez, G. (2017) · Science Immunology

Hemoglobin structure and functionImmune Response and Inflammation

Cited by 127

Innate Nutritional Immunity

Núñez, G., Sakamoto, K., & Soares, M. P. (2018) · The Journal of Immunology

Iron Metabolism and DisordersImmune Response and Inflammation

Cited by 115