Lagares, David

Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis

Liu, F., Lagares, D., Choi, K. M., Stopfer, L., Marinković, A., Vrbanac, V., Probst, C. K., Hiemer, S. E., Sisson, T. H., Horowitz, J. C., et al. (2015) · American Journal of Physiology-Lung Cellular and Molecular Physiology

Hippo pathway signaling and YAP/TAZInterstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

Cited by 874

Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis

Lagares, D., Santos, A., Grasberger, P. E., Liu, F., Probst, C. K., Rahimi, R. A., Sakai, N., Kuehl, T., Ryan, J., Bhola, P., et al. (2017) · Science Translational Medicine

Systemic Sclerosis and Related DiseasesCell death mechanisms and regulation

Cited by 246

PPARγ deficiency results in severe, accelerated osteoarthritis associated with aberrant mTOR signalling in the articular cartilage

Vasheghani, F., Zhang, Y., Li, Y.-H., Blati, M., Fahmi, H., Lussier, B., Roughley, P., Lagares, D., Endisha, H., Saffar, B., et al. (2015) · Annals of the Rheumatic Diseases

Osteoarthritis Treatment and MechanismsPeroxisome Proliferator-Activated Receptors

Cited by 221

Senotherapeutics: targeting senescence in idiopathic pulmonary fibrosis

Merkt, W., Bueno, M., Mora, A. L., & Lagares, D. (2020) · Seminars in Cell & Developmental Biology

Interstitial Lung Diseases and Idiopathic Pulmonary FibrosisTelomeres, Telomerase, and Senescence

Cited by 119

A FAK/HDAC5 signaling axis controls osteocyte mechanotransduction

Sato, T., Verma, S., Andrade, C. D. C., Omeara, M., Campbell, N., Wang, J. S., Cetinbas, M., Lang, A., Ausk, B. J., Brooks, D. J., et al. (2020) · Nature Communications

Bone Metabolism and DiseasesCellular Mechanics and Interactions

Cited by 86

Endothelin 1 contributes to the effect of transforming growth factor β1 on wound repair and skin fibrosis

Lagares, D., García‐Fernández, R. A., Jiménez, C. L., Magán‐Marchal, N., Busnadiego, O., Lamas, S., & Rodríguez‐Pascual, F. (2010) · Arthritis & Rheumatism

TGF-β signaling in diseasesWound Healing and Treatments

Cited by 80

Adenoviral gene transfer of endothelin-1 in the lung induces pulmonary fibrosis through the activation of focal adhesion kinase

Lagares, D., Busnadiego, O., García-Fernández, R. A., Lamas, S., & Rodríguez-Pascual, F. (2012) · American Journal of Respiratory Cell and Molecular Biology

Interstitial Lung Diseases and Idiopathic Pulmonary FibrosisPulmonary Hypertension Research and Treatments

Cited by 40

Selective YAP/TAZ inhibition in fibroblasts via dopamine receptor D1 agonism reverses fibrosis

Haak, A., Kostallari, E., Sicard, D., Ligresti, G., Choi, K. M., Caporarello, N., Jones, D., Tan, Q., Meridew, J., Diaz Espinosa, A., et al. (2019) · Mechanisms of lung injury and repair

Hippo pathway signaling and YAP/TAZInterstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

Cited by 11