Schlessinger, Joseph

Cell Signaling by Receptor Tyrosine Kinases

Lemmon, M. A., & Schlessinger, J. (2010) · Cell

HER2/EGFR in Cancer ResearchProtein Kinase Regulation and GTPase Signaling

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Signal transduction by receptors with tyrosine kinase activity

Ullrich, A., & Schlessinger, J. (1990) · Cell

Receptor Mechanisms and SignalingProtein Kinase Regulation and GTPase Signaling

Cited by 5,435

Cell Signaling by Receptor Tyrosine Kinases

Schlessinger, J. (2000) · Cell

Protein Kinase Regulation and GTPase SignalingCytokine Signaling Pathways and Interactions

Cited by 3,774

Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences

Downward, J., Yarden, Y., Mayes, E., Scrace, G., Totty, N., Stockwell, P., Ullrich, A., Schlessinger, J., & Waterfield, M. D. (1984) · Nature

HER2/EGFR in Cancer ResearchCancer-related Molecular Pathways

Cited by 2,516

Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity

Tsai, J., Lee, J. T., Wang, W., Zhang, J., Cho, H., Mamo, S., Bremer, R., Gillette, S., Kong, J., Haass, N. K., et al. (2008) · Proceedings of the National Academy of Sciences

Melanoma and MAPK PathwaysProtein Kinase Regulation and GTPase Signaling

Cited by 1,346

Crystal Structure of a Ternary FGF-FGFR-Heparin Complex Reveals a Dual Role for Heparin in FGFR Binding and Dimerization

Schlessinger, J., Plotnikov, A. N., Ibrahimi, O. A., Eliseenkova, A. V., Yeh, B. K., Yayon, A., Linhardt, R. J., & Mohammadi, M. (2000) · Molecular Cell

Fibroblast Growth Factor ResearchEnzyme Structure and Function

Cited by 1,199

Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma

Krauthammer, M., Kong, Y., Ha, B. H., Evans, P., Bacchiocchi, A., McCusker, J. P., Cheng, E., Davis, M. J., Goh, G., Choi, M., et al. (2012) · Nature Genetics

Melanoma and MAPK PathwaysCutaneous Melanoma Detection and Management

Cited by 1,191

Impaired HLA Class I Antigen Processing and Presentation as a Mechanism of Acquired Resistance to Immune Checkpoint Inhibitors in Lung Cancer

Gettinger, S., Choi, J., Hastings, K., Truini, A., Datar, I., Sowell, R., Wurtz, A., Dong, W., Cai, G., Melnick, M. A., et al. (2017) · Cancer Discovery

Cancer Immunotherapy and BiomarkersImmunotherapy and Immune Responses

Cited by 787

Ganglioside-mediated modulation of cell growth. Specific effects of GM3 on tyrosine phosphorylation of the epidermal growth factor receptor

Bremer, E. G., Schlessinger, J., & Hakomori, S. (1986) · Journal of Biological Chemistry

Sphingolipid Metabolism and SignalingHER2/EGFR in Cancer Research

Cited by 706

Epidermal growth factor induces rapid, reversible aggregation of the purified epidermal growth factor receptor

Yarden, Y., & Schlessinger, J. (1987) · Biochemistry

HER2/EGFR in Cancer ResearchReceptor Mechanisms and Signaling

Cited by 627

Design of protein-binding proteins from the target structure alone

Cao, L., Coventry, B., Goreshnik, I., Huang, B., Sheffler, W., Park, J. S., Jude, K. M., Marković, I., Kadam, R. U., Verschueren, K. H. G., et al. (2022) · Nature

Protein Structure and DynamicsChemical Synthesis and Analysis

Cited by 577

Specific and high-affinity binding of inositol phosphates to an isolated pleckstrin homology domain

Lemmon, M. A., Ferguson, K. M., O'Brien, R., Sigler, P. B., & Schlessinger, J. (1995) · Proceedings of the National Academy of Sciences

Protein Kinase Regulation and GTPase SignalingCellular transport and secretion

Cited by 566

Identification of a novel contactin‐associated transmembrane receptor with multiple domains implicated in protein–protein interactions

Peles, E., Nativ, M., Lustig, M., Grumet, M., Schilling, J., Martinez, R., Plowman, G. D., & Schlessinger, J. (1997) · The EMBO Journal

Axon Guidance and Neuronal SignalingNeuroscience and Neuropharmacology Research

Cited by 400

The EGF Receptor Provides an Essential Survival Signal for SOS-Dependent Skin Tumor Development

Sibilia, M., Fleischmann, A., Behrens, A., Stingl, L., Carroll, J., Watt, F. M., Schlessinger, J., & Wagner, E. F. (2000) · Cell

HER2/EGFR in Cancer ResearchProtein Kinase Regulation and GTPase Signaling

Cited by 304

Structures of β-klotho reveal a ‘zip code’-like mechanism for endocrine FGF signalling

Lee, S., Choi, J., Mohanty, J., Sousa, L. P., Tome, F., Pardon, E., Steyaert, J., Lemmon, M. A., Lax, I., & Schlessinger, J. (2018) · Nature

Fibroblast Growth Factor ResearchParathyroid Disorders and Treatments

Cited by 236

The Selectivity of Receptor Tyrosine Kinase Signaling Is Controlled by a Secondary SH2 Domain Binding Site

Bae, J. H., Lew, E. D., Yuzawa, S., Tomé, F., Lax, I., & Schlessinger, J. (2009) · Cell

Fibroblast Growth Factor ResearchProtein Kinase Regulation and GTPase Signaling

Cited by 158

FGF1 and FGF19 reverse diabetes by suppression of the hypothalamic–pituitary–adrenal axis

Perry, R. J., Lee, S., Ma, L., Zhang, D., Schlessinger, J., & Shulman, G. I. (2015) · Nature Communications

Fibroblast Growth Factor ResearchPancreatic function and diabetes

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Nuclear Signaling by Receptor Tyrosine Kinases: The First Robin of Spring

Schlessinger, J., & Lemmon, M. A. (2006) · Cell

HER2/EGFR in Cancer ResearchProtein Kinase Regulation and GTPase Signaling

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