Höglinger, Günter U.

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

Klionsky, D. J., Abdelmohsen, K., Abe, A., Abedin, M. J., Abeliovich, H., Acevedo Arozena, A., Adachi, H., Adams, C. M., Adams, P. D., Adeli, K., et al. (2016) · Autophagy

Autophagy in Disease and TherapyCalcium signaling and nucleotide metabolism

Cited by 5,894

Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy

PSP Genetics Study Group, Höglinger, G. U., Melhem, N. M., Dickson, D. W., Sleiman, P. M. A., Wang, L.-S., Klei, L., Rademakers, R., de Silva, R., Litvan, I., et al. (2011) · Nature Genetics

Parkinson's Disease Mechanisms and TreatmentsAlzheimer's disease research and treatments

Cited by 603

Advances in progressive supranuclear palsy: new diagnostic criteria, biomarkers, and therapeutic approaches

Boxer, A. L., Yu, J.-T., Golbe, L. I., Litvan, I., Lang, A. E., & Höglinger, G. U. (2017) · The Lancet Neurology

Parkinson's Disease Mechanisms and TreatmentsDementia and Cognitive Impairment Research

Cited by 485

Distribution patterns of tau pathology in progressive supranuclear palsy

Kovacs, G. G., Lukic, M. J., Irwin, D. J., Arzberger, T., Respondek, G., Lee, E. B., Coughlin, D., Giese, A., Grossman, M., Kurz, C., et al. (2020) · Acta Neuropathologica

Parkinson's Disease Mechanisms and TreatmentsAlzheimer's disease research and treatments

Cited by 483

Extracellular Vesicle-Mediated Transfer of Genetic Information between the Hematopoietic System and the Brain in Response to Inflammation

Ridder, K., Keller, S., Dams, M., Rupp, A.-K., Schlaudraff, J., Del Turco, D., Starmann, J., Macas, J., Karpova, D., Devraj, K., et al. (2014) · PLoS Biology

Extracellular vesicles in diseaseNeuroinflammation and Neurodegeneration Mechanisms

Cited by 412

A phase 2 trial of the GSK‐3 inhibitor tideglusib in progressive supranuclear palsy

Tolosa, E., Litvan, I., Höglinger, G. U., Burn, D., Lees, A., Andrés, M. V., Gómez‐Carrillo, B., León, T., del Ser, T., & for the TAUROS Investigators (2014) · Movement Disorders

Parkinson's Disease Mechanisms and TreatmentsAlzheimer's disease research and treatments

Cited by 320

Davunetide in patients with progressive supranuclear palsy: a randomised, double-blind, placebo-controlled phase 2/3 trial

Boxer, A. L., Lang, A. E., Grossman, M., Knopman, D. S., Miller, B. L., Schneider, L. S., Doody, R. S., Lees, A., Golbe, L. I., Williams, D. R., et al. (2014) · The Lancet Neurology

Parkinson's Disease Mechanisms and TreatmentsAlzheimer's disease research and treatments

Cited by 294

The pRb/E2F cell-cycle pathway mediates cell death in Parkinson's disease

Höglinger, G. U., Breunig, J. J., Depboylu, C., Rouaux, C., Michel, P. P., Alvarez-Fischer, D., Boutillier, A.-L., DeGregori, J., Oertel, W. H., Rakic, P., et al. (2007) · Proceedings of the National Academy of Sciences

Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and Signaling

Cited by 276

Microglial activation states drive glucose uptake and FDG-PET alterations in neurodegenerative diseases.

Xiang, X., Wind, K., Wiedemann, T., Blume, T., Shi, Y., Briel, N., Beyer, L., Biechele, G., Eckenweber, F., Zatcepin, A., et al. (2021) · Science Translational Medicine

Neuroinflammation and Neurodegeneration MechanismsMedical Imaging Techniques and Applications

Cited by 268

Microglial glucocorticoid receptors play a pivotal role in regulating dopaminergic neurodegeneration in parkinsonism

Ros-Bernal, F., Hunot, S., Herrero, M. T., Parnadeau, S., Corvol, J.-C., Lu, L., Alvarez-Fischer, D., Carrillo-de Sauvage, M. A., Saurini, F., Coussieu, C., et al. (2011) · Proceedings of the National Academy of Sciences

Neuroinflammation and Neurodegeneration MechanismsParkinson's Disease Mechanisms and Treatments

Cited by 231

Genome-wide association study of corticobasal degeneration identifies risk variants shared with progressive supranuclear palsy

Kouri, N., Ross, O. A., Dombroski, B., Younkin, C. S., Serie, D. J., Soto-Ortolaza, A., Baker, M., Finch, N. C. A., Yoon, H., Kim, J., et al. (2015) · Nature Communications

Parkinson's Disease Mechanisms and TreatmentsAlzheimer's disease research and treatments

Cited by 219

Exosomal secretion of α-synuclein as protective mechanism after upstream blockage of macroautophagy

Fussi, N., Höllerhage, M., Chakroun, T., Nykänen, N.-P., Rösler, T. W., Koeglsperger, T., Wurst, W., Behrends, C., & Höglinger, G. U. (2018) · Cell Death & Disease

Parkinson's Disease Mechanisms and TreatmentsAutophagy in Disease and Therapy

Cited by 161

Tideglusib reduces progression of brain atrophy in progressive supranuclear palsy in a randomized trial

Höglinger, G. U., Huppertz, H., Wagenpfeil, S., Andrés, M. V., Belloch, V., León, T., del Ser, T., & for the TAUROS MRI Investigators (2014) · Movement Disorders

Parkinson's Disease Mechanisms and TreatmentsDementia and Cognitive Impairment Research

Cited by 161

Differential effects of social and physical environmental enrichment on brain plasticity, cognition, and ultrasonic communication in rats.

Brenes, J. C., Lackinger, M., Höglinger, G. U., Schratt, G., Schwarting, R. K. W., & Wöhr, M. (2016) · Journal of Comparative Neurology

Neurogenesis and neuroplasticity mechanismsMemory and Neural Mechanisms

Cited by 155

Genetic determinants of survival in progressive supranuclear palsy: a genome-wide association study

Jabbari, E., Koga, S., Valentino, R. R., Reynolds, R. H., Ferrari, R., Tan, M. M. X., Rowe, J. B., Dalgard, C. L., Scholz, S. W., Dickson, D. W., et al. (2021) · The Lancet Neurology

Parkinson's Disease Mechanisms and TreatmentsAlzheimer's disease research and treatments

Cited by 111

Shared genetic risk between corticobasal degeneration, progressive supranuclear palsy, and frontotemporal dementia

International FTD-Genomics Consortium (IFGC), Yokoyama, J. S., Karch, C. M., Fan, C. C., Bonham, L. W., Kouri, N., Ross, O. A., Rademakers, R., Kim, J., Wang, Y., et al. (2017) · Acta Neuropathologica

Alzheimer's disease research and treatmentsParkinson's Disease Mechanisms and Treatments

Cited by 99

Parkinson's disease: SNCA-, PARK2-, and LRRK2- targeting microRNAs elevated in cingulate gyrus

Tatura, R., Kraus, T., Giese, A., Arzberger, T., Buchholz, M., Höglinger, G., & Müller, U. (2016) · Parkinsonism & Related Disorders

Parkinson's Disease Mechanisms and TreatmentsMicroRNA in disease regulation

Cited by 81

[18F]‐THK5351 PET correlates with topology and symptom severity in progressive supranuclear palsy

Brendel, M., Schönecker, S., Höglinger, G., Lindner, S., Havla, J., Blautzik, J., Sauerbeck, J., Rohrer, G., Zach, C., Vettermann, F., et al. (2018) · Frontiers in Aging Neuroscience

Parkinson's Disease Mechanisms and TreatmentsDementia and Cognitive Impairment Research

Cited by 72

In Vivo Assessment of Neuroinflammation in 4‐Repeat Tauopathies

Palleis, C., Sauerbeck, J., Beyer, L., Harris, S., Schmitt, J., Morenas‐Rodriguez, E., Finze, A., Nitschmann, A., Ruch‐Rubinstein, F., Eckenweber, F., et al. (2021) · Movement Disorders

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 62

Microglial Activation and Connectivity in Alzheimer Disease and Aging

Rauchmann, B., Brendel, M., Franzmeier, N., Trappmann, L., Zaganjori, M., Ersoezlue, E., Morenas‐Rodriguez, E., Guersel, S., Burow, L., Kurz, C., et al. (2022) · Annals of Neurology

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 61

New classification of tauopathies

Höglinger, G. U., Respondek, G., & Kovacs, G. G. (2018) · Revue Neurologique

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 57

Individual regional associations between Aβ-, tau- and neurodegeneration (ATN) with microglial activation in patients with primary and secondary tauopathies

Finze, A., Biechele, G., Rauchmann, B.-S., Franzmeier, N., Palleis, C., Katzdobler, S., Weidinger, E., Guersel, S., Schuster, S., Harris, S., et al. (2023) · Molecular Psychiatry

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 40

Longitudinal TSPO expression in tau transgenic P301S mice predicts increased tau accumulation and deteriorated spatial learning

Eckenweber, F., Medina-Luque, J., Blume, T., Sacher, C., Biechele, G., Wind, K., Deussing, M., Briel, N., Lindner, S., Boening, G., et al. (2020) · Journal of Neuroinflammation

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 32