Davunetide in patients with progressive supranuclear palsy: a randomised, double-blind, placebo-controlled phase 2/3 trial
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Background In preclinical studies, davunetide promoted microtubule stability and reduced tau phosphorylation. Because progressive supranuclear palsy (PSP) is linked to tau pathology, davunetide could be a treatment for PSP. We assessed the safety and efficacy of davunetide in patients with PSP.Methods In a double-blind, parallel group, phase 2/3 trial, participants were randomly assigned with permuted blocks in a 1:1 ratio to davunetide (30 mg twice daily, intranasally) or placebo for 52 weeks at 48 centres in Australia, Canada, France, Germany, the UK, and the USA. Participants met the modified Neuroprotection and Natural History in Parkinson Plus Syndrome study criteria for PSP. Primary endpoints were the change from baseline in PSP Rating Scale (PSPRS) and Schwab and England Activities of Daily Living (SEADL) scale at up to 52 weeks. All participants and study personnel were masked to treatment assignment. Analysis was by intention to treat. The trial is registered with Clinicaltrials.gov, number NCT01110720.Findings 313 participants were randomly assigned to davunetide (n=157) or to placebo (n=156), and 241 (77%) completed the study (118 and 156 in the davunetide and placebo groups, respectively). There were no differences in the davunetide and placebo groups in the baseline PSPRS and SEADL. The davunetide and placebo groups did not differ in the change from baseline in PSPRS (median 11·8 [95% CI 10·5 to 13·0] vs 11·8 [10·5 to 13·0], respectively, p=0·41) or SEADL (-0·20 [-0·20 to -0·17] vs -0·20 [-0·22 to -0·17], respectively, p=0·92). 54 serious adverse events were reported in each of the treatment groups, including 11 deaths in the davunetide group and ten in the placebo group. The frequency of nasal adverse events was greater in the davunetide group than in the placebo group (epistaxis 18 [12%] of 156 vs 13 [8%] of 156, rhinorrhoea 15 [10%] vs eight [5%], and nasal discomfort 15 [10%] vs one [<1%]).Interpretation Davunetide is not an effective treatment for PSP. Clinical trials of disease-modifying treatment are feasible in patients with PSP and should be pursued with other promising tau-directed treatments.Funding Allon Therapeutics.
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In the latest phase II/III study, patients with PSP treated with NAP for 52 weeks showed no differences between placebo-treated and NAP-treated patients.
“In the latest phase II/III study162, patients with PSP were treated with NAP for 52 weeks, but no differences were found between placebo-treated and NAP-treated patients163.”
From Tau-targeting therapies for Alzheimer disease (2018) · cites this paper as [163]
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Cites
Development and validation of a geriatric depression screening scale: a preliminary report
Yesavage, J. A., Brink, T. L., Rose, T. L., Lum, O., Huang, V., Adey, M., & Leirer, V. O. (1982) · Journal of Psychiatric Research · doi:10.1016/0022-3956(82)90033-4 · Cited by 15,025 · see citing works
Randolph, C., Tierney, M. C., Mohr, E., & Chase, T. N. (1998) · Journal of Clinical and Experimental Neuropsychology · doi:10.1076/jcen.20.3.310.823 · Cited by 2,519 · see citing works
Self-citationProgressive Supranuclear Palsy
Steele, J. C. (1964) · Archives of Neurology · doi:10.1001/archneur.1964.00460160003001 · Cited by 1,930 · see citing works
Maruyama, M., Shimada, H., Suhara, T., Shinotoh, H., Ji, B., Maeda, J., Zhang, M.-R., Trojanowski, J. Q., Lee, V. M.-Y., Ono, M., et al. (2013) · Neuron · doi:10.1016/j.neuron.2013.07.037 · Cited by 760 · see citing works
Progressive supranuclear palsy: clinicopathological concepts and diagnostic challenges
Williams, D. R., & Lees, A. J. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70042-0 · Cited by 650 · see citing works
Self-citationSchneider, L., Olin, J. T., Doody, R. S., Clark, C. M., Morris, J. C., Reisberg, ., Schmitt, F. A., Grundman, M., Thomas, R. G., & Ferris, S. H. (1997) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-199700112-00004 · Cited by 647 · see citing works
Self-citationA clinical rating scale for progressive supranuclear palsy
Golbe, L. I., & Ohman‐Strickland, P. (2007) · Brain · doi:10.1093/brain/awm032 · Cited by 614 · see citing works
Self-citationIdentification of common variants influencing risk of the tauopathy progressive supranuclear palsy
PSP Genetics Study Group, Höglinger, G. U., Melhem, N. M., Dickson, D. W., Sleiman, P. M. A., Wang, L.-S., Klei, L., Rademakers, R., de Silva, R., Litvan, I., et al. (2011) · Nature Genetics · doi:10.1038/ng.859 · Cited by 603 · see citing works
Self-citationHall, S., Öhrfelt, A., Constantinescu, R., Andreasson, U., Surova, Y., Bostrom, F., Nilsson, C., Widner, H., Decraemer, H., Nägga, K., et al. (2012) · Archives of Neurology · doi:10.1001/archneurol.2012.1654 · Cited by 473 · see citing works
Neuropathology of variants of progressive supranuclear palsy
Dickson, D. W., Ahmed, Z., Algom, A. A., Tsuboi, Y., & Josephs, K. A. (2010) · Current Opinion in Neurology · doi:10.1097/wco.0b013e32833be924 · Cited by 386 · see citing works
Axonal damage in relapsing multiple sclerosis is markedly reduced by natalizumab
Gunnarsson, M., Malmeström, C., Axelsson, M., Sundström, P., Dahle, C., Vrethem, M., Olsson, T. P., Piehl, F., Norgren, N., Rosengren, L., et al. (2010) · Annals of Neurology · doi:10.1002/ana.22247 · Cited by 346 · see citing works
Riluzole treatment, survival and diagnostic criteria in Parkinson plus disorders: The NNIPPS Study
Bensimon, G., Ludolph, A., Agid, Y., Vidailhet, M., Payan, C., & Leigh, P. N. (2008) · Brain · doi:10.1093/brain/awn291 · Cited by 345 · see citing works
Self-citationA phase 2 trial of the GSK‐3 inhibitor tideglusib in progressive supranuclear palsy
Tolosa, E., Litvan, I., Höglinger, G. U., Burn, D., Lees, A., Andrés, M. V., Gómez‐Carrillo, B., León, T., del Ser, T., & for the TAUROS Investigators (2014) · Movement Disorders · doi:10.1002/mds.25824 · Cited by 320 · see citing works
Self-citationCognitive impairment in patients with multiple system atrophy and progressive supranuclear palsy
Brown, R. G., Lacomblez, L., Landwehrmeyer, G. B., Bak, T. H., Uttner, I., Dubois, B., Agid, Y., Ludolph, A. C., Bensimon, G., Payan, C., et al. (2010) · Brain · doi:10.1093/brain/awq158 · Cited by 312 · see citing works
Self-citationSchneider, L. S. S., Olin, J. T., Doody, R. S., Clark, C. M., Morris, J. C., Reisberg, ., Ferris, S. H., Schmitt, F. A., Grundman, M., & Thomas, R. G. (1997) · Birkhäuser Boston eBooks · doi:10.1007/978-1-4612-4116-4_64 · Cited by 303 · see citing works
Self-citationThe prevalence of progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome) in the UK
Nath, U. (2001) · Brain · doi:10.1093/brain/124.7.1438 · Cited by 253 · see citing works
Scherling, C. S., Hall, T., Berisha, F., Klepac, K., Karydas, A., Coppola, G., Kramer, J. H., Rabinovici, G., Ahlijanian, M., Miller, B. L., et al. (2014) · Annals of Neurology · doi:10.1002/ana.24052 · Cited by 249 · see citing works
Self-citationZetterberg, H. (2012) · Archives of Neurology · doi:10.1001/archneurol.2012.90 · Cited by 234 · see citing works
Phenotypic correlations in FTDP-17.
Reed, L., Wszolek, Z., & Hutton, M. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00202-5 · Cited by 221 · see citing works
Paviour, D. C., Price, S. L., Jahanshahi, M., Lees, A. J., & Fox, N. C. (2006) · Brain · doi:10.1093/brain/awl021 · Cited by 217 · see citing works
Self-citationFagan, A. M., Shaw, L. M. J., Xiong, C., Vanderstichele, H., Mintun, M. A., Trojanowski, J. Q., Coart, E., Morris, J. C., & Holtzman, D. M. (2011) · Archives of Neurology · doi:10.1001/archneurol.2011.105 · Cited by 190 · see citing works
Rates of cerebral atrophy differ in different degenerative pathologies
Whitwell, J. L., Jack, C. R., Parisi, J. E., Knopman, D. S., Boeve, B. F., Petersen, R. C., Ferman, T. J., Dickson, D. W., & Josephs, K. A. (2006) · Brain · doi:10.1093/brain/awm021 · Cited by 167 · see citing works
Self-citationWorst-Rank Score Analysis with Informatively Missing Observations in Clinical Trials
Lachin, J. M. (1999) · Controlled Clinical Trials · doi:10.1016/s0197-2456(99)00022-7 · Cited by 164 · see citing works
Randomized placebo-controlled trial of donepezil in patients with progressive supranuclear palsy
Litvan, I., Phipps, M., Pharr, V., Hallett, M., Grafman, J. H., & Salazar, A. (2001) · Neurology · doi:10.1212/wnl.57.3.467 · Cited by 163 · see citing works
Self-citationHöglinger, G. U., Huppertz, H., Wagenpfeil, S., Andrés, M. V., Belloch, V., León, T., del Ser, T., & for the TAUROS MRI Investigators (2014) · Movement Disorders · doi:10.1002/mds.25815 · Cited by 161 · see citing works
Self-citationStamelou, M., Reuß, A., Pilatus, U., Magerkurth, J., Niklowitz, P., Eggert, K. M., Krisp, A., Menke, T., Schade‐Brittinger, C., Oertel, W. H., et al. (2008) · Movement Disorders · doi:10.1002/mds.22023 · Cited by 150 · see citing works
Self-citationNAP protects memory, increases soluble tau and reduces tau hyperphosphorylation in a tauopathy model
Shiryaev, N., Jouroukhin, Y., Giladi, E., Polyzoidou, E., Grigoriadis, N., Rosenmann, H., & Gozes, I. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.02.011 · Cited by 122 · see citing works
Self-citationMorimoto, B. H., Schmechel, D., Hirman, J., Blackwell, A., Keith, J., Gold, M., & on behalf of the AL-108-211 Study Investigators (2013) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000348347 · Cited by 115 · see citing works
Self-citationZolpidem in Progressive Supranuclear Palsy
Daniele, A., Moro, E., & Bentivoglio, A. R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199908123410721 · Cited by 94 · see citing works
Rational therapeutic approaches to progressive supranuclear palsy
Stamelou, M., de Silva, R., Arias-Carrion, O., Boura, E., Hollerhage, M., Oertel, W. H., Muller, U., & Hoglinger, G. U. (2010) · Brain · doi:10.1093/brain/awq115 · Cited by 91 · see citing works
Self-citationPayan, C., Viallet, F., Landwehrmeyer, G. B., Bonnet, A.-M., Borg, M., Durif, F., Lacomblez, L., Bloch, F., Verny, M., Fermanian, J., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022293 · Cited by 88 · see citing works
Self-citationIdazoxan treatment in progressive supranuclear palsy
Ghika, J. A., Tennis, M. K., Hoffman, E., Schoenfeld, D., & Growdon, J. H. (1991) · Neurology · doi:10.1212/wnl.41.7.986 · Cited by 74 · see citing works
Serial CSF sampling in Alzheimer's disease: specific versus non-specific markers
Kester, M. I., Scheffer, P. G., Simmelink, M. J. A., Twaalfhoven, H. A. M., Verwey, N. A., Veerhuis, R., Twisk, J. W. R., Bouwman, F. H., Blankenstein, M. A., Scheltens, P., et al. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.05.013 · Cited by 62 · see citing works
Treatment of progressive supranuclear palsy with tricyclic antidepressants
Newman, G. C. (1985) · Neurology · doi:10.1212/wnl.35.8.1189 · Cited by 57 · see citing works
Boxer, A. L., Gold, M., Huey, E. D., Hu, W. T., Rosen, H. J., Kramer, J. H., Gao, F., Burton, E. A., Chow, T. W., Kao, A. W., et al. (2012) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2012.03.003 · Cited by 54 · see citing works
Self-citationControlled trial of pergolide mesylate in Parkinson's disease and progressive supranuclear palsy
Jankovic, J. J. (1983) · Neurology · doi:10.1212/wnl.33.4.505 · Cited by 49 · see citing works
Physostigmine treatment of progressive supranuclear palsy
Litvan, I., Med, C. G., Atack, J. R., Gillespie, M., Kask, A. M., Mouradian, M. M., & Chase, T. N. (1989) · Annals of Neurology · doi:10.1002/ana.410260318 · Cited by 47 · see citing works
Self-citationRandomization-based nonparametric methods for the analysis of multicentre trials
LaVange, L. M., Durham, T. A., & Koch, G. G. (2005) · Statistical Methods in Medical Research · doi:10.1191/0962280205sm397oa · Cited by 47 · see citing works
Modeling trajectories of regional volume loss in progressive supranuclear palsy
Josephs, K. A., Xia, R., Mandrekar, J. N., Gunter, J. L., Senjem, M. L., Jack, C. R., & Whitwell, J. L. (2013) · Movement Disorders · doi:10.1002/mds.25437 · Cited by 45 · see citing works
Self-citationFoster, N. L., Aldrich, M. S., Bluemlein, L., White, R. F., & Berent, S. (1989) · Neurology · doi:10.1212/wnl.39.2.257 · Cited by 44 · see citing works
Frattali, C., Sonies, B. C., Chi‐Fishman, G., & Litvan, I. (1999) · Dysphagia · doi:10.1007/pl00009600 · Cited by 40 · see citing works
Self-citationEfaroxan, an alpha‐2 antagonist, in the treatment of progressive supranuclear palsy
Rascol, O., Sieradzan, K., Peyro-Saint-Paul, H., Thalamas, C., Brefel‐Courbon, C., Sénard, J., Ladure, P., Montastruc, J. L., & Lees, A. J. (1998) · Movement Disorders · doi:10.1002/mds.870130411 · Cited by 35 · see citing works
Self-citationPoujois, A., Vidailhet, M., Trocello, J., Bourdain, F., Gaymard, B. M., & Rivaud-Péchoux, S. (2007) · European Journal of Neurology · doi:10.1111/j.1468-1331.2007.01687.x · Cited by 18 · see citing works
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Wang, Y., & Mandelkow, E. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2015.1 · Cited by 2,251 · see citing works
Tau-targeting therapies for Alzheimer disease
Congdon, E. E., & Sigurdsson, E. M. (2018) · Nature Reviews Neurology · doi:10.1038/s41582-018-0013-z · Cited by 1,113 · see citing works
DeVos, S. L., Miller, R. L., Schoch, K. M., Holmes, B. B., Kebodeaux, C. S., Wegener, A. J., Chen, G., Shen, T., Tran, H., Nichols, B., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aag0481 · Cited by 516 · see citing works
Boxer, A. L., Yu, J.-T., Golbe, L. I., Litvan, I., Lang, A. E., & Höglinger, G. U. (2017) · The Lancet Neurology · doi:10.1016/s1474-4422(17)30157-6 · Cited by 485 · see citing works
Self-citationO'Brien, J. T., Holmes, C., Jones, M. S., Jones, R. W., Livingston, G., McKeith, I. G., Mittler, P. J., Passmore, P., Ritchie, C. W., Robinson, L. A., et al. (2017) · Journal of Psychopharmacology · doi:10.1177/0269881116680924 · Cited by 355 · see citing works
Surface-Modified Nanocarriers for Nose-To-Brain Delivery: From Bioadhesion to Targeting
Sonvico, F., Clementino, A. R., Buttini, F., Colombo, G., Pescina, S., Stanisçuaski Guterres, S., Raffin Pohlmann, A., & Nicoli, S. (2018) · doi:10.20944/preprints201802.0077.v1 · Cited by 306 · see citing works
Drugs in Clinical Trials for Alzheimer's Disease: The Major Trends
Бачурин, С. О., Bovina, E. V., & Ustyugov, A. A. (2017) · Medicinal Research Reviews · doi:10.1002/med.21434 · Cited by 305 · see citing works
Bayesian segmentation of brainstem structures in MRI
Iglesias, J. E., Leemput, K. V., Bhatt, P., Casillas, C., Dutt, S., Schuff, N. W., Truran‐Sacrey, D., Boxer, A. L., & Fischl, B. R. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.02.065 · Cited by 286 · see citing works
Self-citationTau-based therapies in neurodegeneration: opportunities and challenges
Li, C., & Götz, J. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2017.155 · Cited by 272 · see citing works
Frontotemporal lobar degeneration: defining phenotypic diversity through personalized medicine
Irwin, D. J., Cairns, N. J., Grossman, M., McMillan, C. T., Lee, E. B., Deerlin, V. M. V., Lee, V. M. ‐., & Trojanowski, J. Q. (2014) · Acta Neuropathologica · doi:10.1007/s00401-014-1380-1 · Cited by 262 · see citing works
Self-citationGoyal, D., Shuaib, S., Mann, S., & Goyal, B. (2017) · ACS Combinatorial Science · doi:10.1021/acscombsci.6b00116 · Cited by 229 · see citing works
Rösler, T. W., Marvian, A. T., Brendel, M., Nykänen, N.-P., Höllerhage, M., Schwarz, S. C., Hopfner, F., Koeglsperger, T., Respondek, G., Schweyer, K., et al. (2019) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2019.101644 · Cited by 219 · see citing works
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Plasma neurofilament light chain predicts progression in progressive supranuclear palsy
Rojas, J. C., Karydas, A., Bang, J., Tsai, R. M., Blennow, K., Liman, V., Kramer, J. H., Rosen, H., Miller, B. L., Zetterberg, H., et al. (2016) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.290 · Cited by 206 · see citing works
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Self-citationDiagnosis Across the Spectrum of Progressive Supranuclear Palsy and Corticobasal Syndrome
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Höglinger, G. U., Litvan, I., Mendonça, N., Wang, D., Zheng, H., Rendenbach‐Mueller, B., Lon, H., Jin, Z., Fisseha, N., Budur, K. S., et al. (2021) · The Lancet Neurology · doi:10.1016/s1474-4422(20)30489-0 · Cited by 146 · see citing works
Self-citationDam, T., Boxer, A. L., Golbe, L. I., Höglinger, G. U., Morris, H. R., Litvan, I., Lang, A. E., Corvol, J., Aiba, I., Grundman, M., et al. (2021) · Nature Medicine · doi:10.1038/s41591-021-01455-x · Cited by 146 · see citing works
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Self-citationBoxer, A., Qureshi, I., Ahlijanian, M., Grundman, M., Golbe, L., Litvan, I., Honig, L. S., Tuite, P., McFarland, N. R., O'Suilleabhain, P., et al. (2019) · Lancet Neurology · doi:10.1016/s1474-4422(19)30139-5 · Cited by 115 · see citing works
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Tsai, R. M., Miller, Z., KOESTLER, M. E., Rojas, J. C., Ljubenkov, P. A., Rosen, H. J., Rabinovici, G. D., Fagan, A. M., Cobigo, Y., Brown, J. A., et al. (2019) · JAMA Neurology · doi:10.1001/jamaneurol.2019.3812 · Cited by 134 · see citing works
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López, A., Lee, S. E., Wojta, K. J., Ramos, E. M., Klein, E., Chen, J., Boxer, A. L., Gorno‐Tempini, M. L., Geschwind, D. H., Schlotawa, L., et al. (2017) · Brain · doi:10.1093/brain/awx005 · Cited by 118 · see citing works
Self-citationChen, J., Chen, Z., Won, H., Huang, A., Lowe, J. K., Wojta, K. J., Yokoyama, J. S., Bensimon, G., Leigh, P. N., Payan, C., et al. (2018) · Molecular Neurodegeneration · doi:10.1186/s13024-018-0270-8 · Cited by 113 · see citing works
Self-citationMalishkevich, A., Amram, N., Hacohen-Kleiman, G., Magen, I., Giladi, E., & Gozes, I. (2015) · Translational Psychiatry · doi:10.1038/tp.2014.138 · Cited by 109 · see citing works
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Self-citationBrunden, K. R., Lee, V. M. ‐., Smith, A. B., Trojanowski, J. Q., & Ballatore, C. (2016) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.12.021 · Cited by 105 · see citing works
Ivashko-Pachima, Y., Hadar, A., Grigg, I., Korenková, V., Kapitansky, O., Karmon, G., Gershovits, M., Sayas, C. L., Kooy, R. F., Attems, J., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-019-0563-5 · Cited by 107 · see citing works
Self-citationThe cytoskeleton as a novel therapeutic target for old neurodegenerative disorders
Eira, J., Silva, C. S., Sousa, M. M., & Liz, M. A. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.04.007 · Cited by 103 · see citing works
Tau-Based Therapeutics for Alzheimer’s Disease: Active and Passive Immunotherapy
Panza, F., Solfrizzi, V., Seripa, D., Imbimbo, B. P., Lozupone, M., Santamato, A., Tortelli, R., Galizia, I., Prete, C., Daniele, A., et al. (2016) · Immunotherapy · doi:10.2217/imt-2016-0019 · Cited by 105 · see citing works
Ivashko‐Pachima, Y., Sayas, C. L., Malishkevich, A., & Gozes, I. (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.255 · Cited by 102 · see citing works
Self-citationTreatment of Frontotemporal Dementia
Tsai, R. M., & Boxer, A. (2014) · Current Treatment Options in Neurology · doi:10.1007/s11940-014-0319-0 · Cited by 104 · see citing works
Self-citationRyan, P., Patel, B., Makwana, V., Jadhav, H. R., Kiefel, M. J., Davey, A. K., Reekie, T. A., Rudrawar, S., & Kassiou, M. (2018) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.8b00185 · Cited by 99 · see citing works
Targeting tau: clinical trials and novel therapeutic approaches
VandeVrede, L., Boxer, A. L., & Polydoro, M. (2020) · Neuroscience Letters · doi:10.1016/j.neulet.2020.134919 · Cited by 90 · see citing works
Self-citationProgressive Supranuclear Palsy and Corticobasal Degeneration: Pathophysiology and Treatment Options
Lamb, R., Rohrer, J. D., Lees, A. J., & Morris, H. R. (2016) · Current Treatment Options in Neurology · doi:10.1007/s11940-016-0422-5 · Cited by 95 · see citing works
Self-citationThe Role of MAPT in Neurodegenerative Diseases: Genetics, Mechanisms and Therapy
Zhang, C., Xing, A., Tan, M., Tan, L., & Yu, J. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9415-8 · Cited by 91 · see citing works
Clinical Approach to Progressive Supranuclear Palsy
Ling, H. (2016) · Journal of Movement Disorders · doi:10.14802/jmd.15060 · Cited by 93 · see citing works
Progressive Supranuclear Palsy: an Update
Armstrong, M. J. (2018) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-018-0819-5 · Cited by 92 · see citing works
Progression of brain atrophy in PSP and CBS over 6 months and 1 year
Dutt, S., Binney, R. J., Heuer, H. W., Luong, P., Attygalle, S., Bhatt, P., Marx, G. A., Elofson, J., Tartaglia, M. C., Litvan, I., et al. (2016) · Neurology · doi:10.1212/wnl.0000000000003305 · Cited by 91 · see citing works
Self-citationHöglinger, G. U., Schöpe, J., Stamelou, M., Kassubek, J., del Ser, T., Boxer, A. L., Wagenpfeil, S., Huppertz, H., for the AL‐108‐231 Investigators, the Tauros MRI Investigators, et al. (2017) · Movement Disorders · doi:10.1002/mds.26973 · Cited by 84 · see citing works
Self-citationNeuroinflammation predicts disease progression in progressive supranuclear palsy
Malpetti, M., Passamonti, L., Jones, P. S., Street, D., Rittman, T., Fryer, T. D., Hong, Y. T., Vàsquez Rodriguez, P., Bevan-Jones, W. R., Aigbirhio, F. I., et al. (2021) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp-2020-325549 · Cited by 85 · see citing works
Bluett, B., Pantelyat, A. Y., Litvan, I., Ali, F., Apetauerova, D., Bega, D., Bloom, L., Bower, J. H., Boxer, A. L., Dale, M. L., et al. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.694872 · Cited by 82 · see citing works
Self-citationCurrent Understanding of Neurodegenerative Diseases Associated With the Protein Tau
Josephs, K. A. (2017) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2017.04.016 · Cited by 80 · see citing works
Atypical parkinsonian syndromes: a general neurologist's perspective
Deutschländer, A., Ross, O. A., Dickson, D. W., & Wszołek, Z. K. (2017) · European Journal of Neurology · doi:10.1111/ene.13412 · Cited by 81 · see citing works
Aβ-oligomers: A potential therapeutic target for Alzheimer's disease
Ghosh, S., Ali, R., & Verma, S. K. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.124231 · Cited by 79 · see citing works
A critical appraisal of tau‐targeting therapies for primary and secondary tauopathies
Imbimbo, B. P., Ippati, S., Watling, M., & Balducci, C. (2021) · Alzheimer s & Dementia · doi:10.1002/alz.12453 · Cited by 72 · see citing works
Gadhave, K., Kumar, D., Uversky, V. N., & Giri, R. (2020) · Medicinal Research Reviews · doi:10.1002/med.21719 · Cited by 70 · see citing works
Boxer, A. L., Gold, M., Feldman, H., Boeve, B. F., Dickinson, S. L.-J., Fillit, H., Ho, C., Paul, R., Pearlman, R., Sutherland, M., et al. (2020) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2019.06.4956 · Cited by 71 · see citing works
Self-citationLebouvier, T., Pasquier, F., & Buée, L. (2017) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000502 · Cited by 68 · see citing works
The autism/neuroprotection-linked ADNP/NAP regulate the excitatory glutamatergic synapse
Sragovich, S., Malishkevich, A., Piontkewitz, Y., Giladi, E., Touloumi, O., Lagoudaki, R., Grigoriadis, N., & Gozes, I. (2019) · Translational Psychiatry · doi:10.1038/s41398-018-0357-6 · Cited by 60 · see citing works
Self-citationClinicopathologic subtype of Alzheimer's disease presenting as corticobasal syndrome
Sakae, N., Josephs, K. A., Litvan, I., Murray, M. E., Duara, R., Uitti, R. J., Wszołek, Z. K., van Gerpen, J. A., Graff‐Radford, N. R., & Dickson, D. W. (2019) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2019.04.011 · Cited by 59 · see citing works
Self-citationMalishkevich, A., Marshall, G. A., Schultz, A. P., Sperling, R. A., Aharon‐Peretz, J., & Gozes, I. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-150799 · Cited by 58 · see citing works
Self-citationOpen‐Label Phase 1 Futility Studies of Salsalate and Young Plasma in Progressive Supranuclear Palsy
VandeVrede, L. A., Dale, M. L., Fields, S., Frank, M., Hare, E. B., Heuer, H. W., Keith, K., KOESTLER, M. E., Ljubenkov, P. A., McDermott, D., et al. (2020) · Movement Disorders Clinical Practice · doi:10.1002/mdc3.12940 · Cited by 56 · see citing works
Self-citationThe Progressive Supranuclear Palsy Clinical Deficits Scale
Piot, I., Schweyer, K., Respondek, G., Stamelou, M., DescribePSP study group, ProPSP study group, MDS‐endorsed PSP study group, Sckopke, P., Schenk, T., Goetz, C. G., et al. (2020) · Movement Disorders · doi:10.1002/mds.27964 · Cited by 55 · see citing works
Self-citationScarpa, M., Hesse, S., & Bradley, S. J. (2020) · Advances in pharmacology · doi:10.1016/bs.apha.2019.12.003 · Cited by 54 · see citing works
Randomized placebo-controlled trial of sodium valproate in progressive supranuclear palsy
Leclair‐Visonneau, L., Rouaud, T., Debilly, B., Durif, F., Houéto, J., Kreisler, A., Defebvre, L., Lamy, E., Volteau, C., Nguyen, J., et al. (2016) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2016.04.021 · Cited by 53 · see citing works
Canesi, M., Giordano, R., Lazzari, L., Isalberti, M., Isaias, I. U., Benti, R., Rampini, P. M., Marotta, G., Colombo, A., Cereda, E., et al. (2016) · Journal of Translational Medicine · doi:10.1186/s12967-016-0880-2 · Cited by 53 · see citing works
Makani, V. S., Zhang, B., Han, H., Yao, Y., Lassalas, P., Lou, K., Paterson, I., Lee, V. M. ‐., Trojanowski, J. Q., Ballatore, C., et al. (2016) · Acta Neuropathologica Communications · doi:10.1186/s40478-016-0378-4 · Cited by 51 · see citing works
Four-Repeat Tauopathies: Current Management and Future Treatments
VandeVrede, L. A., Ljubenkov, P. A., Rojas, J. C., Welch, A. E., & Boxer, A. L. (2020) · Neurotherapeutics · doi:10.1007/s13311-020-00888-5 · Cited by 53 · see citing works
Self-citationTau-directed approaches for the treatment of Alzheimer’s disease: focus on leuco-methylthioninium
Seripa, D., Solfrizzi, V., Imbimbo, B. P., Daniele, A., Santamato, A., Lozupone, M., Zuliani, G., Greco, A., Logroscino, G., & Panza, F. (2016) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.2016.1140039 · Cited by 50 · see citing works
Managing Cognition in Progressive Supranuclear Palsy
Rittman, T., Coyle-Gilchrist, I. T. S., & Rowe, J. B. (2016) · Neurodegenerative Disease Management · doi:10.2217/nmt-2016-0027 · Cited by 50 · see citing works
Predicting disease progression in progressive supranuclear palsy in multicenter clinical trials
Bang, J., Lobach, I. V., Lang, A. E., Grossman, M., Knopman, D. S., Miller, B. L., Schneider, L. S. S., Doody, R. S., Lees, A. J., Gold, M., et al. (2016) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2016.04.014 · Cited by 48 · see citing works
Self-citationApplication of Bayesian methods to accelerate rare disease drug development: scopes and hurdles
Kidwell, K., Roychoudhury, S., Wendelberger, B. A., Scott, J., Moroz, T., Yin, S., Majumder, M., Zhong, J., Huml, R. A., & Miller, V. (2022) · Orphanet Journal of Rare Diseases · doi:10.1186/s13023-022-02342-5 · Cited by 48 · see citing works
Saranza, G., Whitwell, J. L., Kovács, G. G., & Lang, A. E. (2019) · International review of neurobiology · doi:10.1016/bs.irn.2019.10.014 · Cited by 48 · see citing works
Self-citationAdvancing functional dysconnectivity and atrophy in progressive supranuclear palsy
Brown, J. A., Hua, A. Y., Trujillo, A. J., Attygalle, S., Binney, R. J., Spina, S., Lee, S. E., Kramer, J. H., Miller, B. L., Rosen, H. J., et al. (2017) · NeuroImage Clinical · doi:10.1016/j.nicl.2017.09.008 · Cited by 46 · see citing works
Self-citationDisentangling tau: One protein, many therapeutic approaches
Lane‐Donovan, C., & Boxer, A. L. (2024) · Neurotherapeutics · doi:10.1016/j.neurot.2024.e00321 · Cited by 44 · see citing works
Self-citationVandeVrede, L. A., Joie, R. L., Thijssen, E. H., Asken, B. M., Vento, S. A., Tsuei, T., Baker, S. L., Cobigo, Y., Fonseca, C. S., Heuer, H. W., et al. (2023) · JAMA Neurology · doi:10.1001/jamaneurol.2023.0488 · Cited by 44 · see citing works
Self-citationStamelou, M., & Bhatia, K. P. (2014) · Neurologic Clinics · doi:10.1016/j.ncl.2014.09.012 · Cited by 43 · see citing works
Magen, I., Ostritsky, R., Richter, F., Zhu, C., Fleming, S. M., Lemesre, V., Stewart, A. J., Morimoto, B. H., Gozes, I., & Chesselet, M. (2014) · Pharmacology Research & Perspectives · doi:10.1002/prp2.65 · Cited by 43 · see citing works
Self-citationA Review of Treatment Options for Progressive Supranuclear Palsy
Stamelou, M., & Höglinger, G. U. (2016) · CNS Drugs · doi:10.1007/s40263-016-0347-2 · Cited by 42 · see citing works
Self-citationProgression of atypical parkinsonian syndromes: PROSPECT-M-UK study implications for clinical trials
Street, D., Jabbari, E., Costantini, A. A., Jones, P. S., Holland, N., Rittman, T., Jensen, M. T., Chelban, V., Goh, Y. Y., Guo, T., et al. (2023) · Brain · doi:10.1093/brain/awad105 · Cited by 41 · see citing works
Self-citationEarly investigational drugs targeting tau protein for the treatment of Alzheimer’s disease
Anand, K., & Sabbagh, M. N. (2015) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2015.1075002 · Cited by 41 · see citing works
Power calculations and placebo effect for future clinical trials in progressive supranuclear palsy
Stamelou, M., Schöpe, J., Wagenpfeil, S., del Ser, T., Bang, J., Lobach, I. V., Luong, P., Respondek, G., Oertel, W. H., Boxer, A. M., et al. (2016) · Movement Disorders · doi:10.1002/mds.26580 · Cited by 41 · see citing works
Self-citationProgressive supranuclear palsy
Giagkou, N., Höglinger, G. U., & Stamelou, M. (2019) · International review of neurobiology · doi:10.1016/bs.irn.2019.10.013 · Cited by 41 · see citing works
Self-citationIvashko‐Pachima, Y., Maor-Nof, M., & Gozes, I. (2019) · PLoS ONE · doi:10.1371/journal.pone.0213666 · Cited by 40 · see citing works
Self-citationLocus coeruleus pathology in progressive supranuclear palsy, and its relation to disease severity
Kaalund, S. S., Passamonti, L., Allinson, K. S. J., Murley, A. G., Robbins, T. W., Spillantini, M. G., & Rowe, J. B. (2020) · Acta Neuropathologica Communications · doi:10.1186/s40478-020-0886-0 · Cited by 42 · see citing works
The ADNP Syndrome and CP201 (NAP) Potential and Hope
Gozes, I. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.608444 · Cited by 39 · see citing works
Self-citationEmerging Diagnostic and Therapeutic Strategies for Tauopathies
Coughlin, D. G., & Irwin, D. J. (2017) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-017-0779-1 · Cited by 39 · see citing works
Finger, E. C., Berry, S. M., Cummings, J. L., Coleman, K. K. L., Hsiung, G. R., Feldman, H., & Boxer, A. L. (2018) · Alzheimer s Research & Therapy · doi:10.1186/s13195-018-0427-2 · Cited by 37 · see citing works
Self-citationFrontrunner in Translation: Progressive Supranuclear Palsy
Shoeibi, A., Olfati, N., & Litvan, I. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.01125 · Cited by 39 · see citing works
Self-citationNew Approaches to the Treatment of Frontotemporal Dementia
Neylan, K. D., & Miller, B. L. (2023) · Neurotherapeutics · doi:10.1007/s13311-023-01380-6 · Cited by 26 · see citing works
Self-citationClinical progression of progressive supranuclear palsy: impact of trials bias and phenotype variants
Street, D., Malpetti, M., Rittman, T., Ghosh, B. C. P., Murley, A. G., Coyle-Gilchrist, I. T. S., Passamonti, L., & Rowe, J. B. (2021) · Brain Communications · doi:10.1093/braincomms/fcab206 · Cited by 37 · see citing works
Therapeutic interventions in parkinsonism: Corticobasal degeneration
Marsili, L., Suppa, A., Berardelli, A., & Colosimo, C. (2015) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2015.09.023 · Cited by 34 · see citing works
The Role of Tau beyond Alzheimer’s Disease: A Narrative Review
Virgilio, E., Marchi, F. D., Contaldi, E., Dianzani, U., Cantello, R. M., Mazzini, L., & Comi, C. (2022) · Biomedicines · doi:10.3390/biomedicines10040760 · Cited by 32 · see citing works
Falls in Progressive Supranuclear Palsy
Brown, F. S., Rowe, J. B., Passamonti, L., & Rittman, T. (2019) · Movement Disorders Clinical Practice · doi:10.1002/mdc3.12879 · Cited by 33 · see citing works
A Modified Progressive Supranuclear Palsy Rating Scale
Grötsch, M., Respondek, G., Colosimo, C., Compta, Y., Corvol, J., Ferreira, J. J., Huber, M. K., Klietz, M., Krey, L., Levin, J., et al. (2021) · Movement Disorders · doi:10.1002/mds.28470 · Cited by 33 · see citing works
Self-citationProgressive Supranuclear Palsy and Corticobasal Degeneration
Coughlin, D. G., Dickson, D. W., Josephs, K. A., & Litvan, I. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-51140-1_11 · Cited by 32 · see citing works
Self-citationPROSPERA: a randomized, controlled trial evaluating rasagiline in progressive supranuclear palsy
Nübling, G., Hensler, M., Paul, S., Zwergal, A., Crispin, A., & Lorenzl, S. (2016) · Journal of Neurology · doi:10.1007/s00415-016-8169-1 · Cited by 32 · see citing works
Self-citationTherapeutic trial design for frontotemporal dementia and related disorders
Desmarais, P., Rohrer, J. D., Nguyên, Q. D., Herrmann, N., Stuss, D. T., Lang, A. E., Boxer, A. L., Dickerson, B. C., Rosen, H. J., Swieten, J. C. V., et al. (2018) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2018-318603 · Cited by 32 · see citing works
Self-citationJabbari, E., Zetterberg, H., & Morris, H. R. (2017) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2017-315857 · Cited by 31 · see citing works
Available and future treatments for atypical parkinsonism. A systematic review
Moretti, D. V. (2018) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13068 · Cited by 31 · see citing works
- Authors
- Boxer, A. L., Lang, A. E., Grossman, M., Knopman, D. S., Miller, B. L., Schneider, L. S., Doody, R. S., Lees, A., Golbe, L. I., Williams, D. R., Corvol, J.-C., Ludolph, A., Burn, D., Lorenzl, S., Litvan, I., Roberson, E. D., Höglinger, G. U., Koestler, M., Jack, C. R., Van Deerlin, V., Randolph, C., Lobach, I. V., Heuer, H. W., Gozes, I., Parker, L., Whitaker, S., Hirman, J., Stewart, A. J., Gold, M., & Morimoto, B. H.
- Affiliations
- University of California, San Francisco (US)
- University of Toronto (CA)
- University of Pennsylvania (US)
- Mayo Clinic (US)
- University of Southern California (US)
- Baylor College of Medicine (US)
- UCL Queen Square Institute of Neurology (GB)
- Rutgers, The State University of New Jersey (US)
- Monash University (AU)
- University Hospital Ulm (DE)
- Newcastle University (GB)
- LMU Klinikum (DE)
- University of California San Diego (US)
- University of Alabama at Birmingham (US)
- Technical University of Munich (DE)
- Loyola University Chicago (US)
- Tel Aviv University (IL)
- Arbutus Biopharma (Canada) (CA)
- Omeros Corporation (United States) (US)
- Paladin Labs (Canada) (CA)
- Celerion (United States) (US)
- Corresponding author
- Boxer, Adam L
- ORCID
- Boxer, Adam L
- Lang, Anthony E
- Grossman, Murray
- Knopman, David S
- Miller, Bruce L
- Schneider, Lon S
- Lees, Andrew
- Golbe, Lawrence I
- Williams, David R
- Burn, David
- Lorenzl, Stefan
- Litvan, Irene
- Roberson, Erik D
- Höglinger, Günter U
- Jack, Clifford R
- Randolph, Christopher
- Lobach, Iryna V
- Heuer, Hilary W
- Gozes, Illana
- Stewart, Alistair J
- Venue
- The Lancet Neurology
- Publisher
- Elsevier BV
- Published
- 2014-07
- Volume
- 13
- Issue
- 7
- Pages
- 676-685
- ISSN
- 1474-4422 (ISSN-L)
- PMC
- PMC4129545
- OpenAlex
- W2129669150
- Cited by
- 294
- References
- 43
- Citations by year
- 2026: 21 · 2025: 18 · 2024: 15 · 2023: 22 · 2022: 16 · 2021: 25 · 2020: 27 · 2019: 33 · 2018: 23 · 2017: 27 · 2016: 36 · 2015: 20 · 2014: 10 · 2013: 1
- FWCI
- 20.20
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Lancet Neurology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- UCL Discovery (University College London) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Funders
- Allos Therapeutics
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Keywords
- davunetide, progressive supranuclear palsy, tau pathology, microtubule stabilization, tau phosphorylation, intranasal drug delivery, neuroprotection, PSP Rating Scale, activities of daily living, drug safety, epistaxis, serious adverse events, atypical parkinsonism, disease-modifying therapy
- MeSH terms
- Aged, Double-Blind Method, Female, Humans, Male, Oligopeptides, Supranuclear Palsy, Progressive, Treatment Outcome
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