Nicola, Nicos A.

A family of cytokine-inducible inhibitors of signalling

Starr, R., Willson, T. A., Viney, E. M., Murray, L. J. L., Rayner, J. R., Jenkins, B. J., Gonda, T. J., Alexander, W. S., Metcalf, D., Nicola, N. A., et al. (1997) · Nature

Cytokine Signaling Pathways and InteractionsProtein Tyrosine Phosphatases

Cited by 2,066

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

Murphy, J. M., Czabotar, P. E., Hildebrand, J. M., Lucet, I. S., Zhang, J.-G., Alvarez-Diaz, S., Lewis, R., Lalaoui, N., Metcalf, D., Webb, A. I., et al. (2013) · Immunity

Cell death mechanisms and regulationNF-κB Signaling Pathways

Cited by 1,220

SOCS3 negatively regulates IL-6 signaling in vivo

Croker, B. A., Krebs, D. L., Zhang, J.-G., Wormald, S., Willson, T. A., Stanley, E. G., Robb, L., Greenhalgh, C. J., Förster, I., Clausen, B. E., et al. (2003) · Nature Immunology

Cytokine Signaling Pathways and InteractionsProtein Tyrosine Phosphatases

Cited by 840

SOCS1 Is a Critical Inhibitor of Interferon γ Signaling and Prevents the Potentially Fatal Neonatal Actions of this Cytokine

Alexander, W. S., Starr, R., Fenner, J. E., Scott, C. L., Handman, E., Sprigg, N. S., Corbin, J. E., Cornish, A. L., Darwiche, R., Owczarek, C. M., et al. (1999) · Cell

Cytokine Signaling Pathways and Interactionsinterferon and immune responses

Cited by 762

Leukemia inhibitory factor (LIF)

Nicola, N. A., & Babon, J. J. (2015) · Cytokine & Growth Factor Reviews

Cytokine Signaling Pathways and InteractionsPluripotent Stem Cells Research

Cited by 478

The molecular basis of JAK/STAT inhibition by SOCS1

Liau, N. P. D., Laktyushin, A., Lucet, I. S., Murphy, J. M., Yao, S., Whitlock, E., Callaghan, K., Nicola, N. A., Kershaw, N. J., & Babon, J. J. (2018) · Nature Communications

Cytokine Signaling Pathways and InteractionsProtein Tyrosine Phosphatases

Cited by 456

Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130

Nicholson, S. E., De Souza, D., Fabri, L. J., Corbin, J., Willson, T. A., Zhang, J.-G., Silva, A., Asimakis, M., Farley, A., Nash, A. D., et al. (2000) · Proceedings of the National Academy of Sciences

Cytokine Signaling Pathways and InteractionsProtein Tyrosine Phosphatases

Cited by 456

Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL‐6 signal transduction

Nicholson, S. E., Willson, T. A., Farley, A., Starr, R., Zhang, J., Baca, M., Alexander, W. S., Metcalf, D., Hilton, D. J., & Nicola, N. A. (1999) · The EMBO Journal

Cytokine Signaling Pathways and InteractionsProtein Tyrosine Phosphatases

Cited by 407

SOCS3 binds specific receptor–JAK complexes to control cytokine signaling by direct kinase inhibition

Kershaw, N. J., Murphy, J. M., Liau, N. P. D., Varghese, L. N., Laktyushin, A., Whitlock, E. L., Lucet, I. S., Nicola, N. A., & Babon, J. J. (2013) · Nature Structural & Molecular Biology

Cytokine Signaling Pathways and InteractionsProtein Tyrosine Phosphatases

Cited by 301

Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3

Roberts, A. W., Robb, L., Rakar, S., Hartley, L., Cluse, L., Nicola, N. A., Metcalf, D., Hilton, D. J., & Alexander, W. S. (2001) · Proceedings of the National Academy of Sciences

Cytokine Signaling Pathways and InteractionsReproductive System and Pregnancy

Cited by 300

SOCS3 Is a Critical Physiological Negative Regulator of G-CSF Signaling and Emergency Granulopoiesis

Croker, B. A., Metcalf, D., Robb, L., Wei, W., Mifsud, S., DiRago, L., Cluse, L. A., Sutherland, K. D., Hartley, L., Williams, E., et al. (2004) · Immunity

Cytokine Signaling Pathways and InteractionsBlood disorders and treatments

Cited by 285

Suppression of Cytokine Signaling by SOCS3: Characterization of the Mode of Inhibition and the Basis of Its Specificity

Babon, J. J., Kershaw, N. J., Murphy, J. M., Varghese, L. N., Laktyushin, A., Young, S. N., Lucet, I. S., Norton, R. S., & Nicola, N. A. (2012) · Immunity

Cytokine Signaling Pathways and InteractionsProtein Tyrosine Phosphatases

Cited by 279

Suppressor screen in Mpl -/- mice: c-Myb mutation causes supraphysiological production of platelets in the absence of thrombopoietin signaling

Carpinelli, M. R., Hilton, D. J., Metcalf, D., Antonchuk, J. L., Hyland, C. D., Mifsud, S. L., Di Rago, L., Hilton, A. A., Willson, T. A., Roberts, A. W., et al. (2004) · Proceedings of the National Academy of Sciences

Platelet Disorders and TreatmentsMyeloproliferative Neoplasms: Diagnosis and Treatment

Cited by 179

Growth enhancement in suppressor of cytokine signaling 2 (SOCS-2)-deficient mice is dependent on signal transducer and activator of transcription 5b (STAT5b)

Greenhalgh, C. J., Bertolino, P., Asa, S. L., Metcalf, D., Corbin, J. E., Adams, T. E., Davey, H. W., Nicola, N. A., Hilton, D. J., & Alexander, W. S. (2002) · Molecular Endocrinology

Growth Hormone and Insulin-like Growth FactorsCytokine Signaling Pathways and Interactions

Cited by 166

The Structure of SOCS3 Reveals the Basis of the Extended SH2 Domain Function and Identifies an Unstructured Insertion That Regulates Stability

Babon, J. J., McManus, E. J., Yao, S., DeSouza, D. P., Mielke, L. A., Sprigg, N. S., Willson, T. A., Hilton, D. J., Nicola, N. A., Baca, M., et al. (2006) · Molecular Cell

Cytokine Signaling Pathways and InteractionsProtein Structure and Dynamics

Cited by 163

The Comparative Roles of Suppressor of Cytokine Signaling-1 and -3 in the Inhibition and Desensitization of Cytokine Signaling

Wormald, S., Zhang, J.-G., Krebs, D. L., Mielke, L. A., Silver, J., Alexander, W. S., Speed, T. P., Nicola, N. A., & Hilton, D. J. (2006) · Journal of Biological Chemistry

Cytokine Signaling Pathways and InteractionsProtein Tyrosine Phosphatases

Cited by 123

Suppressor of Cytokine Signaling-1 Attenuates the Duration of Interferon γ Signal Transduction in Vitro and in Vivo

Brysha, M., Zhang, J.-G., Bertolino, P., Corbin, J. E., Alexander, W. S., Nicola, N. A., Hilton, D. J., & Starr, R. (2001) · Journal of Biological Chemistry

Cytokine Signaling Pathways and Interactionsinterferon and immune responses

Cited by 102

Negative regulation of gp130 signalling mediated through tyrosine-757 is not dependent on the recruitment of SHP2

FAIRLIE, W. D., SOUZA, D. D., NICOLA, N. A., & BACA, M. (2003) · Biochemical Journal

Cytokine Signaling Pathways and InteractionsProtein Tyrosine Phosphatases

Cited by 20