Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3
Open accessAbstract
Mice lacking suppressor of cytokine signaling 3 (SOCS3) exhibited embryonic lethality with death occurring between days 11 and 13 of gestation. At this stage, SOCS3 −/− embryos were slightly smaller than wild type but appeared otherwise normal, and histological analysis failed to detect any anatomical abnormalities responsible for the lethal phenotype. Rather, in all SOCS3 −/− embryos examined, defects were evident in placental development that would account for their developmental arrest and death. The placental spongiotrophoblast layer was significantly reduced and accompanied by increased numbers of giant trophoblast cells. Delayed branching of the chorioallantois was evident, and, although embryonic blood vessels were present in the labyrinthine layer of SOCS3 −/− placentas, the network of embryonic vessels and maternal sinuses was poorly developed. Yolk sac erythropoiesis was normal, and, although the SOCS3 −/− fetal liver was small at day 12.5 of gestation (E12.5), normal frequencies of erythroblasts and hematopoietic progenitor cells, including blast forming unit-erythroid (BFU-E) and, colony forming unit-erythroid (CFU-E) were present at both E11.5 and E12.5. Colony formation for both BFU-E and CFU-E from SOCS3 −/− mice displayed wild-type quantitative responsiveness to erythropoietin (EPO), in the presence or absence of IL-3 or stem cell factor (SCF). These data suggest that SOCS3 is required for placental development but dispensable for normal hematopoiesis in the mouse embryo.
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Mice lacking Socs3 die during embryogenesis.
“Mice lacking Socs3 die during embryogenesis (23);”
From The Comparative Roles of Suppressor of Cytokine Signaling-1 and -3 in the Inhibition and Desensitization of Cytokine Signaling (2006) · cites this paper as [23]
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SOCS3, a Major Regulator of Infection and Inflammation
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The molecular basis of JAK/STAT inhibition by SOCS1
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Self-citationSTAT3 activation in response to IL-6 is prolonged by the binding of IL-6 receptor to EGF receptor
Wang, Y., van Boxel-Dezaire, A. H. H., Cheon, H., Yang, J., & Stark, G. R. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1315862110 · Cited by 327 · see citing works
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Self-citationKimura, A., Kinjyo, I., Matsumura, Y., Mori, H., Mashima, R., Harada, M., Chien, K. R., Yasukawa, H., & Yoshimura, A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.c300496200 · Cited by 119 · see citing works
Structural Basis for Phosphotyrosine Recognition by Suppressor of Cytokine Signaling-3
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- Authors
- Roberts, A. W., Robb, L., Rakar, S., Hartley, L., Cluse, L., Nicola, N. A., Metcalf, D., Hilton, D. J., & Alexander, W. S.
- Affiliations
- The Royal Melbourne Hospital (AU)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2001-07-31
- Volume
- 98
- Issue
- 16
- Pages
- 9324-9329
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC55419
- OpenAlex
- W2040810264
- Cited by
- 300
- References
- 2
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 3 · 2023: 3 · 2022: 9 · 2021: 8 · 2020: 8 · 2019: 5 · 2018: 9 · 2017: 4 · 2016: 11 · 2015: 9 · 2014: 11 · 2013: 17 · 2012: 23
- FWCI
- 9.86
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (R37CA022556, CA22556, R01CA022556)
- Topics
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Keywords
- SOCS3, embryonic lethality, placental development, spongiotrophoblast, fetal liver hematopoiesis, BFU-E, CFU-E, erythropoietin, stem cell factor, interleukin-3, hematopoietic progenitor cells, mouse embryo
- MeSH terms
- Suppressor of Cytokine Signaling 3 Protein, Animals, Base Sequence, Erythropoietin, Fetal Death, Hematopoiesis, Proteins, Repressor Proteins, Transcription Factors, DNA Primers, Suppressor of Cytokine Signaling Proteins, Mice
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