Toyokuni, Shinya

Asbestos Surface Provides a Niche for Oxidative Modification

Nagai, H., Ishihara, T., Lee, W., Ohara, H., Okazaki, Y., Okawa, K., & Toyokuni, S. (2011) · Cancer Science

Occupational and environmental lung diseasesCarcinogens and Genotoxicity Assessment

Cited by 86

Induction of a wide range of C2-12 aldehydes and C7-12 acyloins in the kidney of Wistar rats after treatment with a renal carcinogen, ferric nitrilotriacetate

Toyokuni, S., Luo, X.-P., Tanaka, T., Uchida, K., Hiai, H., & Lehotay, D. C. (1997) · Free Radical Biology and Medicine

Carcinogens and Genotoxicity AssessmentAntioxidant Activity and Oxidative Stress

Cited by 84

Pericentromeric noncoding RNA changes DNA binding of CTCF and inflammatory gene expression in senescence and cancer

Miyata, K., Imai, Y., Hori, S., Nishio, M., Loo, T. M., Okada, R., Yang, L., Nakadai, T., Maruyama, R., Fujii, R., et al. (2021) · Proceedings of the National Academy of Sciences

Telomeres, Telomerase, and SenescenceGenomics and Chromatin Dynamics

Cited by 74

The iron chaperone poly(rC)-binding protein 2 forms a metabolon with the heme oxygenase 1/cytochrome P450 reductase complex for heme catabolism and iron transfer

Yanatori, I., Richardson, D. R., Toyokuni, S., & Kishi, F. (2017) · Journal of Biological Chemistry

Heme Oxygenase-1 and Carbon MonoxideHemoglobin structure and function

Cited by 69

Low Incidence of Point Mutations in H‐, K‐ and N‐ras Oncogenes and p53 Tumor Suppressor Gene in Renal Cell Carcinoma and Peritoneal Mesothelioma of Wistar Rats Induced by Ferric Nitrilotriacetate

Nishiyama, Y., Suwa, H., Okamoto, K., Fukumoto, M., Hiai, H., & Toyokuni, S. (1995) · Japanese Journal of Cancer Research

Carcinogens and Genotoxicity AssessmentCancer and biochemical research

Cited by 68

Oxidative stress as an iceberg in carcinogenesis and cancer biology

Toyokuni, S. (2016) · Archives of Biochemistry and Biophysics

Redox biology and oxidative stressCancer and biochemical research

Cited by 66

Induction of mesothelioma by intraperitoneal injections of ferric saccharate in male Wistar rats

Okada, S., Hamazaki, S., Toyokuni, S., & Midorikawa, O. (1989) · British Journal of Cancer

Occupational and environmental lung diseasesCarcinogens and Genotoxicity Assessment

Cited by 65

Homozygous deletion of CDKN2A/2B is a hallmark of iron-induced high-grade rat mesothelioma

Hu, Q., Akatsuka, S., Yamashita, Y., Ohara, H., Nagai, H., Okazaki, Y., Takahashi, T., & Toyokuni, S. (2010) · Laboratory Investigation

Occupational and environmental lung diseasesIntraperitoneal and Appendiceal Malignancies

Cited by 62

Specific Allelic Loss of p16 Tumor Suppressor Gene after Weeks of Iron-Mediated Oxidative Damage during Rat Renal Carcinogenesis

Hiroyasu, M., Ozeki, M., Kohda, H., Echizenya, M., Tanaka, T., Hiai, H., & Toyokuni, S. (2002) · The American Journal of Pathology

Carcinogens and Genotoxicity AssessmentCancer-related Molecular Pathways

Cited by 61

Iron overload as a major targetable pathogenesis of asbestos-induced mesothelial carcinogenesis

Toyokuni, S. (2014) · Redox Report

Occupational and environmental lung diseasesIron Metabolism and Disorders

Cited by 56

Contrasting genome-wide distribution of 8-hydroxyguanine and acrolein-modified adenine during oxidative stress-induced renal carcinogenesis

Akatsuka, S., Aung, T. T., Dutta, K. K., Jiang, L., Lee, W.-H., Liu, Y.-T., Onuki, J., Shirase, T., Yamasaki, K., Ochi, H., et al. (2006) · The American Journal of Pathology

Carcinogens and Genotoxicity AssessmentDNA Repair Mechanisms

Cited by 51

Asbestos conceives Fe(II)-dependent mutagenic stromal milieu through ceaseless macrophage ferroptosis and β-catenin induction in mesothelium

Ito, F., Yanatori, I., Maeda, Y., Nimura, K., Ito, S., Hirayama, T., Nagasawa, H., Kohyama, N., Okazaki, Y., Akatsuka, S., et al. (2020) · Redox Biology

Occupational and environmental lung diseasesFerroptosis and cancer prognosis

Cited by 45

Connective tissue growth factor-specific monoclonal antibody inhibits growth of malignant mesothelioma in an orthotopic mouse model

Ohara, Y., Chew, S. H., Misawa, N., Wang, S., Somiya, D., Nakamura, K., Kajiyama, H., Kikkawa, F., Tsuyuki, Y., Jiang, L., et al. (2018) · Oncotarget

Connective Tissue Growth Factor ResearchOccupational and environmental lung diseases

Cited by 44

Contrasting intra- and extracellular distribution of catalytic ferrous iron in ovalbumin-induced peritonitis

Ito, F., Nishiyama, T., Shi, L., Mori, M., Hirayama, T., Nagasawa, H., Yasui, H., & Toyokuni, S. (2016) · Biochemical and Biophysical Research Communications

Iron Metabolism and DisordersMolecular Sensors and Ion Detection

Cited by 41

Deferasirox induces mesenchymal-epithelial transition in crocidolite-induced mesothelial carcinogenesis in rats

Nagai, H., Okazaki, Y., Chew, S. H., Misawa, N., Yasui, H., & Toyokuni, S. (2013) · Cancer Prevention Research

Occupational and environmental lung diseasesIntraperitoneal and Appendiceal Malignancies

Cited by 39

Connective tissue growth factor and β‐catenin constitute an autocrine loop for activation in rat sarcomatoid mesothelioma

Jiang, L., Yamashita, Y., Chew, S., Akatsuka, S., Ukai, S., Wang, S., Nagai, H., Okazaki, Y., Takahashi, T., & Toyokuni, S. (2014) · The Journal of Pathology

Connective Tissue Growth Factor ResearchOccupational and environmental lung diseases

Cited by 34

Carcinogenesis as Side Effects of Iron and Oxygen Utilization: From the Unveiled Truth toward Ultimate Bioengineering

Toyokuni, S., Kong, Y., Cheng, Z., Sato, K., Hayashi, S., Ito, F., Jiang, L., Yanatori, I., Okazaki, Y., & Akatsuka, S. (2020) · Cancers

Ferroptosis and cancer prognosisIron Metabolism and Disorders

Cited by 33

Phlebotomy as a preventive measure for crocidolite-induced mesothelioma in male rats

Ohara, Y., Chew, S., Shibata, T., Okazaki, Y., Yamashita, K., & Toyokuni, S. (2018) · Cancer Science

Occupational and environmental lung diseasesOccupational Health and Global Justice

Cited by 28

Dual preventive benefits of iron elimination by desferal in asbestos‐induced mesothelial carcinogenesis

Jiang, L., Chew, S., Nakamura, K., Ohara, Y., Akatsuka, S., & Toyokuni, S. (2016) · Cancer Science

Occupational and environmental lung diseasesHeavy Metal Exposure and Toxicity

Cited by 19

Mth1 deficiency provides longer survival upon intraperitoneal crocidolite injection in female mice

Funahashi, S., Okazaki, Y., Akatsuka, S., Takahashi, T., Sakumi, K., Nakabeppu, Y., & Toyokuni, S. (2020) · Free Radical Research

Occupational and environmental lung diseasesDNA Repair Mechanisms

Cited by 7