Toyokuni, Shinya

Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease

Stockwell, B. R., Friedmann Angeli, J. P., Bayir, H., Bush, A. I., Conrad, M., Dixon, S. J., Fulda, S., Gascón, S., Hatzios, S. K., Kagan, V. E., et al. (2017) · Cell

Ferroptosis and cancer prognosisIron Metabolism and Disorders

Cited by 7,695

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1

Klionsky, D. J., Abdel-Aziz, A. K., Abdelfatah, S., Abdellatif, M., Abdoli, A., Abel, S., Abeliovich, H., Abildgaard, M. H., Abudu, Y. P., Acevedo-Arozena, A., et al. (2021) · Autophagy

Autophagy in Disease and TherapyCalcium signaling and nucleotide metabolism

Cited by 2,897

Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo

Murphy, M. P., Bayir, H., Belousov, V., Chang, C. J., Davies, K. J. A., Davies, M. J., Dick, T. P., Finkel, T., Forman, H. J., Janssen-Heininger, Y., et al. (2022) · Nature Metabolism

Redox biology and oxidative stressAntioxidant Activity and Oxidative Stress

Cited by 1,514

Persistent oxidative stress in cancer

Toyokuni, S., Okamoto, K., Yodoi, J., & Hiai, H. (1995) · FEBS Letters

Redox biology and oxidative stressCancer and biochemical research

Cited by 1,219

Inhibition of gastric inhibitory polypeptide signaling prevents obesity

Miyawaki, K., Yamada, Y., Ban, N., Ihara, Y., Tsukiyama, K., Zhou, H., Fujimoto, S., Oku, A., Tsuda, K., Toyokuni, S., et al. (2002) · Nature Medicine

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 963

Generation of Pluripotent Stem Cells from Neonatal Mouse Testis

Kanatsu-Shinohara, M., Inoue, K., Lee, J., Yoshimoto, M., Ogonuki, N., Miki, H., Baba, S., Kato, T., Kazuki, Y., Toyokuni, S., et al. (2004) · Cell

Pluripotent Stem Cells ResearchAnimal Genetics and Reproduction

Cited by 814

Role of iron in carcinogenesis: cancer as a ferrotoxic disease

Toyokuni, S. (2009) · Cancer Science

Iron Metabolism and DisordersFerroptosis and cancer prognosis

Cited by 552

Diameter and rigidity of multiwalled carbon nanotubes are critical factors in mesothelial injury and carcinogenesis

Nagai, H., Okazaki, Y., Chew, S. H., Misawa, N., Yamashita, Y., Akatsuka, S., Ishihara, T., Yamashita, K., Yoshikawa, Y., Yasui, H., et al. (2011) · Proceedings of the National Academy of Sciences

Occupational and environmental lung diseasesGraphene and Nanomaterials Applications

Cited by 535

Formation of 4-hydroxy-2-nonenal-modified proteins in the renal proximal tubules of rats treated with a renal carcinogen, ferric nitrilotriacetate

Toyokuni, S., Uchida, K., Okamoto, K., Hattori-Nakakuki, Y., Hiai, H., & Stadtman, E. R. (1994) · Proceedings of the National Academy of Sciences

Antioxidant Activity and Oxidative StressCarcinogens and Genotoxicity Assessment

Cited by 331

Contents of Endometriotic Cysts, Especially the High Concentration of Free Iron, Are a Possible Cause of Carcinogenesis in the Cysts through the Iron-Induced Persistent Oxidative Stress

Yamaguchi, K., Mandai, M., Toyokuni, S., Hamanishi, J., Higuchi, T., Takakura, K., & Fujii, S. (2008) · Clinical Cancer Research

Endometriosis Research and TreatmentOvarian cancer diagnosis and treatment

Cited by 324

Iron and thiol redox signaling in cancer: an exquisite balance to escape ferroptosis

Toyokuni, S., Ito, F., Yamashita, K., Okazaki, Y., & Akatsuka, S. (2017) · Free Radical Biology and Medicine

Ferroptosis and cancer prognosisGenomics, phytochemicals, and oxidative stress

Cited by 252

CD63 is regulated by iron via the IRE-IRP system and is important for ferritin secretion by extracellular vesicles

Yanatori, I., Richardson, D. R., Dhekne, H. S., Toyokuni, S., & Kishi, F. (2021) · Blood

Extracellular vesicles in diseaseIron Metabolism and Disorders

Cited by 148

Ferroptosis at the crossroads of infection, aging and cancer

Toyokuni, S., Yanatori, I., Kong, Y., Zheng, H., Motooka, Y., & Jiang, L. (2020) · Cancer Science

Ferroptosis and cancer prognosisIron Metabolism and Disorders

Cited by 142

Antioxidant α‐tocopherol ameliorates glycemic control of GK rats, a model of type 2 diabetes

Ihara, Y., Yamada, Y., Toyokuni, S., Miyawaki, K., Ban, N., Adachi, T., Kuroe, A., Iwakura, T., Kubota, A., Hiai, H., et al. (2000) · FEBS Letters

Antioxidant Activity and Oxidative StressNatural Antidiabetic Agents Studies

Cited by 124

Genotoxicity and carcinogenicity risk of carbon nanotubes

Toyokuni, S. (2013) · Advanced Drug Delivery Reviews

Carcinogens and Genotoxicity AssessmentGraphene and Nanomaterials Applications

Cited by 117

The origin and future of oxidative stress pathology: From the recognition of carcinogenesis as an iron addiction with ferroptosis‐resistance to non‐thermal plasma therapy

Toyokuni, S. (2016) · Pathology International

Cancer and biochemical researchAntioxidant Activity and Oxidative Stress

Cited by 111

Novel aspects of oxidative stress-associated carcinogenesis

Toyokuni, S. (2006) · Antioxidants & Redox Signaling

Redox biology and oxidative stressAntioxidant Activity and Oxidative Stress

Cited by 104

Iron overload signature in chrysotile-induced malignant mesothelioma

Jiang, L., Akatsuka, S., Nagai, H., Chew, S., Ohara, H., Okazaki, Y., Yamashita, Y., Yoshikawa, Y., Yasui, H., Ikuta, K., et al. (2012) · The Journal of Pathology

Occupational and environmental lung diseasesOccupational Health and Global Justice

Cited by 104

Ferroptosis contributes to multiple sclerosis and its pharmacological targeting suppresses experimental disease progression

Van San, E., Debruyne, A. C., Veeckmans, G., Tyurina, Y. Y., Tyurin, V. A., Zheng, H., Choi, S. M., Augustyns, K., van Loo, G., Michalke, B., et al. (2023) · Cell Death & Differentiation

Multiple Sclerosis Research StudiesFerroptosis and cancer prognosis

Cited by 103

Malignant mesothelioma as an oxidative stress-induced cancer: An update

Chew, S. H., & Toyokuni, S. (2015) · Free Radical Biology and Medicine

Occupational and environmental lung diseasesOccupational Health and Global Justice

Cited by 102

Fenton reaction induced cancer in wild type rats recapitulates genomic alterations observed in human cancer

Akatsuka, S., Yamashita, Y., Ohara, H., Liu, Y.-T., Izumiya, M., Abe, K., Ochiai, M., Jiang, L., Nagai, H., Okazaki, Y., et al. (2012) · PLoS ONE

Genomic variations and chromosomal abnormalitiesCancer Genomics and Diagnostics

Cited by 102

Differences and similarities between carbon nanotubes and asbestos fibers during mesothelial carcinogenesis: shedding light on fiber entry mechanism

Nagai, H., & Toyokuni, S. (2012) · Cancer Science

Occupational and environmental lung diseasesGraphene and Nanomaterials Applications

Cited by 98

Iron addiction with ferroptosis-resistance in asbestos-induced mesothelial carcinogenesis: Toward the era of mesothelioma prevention

Toyokuni, S. (2019) · Free Radical Biology and Medicine

Occupational and environmental lung diseasesFerroptosis and cancer prognosis

Cited by 96

Ferroptosis-dependent extracellular vesicles from macrophage contribute to asbestos-induced mesothelial carcinogenesis through loading ferritin

Ito, F., Kato, K., Yanatori, I., Murohara, T., & Toyokuni, S. (2021) · Redox Biology

Extracellular vesicles in diseaseOccupational and environmental lung diseases

Cited by 88