Gopal, Purva

Somatic Mutations Increase Hepatic Clonal Fitness and Regeneration in Chronic Liver Disease

Zhu, M., Lu, T., Jia, Y., Luo, X., Gopal, P., Li, L., Odewole, M., Renteria, V., Singal, A. G., Jang, Y., et al. (2019) · Cell

Liver physiology and pathologyCancer Genomics and Diagnostics

Cited by 250

The Polyploid State Plays a Tumor-Suppressive Role in the Liver

Zhang, S., Zhou, K., Luo, X., Li, L., Tu, H.-C., Sehgal, A., Nguyen, L. H., Zhang, Y., Gopal, P., Tarlow, B. D., et al. (2018) · Developmental Cell

Liver physiology and pathologyCancer-related Molecular Pathways

Cited by 180

Positive selection of somatically mutated clones identifies adaptive pathways in metabolic liver disease

Wang, Z., Zhu, S., Jia, Y., Wang, Y., Kubota, N., Fujiwara, N., Gordillo, R., Lewis, C., Zhu, M., Sharma, T., et al. (2023) · Cell

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 72

In vivo CRISPR screening identifies BAZ2 chromatin remodelers as druggable regulators of mammalian liver regeneration

Jia, Y., Li, L., Lin, Y.-H., Gopal, P., Shen, S., Zhou, K., Yu, X., Sharma, T., Zhang, Y., Siegwart, D. J., et al. (2022) · Cell Stem Cell

Liver physiology and pathologyTissue Engineering and Regenerative Medicine

Cited by 59

The origin of hepatocellular carcinoma depends on metabolic zonation

Guo, J., Liang, R., Chung, A., Li, Z., Li, B., Chen, E., Li, L., Wang, J., Hsieh, M.-H., Fang, I. X., et al. (2026) · Science

Liver physiology and pathologyCancer Genomics and Diagnostics

Cited by 24

PKD1 mutant clones within cirrhotic livers inhibit steatohepatitis without promoting cancer

Zhu, M., Wang, Y., Lu, T., Guo, J., Li, L., Hsieh, M.-H., Gopal, P., Han, Y., Fujiwara, N., Wallace, D. P., et al. (2024) · Cell Metabolism

Liver physiology and pathologyCancer Genomics and Diagnostics

Cited by 9

Somatic mutations in TBX3 promote hepatic clonal expansion by accelerating VLDL secretion

Mannino, G., Quinn, G., Zhu, M., Wang, Z., Wang, X., Li, B., Hsieh, M.-H., Mathews, T., Zacharias, L., Gu, W., et al. (2025) · Journal of Clinical Investigation

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 4