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Genome-scale CRISPR screening in a single mouse liver

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LIFR regulates cholesterol-driven bidirectional hepatocyte–neutrophil cross-talk to promote liver regeneration

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Pkd1l1-deficiency drives biliary atresia through ciliary dysfunction in biliary epithelial cells

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Methods and applications of in vivo CRISPR screening

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Is liver regeneration key in hepatocellular carcinoma development?

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Targeting the chromatin remodeler BAZ2B mitigates hepatic senescence and MASH fibrosis

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Targeting BRD4 mitigates hepatocellular lipotoxicity by suppressing the NLRP3 inflammasome activation and GSDMD-mediated hepatocyte pyroptosis

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Relationships Between Regeneration, Wound Healing, and Cancer

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Epigenetic Regulation of Innate and Adaptive Immune Cells in Salt-Sensitive Hypertension

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A platform for multimodal in vivo pooled genetic screens reveals regulators of liver functionPreprint

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Somatic loss-of-function mutations in CIDEB reduce hepatic steatosis by increasing lipolysis and fatty acid oxidation

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Signal control during tissue regeneration in adult animals

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A roadmap toward genome-wide CRISPR screening throughout the organism

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Hepatic zonation determines tumorigenic potential of mutant β-catenin

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GSK2801 Reverses Paclitaxel Resistance in Anaplastic Thyroid Cancer Cell Lines through MYCN Downregulation

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Rapid in vivo multiplexed editing (RIME) of the adult mouse liver

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Alternative splicing of BAZ1A in colorectal cancer disrupts the DNA damage response and increases chemosensitization

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SETDB1 promotes mammalian liver regeneration by stimulating cytokine CSF3 in hepatocytes

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In Vivo CRISPR Activation Screening Reveals Chromosome 1q Genes VPS72, GBA1, and MRPL9 Drive Hepatocellular Carcinoma

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In vivo CRISPR screening directly targeting testicular cells

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In vivo screening identifies SPP2, a secreted factor that negatively regulates liver regeneration

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CRISPR-epigenetic crosstalk: From bidirectional regulation to therapeutic potential

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SPACE-seq integrates spatial transcriptomics and lineage tracing in native tissues

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Discovery of First-in-Class BAZ2A/B and BAZ2B-Selective Degraders

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mRNA translational control of regeneration

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Genome-Wide Screening Approaches for Biochemical Reactions Independent of Cell Growth

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LIFR recruits HGF-producing neutrophils to promote liver injury repair and regenerationPreprint

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How CRISPR Is Revolutionizing the Generation of New Models for Cancer ResearchPreprint

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Spatiotemporal control of SMARCA5 by a MAPK–RUNX1 axis distinguishes mutant KRAS-driven pancreatic malignancy from tissue regeneration

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Liver cancer initiation is dependent on metabolic zonation but decoupled from premalignant clonal expansionPreprint

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Clinical translation of epigenome editing technologies

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Ribosomal Dysregulation in Metastatic Laryngeal Squamous Cell Carcinoma: Proteomic Insights and CX-5461’s Therapeutic Promise

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Mechanistic basis for protection against fatty liver disease by CIDEB loss-of-function mutationsPreprint

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Unraveling enhanced liver regeneration in ALPPS: Integrating multi-omics profiling and in vivo CRISPR in mouse models

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Smart Nanomaterials in Tissue Engineering: Scaffolds, Bioprinting, and Stem Cell Integration

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Somatic mutations impose an entropic upper bound on human lifespan

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The Role of BAZ2-dependent Chromatin Remodeling in Suppressing G4 DNA Structures and Associated Genomic InstabilityPreprint

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Curing Classical Homocysteinuria with Pediatric in vitro engineered Liver Organoid Transplantation?

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Engineering Cancer with Next-Generation Genome Editing Tools

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Butachlor-Induced BAZ2B Activation Promotes Cardiomyocyte Senescence through cGAS-STING pathway

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BAZ2B contributes to endometrial fibrosis by promoting fibroblast-to-myofibroblast differentiation

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Identification of key genes related to macrophages and metabolic reprogramming in myocardial infarct based on single-cell and bulk transcriptomics data and experimental validation

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Parallel In Vivo Screening of Gene Knockout and Activation in the Mouse Mammary Gland

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Chemical tools for BAZ2A/B biology: discovery of dual and BAZ2B-selective PROTAC degraders

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Stress triggers global histone synthesis in the liverPreprint

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BindingDB Entry 50023134: Discovery of First-in-Class BAZ2A/B and BAZ2B-Selective Degraders.

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In vivo screening identifies SPP2, a secreted factor that negatively regulates liver regeneration

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59 IN VIVO RNAI SCREENING IDENTIFIES NEW REGULATORS OF LIVER REGENERATION

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SETDB1 promotes mammalian liver regeneration by stimulating cytokine CSF3 in hepatocytes

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ZBTB20 regulates EGFR expression and hepatocyte proliferation in mouse liver regeneration

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