Song, Weihong

Amyloid β-based therapy for Alzheimer’s disease: Challenges, successes and future

Zhang, Y., Chen, H., Li, R., Sterling, K., & Song, W. (2023) · Signal Transduction and Targeted Therapy

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 988

Brain-Derived Neurotrophic Factor in Alzheimer’s Disease and Its Pharmaceutical Potential

Gao, L., Zhang, Y., Sterling, K., & Song, W. (2022) · Translational Neurodegeneration

Alzheimer's disease research and treatmentsNerve injury and regeneration

Cited by 606

Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expression

Sun, X., He, G., Qing, H., Zhou, W., Dobie, F., Cai, F., Staufenbiel, M., Huang, L. E., & Song, W. (2006) · Proceedings of the National Academy of Sciences

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 605

Inhibition of GSK3β-mediated BACE1 expression reduces Alzheimer-associated phenotypes

Ly, P. T. T., Wu, Y., Zou, H., Wang, R., Zhou, W., Kinoshita, A., Zhang, M., Yang, Y., Cai, F., Woodgett, J., et al. (2013) · Journal of Clinical Investigation

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 442

Increased NF-Κb Signalling Up-Regulates BACE1 Expression and its Therapeutic Potential in Alzheimer's Disease

Chen, C.-H., Zhou, W., Liu, S., Deng, Y., Cai, F., Tone, M., Tone, Y., Tong, Y., & Song, W. (2012) · The International Journal of Neuropsychopharmacology

Alzheimer's disease research and treatmentsNF-κB Signaling Pathways

Cited by 433

Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations

Song, W., Nadeau, P., Yuan, M., Yang, X., Shen, J., & Yankner, B. A. (1999) · Proceedings of the National Academy of Sciences

Alzheimer's disease research and treatmentsDevelopmental Biology and Gene Regulation

Cited by 362

Metformin decelerates aging clock in male monkeys

Yang, Y., Lu, X., Liu, N., Ma, S., Zhang, H., Zhang, Z., Yang, K., Jiang, M., Zheng, Z., Qiao, Y., et al. (2024) · Cell

Genetics, Aging, and Longevity in Model OrganismsMetabolism, Diabetes, and Cancer

Cited by 227

Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances

Jiang, Q., Liu, J., Huang, S., Wang, X.-Y., Chen, X., Liu, G.-H., Ye, K., Song, W., Masters, C. L., Wang, J., et al. (2025) · Signal Transduction and Targeted Therapy

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 165

Spatial transcriptomic landscape unveils immunoglobin-associated senescence as a hallmark of aging

Ma, S., Ji, Z., Zhang, B., Geng, L., Cai, Y., Nie, C., Li, J., Zuo, Y., Sun, Y., Xu, G., et al. (2024) · Cell

Single-cell and spatial transcriptomicsGenetics, Aging, and Longevity in Model Organisms

Cited by 162

Amyloid‐β protein (Aβ) Glu11 is the major β‐secretase site of β‐site amyloid‐β precursor protein‐cleaving enzyme 1(BACE1), and shifting the cleavage site to Aβ Asp1 contributes to Alzheimer pathogenesis

Deng, Y., Wang, Z., Wang, R., Zhang, X., Zhang, S., Wu, Y., Staufenbiel, M., Cai, F., & Song, W. (2013) · European Journal of Neuroscience

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 108

TRPV1 activation alleviates cognitive and synaptic plasticity impairments through inhibiting AMPAR endocytosis in APP23/PS45 mouse model of Alzheimer’s disease

Du, Y., Fu, M., Huang, Z., Tian, X., Li, J., Pang, Y., Song, W., Tian Wang, Y., & Dong, Z. (2020) · Aging Cell

Alzheimer's disease research and treatmentsNeuroscience and Neuropharmacology Research

Cited by 95

Capsaicin consumption reduces brain amyloid-beta generation and attenuates Alzheimer’s disease-type pathology and cognitive deficits in APP/PS1 mice

Wang, J., Sun, B.-L., Xiang, Y., Tian, D.-Y., Zhu, C., Li, W.-W., Liu, Y.-H., Bu, X.-L., Shen, L.-L., Jin, W.-S., et al. (2020) · Translational Psychiatry

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 87

Upregulation of MIF as a defense mechanism and a biomarker of Alzheimer’s disease

Zhang, S., Zhao, J., Zhang, Y., Zhang, Y., Cai, F., Wang, L., & Song, W. (2019) · Alzheimer's Research & Therapy

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 73

USP25 inhibition ameliorates Alzheimer’s pathology through the regulation of APP processing and Aβ generation

Zheng, Q., Song, B., Li, G., Cai, F., Wu, M., Zhao, Y., Jiang, L., Guo, T., Shen, M., Hou, H., et al. (2022) · Journal of Clinical Investigation

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 73

A presenilin-1 mutation causes Alzheimer disease without affecting Notch signaling

Zhang, S., Cai, F., Wu, Y., Bozorgmehr, T., Wang, Z., Zhang, S., Huang, D., Guo, J., Shen, L., Rankin, C., et al. (2020) · Molecular Psychiatry

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 66

Blood cell-produced amyloid-β induces cerebral Alzheimer-type pathologies and behavioral deficits

Sun, H.-L., Chen, S.-H., Yu, Z.-Y., Cheng, Y., Tian, D.-Y., Fan, D.-Y., He, C.-Y., Wang, J., Sun, P.-Y., Chen, Y., et al. (2021) · Molecular Psychiatry

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 56

Clusterin transduces Alzheimer-risk signals to amyloidogenesis

Liu, X., Che, R., Liang, W., Zhang, Y., Wu, L., Han, C., Lu, H., Song, W., Wu, Y., & Wang, Z. (2022) · Signal Transduction and Targeted Therapy

Alzheimer's disease research and treatmentsClusterin in disease pathology

Cited by 45

No Significant Effect of 7,8-Dihydroxyflavone on APP Processing and Alzheimer-Associated Phenotypes

Zhou, W., Li, X., Huang, D., Zhou, W., Li, T., & Song, W. (2015) · Current Alzheimer Research

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 19