Increased NF-Κb Signalling Up-Regulates BACE1 Expression and its Therapeutic Potential in Alzheimer's Disease

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Protective role of luteolin against cognitive dysfunction induced by chronic cerebral hypoperfusion in rats

Fu, X., Zhang, J., Guo, L., Xu, Y., Sun, L., Wang, S., Feng, Y., Gou, L., Zhang, L., & Liu, Y. (2014) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2014.09.005 · Cited by 99 · see citing works

Regulation of β‐site APP‐cleaving enzyme 1 gene expression and its role in Alzheimer’s Disease

Sun, X., Bromley‐Brits, K., & Song, W. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07515.x · Cited by 97 · see citing works

MCC950 reduces autophagy and improves cognitive function by inhibiting NLRP3-dependent neuroinflammation in a rat model of Alzheimer's disease

Naeem, A., Prakash, R., Kumari, N., Ali Khan, M., Quaiyoom Khan, A., Uddin, S., Verma, S., AB Robertson, A., Boltze, J., & Shadab Raza, S. (2024) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2023.11.031 · Cited by 96 · see citing works

Curcumin Ameliorates Memory Decline via Inhibiting BACE1 Expression and β-Amyloid Pathology in 5×FAD Transgenic Mice

Zheng, K.-M., Dai, X., Xiao, N., Wu, X., Wei, Z., Fang, W., Zhu, Y., Zhang, J., & Chen, X. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9802-9 · Cited by 96 · see citing works

Marginal vitamin A deficiency facilitates Alzheimer’s pathogenesis

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Intranasal Insulin Administration Ameliorates Streptozotocin (ICV)-Induced Insulin Receptor Dysfunction, Neuroinflammation, Amyloidogenesis, and Memory Impairment in Rats

Rajasekar, N., Nath, C., Hanif, K., & Shukla, R. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0169-8 · Cited by 94 · see citing works

Chronic oral administration of adipoRon reverses cognitive impairments and ameliorates neuropathology in an Alzheimer’s disease mouse model

Ng, R. C.-L., Jian, M., Ma, O. K.-F., Bunting, M., Kwan, J., Zhou, G.-J., Krishnamoorthi, S., Iyaswamy, A., Chan, P., Li, M., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0701-0 · Cited by 94 · see citing works

Effects of RAGE-Specific Inhibitor FPS-ZM1 on Amyloid-β Metabolism and AGEs-Induced Inflammation and Oxidative Stress in Rat Hippocampus

Yan, H., Shen, C., Yin, Q., Sun, M., Ma, Y., & Liu, X. (2016) · Neurochemical Research · doi:10.1007/s11064-015-1814-8 · Cited by 93 · see citing works

Control of BACE1 degradation and APP processing by ubiquitin carboxyl‐terminal hydrolase L1

Zhang, M., Deng, Y., Luo, Y., Zhang, S., Zou, H., Cai, F., Wada, K., & Song, W. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07644.x · Cited by 92 · see citing works

Calcium channelopathies and Alzheimer's disease: Insight into therapeutic success and failures

Chakroborty, S., & Stutzmann, G. E. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.11.012 · Cited by 91 · see citing works

Alzheimer’s disease: natural products as inhibitors of neuroinflammation

Olajide, O. A., & Sarker, S. D. (2020) · Inflammopharmacology · doi:10.1007/s10787-020-00751-1 · Cited by 91 · see citing works

Intelligent lesion blood–brain barrier targeting nano-missiles for Alzheimer's disease treatment by anti-neuroinflammation and neuroprotection

He, X., Wang, X., Yang, L., Yang, Z., Yu, W., Wang, Y., Liu, R., Chen, M., & Gao, H. (2022) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2022.02.001 · Cited by 89 · see citing works

Sulforaphane Inhibits the Generation of Amyloid- β Oligomer and Promotes Spatial Learning and Memory in Alzheimer’s Disease (PS1V97L) Transgenic Mice

Hou, T., Yang, H., Wang, W., Wu, Q., Tian, Y., & Jia, J. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-171110 · Cited by 84 · see citing works

Neuroinflammation: Mechanisms, Dual Roles, and Therapeutic Strategies in Neurological Disorders

García‐Domínguez, M. (2025) · Current Issues in Molecular Biology · doi:10.3390/cimb47060417 · Cited by 85 · see citing works

Nuclear Factor-κB Dysregulation and α-Synuclein Pathology: Critical Interplay in the Pathogenesis of Parkinson’s Disease

Bellucci, A., Bubacco, L., Longhena, F., Parrella, E., Faustini, G., Porrini, V., Bono, F., Missale, C., & Pizzi, M. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.00068 · Cited by 82 · see citing works

LXR Agonists: New Potential Therapeutic Drug for Neurodegenerative Diseases

Xu, P., Li, D.-B., Tang, X., Bao, X., Huang, J., Tang, Y.-P., Yang, Y., Xu, H., & Fan, X.-T. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8461-3 · Cited by 84 · see citing works

Periodontitis Induced by P. gingivalis-LPS Is Associated With Neuroinflammation and Learning and Memory Impairment in Sprague-Dawley Rats

Hu, Y., Li, H., Zhang, J., Zhang, X., Xia, X., Qiu, C., Liao, Y., Chen, H., Song, Z., & Zhou, W. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00658 · Cited by 81 · see citing works

Targeting neuroinflammation in Alzheimer’s disease: evidence for NSAIDs and novel therapeutics

Deardorff, W. J., & Grossberg, G. T. (2016) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2016.1200972 · Cited by 80 · see citing works

Olive Oil Phenols as Promising Multi-targeting Agents Against Alzheimer’s Disease

Rigacci, S. (2015) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-18365-7_1 · Cited by 80 · see citing works

All-trans-retinoic Acid Reduces BACE1 Expression under Inflammatory Conditions via Modulation of Nuclear Factor κB (NFκB) Signaling

Wang, R., Chen, S., Liu, Y., Diao, S., Xue, Y.-Q., You, X., Park, E. A., & Liao, F. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.662908 · Cited by 79 · see citing works

BACE2, a conditional β-secretase, contributes to Alzheimer’s disease pathogenesis

Wang, Z., Xu, Q., Cai, F., Liu, X., Wu, Y., & Song, W. (2019) · JCI Insight · doi:10.1172/jci.insight.123431 · Cited by 78 · see citing works

When Good Kinases Go Rogue: GSK3, p38 MAPK and CDKs as Therapeutic Targets for Alzheimer’s and Huntington’s Disease

D’Mello, S. R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115911 · Cited by 77 · see citing works

Bee venom ameliorates lipopolysaccharide-induced memory loss by preventing NF-kappaB pathway

Gu, S. M., Park, M. H., Hwang, C. J., Song, H. S., Lee, U. S., Han, S., Oh, K. W., Ham, Y. W., Song, M. J., Son, D. J., et al. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0344-2 · Cited by 76 · see citing works

Inhibition of PKCδ reduces amyloid-β levels and reverses Alzheimer disease phenotypes

Du, Y., Zhao, Y., Li, C.-B., Zheng, Q.-Y., Tian, J., Li, Z.-Y., Huang, T. Y., Zhang, W., & Xu, H.-X. (2018) · Journal of Experimental Medicine · doi:10.1084/jem.20171193 · Cited by 66 · see citing works

Aquaporin 4 deletion exacerbates brain impairments in a mouse model of chronic sleep disruption

Zhang, R., Liu, Y., Chen, Y., Li, Q., Marshall, C., Wu, T., Hu, G., & Xiao, M. (2019) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13194 · Cited by 75 · see citing works

MafK positively regulates NF-κB activity by enhancing CBP-mediated p65 acetylation

Hwang, Y.-J., Lee, E., Song, J., Kim, H.-R., Jun, Y.-C., & Hwang, K. (2013) · Scientific Reports · doi:10.1038/srep03242 · Cited by 74 · see citing works

Exploring the Therapeutic Potential of Phytochemicals in Alzheimer’s Disease: Focus on Polyphenols and Monoterpenes

Piccialli, I., Tedeschi, V., Caputo, L., D’Errico, S., Ciccone, R., De Feo, V., Secondo, A., & Pannaccione, A. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.876614 · Cited by 73 · see citing works

Physical Exercise, a Potential Non-Pharmacological Intervention for Attenuating Neuroinflammation and Cognitive Decline in Alzheimer’s Disease Patients

Ribarič, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063245 · Cited by 72 · see citing works

Palmitic Acid-BSA enhances Amyloid-β production through GPR40-mediated dual pathways in neuronal cells: Involvement of the Akt/mTOR/HIF-1α and Akt/NF-κB pathways

Kim, J. Y., Lee, H. J., Lee, S., Jung, Y. H., Yoo, D. Y., Hwang, I. K., Seong, J. K., Ryu, J. M., & Han, H. J. (2017) · Scientific Reports · doi:10.1038/s41598-017-04175-w · Cited by 72 · see citing works

Estrogen deficiency exacerbates Aβ-induced memory impairment through enhancement of neuroinflammation, amyloidogenesis and NF-ĸB activation in ovariectomized mice

Yun, J., Yeo, I. J., Hwang, C. J., Choi, D., Im, H.-S., Kim, J. Y., Choi, W. R., Jung, M. H., Han, S., & Hong, J. T. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.05.013 · Cited by 72 · see citing works

Ethanol Alters APP Processing and Aggravates Alzheimer-Associated Phenotypes

Huang, D., Yu, M., Yang, S., Lou, D., Zhou, W., Zheng, L., Wang, Z., Cai, F., Zhou, W., Li, T., et al. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0703-3 · Cited by 70 · see citing works

Icariside II inhibits lipopolysaccharide-induced inflammation and amyloid production in rat astrocytes by regulating IKK/IκB/NF-κB/BACE1 signaling pathway

Zheng, Y. M., Deng, Y., Gao, J.-M., Lv, C., Lang, L.-H., Shi, J., Yu, C., & Gong, Q. (2019) · Acta Pharmacologica Sinica · doi:10.1038/s41401-019-0300-2 · Cited by 70 · see citing works

Protective Effects of Flavonoids against Alzheimer’s Disease: Pathological Hypothesis, Potential Targets, and Structure–Activity Relationship

Li, J., Sun, M., Cui, X., & Li, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231710020 · Cited by 70 · see citing works

Microglial Activation and Priming in Alzheimer’s Disease: State of the Art and Future Perspectives

Bivona, G., Iemmolo, M., Agnello, L., Sasso, B. L., Gambino, C. M., Giglio, R. V., Scazzone, C., Ghersi, G., & Ciaccio, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24010884 · Cited by 71 · see citing works

Melatonin regulates the transcription of βAPP‐cleaving secretases mediated through melatonin receptors in human neuroblastoma SH‐SY5Y cells

Panmanee, J., Nopparat, C., Chavanich, N., Shukla, M., Mukda, S., Song, W., Vincent, B., & Govitrapong, P. (2015) · Journal of Pineal Research · doi:10.1111/jpi.12260 · Cited by 68 · see citing works

Network Medicine for Alzheimer’s Disease and Traditional Chinese Medicine

Jarrell, J. T., Gao, L., Cohen, D. S., & Huang, X. (2018) · Molecules · doi:10.3390/molecules23051143 · Cited by 67 · see citing works

Mild oxidative stress induces redistribution of BACE1 in non-apoptotic conditions and promotes the amyloidogenic processing of Alzheimer's disease amyloid precursor protein

Tan, J.-L., Li, Q.-X., Ciccotosto, G. D., Crouch, P. J., Culvenor, J. G., White, A. R., & Evin, G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061246 · Cited by 66 · see citing works

Melatonin ameliorates Aβ42‐induced alteration of β APP ‐processing secretases via the melatonin receptor through the Pin1/ GSK 3β/ NF ‐κB pathway in SH ‐ SY 5Y cells

Chinchalongporn, V., Shukla, M., & Govitrapong, P. (2018) · Journal of Pineal Research · doi:10.1111/jpi.12470 · Cited by 66 · see citing works

The amyloid precursor protein (APP) processing as a biological link between Alzheimer’s disease and cancer

Galvão, F., Grokoski, K. C., da Silva, B. B., Lamers, M. L., & Siqueira, I. R. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.11.007 · Cited by 66 · see citing works

Psychedelic‐inspired approaches for treating neurodegenerative disorders

Saeger, H. N., & Olson, D. E. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15544 · Cited by 65 · see citing works

Activation of AMPK by GLP-1R agonists mitigates Alzheimer-related phenotypes in transgenic mice

Zhang, Y., Chen, H., Feng, Y., Liu, M., Lu, Z., Hu, B., Chen, L., Zhang, Y., Liu, J., Cai, F., et al. (2025) · Nature Aging · doi:10.1038/s43587-025-00869-3 · Cited by 64 · see citing works

3K3A-activated protein C blocks amyloidogenic BACE1 pathway and improves functional outcome in mice

Lazić, D., Sagare, A. P., Nikolakopoulou, A. M., Griffin, J. H., Vassar, R. J., & Zloković, B. V. (2019) · The Journal of Experimental Medicine · doi:10.1084/jem.20181035 · Cited by 64 · see citing works

Hypoxia-Induced Neuroinflammation in Alzheimer’s Disease: Potential Neuroprotective Effects of Centella asiatica

Hambali, A., Kumar, J., Hashim, N. F. M., Maniam, S., Mehat, M. Z., Cheema, M. S., Mustapha, M., Adenan, M. I., Stanslas, J., & Hamid, H. A. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.712317 · Cited by 62 · see citing works

Revisiting the intersection of microglial activation and neuroinflammation in Alzheimer's disease from the perspective of ferroptosis

Wang, M., Tang, G., Zhou, C., Guo, H., Hu, Z., Hu, Q., & Li, G. (2023) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2023.110387 · Cited by 62 · see citing works

Exercise mimetics: a novel strategy to combat neuroinflammation and Alzheimer’s disease

Zhao, R. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03031-9 · Cited by 62 · see citing works

Epigallocatechin Gallate Attenuates β-Amyloid Generation and Oxidative Stress Involvement of PPARγ in N2a/APP695 Cells

Zhang, Z.-X., Li, Y., & Zhao, R. (2016) · Neurochemical Research · doi:10.1007/s11064-016-2093-8 · Cited by 60 · see citing works

Regulation of human BACE1 gene expression by NF-kappa B signaling

Chen, C.-H. A. (2011) · cIRcle (University of British Columbia) · doi:10.14288/1.0100990 · Cited by 1 · see citing works

Differential regulation of BACE1 promoter activity by nuclear factor‐κB in neurons and glia upon exposure to β‐amyloid peptides

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Transcriptional and translational regulation of BACE1 expression—Implications for Alzheimer's disease

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BAG-1M co-activates BACE1 transcription through NF-κB and accelerates Aβ production and memory deficit in Alzheimer’s disease mouse model

Shi, Z., Hong, Y., Zhang, K., Wang, J., Zheng, L., Zhang, Z., Hu, Z., Han, X., Han, Y., Chen, T., et al. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.05.014 · Cited by 27 · see citing works

P1–414: DNA decoy intervention of BACE1 synthesis in the guinea pig brain: A therapeutic approach

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