Burslem, George M.

Proteolysis-Targeting Chimeras as Therapeutics and Tools for Biological Discovery

Burslem, G. M., & Crews, C. M. (2020) · Cell

Protein Degradation and InhibitorsUbiquitin and proteasome pathways

Cited by 1,079

Lessons in PROTAC Design from Selective Degradation with a Promiscuous Warhead

Bondeson, D. P., Smith, B. E., Burslem, G. M., Buhimschi, A. D., Hines, J., Jaime-Figueroa, S., Wang, J., Hamman, B. D., Ishchenko, A., & Crews, C. M. (2018) · Cell Chemical Biology

Protein Degradation and InhibitorsUbiquitin and proteasome pathways

Cited by 923

The Advantages of Targeted Protein Degradation Over Inhibition: An RTK Case Study

Burslem, G. M., Smith, B. E., Lai, A. C., Jaime-Figueroa, S., McQuaid, D. C., Bondeson, D. P., Toure, M., Dong, H., Qian, Y., Wang, J., et al. (2018) · Cell Chemical Biology

Protein Degradation and InhibitorsChemical Synthesis and Analysis

Cited by 686

Targeting BCR-ABL1 in Chronic Myeloid Leukemia by PROTAC-Mediated Targeted Protein Degradation

Burslem, G. M., Schultz, A. R., Bondeson, D. P., Eide, C. A., Savage Stevens, S. L., Druker, B. J., & Crews, C. M. (2019) · Cancer Research

Protein Degradation and InhibitorsChronic Myeloid Leukemia Treatments

Cited by 212

Enhancing Antiproliferative Activity and Selectivity of a FLT-3 Inhibitor by Proteolysis Targeting Chimera Conversion

Burslem, G. M., Song, J., Chen, X., Hines, J., & Crews, C. M. (2018) · Journal of the American Chemical Society

Protein Degradation and InhibitorsAcute Myeloid Leukemia Research

Cited by 176

Hypoxia inducible factor (HIF) as a model for studying inhibition of protein–protein interactions

Burslem, G. M., Kyle, H. F., Nelson, A., Edwards, T. A., & Wilson, A. J. (2017) · Chemical Science

Cancer, Hypoxia, and MetabolismHeterocyclic Compound Synthesis and Bioactivity

Cited by 39

Pooled tagging and hydrophobic targeting of endogenous proteins for unbiased mapping of unfolded protein responses

Sansbury, S. E., Serebrenik, Y. V., Lapidot, T., Burslem, G. M., & Shalem, O. (2023) · Molecular Cell

Lipid Membrane Structure and BehaviorCellular transport and secretion

Cited by 21

Focused Libraries for Epigenetic Drug Discovery: The Importance of Isosteres: Miniperspective

Green, A. I., & Burslem, G. M. (2021) · Journal of Medicinal Chemistry

Computational Drug Discovery MethodsEpigenetics and DNA Methylation

Cited by 21

Acetylation: a new target for protein degradation in cancer

Crawford, C. E. W., & Burslem, G. M. (2025) · Trends in Cancer

Ubiquitin and proteasome pathwaysHistone Deacetylase Inhibitors Research

Cited by 20

The Interplay of Acetylation and Ubiquitination Controls PRMT1 Homeostasis

Najar, M. A., Beyer, J. N., Crawford, C. E. W., & Burslem, G. M. (2024) · bioRxiv (Cold Spring Harbor Laboratory)

Cancer-related gene regulationUbiquitin and proteasome pathways

Cited by 3