Montini, Eugenio

Lentiviral Hematopoietic Stem Cell Gene Therapy Benefits Metachromatic Leukodystrophy

Biffi, A., Montini, E., Lorioli, L., Cesani, M., Fumagalli, F., Plati, T., Baldoli, C., Martino, S., Calabria, A., Canale, S., et al. (2013) · Science

Virus-based gene therapy researchLysosomal Storage Disorders Research

Cited by 1,180

Lentiviral Hematopoietic Stem Cell Gene Therapy in Patients with Wiskott-Aldrich Syndrome

Aiuti, A., Biasco, L., Scaramuzza, S., Ferrua, F., Cicalese, M. P., Baricordi, C., Dionisio, F., Calabria, A., Giannelli, S., Castiello, M. C., et al. (2013) · Science

Virus-based gene therapy researchCAR-T cell therapy research

Cited by 1,025

The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy

Montini, E., Cesana, D., Schmidt, M., Sanvito, F., Bartholomae, C. C., Ranzani, M., Benedicenti, F., Sergi, L. S., Ambrosi, A., Ponzoni, M., et al. (2009) · Journal of Clinical Investigation

Virus-based gene therapy researchCRISPR and Genetic Engineering

Cited by 571

Targeted genome editing in human repopulating haematopoietic stem cells

Genovese, P., Schiroli, G., Escobar, G., Di Tomaso, T., Firrito, C., Calabria, A., Moi, D., Mazzieri, R., Bonini, C., Holmes, M. C., et al. (2014) · Nature

CRISPR and Genetic EngineeringVirus-based gene therapy research

Cited by 555

Lentiviral haemopoietic stem-cell gene therapy in early-onset metachromatic leukodystrophy: an ad-hoc analysis of a non-randomised, open-label, phase 1/2 trial

Sessa, M., Lorioli, L., Fumagalli, F., Acquati, S., Redaelli, D., Baldoli, C., Canale, S., Lopez, I. D., Morena, F., Calabria, A., et al. (2016) · The Lancet

Lysosomal Storage Disorders ResearchVirus-based gene therapy research

Cited by 502

AAV serotype 2 vectors preferentially integrate into active genes in mice

Nakai, H., Montini, E., Fuess, S., Storm, T. A., Grompe, M., & Kay, M. A. (2003) · Nature Genetics

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 392

Precise Gene Editing Preserves Hematopoietic Stem Cell Function following Transient p53-Mediated DNA Damage Response

Schiroli, G., Conti, A., Ferrari, S., della Volpe, L., Jacob, A., Albano, L., Beretta, S., Calabria, A., Vavassori, V., Gasparini, P., et al. (2019) · Cell Stem Cell

CRISPR and Genetic EngineeringDNA Repair Mechanisms

Cited by 342

Large‐scale molecular characterization of adeno‐associated virus vector integration in mouse liver

Nakai, H., Wu, X., Fuess, S., Storm, T. A., Munroe, D., Montini, E., Burgess, S. M., Grompe, M., & Kay, M. A. (2005) · Journal of Virology

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 190

Uncovering and Dissecting the Genotoxicity of Self-inactivating Lentiviral Vectors In Vivo

Cesana, D., Ranzani, M., Volpin, M., Bartholomae, C., Duros, C., Artus, A., Merella, S., Benedicenti, F., Sergi Sergi, L., Sanvito, F., et al. (2014) · Molecular Therapy

Virus-based gene therapy researchCRISPR and Genetic Engineering

Cited by 189

In vivo tracking of T cells in humans unveils decade-long survival and activity of genetically modified T memory stem cells

Biasco, L., Scala, S., Basso Ricci, L., Dionisio, F., Baricordi, C., Calabria, A., Giannelli, S., Cieri, N., Barzaghi, F., Pajno, R., et al. (2015) · Science Translational Medicine

Virus-based gene therapy researchT-cell and B-cell Immunology

Cited by 175

Liver-directed lentiviral gene therapy in a dog model of hemophilia B

Cantore, A., Ranzani, M., Bartholomae, C. C., Volpin, M., Valle, P. D., Sanvito, F., Sergi, L. S., Gallina, P., Benedicenti, F., Bellinger, D., et al. (2015) · Science Translational Medicine

Virus-based gene therapy researchHemophilia Treatment and Research

Cited by 158

Choice of template delivery mitigates the genotoxic risk and adverse impact of editing in human hematopoietic stem cells

Ferrari, S., Jacob, A., Cesana, D., Laugel, M., Beretta, S., Varesi, A., Unali, G., Conti, A., Canarutto, D., Albano, L., et al. (2022) · Cell stem cell

Virus-based gene therapy researchCRISPR and Genetic Engineering

Cited by 133

Helper‐independent and AAV‐ITR‐independent chromosomal integration of double‐stranded linear DNA vectors in mice

Nakai, H., Montini, E., Fuess, S., Storm, T. A., Meuse, L., Finegold, M., Grompe, M., & Kay, M. A. (2003) · Molecular Therapy

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 52

Oncogene-induced senescence in hematopoietic progenitors features myeloid restricted hematopoiesis, chronic inflammation and histiocytosis

Biavasco, R., Lettera, E., Giannetti, K., Gilioli, D., Beretta, S., Conti, A., Scala, S., Cesana, D., Gallina, P., Norelli, M., et al. (2021) · Nature Communications

Histiocytic Disorders and TreatmentsTelomeres, Telomerase, and Senescence

Cited by 47

Lentiviral Vector-based Insertional Mutagenesis Identifies Genes Involved in the Resistance to Targeted Anticancer Therapies

Ranzani, M., Annunziato, S., Calabria, A., Brasca, S., Benedicenti, F., Gallina, P., Naldini, L., & Montini, E. (2014) · Molecular Therapy

Virus-based gene therapy researchLung Cancer Treatments and Mutations

Cited by 17