In vivo tracking of T cells in humans unveils decade-long survival and activity of genetically modified T memory stem cells

Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

Sallusto, F., Lenig, D., Förster, R., Lipp, M., & Lanzavecchia, A. (1999) · Nature · doi:10.1038/44385 · Cited by 5,846 · see citing works

GREAT improves functional interpretation of cis-regulatory regions

McLean, C. Y., Bristor, D., Hiller, M., Clarke, S. L., Schaar, B. T., Lowe, C. B., Wenger, A. M., & Bejerano, G. (2010) · Nature Biotechnology · doi:10.1038/nbt.1630 · Cited by 4,502 · see citing works

A human memory T cell subset with stem cell–like properties

Gattinoni, L., Lugli, E., Ji, Y., Pos, Z., Paulos, C. M., Quigley, M. F., Almeida, J. R., Gostick, E., Yu, Z., Carpenito, C., et al. (2011) · Nature Medicine · doi:10.1038/nm.2446 · Cited by 1,974 · see citing works

Transcriptional control of effector and memory CD8+ T cell differentiation

Kaech, S. M., & Cui, W. (2012) · Nature Reviews Immunology · doi:10.1038/nri3307 · Cited by 1,628 · see citing works

T Lymphocyte-Directed Gene Therapy for ADA − SCID: Initial Trial Results After 4 Years

Blaese, R. M., Culver, K. W., Miller, A. D., Carter, C. S., Fleisher, T. A., Clerici, M., Shearer, G. M., Chang, L., Chiang, Y. L., Tolstoshev, P., et al. (1995) · Science · doi:10.1126/science.270.5235.475 · Cited by 1,546 · see citing works

Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients

Howe, S. J., Mansour, M. R., Schwarzwaelder, K., Bartholomae, C., Hubank, M., Kempski, H., Brugman, M. H., Pike-Overzet, K., Chatters, S. J., de Ridder, D., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci35798 · Cited by 1,286 · see citing works

Lentiviral Hematopoietic Stem Cell Gene Therapy Benefits Metachromatic Leukodystrophy

Biffi, A., Montini, E., Lorioli, L., Cesani, M., Fumagalli, F., Plati, T., Baldoli, C., Martino, S., Calabria, A., Canale, S., et al. (2013) · Science · doi:10.1126/science.1233158 · Cited by 1,180 · see citing works

Correction of ADA-SCID by Stem Cell Gene Therapy Combined with Nonmyeloablative Conditioning

Aiuti, A., Slavin, S., Aker, M., Ficara, F., Deola, S., Mortellaro, A., Morecki, S., Andolfi, G., Tabucchi, A., Carlucci, F., et al. (2002) · Science · doi:10.1126/science.1070104 · Cited by 1,137 · see citing works

Lentiviral Hematopoietic Stem Cell Gene Therapy in Patients with Wiskott-Aldrich Syndrome

Aiuti, A., Biasco, L., Scaramuzza, S., Ferrua, F., Cicalese, M. P., Baricordi, C., Dionisio, F., Calabria, A., Giannelli, S., Castiello, M. C., et al. (2013) · Science · doi:10.1126/science.1233151 · Cited by 1,025 · see citing works

Gene Therapy for Immunodeficiency Due to Adenosine Deaminase Deficiency

Aiuti, A., Cattaneo, F., Galimberti, S., Benninghoff, U., Cassani, B., Callegaro, L., Scaramuzza, S., Andolfi, G., Mirolo, M., Brigida, I., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0805817 · Cited by 1,003 · see citing works

Skewed maturation of memory HIV-specific CD8 T lymphocytes

Champagne, P., Ogg, G. S., King, A. S., Knabenhans, C., Ellefsen, K., Nobile, M., Appay, V., Rizzardi, G. P., Fleury, S., Lipp, M., et al. (2001) · Nature · doi:10.1038/35065118 · Cited by 1,002 · see citing works

Human memory T cells: generation, compartmentalization and homeostasis

Farber, D. L., Yudanin, N. A., & Restifo, N. P. (2014) · Nature Reviews Immunology · doi:10.1038/nri3567 · Cited by 897 · see citing works

Gene Therapy in Peripheral Blood Lymphocytes and Bone Marrow for ADA − Immunodeficient Patients

Bordignon, C., Notarangelo, L. D., Nobili, N., Ferrari, G., Casorati, G., Panina‐Bordignon, P., Mazzolari, E., Maggioni, D., Rossi, C., Servida, P., et al. (1995) · Science · doi:10.1126/science.270.5235.470 · Cited by 830 · see citing works

Decade-Long Safety and Function of Retroviral-Modified Chimeric Antigen Receptor T Cells

Scholler, J., Brady, T., Binder-Scholl, G. K., Hwang, W., Plesa, G., Hege, K. M., Vogel, A. N., Kalos, M. D., Riley, J. L., Deeks, S. G., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003761 · Cited by 651 · see citing works

IL-7 and IL-15 instruct the generation of human memory stem T cells from naive precursors.

Cieri, N., Camisa, B., Cocchiarella, F., Forcato, M., Oliveira, G., Provasi, E., Bondanza, A., Bordignon, C., Peccatori, J., Ciceri, F., et al. (2013) · Blood · doi:10.1182/blood-2012-05-431718 · Cited by 611 · see citing works

Proliferation and differentiation potential of human CD8+ memory T-cell subsets in response to antigen or homeostatic cytokines

Geginat, J., Lanzavecchia, A., & Sallusto, F. (2003) · Blood · doi:10.1182/blood-2002-11-3577 · Cited by 604 · see citing works

HIV-1 persistence in CD4+ T cells with stem cell–like properties

Buzón, M. J., Sun, H., Li, C., Shaw, A., Seiss, K., Ouyang, Z., Martín‐Gayo, E., Leng, J., Henrich, T. J., Li, J. Z., et al. (2014) · Nature Medicine · doi:10.1038/nm.3445 · Cited by 415 · see citing works

Disparate Individual Fates Compose Robust CD8 + T Cell Immunity

Buchholz, V. R., Floßdorf, M., Hensel, I., Kretschmer, L., Weißbrich, B., Gräf, P., Verschoor, A., Schiemann, M., Höfer, T., & Busch, D. H. (2013) · Science · doi:10.1126/science.1235454 · Cited by 406 · see citing works

Ex vivo gene transfer and correction for cell-based therapies

Naldini, L. (2011) · Nature Reviews Genetics · doi:10.1038/nrg2985 · Cited by 386 · see citing works

Diversity in T Cell Memory: An Embarrassment of Riches

Jameson, S. C., & Masopust, D. (2009) · Immunity · doi:10.1016/j.immuni.2009.11.007 · Cited by 382 · see citing works

Heterogeneous Differentiation Patterns of Individual CD8 + T Cells

Gerlach, C., Rohr, J., Perié, L., van Rooij, N., van Heijst, J. W. J., Velds, A., Urbanus, J. H. M., Naik, S. H., Jacobs, H., Beltman, J. B., et al. (2013) · Science · doi:10.1126/science.1235487 · Cited by 361 · see citing works

The Yellow Fever Virus Vaccine Induces a Broad and Polyfunctional Human Memory CD8+ T Cell Response

Akondy, R. S., Monson, N. D., Miller, J. D., Edupuganti, S., Teuwen, D. E., Wu, H. G., Quyyumi, F. F., Garg, S., Altman, J. D., del Rı́o, C., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803903 · Cited by 345 · see citing works

Superior T memory stem cell persistence supports long-lived T cell memory.

Lugli, E., Dominguez, M., Gattinoni, L., Chattopadhyay, P. K., Bolton, D., Song, K.-M., Klatt, N., Brenchley, J., Vaccari, M., Gostick, E., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci66327 · Cited by 321 · see citing works

Hematopoietic Stem Cell Gene Therapy for Adenosine Deaminase–Deficient Severe Combined Immunodeficiency Leads to Long-Term Immunological Recovery and Metabolic Correction

Gaspar, H. B., Cooray, S., Gilmour, K. C., Parsley, K. L., Zhang, F., Adams, S. P., Bjorkegren, E., Xu‐Bayford, J., Brown, L., Davies, E. G., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002716 · Cited by 284 · see citing works

Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy

Deichmann, A., Hacein‐Bey‐Abina, S., Schmidt, M., Garrigue, A., Brugman, M. H., Hu, J., Glimm, H., Gyapay, G., Prum, B., Fraser, C. C., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31659 · Cited by 257 · see citing works

Multilineage hematopoietic reconstitution without clonal selection in ADA-SCID patients treated with stem cell gene therapy

Aiuti, A., Cassani, B., Andolfi, G., Mirolo, M., Biasco, L., Recchia, A., Urbinati, F., Valacca, C., Scaramuzza, S., Aker, M., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31666 · Cited by 252 · see citing works

Long-term outcome after hematopoietic stem cell transplantation of a single-center cohort of 90 patients with severe combined immunodeficiency.

Neven, B., Leroy, S., Decaluwe, H., le Deist, F., Picard, C., Moshous, D., Mahlaoui, N., Debré, M., Casanova, J., Cortivo, L. D., et al. (2009) · Blood · doi:10.1182/blood-2008-09-177923 · Cited by 241 · see citing works

Gene therapy for adenosine deaminase–deficient severe combined immune deficiency: clinical comparison of retroviral vectors and treatment plans

Candotti, F., Shaw, K. L., Muul, L. M., Carbonaro, D. A., Sokolic, R. A., Choi, C., Schurman, S. H., Garabedian, E., Kesserwan, C. A., Jagadeesh, G. J., et al. (2012) · Blood · doi:10.1182/blood-2012-02-400937 · Cited by 233 · see citing works

Lineage relationship of effector and memory T cells

Restifo, N. P., & Gattinoni, L. (2013) · Current Opinion in Immunology · doi:10.1016/j.coi.2013.09.003 · Cited by 230 · see citing works

How I treat ADA deficiency

Gaspar, H. B., Aiuti, A., Porta, F., Candotti, F., Hershfield, M. S., & Notarangelo, L. D. (2009) · Blood · doi:10.1182/blood-2009-06-189209 · Cited by 217 · see citing works

Immune reconstitution in ADA-SCID after PBL gene therapy and discontinuation of enzyme replacement

Aiuti, A., Vai, S., Mortellaro, A., Casorati, G., Ficara, F., Andolfi, G., Ferrari, G., Tabucchi, A., Carlucci, F., Ochs, H. D., et al. (2002) · Nature Medicine · doi:10.1038/nm0502-423 · Cited by 207 · see citing works

Gammaretrovirus-mediated correction of SCID-X1 is associated with skewed vector integration site distribution in vivo

Schwarzwaelder, K., Howe, S. J., Schmidt, M., Brugman, M. H., Deichmann, A., Glimm, H., Schmidt, S. K., Prinz, C., Wissler, M., King, D., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31661 · Cited by 203 · see citing works

Resistance of mature T cells to oncogene transformation.

Newrzela, S., Cornils, K., Li, Z.-X., Baum, C., Brugman, M., Hartmann, M., Meyer, J., Hartmann, S., Hansmann, M., Fehse, B., et al. (2008) · Blood · doi:10.1182/blood-2007-12-128751 · Cited by 196 · see citing works

Lentiviral vector integration in the human genome induces alternative splicing and generates aberrant transcripts

Moiani, A., Paleari, Y., Sartori, D., Mezzadra, R., Miccio, A., Cattoglio, C., Cocchiarella, F., Lidonnici, M. R., Ferrari, G., & Mavilio, F. (2012) · Journal of Clinical Investigation · doi:10.1172/jci61852 · Cited by 183 · see citing works

T‐cell memory differentiation: insights from transcriptional signatures and epigenetics

Youngblood, B., Hale, J., & Ahmed, R. (2013) · Immunology · doi:10.1111/imm.12074 · Cited by 159 · see citing works

Whole transcriptome characterization of aberrant splicing events induced by lentiviral vector integrations

Cesana, D., Sgualdino, J., Rudilosso, L., Merella, S., Naldini, L., & Montini, E. (2012) · Journal of Clinical Investigation · doi:10.1172/jci62189 · Cited by 127 · see citing works

Retroviral Integrations in Gene Therapy Trials

Biasco, L., Baricordi, C., & Aiuti, A. (2012) · Molecular Therapy · doi:10.1038/mt.2011.289 · Cited by 126 · see citing works

Mechanisms of Retroviral Integration and Mutagenesis

Cavazza, A., Moiani, A., & Mavilio, F. (2013) · Human Gene Therapy · doi:10.1089/hum.2012.203 · Cited by 126 · see citing works

Integration profile of retroviral vector in gene therapy treated patients is cell-specific according to gene expression and chromatin conformation of target cell

Biasco, L., Ambrosi, A., Pellin, D., Bartholomae, C., Brigida, I., Roncarolo, M., Serio, C. D., von Kalle, C., Schmidt, M., & Aiuti, A. (2011) · EMBO Molecular Medicine · doi:10.1002/emmm.201000108 · Cited by 102 · see citing works

Early determinants of long-term T-cell reconstitution after hematopoietic stem cell transplantation for severe combined immunodeficiency

Borghans, J. A. M., Bredius, R. G. M., Hazenberg, M. D., Roelofs, H., der Zijde, E. C. J., Heidt, J., Otto, S. A., Kuijpers, T. W., Fibbe, W. E., Vossen, J. M. J. J., et al. (2006) · Blood · doi:10.1182/blood-2006-01-009241 · Cited by 77 · see citing works

Assessment of thymic output in common variable immunodeficiency patients by evaluation of T cell receptor excision circles

Guazzi, V., Aiuti, F., Mezzaroma, I., Mazzetta, F., Andolfi, G., Mortellaro, A., Pierdominici, M., Fantini, R., Marziali, M., & Aiuti, A. (2002) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2002.01893.x · Cited by 70 · see citing works

Reduced thymic output, increased spontaneous apoptosis and oligoclonal B cells in polyethylene glycol-adenosine deaminase-treated patients

Malacarne, F., Benicchi, T., Notarangelo, L. D., Mori, L., Parolini, S., Caimi, L., Hershfield, M. S., Notarangelo, L. D., & Imberti, L. (2005) · European Journal of Immunology · doi:10.1002/eji.200526248 · Cited by 67 · see citing works

Massively Parallel Pyrosequencing in HIV Research

Bushman, F., Hoffmann, C., Ronen, K., Malani, N., Minkah, N., Rose, H. M., Tebas, P., & Wang, G. P. (2008) · AIDS (London) · doi:10.1097/qad.0b013e3282fc972e · Cited by 65 · see citing works

The Different Extent of B and T Cell Immune Reconstitution after Hematopoietic Stem Cell Transplantation and Enzyme Replacement Therapies in SCID Patients with Adenosine Deaminase Deficiency

Serana, F., Sottini, A., Chiarini, M., Zanotti, C., Ghidini, C., Lanfranchi, A., Notarangelo, L. D., Caimi, L., & Imberti, L. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001770 · Cited by 62 · see citing works

B-cell development and functions and therapeutic options in adenosine deaminase–deficient patients

Brigida, I., Sauer, A. V., Ferrua, F., Giannelli, S., Scaramuzza, S., Pistoia, V., Castiello, M. C., Barendregt, B. H., Cicalese, M. P., Casiraghi, M., et al. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.12.1043 · Cited by 34 · see citing works

An embarrassment of riches

Klein, M. H., & Convertino, G. (2014) · Communications of the ACM · doi:10.1145/2629560 · Cited by 33 · see citing works

Integration of retroviral vectors

Gabriel, R., Schmidt, M., & Kalle, C. V. (2012) · Current Opinion in Immunology · doi:10.1016/j.coi.2012.08.006 · Cited by 29 · see citing works

Cutting Edge: The Signals for the Generation of T Cell Memory Are Qualitatively Different Depending on TCR Ligand Strength

Knudson, K. M., Hamilton, S. E., Daniëls, M. A., Jameson, S. C., & Teixeiro, E. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1300905 · Cited by 22 · see citing works

Role of reduced intensity conditioning in T-cell and B-cell immune reconstitution after HLA-identical bone marrow transplantation in ADA-SCID

Cancrini, C., Ferrua, F., Scarselli, A., Brigida, I., Romiti, M. L., Barera, G., Finocchi, A., Roncarolo, M., Caniglia, M., & Aiuti, A. (2010) · Haematologica · doi:10.3324/haematol.2010.025098 · Cited by 21 · see citing works

Parachuting in the epigenome: the biology of gene vector insertion profiles in the context of clinical trials

Baum, C. (2011) · EMBO Molecular Medicine · doi:10.1002/emmm.201000110 · Cited by 10 · see citing works

Gene therapy returns to centre stage

Naldini, L. (2015) · Nature · doi:10.1038/nature15818 · Cited by 1,184 · see citing works

T memory stem cells in health and disease

Gattinoni, L., Speiser, D. E., Lichterfeld, M. D., & Bonini, C. (2017) · Nature Medicine · doi:10.1038/nm.4241 · Cited by 619 · see citing works

Generation of clinical-grade CD19-specific CAR-modified CD8+ memory stem cells for the treatment of human B-cell malignancies

Sabatino, M., Hu, J., Sommariva, M., Gautam, S., Fellowes, V. S., Hocker, J. D., Dougherty, S. C., Qin, H., Klebanoff, C. A., Fry, T. J., et al. (2016) · Blood · doi:10.1182/blood-2015-11-683847 · Cited by 384 · see citing works

Successful and Maladaptive T Cell Aging

Goronzy, J. J., & Weyand, C. M. (2017) · Immunity · doi:10.1016/j.immuni.2017.03.010 · Cited by 362 · see citing works

Two subsets of stem-like CD8+ memory T cell progenitors with distinct fate commitments in humans

Galletti, G., De Simone, G., Mazza, E. M. C., Puccio, S., Mezzanotte, C., Bi, T. M., Davydov, A. N., Metsger, M., Scamardella, E., Alvisi, G., et al. (2020) · Nature Immunology · doi:10.1038/s41590-020-0791-5 · Cited by 299 · see citing works

Lentiviral gene therapy for X-linked chronic granulomatous disease

Kohn, D. B., Booth, C., Kang, E. M., Pai, S., Shaw, K. L., Santilli, G., Armant, M. A., Buckland, K. F., Choi, U., Ravin, S. S. D., et al. (2020) · Nature Medicine · doi:10.1038/s41591-019-0735-5 · Cited by 263 · see citing works

In vivo tracking of human hematopoiesis reveals patterns of clonal dynamics during early and steady-state reconstitution phases

Biasco, L., Pellin, D., Scala, S., Dionisio, F., Basso-Ricci, L., Leonardelli, L., Scaramuzza, S., Baricordi, C., Ferrua, F., Cicalese, M. P., et al. (2016) · Cell stem cell · doi:10.1016/j.stem.2016.04.016 · Cited by 243 · see citing works

The epigenetic control of stemness in CD8 + T cell fate commitment

Pace, L., Goudot, C., Zueva, E., Gueguen, P., Burgdorf, N., Waterfall, J. J., Quivy, J., Almouzni, G., & Amigorena, S. (2018) · Science · doi:10.1126/science.aah6499 · Cited by 232 · see citing works

The role of cytokines in T‐cell memory in health and disease

Raeber, M. E., Zurbuchen, Y., Impellizzieri, D., & Boyman, O. (2018) · Immunological Reviews · doi:10.1111/imr.12644 · Cited by 226 · see citing works

Long-lasting stem cell–like memory CD8 ⁺ T cells with a naïve-like profile upon yellow fever vaccination

Fuertes Marraco, S. A., Soneson, C., Cagnon, L., Gannon, P. O., Allard, M., Maillard, S. A., Montandon, N., Rufer, N., Waldvogel, S., Delorenzi, M., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aaa3700 · Cited by 206 · see citing works

Gene therapy targeting haematopoietic stem cells for inherited diseases: progress and challenges

Cavazzana, M., Bushman, F. D., Miccio, A., André‐Schmutz, I., & Six, E. M. (2019) · Nature Reviews Drug Discovery · doi:10.1038/s41573-019-0020-9 · Cited by 198 · see citing works

Bone marrow central memory and memory stem T-cell exhaustion in AML patients relapsing after HSCT

Noviello, M., Manfredi, F., Ruggiero, E., Perini, T., Oliveira, G., Cortesi, F., Simone, P. D., Toffalori, C., Gambacorta, V., Greco, R., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-08871-1 · Cited by 200 · see citing works

New cell sources for T cell engineering and adoptive immunotherapy

Themeli, M., Rivière, I., & Sadelain, M. (2015) · Cell stem cell · doi:10.1016/j.stem.2015.03.011 · Cited by 179 · see citing works

Induction of a central memory and stem cell memory phenotype in functionally active CD4+ and CD8+ CAR T cells produced in an automated good manufacturing practice system for the treatment of CD19+ acute lymphoblastic leukemia

Blaeschke, F., Stenger, D., Kaeuferle, T., Willier, S., Lotfi, R., Kaiser, A. D., Assenmacher, M., Döring, M., Feucht, J., & Feuchtinger, T. (2018) · Cancer Immunology, Immunotherapy · doi:10.1007/s00262-018-2155-7 · Cited by 155 · see citing works

Clonal expansion of T memory stem cells determines early anti-leukemic responses and long-term CAR T cell persistence in patients

Biasco, L., Izotova, N., Rivat, C., Ghorashian, S., Richardson, R., Guvenel, A., Hough, R., Wynn, R., Popova, B., Lopes, A., et al. (2021) · Nature Cancer · doi:10.1038/s43018-021-00207-7 · Cited by 138 · see citing works

IL15 and T-cell Stemness in T-cell–Based Cancer Immunotherapy

Pilipow, K., Roberto, A., Roederer, M., Waldmann, T. A., Mavilio, D., & Lugli, E. (2015) · Cancer Research · doi:10.1158/0008-5472.can-15-1498 · Cited by 136 · see citing works

Antioxidant metabolism regulates CD8+ T memory stem cell formation and antitumor immunity.

Pilipow, K., Scamardella, E., Puccio, S., Gautam, S., Paoli, F. D., Mazza, E. M. C., Simone, G. D., Polletti, S., Buccilli, M., Zanon, V., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.122299 · Cited by 127 · see citing works

CDK4/6 Inhibition Promotes Antitumor Immunity through the Induction of T-cell Memory

Lelliott, E. J., Kong, I. Y., Zethoven, M., Ramsbottom, K. M., Martelotto, L. G., Meyran, D., Zhu, J. J., Costacurta, M., Kirby, L., Sandow, J. J., et al. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-20-1554 · Cited by 129 · see citing works

T-cell defects in patients with ARPC1B germline mutations account for combined immunodeficiency

Brigida, I., Zoccolillo, M., Cicalese, M. P., Pfajfer, L., Barzaghi, F., Scala, S., Oleaga‐Quintas, C., Álvarez‐Álvarez, J. A., Sereni, L. P., Giannelli, S., et al. (2018) · Blood · doi:10.1182/blood-2018-07-863431 · Cited by 119 · see citing works

Tracking genetically engineered lymphocytes long-term reveals the dynamics of T cell immunological memory

Oliveira, G., Ruggiero, E., Stanghellini, M., Cieri, N., D'Agostino, M., Fronza, R., Lulay, C., Dionisio, F., Mastaglio, S., Greco, R., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aac8265 · Cited by 117 · see citing works

Improving CAR T-Cell Persistence

Pietrobon, V., Todd, L. A., Goswami, A., Stefanson, O., Yang, Z., & Marincola, F. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910828 · Cited by 118 · see citing works

Dynamics of genetically engineered hematopoietic stem and progenitor cells after autologous transplantation in humans

Scala, S., Ricci, L. B., Dionisio, F., Pellin, D., Giannelli, S., Salerio, F. A., Leonardelli, L., Cicalese, M. P., Ferrua, F., Aiuti, A., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0195-3 · Cited by 111 · see citing works

The Single-Cell Phenotypic Identity of Human CD8+ and CD4+ T Cells

Brummelman, J., Pilipow, K., & Lugli, E. (2018) · International review of cytology · doi:10.1016/bs.ircmb.2018.05.007 · Cited by 110 · see citing works

Understanding T cell phenotype for the design of effective chimeric antigen receptor T cell therapies

Tantalo, D. G. M., Oliver, A. J., von Scheidt, B., Harrison, A. J., Mueller, S. N., Kershaw, M. H., & Slaney, C. Y. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2021-002555 · Cited by 109 · see citing works

Stem, Effector, and Hybrid States of Memory CD8+ T Cells

Lugli, E., Galletti, G., Boi, S. K., & Youngblood, B. (2019) · Trends in Immunology · doi:10.1016/j.it.2019.11.004 · Cited by 106 · see citing works

Gene Therapy for X-Linked Severe Combined Immunodeficiency: Where Do We Stand?

Cavazzana, M., Six, E. M., Lagresle‐Peyrou, C., André‐Schmutz, I., & Hacein‐Bey‐Abina, S. (2016) · Human Gene Therapy · doi:10.1089/hum.2015.137 · Cited by 104 · see citing works

Neonatal thymectomy reveals differentiation and plasticity within human naive T cells

van den Broek, T., Delemarre, E. M., Janssen, W. J. M., Nievelstein, R. A. J., Broen, J. C., Tesselaar, K., Borghans, J. A. M., Nieuwenhuis, E. E. S., Prakken, B. J., Mokry, M., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci84997 · Cited by 104 · see citing works

Twenty-Five Years of Gene Therapy for ADA-SCID: From Bubble Babies to an Approved Drug

Ferrua, F., & Aiuti, A. (2017) · Human Gene Therapy · doi:10.1089/hum.2017.175 · Cited by 104 · see citing works

Automated manufacture of autologous CD19 CAR-T cells for treatment of non-hodgkin lymphoma

Jackson, Z., Roe, A., Sharma, A. A., Lopes, F. B. T. P., Talla, A., Kleinsorge-Block, S., Zamborsky, K., Schiavone, J., Manjappa, S., Schauner, R., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01941 · Cited by 102 · see citing works

Adoptive T-cell therapy for cancer: the era of engineered T cells

Bonini, C., & Mondino, A. (2015) · European Journal of Immunology · doi:10.1002/eji.201545552 · Cited by 93 · see citing works

Decentralized manufacturing of anti CD19 CAR-T cells using CliniMACS Prodigy®: real-world experience and cost analysis in India

Palani, H. K., Arunachalam, A. K., Yasar, M., Venkatraman, A., Kulkarni, U., Lionel, S. A., Selvarajan, S., Korula, A., Abraham, A., George, B., et al. (2023) · Bone Marrow Transplantation · doi:10.1038/s41409-022-01866-5 · Cited by 89 · see citing works

Surmounting the obstacles that impede effective CAR T cell trafficking to solid tumors

Donnadieu, E., Dupré, L., Pinho, L. G., & Cotta-de-Almeida, V. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.1mr0520-746r · Cited by 82 · see citing works

Improving Adoptive T Cell Therapy: The Particular Role of T Cell Costimulation, Cytokines, and Post-Transfer Vaccination

Redeker, A., & Arens, R. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00345 · Cited by 80 · see citing works

Clinical Applications of Gene Therapy for Primary Immunodeficiencies

Cicalese, M. P., & Aiuti, A. (2015) · Human Gene Therapy · doi:10.1089/hum.2015.047 · Cited by 79 · see citing works

Survival Advantage of Both Human Hepatocyte Xenografts and Genome-Edited Hepatocytes for Treatment of α-1 Antitrypsin Deficiency

Borel, F., Tang, Q., Gernoux, G., Greer, C., Wang, Z., Barzel, A., Kay, M. A., Shultz, L. D., Greiner, D. L., Flotte, T. R., et al. (2017) · Molecular Therapy · doi:10.1016/j.ymthe.2017.09.020 · Cited by 79 · see citing works

Reconstitution of T Cell Subsets Following Allogeneic Hematopoietic Cell Transplantation

Dekker, L., de Koning, C. C. H., Lindemans, C. A., & Nierkens, S. (2020) · Cancers · doi:10.3390/cancers12071974 · Cited by 78 · see citing works

Efficient recovery of potent tumour-infiltrating lymphocytes through quantitative immunomagnetic cell sorting

Wang, Z., Ahmed, S. U., Labib, M., Wang, H., Hu, X., Wei, J., Yao, Y., Moffat, J., Sargent, E. H., & Kelley, S. O. (2022) · Nature Biomedical Engineering · doi:10.1038/s41551-021-00820-y · Cited by 75 · see citing works

Current approaches to develop “off-the-shelf” chimeric antigen receptor (CAR)-T cells for cancer treatment: a systematic review

Aparicio, C., Acebal, C., & González‐Vallinas, M. (2023) · Experimental Hematology and Oncology · doi:10.1186/s40164-023-00435-w · Cited by 75 · see citing works

Human TSCM cell dynamics in vivo are compatible with long-lived immunological memory and stemness

del Amo, P. C., Lahoz-Beneytez, J., Boelen, L., Ahmed, R., Miners, K. L., Zhang, Y., Roger, L., Jones, R. E., Marraco, S. A. F., Speiser, D. E., et al. (2018) · PLoS Biology · doi:10.1371/journal.pbio.2005523 · Cited by 74 · see citing works

From humble beginnings to success in the clinic: Chimeric antigen receptor-modified T-cells and implications for immunotherapy

Firor, A. E., Jares, A., & Ma, Y. (2015) · Experimental Biology and Medicine · doi:10.1177/1535370215584936 · Cited by 71 · see citing works

The antitumor capacity of mesothelin-CAR-T cells in targeting solid tumors in mice

Zhang, Q., Liu, G., Liu, J., Yang, M., Fu, J. L., Liu, G., Li, D., Gu, Z., Zhang, L., Pan, Y., et al. (2021) · Molecular Therapy — Oncolytics · doi:10.1016/j.omto.2021.02.013 · Cited by 70 · see citing works

In Situ Programming of CAR T Cells

Parayath, N. N., & Stephan, M. T. (2021) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-070620-033348 · Cited by 71 · see citing works

Harnessing CD3 diversity to optimize CAR T cells

Cárdenas, R. M.-H. V., Brandl, S. M., Meléndez, A. V., Schlaak, A. E., Buschky, A., Peters, T., Beier, F., Serrels, B., Taromi, S., Raute, K., et al. (2023) · Nature Immunology · doi:10.1038/s41590-023-01658-z · Cited by 70 · see citing works

Quantitative stability of hematopoietic stem and progenitor cell clonal output in rhesus macaques receiving transplants

Koelle, S., Espinoza, D. A., Wu, C., Xu, J., Lu, R., Li, B., Donahue, R. E., & Dunbar, C. E. (2017) · Blood · doi:10.1182/blood-2016-07-728691 · Cited by 61 · see citing works

Immune Reconstitution Following Autologous Hematopoietic Stem Cell Transplantation for Multiple Sclerosis: A Review on Behalf of the EBMT Autoimmune Diseases Working Party

Cencioni, M. T., Genchi, A., Brittain, G., de Silva, T. I., Sharrack, B., Snowden, J. A., Alexander, T., Greco, R., & Muraro, P. A. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2021.813957 · Cited by 60 · see citing works

Cas-CLOVER is a novel high-fidelity nuclease for safe and robust generation of TSCM-enriched allogeneic CAR-T cells

Madison, B., Patil, D., Richter, M., Li, X., Tong, M., Cranert, S., Wang, X.-X., Martin, R. M., Xi, H.-B., Tan, Y., et al. (2022) · Molecular Therapy: Nucleic Acids · doi:10.1016/j.omtn.2022.06.003 · Cited by 58 · see citing works

T-cell exhaustion and stemness in antitumor immunity: Characteristics, mechanisms, and implications

Chi, X., Luo, S., Ye, P., Hwang, W., Cha, J., Yan, X., & Yang, W. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1104771 · Cited by 59 · see citing works

Comprehensive Approach for Identifying the T Cell Subset Origin of CD3 and CD28 Antibody–Activated Chimeric Antigen Receptor–Modified T Cells

Schmueck‐Henneresse, M., Omer, B. A., Shum, T., Tashiro, H., Mamonkin, M., Lapteva, N., Sharma, S., Rollins, L. A., Dotti, G., Reinke, P., et al. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601494 · Cited by 57 · see citing works

Functional, Antigen-Specific Stem Cell Memory (TSCM) CD4+ T Cells Are Induced by Human Mycobacterium tuberculosis Infection

Mpande, C. A. M., Dintwe, O., Musvosvi, M., Mabwe, S., Bilek, N., Hatherill, M., Nemes, E., & Scriba, T. J. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00324 · Cited by 53 · see citing works

CRISPR-based gene disruption and integration of high-avidity, WT1-specific T cell receptors improve antitumor T cell function

Ruggiero, E., Carnevale, E., Prodeus, A., Magnani, Z. I., Camisa, B., Merelli, I., Politano, C., Stasi, L., Potenza, A., Cianciotti, B. C., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abg8027 · Cited by 54 · see citing works

The Role of Conditioning in Hematopoietic Stem-Cell Gene Therapy

Bernardo, M. E., & Aiuti, A. (2016) · Human Gene Therapy · doi:10.1089/hum.2016.103 · Cited by 54 · see citing works

Stem cell like memory T cells: A new paradigm in cancer immunotherapy

Wang, F., Cheng, F., & Fang, Z. (2022) · Clinical Immunology · doi:10.1016/j.clim.2022.109078 · Cited by 50 · see citing works

The Progress and Prospects of Immune Cell Therapy for the Treatment of Cancer

Han, J., Zhang, B., Zheng, S., Jiang, Y. H., Zhang, X., & Mao, K. (2024) · Cell Transplantation · doi:10.1177/09636897241231892 · Cited by 53 · see citing works

Progress and challenges in developing allogeneic cell therapies

Deuse, T., & Schrepfer, S. (2025) · Cell Stem Cell · doi:10.1016/j.stem.2025.03.004 · Cited by 51 · see citing works

Multiparameter comparative analysis reveals differential impacts of various cytokines on CART cell phenotype and function ex vivo and in vivo

Xu, X., Song, D.-G., Poussin, M., Ye, Q., Sharma, P., Rodríguez-García, A., Tang, Y., & Powell, D. J. (2016) · Oncotarget · doi:10.18632/oncotarget.10510 · Cited by 51 · see citing works

Effect of the mitophagy inducer urolithin A on age-related immune decline: a randomized, placebo-controlled trial

Denk, D., Singh, A., Kasler, H. G., D’Amico, D., Rey, J., Alcober-Boquet, L., Gorol, J. M., Steup, C., Tiwari, R., Kwok, R., et al. (2025) · Nature Aging · doi:10.1038/s43587-025-00996-x · Cited by 53 · see citing works

Stem cell-like memory T cells: The generation and application

Wang, Y., Qiu, F., Xu, Y., Hou, X., Zhang, Z., Huang, L., Wang, H., Xing, H., & Wu, S. (2021) · Journal of Leukocyte Biology · doi:10.1002/jlb.5mr0321-145r · Cited by 49 · see citing works

Prolonged Antiretroviral Therapy Preserves HIV-1-Specific CD8 T Cells with Stem Cell-Like Properties

Viganó, S., Negron, J., Ouyang, Z., Rosenberg, E. S., Walker, B. D., Lichterfeld, M. D., & Yu, X. G. (2015) · Journal of Virology · doi:10.1128/jvi.00789-15 · Cited by 47 · see citing works

T-Cell Therapy: Options for Infectious Diseases: Table 1.

Parida, S. K., Poiret, T., Zhenjiang, L., Meng, Q., Heyckendorf, J., Lange, C. G., Ambati, A., Rao, M., Valentini, D., Ferrara, G., et al. (2015) · Clinical Infectious Diseases · doi:10.1093/cid/civ615 · Cited by 47 · see citing works

Development and Function of Protective and Pathologic Memory CD4 T Cells

Jaigirdar, S. A., & MacLeod, M. K. L. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00456 · Cited by 46 · see citing works

The roles of stem cell memory T cells in hematological malignancies

Xu, L., Zhang, Y., Luo, G., & Li, Y. (2015) · Journal of Hematology & Oncology · doi:10.1186/s13045-015-0214-5 · Cited by 46 · see citing works

Immunological history governs human stem cell memory CD4 heterogeneity via the Wnt signaling pathway

Kared, H., Tan, S. W., Lau, M. C., Chevrier, M., Tan, C. T. Y., How, W., Wong, G. C. L., Strickland, M., Malleret, B., Amoah, A., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14442-6 · Cited by 46 · see citing works

Analyzing the Genotoxicity of Retroviral Vectors in Hematopoietic Cell Gene Therapy

Biasco, L., Rothe, M., Büning, H., & Schambach, A. (2017) · Molecular Therapy: Methods & Clinical Development · doi:10.1016/j.omtm.2017.10.002 · Cited by 35 · see citing works

CD4+ Memory Stem T Cells Recognizing Citrullinated Epitopes Are Expanded in Patients With Rheumatoid Arthritis and Sensitive to Tumor Necrosis Factor Blockade

Cianciotti, B. C., Ruggiero, E., Campochiaro, C., Oliveira, G., Magnani, Z. I., Baldini, M., Doglio, M., Tassara, M. G., Manfredi, A. A., Baldissera, E. M., et al. (2019) · Arthritis & Rheumatology · doi:10.1002/art.41157 · Cited by 45 · see citing works

Schrödinger’s T Cells: Molecular Insights Into Stemness and Exhaustion

Gonzalez, N. M., Zou, D., Gu, A., & Chen, W. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.725618 · Cited by 45 · see citing works

Interrupting the nitrosative stress fuels tumor-specific cytotoxic T lymphocytes in pancreatic cancer

Sanctis, F. D., Lamolinara, A., Boschi, F., Musiu, C., Caligola, S., Trovato, R., Fiore, A., Frusteri, C., Anselmi, C., Poffe, O., et al. (2022) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2021-003549 · Cited by 46 · see citing works

T Cell Reprogramming Against Cancer

Katz, S. G., & Rabinovich, P. M. (2019) · Methods in molecular biology · doi:10.1007/978-1-0716-0203-4_1 · Cited by 44 · see citing works

Effect of radiotherapy on T cell and PD-1 / PD-L1 blocking therapy in tumor microenvironment

Chen, C., Liu, Y., & Cui, B. (2021) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2020.1840254 · Cited by 42 · see citing works

Transfer of gene-corrected T cells corrects humoral and cytotoxic defects in patients with X-linked lymphoproliferative disease

Panchal, N., Houghton, B., Díez, B., Ghosh, S., Ricciardelli, I., Thrasher, A. J., Gaspar, H. B., & Booth, C. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2018.02.053 · Cited by 41 · see citing works

CD276-CAR T cells and Dual-CAR T cells targeting CD276/FGFR4 promote rhabdomyosarcoma clearance in orthotopic mouse models

Timpanaro, A., Piccand, C., Dzhumashev, D., Anton-Joseph, S., Robbi, A., Moser, J. J., Rössler, J. K., & Bernasconi, M. (2023) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-023-02838-3 · Cited by 36 · see citing works

Synthetic biology approaches to engineer T cells

Wu, C., Rupp, L. J., Roybal, K. T., & Lim, W. A. (2015) · Current Opinion in Immunology · doi:10.1016/j.coi.2015.06.015 · Cited by 36 · see citing works

Reversion Mosaicism in Primary Immunodeficiency Diseases

Miyazawa, H., & Wada, T. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.783022 · Cited by 34 · see citing works

Reference range of naïve T and T memory lymphocyte subsets in peripheral blood of healthy adult

Xia, Y., Liu, A., Li, W., Liu, Y., Zhang, G., Ye, S., Zhao, Z.-R., Shi, J., Jia, Y., Liu, X., et al. (2021) · Clinical & Experimental Immunology · doi:10.1093/cei/uxab038 · Cited by 34 · see citing works

Meeting FDA Guidance recommendations for replication-competent virus and insertional oncogenesis testing

Cornetta, K. G., Lin, T., Pellin, D., & Kohn, D. B. (2022) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2022.11.009 · Cited by 33 · see citing works

Hematopoiesis during Ontogenesis, Adult Life, and Aging

Belyavsky, A. V., Петинати, Н. А., & Дризе, Н. И. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179231 · Cited by 32 · see citing works

TIM-3, LAG-3, or 2B4 gene disruptions increase the anti-tumor response of engineered T cells

Cianciotti, B. C., Magnani, Z. I., Ugolini, A., Camisa, B., Merelli, I., Vavassori, V., Potenza, A., Imparato, A., Manfredi, F., Abbati, D., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1315283 · Cited by 31 · see citing works

Gene-corrected human Munc13-4–deficient CD8+ T cells can efficiently restrict EBV-driven lymphoproliferation in immunodeficient mice

Soheili, T. S., Rivière, J., Ricciardelli, I., Durand, A., Verhoeyen, E., Derrien, A., Lagresle‐Peyrou, C., Basile, G. D. S., Cosset, F., Amrolia, P. J., et al. (2016) · Blood · doi:10.1182/blood-2016-07-729871 · Cited by 30 · see citing works

The TRACE-Seq method tracks recombination alleles and identifies clonal reconstitution dynamics of gene targeted human hematopoietic stem cells

Sharma, R., Dever, D. P., Lee, C. M., Azizi, A., Pan, Y., Camarena, J., Köhnke, T., Bao, G., Porteus, M. H., & Majeti, R. (2021) · Nature Communications · doi:10.1038/s41467-020-20792-y · Cited by 30 · see citing works

The impact of inflationary cytomegalovirus‐specific memory T cells on anti‐tumour immune responses in patients with cancer

Luo, X., Meng, Q., Rao, M., Liu, Z., Paraschoudi, G., Dodoo, E., & Maeurer, M. J. (2018) · Immunology · doi:10.1111/imm.12991 · Cited by 32 · see citing works

Curtailed T‐cell activation curbs effector differentiation and generates CD8+ T cells with a naturally‐occurring memory stem cell phenotype

Zanon, V., Pilipow, K., Scamardella, E., Paoli, F. D., Simone, G. D., Price, D., Martinez-Usatorre, A., Romero, P., Mavilio, D., Roberto, A., et al. (2017) · European Journal of Immunology · doi:10.1002/eji.201646732 · Cited by 28 · see citing works

Effective control of acute myeloid leukaemia and acute lymphoblastic leukaemia progression by telomerase specific adoptive T-cell therapy

Sandri, S., Sanctis, F. D., Lamolinara, A., Boschi, F., Poffe, O., Trovato, R., Fiore, A., Sartori, S., Sbarbati, A., Bondanza, A., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.18115 · Cited by 29 · see citing works

Circulating hematopoietic stem/progenitor cell subsets contribute to human hematopoietic homeostasis

Quaranta, P., Ricci, L. B., Hernández, R. J., Pacini, G., Naldini, M. M., Barcella, M., Seffin, L., Pais, G., Spinozzi, G., Benedicenti, F., et al. (2024) · Blood · doi:10.1182/blood.2023022666 · Cited by 27 · see citing works

CAR T Cells Generated Using Sleeping Beauty Transposon Vectors and Expanded with an EBV-Transformed Lymphoblastoid Cell Line Display Antitumor Activity In Vitro and In Vivo

Chicaybam, L., Abdo, L. D. M., Carneiro, M., Peixoto, B., Viegas, M. S., de Sousa, P., Fornazin, M. C., Spago, M. C., Laranjeira, A. B. A., de Campos-Lima, P. O., et al. (2019) · Human Gene Therapy · doi:10.1089/hum.2018.218 · Cited by 27 · see citing works

Initiation of Antiretroviral Therapy Restores CD4 + T Memory Stem Cell Homeostasis in Simian Immunodeficiency Virus-Infected Macaques

Cartwright, E. K., Palesch, D., Mavigner, M., Paiardini, M., Chahroudi, A., & Silvestri, G. (2016) · Journal of Virology · doi:10.1128/jvi.00492-16 · Cited by 26 · see citing works

The construction of modular universal chimeric antigen receptor T (MU-CAR-T) cells by covalent linkage of allogeneic T cells and various antibody fragments

Chen, T., Deng, J., Zhang, Y., Liu, B., Liu, R., Zhu, Y., Zhou, M., Lin, Y., Xia, B., Lin, K., et al. (2024) · Molecular Cancer · doi:10.1186/s12943-024-01938-8 · Cited by 25 · see citing works

Preclinical Efficacy and Safety Evaluation of Hematopoietic Stem Cell Gene Therapy in a Mouse Model of MNGIE

Yadak, R., Cabrera-Pérez, R., Torres‐Torronteras, J., Bugiani, M., Haeck, J. C., Huston, M. W., Bogaerts, E., Goffart, S., Jacobs, E. H., Stok, M., et al. (2018) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2018.01.001 · Cited by 25 · see citing works

Naive and Stem Cell Memory T Cell Subset Recovery Reveals Opposing Reconstitution Patterns in CD4 and CD8 T Cells in Chronic Graft vs. Host Disease

Soares, M. V. D., Azevedo, R. I., Ferreira, I., Bucar, S., Ribeiro, A. C., Vieira, A. I. S., Pereira, P. N. G., Ribeiro, R. M., Ligeiro, D., Alho, A. C., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00334 · Cited by 24 · see citing works

CD40 Accelerates the Antigen-Specific Stem-Like Memory CD8+ T Cells Formation and Human Papilloma Virus (HPV)-Positive Tumor Eradication

Zhang, Y., Wang, N., Ding, M., Yang, Y., Wang, Z., Huang, L., Zhu, W., Mellor, A. L., Hou, X., Zhou, C., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01012 · Cited by 23 · see citing works

Early-phenotype CAR-T cells for the treatment of pediatric cancers

Meyran, D., Terry, R. L., Zhu, J. J., Haber, M., Ziegler, D. S., Ekert, P. G., Trapani, J. A., Darcy, P. K., & Neeson, P. J. (2021) · Annals of Oncology · doi:10.1016/j.annonc.2021.07.018 · Cited by 23 · see citing works

Nonclinical safety assessment of engineered T cell therapies

Lebrec, H. N., Maier, C. C., Maki, K., Ponce, R. A., Shenton, J. M., & Green, S. (2021) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2021.105064 · Cited by 25 · see citing works

CD8-positive memory T cells in tumor-draining lymph nodes of patients with breast cancer

Vahidi, Y., Bagheri, M., Ghaderi, A. A., & Faghih, Z. (2020) · BMC Cancer · doi:10.1186/s12885-020-6714-x · Cited by 23 · see citing works

Memory T Cells in the Immunoprevention of Cancer: A Switch from Therapeutic to Prophylactic Approaches

Mittra, S., Harding, S. M., & Kaech, S. M. (2023) · The Journal of Immunology · doi:10.4049/jimmunol.2300049 · Cited by 19 · see citing works

Genome-edited adult stem cells: Next-generation advanced therapy medicinal products

Benabdellah, K., Sánchez-Hernández, S., Aguilar-González, A., Maldonado‐Pérez, N., Gutiérrez-Guerrero, A., Cortijo-Gutierréz, M., Ramos-Hernández, I., Tristán‐Manzano, M., Galindo‐Moreno, P., Herrera, C., et al. (2020) · Stem Cells Translational Medicine · doi:10.1002/sctm.19-0338 · Cited by 21 · see citing works

Haematopoietic stem cell transplantation for severe autoimmune diseases in children: A review of current literature, registry activity and future directions on behalf of the autoimmune diseases and paediatric diseases working parties of the European Society for Blood and Marrow Transplantation

Achini, F., Snowden, J. A., Corbacioglu, S., Greco, R., & Parties, T. E. A. D. (. A. P. D. (. W. (2022) · British Journal of Haematology · doi:10.1111/bjh.18176 · Cited by 19 · see citing works

Efficient derivation of chimeric-antigen receptor-modified TSCM cells

Kranz, E. O., Kuhlmann, C. J., Chan, J., Kim, P. Y., Chen, I. S. Y., & Kamata, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.877682 · Cited by 19 · see citing works

Tissue‐resident and memory properties of human T‐cell and NK‐cell subsets

Lugli, E., Hudspeth, K. L., Roberto, A., & Mavilio, D. (2016) · European Journal of Immunology · doi:10.1002/eji.201545702 · Cited by 18 · see citing works

Characterizing Hepatitis C Virus–Specific CD4+ T Cells Following Viral‐Vectored Vaccination, Directly Acting Antivirals, and Spontaneous Viral Cure

Hartnell, F., Esposito, I., Swadling, L., Brown, A., Phetsouphanh, C., de Lara, C., Gentile, C., Turner, B., Dorrell, L., Capone, S., et al. (2020) · Hepatology · doi:10.1002/hep.31160 · Cited by 18 · see citing works

Allogeneic gene-edited HIV-specific CAR-T cells secreting PD-1 blocking scFv enhance specific cytotoxic activity against HIV Env+ cells in vivo

Pan, H., Yang, X., Wang, J., Liang, H., Jiang, Z., Zhao, L., Wang, Y., Liang, Z., Shen, X., Lin, Q., et al. (2023) · Virologica Sinica · doi:10.1016/j.virs.2023.01.003 · Cited by 19 · see citing works

Integrating Vectors for Gene Therapy and Clonal Tracking of Engineered Hematopoiesis

Biasco, L., Rothe, M., Schott, J. W., & Schambach, A. (2017) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2017.06.009 · Cited by 17 · see citing works

T cell gene therapy to treat immunodeficiency

Panchal, N., Ghosh, S., & Booth, C. (2020) · British Journal of Haematology · doi:10.1111/bjh.17070 · Cited by 17 · see citing works

Long-term tracking of transplanted T cells

Colmone, A. C. (2015) · Science · doi:10.1126/science.347.6222.623-e

T cell therapies-are T memory stem cells the answer?

Flynn, J. K., & Gorry, P. R. (2015) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.2305-5839.2015.08.13 · Cited by 8 · see citing works

Tracking genetically engineered lymphocytes long-term reveals the dynamics of T cell immunological memory

Oliveira, G., Ruggiero, E., Stanghellini, M., Cieri, N., D'Agostino, M., Fronza, R., Lulay, C., Dionisio, F., Mastaglio, S., Greco, R., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aac8265 · Cited by 117 · see citing works

Immune cell tracking following hematopoietic cell and gene therapy

Izotova, N. (2022) · UCL Discovery (University College London)

Human TSCM cell dynamics in vivo are compatible with long-lived immunological memory and stemness

del Amo, P. C., Lahoz-Beneytez, J., Boelen, L., Ahmed, R., Miners, K. L., Zhang, Y., Roger, L., Jones, R. E., Marraco, S. A. F., Speiser, D. E., et al. (2018) · PLoS Biology · doi:10.1371/journal.pbio.2005523 · Cited by 74 · see citing works