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SUMO—Nonclassical Ubiquitin

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E2F target genes: unraveling the biology

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P19 ARF stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2

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ARF-BP1/Mule Is a Critical Mediator of the ARF Tumor Suppressor

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Tumor Suppressor ARF Degrades B23, a Nucleolar Protein Involved in Ribosome Biogenesis and Cell Proliferation

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Yin Yang 1 Is a Negative Regulator of p53

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The Ubiquitin Ligase HectH9 Regulates Transcriptional Activation by Myc and Is Essential for Tumor Cell Proliferation

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MYC recruits the TIP60 histone acetyltransferase complex to chromatin

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Physical and Functional Interactions of the Arf Tumor Suppressor Protein with Nucleophosmin/B23

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Foxm1b transcription factor is essential for development of hepatocellular carcinomas and is negatively regulated by the p19ARF tumor suppressorPreprint

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p53-independent functions of the p19ARF tumor suppressorPreprint

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Evidence of p53-Dependent Cross-Talk between Ribosome Biogenesis and the Cell Cycle: Effects of Nucleolar Protein Bop1 on G1/S Transition

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Nucleophosmin (B23) Targets ARF to Nucleoli and Inhibits Its Function

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Repression of RNA Polymerase I Transcription by the Tumor Suppressor p53

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p16INK4A and p19ARF act in overlapping pathways in cellular immortalization

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Nucleolar Arf Tumor Suppressor Inhibits Ribosomal RNA Processing

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Cooperative Signals Governing ARF-Mdm2 Interaction and Nucleolar Localization of the Complex

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Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress

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Mapping the Functional Domains of Nucleolar Protein B23

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Nucleolar protein B23 has molecular chaperone activities

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Stabilization of p53 by p14ARF without relocation of MDM2 to the nucleolus

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A Short Mitochondrial Form of p19ARF Induces Autophagy and Caspase-Independent Cell Death

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Nucleophosmin Is Essential for Ribosomal Protein L5 Nuclear Export

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Cancer-associated mutations at the INK4a locus cancel cell cycle arrest by p16 INK4a but not by the alternative reading frame protein p19 ARF

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p19ARF directly and differentially controls the functions of c-Myc independently of p53

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Nucleophosmin Is Required for DNA Integrity and p19Arf Protein Stability

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N-terminal polyubiquitination and degradation of the Arf tumor suppressorPreprint

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p53- and Mdm2-Independent Repression of NF-κB Transactivation by the ARF Tumor Suppressor

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Identification of a cryptic nucleolar-localization signal in MDM2

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Control of p53 ubiquitination and nuclear export by MDM2 and ARF.

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Repression of the Arf tumor suppressor by E2F3 is required for normal cell cycle kineticsPreprint

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A novel norindenoisoquinoline structure reveals a common interfacial inhibitor paradigm for ternary trapping of the topoisomerase I-DNA covalent complex

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p19ARF targets certain E2F species for degradation

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Human ARF binds E2F1 and inhibits its transcriptional activity

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Regulation of NF‐κB and p53 through activation of ATR and Chk1 by the ARF tumour suppressor

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ARF Impedes NPM/B23 Shuttling in an Mdm2-Sensitive Tumor Suppressor Pathway

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p53 represses ribosomal gene transcription

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Defective double-strand DNA break repair and chromosomal translocations by MYC overexpression

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ATM promotes apoptosis and suppresses tumorigenesis in response to Myc

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Efficient IgG-mediated suppression of primary antibody responses in Fcγ receptor-deficient mice

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Delocalization and Destabilization of the Arf Tumor Suppressor by the Leukemia-Associated NPM Mutant

Colombo, E., Martinelli, P., Zamponi, R., Shing, D. C., Bonetti, P., Luzi, L., Volorio, S., Bernard, L., Pruneri, G., Alcalay, M., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-2378 · Cited by 145 · see citing works

A senescence rescue screen identifies BCL6 as an inhibitor of anti-proliferative p19 ARF –p53 signalingPreprint

Shvarts, A., Brummelkamp, T. R., Scheeren, F., Koh, E., Daley, G. Q., Spits, H., & Bernards, R. (2002) · Genes & Development · doi:10.1101/gad.929302 · Cited by 142 · see citing works

MDM2-ARF complex regulates p53 sumoylation

Chen, L., & Chen, J. (2003) · Oncogene · doi:10.1038/sj.onc.1206851 · Cited by 134 · see citing works

Hitting their targets: an emerging picture of E2F and cell cycle control

Blais, A., & Dynlacht, B. D. (2004) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2004.07.003 · Cited by 131 · see citing works

Cyclin G1 has growth inhibitory activity linked to the ARF-Mdm2-p53 and pRb tumor suppressor pathways.

Zhao, L., Samuels, T. L., Winckler, S., Korgaonkar, C. K., Tompkins, V. S., Horne, M. C., & Quelle, D. E. (2003) · PubMed · Cited by 126 · see citing works

Sumoylation induced by the Arf tumor suppressor: A p53-independent function

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E2F transcriptional repressor complexes are critical downstream targets of p19ARF/p53-induced proliferative arrest

Rowland, B. D., Denissov, S. G., Douma, S., Stunnenberg, H. G., Bernards, R., & Peeper, D. S. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00085-5 · Cited by 120 · see citing works

The Arf tumor suppressor gene promotes hyaloid vascular regression during mouse eye development

McKeller, R. N., Fowler, J. L., Cunningham, J. J., Warner, N., Smeyne, R. J., Zindy, F., & Skapek, S. X. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.052484199 · Cited by 118 · see citing works

p14ARF induces G2 arrest and apoptosis independently of p53 leading to regression of tumours established in nude mice

Eymin, B., Leduc, C., Coll, J., Brambilla, E. M., & Gazzéri, S. (2003) · Oncogene · doi:10.1038/sj.onc.1206303 · Cited by 117 · see citing works

Histone modifications: Now summoning sumoylation

Nathan, D., Sterner, D. E., & Berger, S. L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2436173100 · Cited by 116 · see citing works

Myc-ARF (Alternate Reading Frame) Interaction Inhibits the Functions of Myc

Datta, A., Nag, A., Pan, W., Hay, N., Gartel, A. L., Colamonici, O. R., Mori, Y., & Raychaudhuri, P. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312305200 · Cited by 112 · see citing works

Myeloid Leukemia-Associated Nucleophosmin Mutants Perturb p53-Dependent and Independent Activities of the Arf Tumor Suppressor Protein

den Besten, W., Kuo, M.-L., Williams, R. T., & Sherr, C. J. (2005) · Cell Cycle · doi:10.4161/cc.4.11.2174 · Cited by 109 · see citing works

Adenovirus-mediated overexpression of p14ARF induces p53 and Bax-independent apoptosis

Hemmati, P., Gillissen, B. F., von Haefen, C., Wendt, J., Stärck, L., Güner, D., Dörken, B., & Daniel, P. T. (2002) · Oncogene · doi:10.1038/sj.onc.1205458 · Cited by 109 · see citing works

The p14ARF Tumor Suppressor Protein Facilitates Nucleolar Sequestration of Hypoxia-inducible Factor-1α (HIF-1α) and Inhibits HIF-1-mediated Transcription

Fátyol, K., & Szalay, A. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102847200 · Cited by 108 · see citing works

DNA Damage Disrupts the p14ARF-B23(Nucleophosmin) Interaction and Triggers a Transient Subnuclear Redistribution of p14ARF

Lee, C., Smith, B. A., Bandyopadhyay, K., & Gjerset, R. A. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1759 · Cited by 106 · see citing works

p14 ARF Activates a Tip60-Dependent and p53-Independent ATM/ATR/CHK Pathway in Response to Genotoxic Stress

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Differential requirement for p19ARF in the p53-dependent arrest induced by DNA damage, microtubule disruption, and ribonucleotide depletion

Khan, S. H., Moritsugu, J., & Wahl, G. M. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.7.3266 · Cited by 103 · see citing works

Targeting of C-Terminal Binding Protein (CtBP) by ARF Results in p53-Independent Apoptosis

Paliwal, S., Pande, S., Kovi, R. C., Sharpless, N. E., Bardeesy, N. M., & Grossman, S. R. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.6.2360-2372.2006 · Cited by 100 · see citing works

Unleashing the power of p53: lessons from mice and men: Figure 1.Preprint

Poyurovsky, M. V., & Prives, C. L. (2006) · Genes & Development · doi:10.1101/gad.1397506 · Cited by 96 · see citing works

P14ARF promotes accumulation of SUMO-1 conjugated (H)Mdm2

Xirodimas, D. P., Chisholm, J., Desterro, J. M. S., Lane, D. P., & Hay, R. T. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)03310-0 · Cited by 94 · see citing works

Human ARF protein interacts with Topoisomerase I and stimulates its activity

Karayan, L., Riou, J., Seité, P., Migeon, J., Cantereau, A., & Larsen, C. (2001) · Oncogene · doi:10.1038/sj.onc.1204170 · Cited by 89 · see citing works

Distinct E2F‐mediated transcriptional program regulates p14 ARF gene expression

Komori, H., Enomoto, M., Nakamura, M., Iwanaga, R., & Ohtani, K. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600836 · Cited by 82 · see citing works

p19 Arf Suppresses Growth, Progression, and Metastasis of Hras-Driven Carcinomas through p53-Dependent and -Independent Pathways

Kelly‐Spratt, K. S., Gurley, K. E., Yasui, Y., & Kemp, C. J. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020242 · Cited by 82 · see citing works

What have animal models taught us about the p53 pathway?

Lozano, G., & Zambetti, G. P. (2005) · The Journal of Pathology · doi:10.1002/path.1704 · Cited by 76 · see citing works

MdmX inhibits ARF mediated Mdm2 sumoylation

Ghosh, M., Weghorst, K., & Berberich, S. J. (2005) · Cell Cycle · doi:10.4161/cc.4.4.1597 · Cited by 71 · see citing works

p14ARF Interacts with the SUMO-Conjugating Enzyme Ubc9 and Promotes the Sumoylation of Its Binding Partners

Rizos, H., Woodruff, S., & Kefford, R. F. (2005) · Cell Cycle · doi:10.4161/cc.4.4.1588 · Cited by 69 · see citing works

ARF and ATM/ATR cooperate in p53-mediated apoptosis upon oncogenic stress

Pauklin, S., Kristjuhan, A., Maimets, T., & Jaks, V. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.06.097 · Cited by 67 · see citing works

New and unexpected: forkhead meets ARF

Costa, R. H., Kalinichenko, V. V., Major, M. L., & Raychaudhuri, P. (2004) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2004.12.007 · Cited by 65 · see citing works

CARF Is a Novel Protein That Cooperates with Mouse p19 (Human p14 ) in Activating p53

Hasan, M. K., Yaguchi, T., Sugihara, T., Kumar, P. K. R., Taira, K., Reddel, R. R., Kaul, S. C., & Wadhwa, R. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204177200 · Cited by 65 · see citing works

Association of p14ARF with the p120E4FTranscriptional Repressor Enhances Cell Cycle Inhibition

Rizos, H., Diefenbach, E., Badhwar, P., Woodruff, S., Becker, T. M., Rooney, R. J., & Kefford, R. F. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210978200 · Cited by 64 · see citing works

Differential Regulation of E2F1, DP1, and the E2F1/DP1 Complex by ARF

Datta, A., Nag, A., & Raychaudhuri, P. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.24.8398-8408.2002 · Cited by 63 · see citing works

Absence of p16 ^INK4a and truncation of ARF tumor suppressors in chickens

Kim, S.-H., Mitchell, M., Fujii, H., Llanos, S., & Peters, G. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0135557100 · Cited by 63 · see citing works

p14 Arf Promotes Small Ubiquitin-like Modifier Conjugation of Werners Helicase

Woods, Y. L., Xirodimas, D. P., Prescott, A. R., Sparks, A., Lane, D. P., & Saville, M. K. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405414200 · Cited by 59 · see citing works

The Human Tumor Suppressor ARF Interacts with Spinophilin/Neurabin II, a Type 1 Protein-phosphatase-binding Protein

Vivo, M., Calogero, R., Sansone, F., Calabrò, V., Parisi, T., Borrelli, L., Saviozzi, S., & Mantia, G. L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006845200 · Cited by 57 · see citing works

A novel ARF-binding protein (LZAP) alters ARF regulation of HDM2

Wang, J., He, X., Luo, Y., & Yarbrough, W. G. (2005) · Biochemical Journal · doi:10.1042/bj20050960 · Cited by 53 · see citing works

Stability of nucleolar versus non-nucleolar forms of human p14ARF

RODWAY, H. A., Llanos, S., Rowe, J., & Peters, G. G. (2004) · Oncogene · doi:10.1038/sj.onc.1207854 · Cited by 53 · see citing works

Constitutively active DNA damage checkpoint pathways as the driving force for the high frequency of p53 mutations in human cancer

Halazonetis, T. D. (2004) · DNA repair · doi:10.1016/j.dnarep.2004.03.036 · Cited by 53 · see citing works

Arf‐dependent regulation of Pdgf signaling in perivascular cells in the developing mouse eye

Silva, R. L. A., Thornton, J. D., Martin, A. C., Rehg, J. E., Bertwistle, D., Zindy, F., & Skapek, S. X. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600751 · Cited by 52 · see citing works

Human tumor suppressor ARF impedes S-phase progression independent of p53.

Yarbrough, W. G., Bessho, M., Zanation, A. M., Bisi, J., & Xiong, Y. (2002) · PubMed · Cited by 51 · see citing works

Cooperativity of p19ARF, Mdm2, and p53 in murine tumorigenesis

Moore, L., Venkatachalam, S., Vogel, H., Watt, J. C., Wu, C.-L., Steinman, H., Jones, S. N., & Donehower, L. A. (2003) · Oncogene · doi:10.1038/sj.onc.1206985 · Cited by 48 · see citing works

ARF Directly Binds DP1: Interaction with DP1 Coincides with the G1 Arrest Function of ARF

Datta, A., Sen, J., Hagen, J., Korgaonkar, C. K., Caffrey, M. S., Quelle, D. E., Hughes, D. E., Ackerson, T. J., Costa, R. H., & Raychaudhuri, P. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.18.8024-8036.2005 · Cited by 45 · see citing works

Human Arf tumor suppressor specifically interacts with chromatin containing the promoter of rRNA genes

Ayrault, O., Andrique, L., Larsen, C., & Seité, P. (2004) · Oncogene · doi:10.1038/sj.onc.1207968 · Cited by 44 · see citing works

Functional and Physical Interaction of the Human ARF Tumor Suppressor with Tat-binding Protein-1

Pollice, A., Nasti, V., Ronca, R., Vivo, M., Iacono, M. L., Calogero, R., Calabrò, V., & Mantia, G. L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m310957200 · Cited by 44 · see citing works

Pex19p Dampens the p19ARF-p53-p21WAF1 Tumor Suppressor Pathway*

Sugihara, T., Kaul, S. C., Kato, J., Reddel, R. R., Nomura, H., & Wadhwa, R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100011200 · Cited by 44 · see citing works

Alternative reading frame protein (ARF)-independent function of CARF (collaborator of ARF) involves its interactions with p53: evidence for a novel p53-activation pathway and its negative feedback control

Hasan, M. K., Yaguchi, T., MINODA, Y., Hirano, T., Taira, K., Wadhwa, R., & Kaul, S. C. (2004) · Biochemical Journal · doi:10.1042/bj20040337 · Cited by 44 · see citing works

Regulation of p14ARF Through Subnuclear Compartmentalization

Gjerset, R. A., & Bandyopadhyay, K. (2006) · Cell Cycle · doi:10.4161/cc.5.7.2623 · Cited by 43 · see citing works

Identification of Novel ARF Binding Proteins by Two-Hybrid Screening

Tompkins, V. S., Hagen, J., Zediak, V. P., & Quelle, D. E. (2006) · Cell Cycle · doi:10.4161/cc.5.6.2560 · Cited by 43 · see citing works

p14ARF is a component of the p53 response following ionizing irradiation of normal human fibroblasts

Khan, S. H., Guevara, C. I., Fujii, G., & Parry, D. (2004) · Oncogene · doi:10.1038/sj.onc.1207824 · Cited by 41 · see citing works

Antagonism of Myc functions by Arf

Cleveland, J. L., & Sherr, C. J. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.09.020 · Cited by 40 · see citing works

ATM activity contributes to the tumor-suppressing functions of p14ARF

Li, Y., Wu, D., Chen, B., Ingram, A. J., He, L., Liu, L., Zhu, D., Kapoor, A., & Tang, D. (2004) · Oncogene · doi:10.1038/sj.onc.1207957 · Cited by 37 · see citing works

Oligomerization of the Human ARF Tumor Suppressor and Its Response to Oxidative Stress

Ménendez, S., Khan, Z., Coomber, D., Lane, D. P., Higgins, M., Koufali, M. M., & Laı́n, S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211007200 · Cited by 35 · see citing works

The ARF Tumor Suppressor: Keeping Myc on a Leash

Gregory, M. A., Qi, Y., & Hann, S. R. (2004) · Cell Cycle · doi:10.4161/cc.4.2.1491 · Cited by 29 · see citing works

p53-independent apoptosis is induced by the p19ARF tumor suppressor

Tsuji, K., Mizumoto, K., Sudo, H., Kouyama, K., Ogata, E., & Matsuoka, M. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)00723-4 · Cited by 29 · see citing works

Inhibition of p63 Transcriptional Activity by p14ARF: Functional and Physical Link between Human ARF Tumor Suppressor and a Member of the p53 Family

Calabrò, V., Mansueto, G., Santoro, R., Gentilella, A., Pollice, A., Ghioni, P., Guerrini, L., & Mantia, G. L. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.19.8529-8540.2004 · Cited by 26 · see citing works

ARF the Integrator: Linking NF-?B, p53 and Checkpoint Kinases

Rocha, S., & Perkins, N. D. (2005) · Cell Cycle · doi:10.4161/cc.4.6.1739 · Cited by 26 · see citing works

p14ARF directly interacts with Myc through the Myc BoxII domain

Amente, S., Gargano, B., Varrone, F., et al. (2006) · Cancer Biology & Therapy · doi:10.4161/cbt.5.3.2389 · Cited by 18 · see citing works

A novel putative collaborator of p19ARF

Wadhwa, R. (2003) · Experimental Gerontology · doi:10.1016/s0531-5565(02)00180-8 · Cited by 17 · see citing works

P19ARF inhibits the functions of the HPV16 E7 oncoprotein

Pan, W., Datta, A., Adami, G. R., et al. (2003) · Oncogene · doi:10.1038/sj.onc.1206857 · Cited by 16 · see citing works

The ARF tumor suppressor inhibits BCL6-mediated transcriptional repression

Suzuki, H., Kurita, M., Mizumoto, K., Moriyama, M., Aiso, S., Nishimoto, I., & Matsuoka, M. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.11.016 · Cited by 12 · see citing works

Cellular senescence in ageing: from mechanisms to therapeutic opportunities

Di Micco, R., Krizhanovsky, V., Baker, D., & d’Adda di Fagagna, F. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-00314-w · Cited by 2,277 · see citing works

Targeting Ferroptosis as a Vulnerability in Cancer

Lei, G., Zhuang, L., & Gan, B. (2022) · Nature reviews. Cancer · doi:10.1038/s41568-022-00459-0 · Cited by 2,252 · see citing works

Modes of p53 regulation.

Kruse, J.-P., & Gu, W. (2009) · Cell · doi:10.1016/j.cell.2009.04.050 · Cited by 1,610 · see citing works

Living on a break: cellular senescence as a DNA-damage response

d'Adda di Fagagna, F. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2440 · Cited by 1,170 · see citing works

The nucleolus under stress

Boulon, S., Westman, B. J., Hutten, S., Boisvert, F.-M., & Lamond, A. I. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.024 · Cited by 1,103 · see citing works

The Ink4/Arf locus is a barrier for iPS cell reprogramming

Li, H., Collado, M., Villasante, A., Strati, K., Ortega, S., Cañamero, M., Blasco, M. A., & Serrano, M. (2009) · Nature · doi:10.1038/nature08290 · Cited by 968 · see citing works

Signaling to p53: ribosomal proteins find their way

Zhang, Y., & Lu, H. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.09.024 · Cited by 591 · see citing works

Coping with stress: multiple ways to activate p53

Horn, H. F., & Vousden, K. H. (2007) · Oncogene · doi:10.1038/sj.onc.1210263 · Cited by 522 · see citing works

Tight Regulation of Unstructured Proteins: From Transcript Synthesis to Protein Degradation

Gsponer, J., Futschik, M. E., Teichmann, S. A., & Babu, M. M. (2008) · Science · doi:10.1126/science.1163581 · Cited by 466 · see citing works

Regulating tumor suppressor genes: post-translational modifications

Chen, L., Liu, S., & Tao, Y. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-0196-9 · Cited by 449 · see citing works

The Role of SIRT1 on DNA Damage Response and Epigenetic Alterations in Cancer

Alves-Fernandes, D. K., & Jasiulionis, M. G. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20133153 · Cited by 385 · see citing works

Mdm2-mediated ubiquitylation: p53 and beyond

Marine, J.-C., & Lozano, G. (2010) · Cell Death & Differentiation · doi:10.1038/cdd.2009.68 · Cited by 354 · see citing works

The Mdm2–p53 relationship evolves: Mdm2 swings both ways as an oncogene and a tumor suppressor

Manfredi, J. J. (2010) · Genes & Development · doi:10.1101/gad.1941710 · Cited by 344 · see citing works

The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism

Chang, S., Yim, S., & Park, H. (2019) · Experimental & Molecular Medicine · doi:10.1038/s12276-019-0230-6 · Cited by 228 · see citing works

Structure-based Design of High Affinity Peptides Inhibiting the Interaction of p53 with MDM2 and MDMX

Phan, J., Li, Z., Kasprzak, A., Li, B., Sebti, S., Guida, W., Schönbrunn, E., & Chen, J. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.073056 · Cited by 173 · see citing works

The role of ubiquitin modification in the regulation of p53

Hock, A. K., & Vousden, K. H. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2013.05.022 · Cited by 168 · see citing works

Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses

Chen, D., Shan, J., Zhu, W.-G., Qin, J., & Gu, W. (2010) · Nature · doi:10.1038/nature08820 · Cited by 160 · see citing works

Elimination of p19ARF-expressing cells enhances pulmonary function in mice

Hashimoto, M., Asai, A., Kawagishi, H., Mikawa, R., Iwashita, Y., Kanayama, K., Sugimoto, K., Sato, T., Maruyama, M., & Sugimoto, M. (2016) · JCI Insight · doi:10.1172/jci.insight.87732 · Cited by 162 · see citing works

Functional interplay between the DNA-damage-response kinase ATM and ARF tumour suppressor protein in human cancer

Velimezi, G., Liontos, M., Vougas, K., Roumeliotis, T., Bartkova, J., Sideridou, M., Dereli-Oz, A., Kocylowski, M., Pateras, I. S., Evangelou, K., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2795 · Cited by 131 · see citing works

Stressing the cell cycle in senescence and aging

Chandler, H., & Peters, G. (2013) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2013.07.005 · Cited by 119 · see citing works

TSPYL5 suppresses p53 levels and function by physical interaction with USP7.

Epping, M. T., Meijer, L. A. T., Krijgsman, O., Bos, J. L., Pandolfi, P. P., & Bernards, R. (2011) · Nature Cell Biology · doi:10.1038/ncb2142 · Cited by 117 · see citing works

Integrating the DNA damage and protein stress responses during cancer development and treatment

Gorgoulis, V. G., Pefani, D., Pateras, I. S., & Trougakos, I. P. (2018) · The Journal of Pathology · doi:10.1002/path.5097 · Cited by 108 · see citing works

Transcriptional regulation of cellular senescence

Lanigan, F., Geraghty, J. G., & Bracken, A. P. (2011) · Oncogene · doi:10.1038/onc.2011.34 · Cited by 95 · see citing works

The Mdm network and its regulation of p53 activities: a rheostat of cancer risk

Eischen, C. M., & Lozano, G. (2014) · Human Mutation · doi:10.1002/humu.22524 · Cited by 79 · see citing works

Mdm2 affects genome stability independent of p53

Bouska, A., & Eischen, C. M. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-3732 · Cited by 71 · see citing works

Resistance mechanisms to TP53-MDM2 inhibition identified by in vivo piggyBac transposon mutagenesis screen in an Arf ^−/− mouse model

Chapeau, E. A., Gembarska, A., Durand, E. Y., Mandon, E., Estadieu, C., Romanet, V., Wiesmann, M., Tiedt, R., Lehar, J., de Weck, A., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1620262114 · Cited by 64 · see citing works

BH3 activation blocks Hdmx suppression of apoptosis and cooperates with Nutlin to induce cell death

Wade, M., Rodewald, L. W., Espinosa, J. M., & Wahl, G. M. (2008) · Cell Cycle · doi:10.4161/cc.7.13.6072 · Cited by 48 · see citing works

Loss of ARF Sensitizes Transgenic BRAFV600E Mice to UV-Induced Melanoma via Suppression of XPC

Luo, C., Sheng, J., Hu, M. G., Haluska, F. G., Cui, R., Xu, Z., Tsichlis, P. N., Hu, G.-F., & Hinds, P. W. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-4454 · Cited by 31 · see citing works

The roles of MDM2 and MDMX phosphorylation in stress signaling to p53

Chen, J. (2012) · Genes & Cancer · doi:10.1177/1947601912454733 · Cited by 33 · see citing works

Abnormal MDMX degradation in tumor cells due to ARF deficiency

Li, X., Gilkes, D., Li, B., Cheng, Q., Pernazza, D., Lawrence, H., Lawrence, N., & Chen, J. (2012) · Oncogene · doi:10.1038/onc.2011.534 · Cited by 32 · see citing works

Stress-induced cellular senescence contributes to chronic inflammation and cancer progression.

KOBASHIGAWA, S., M. SAKAGUCHI, Y., MASUNAGA, S., & MORI, E. (2019) · Thermal Medicine · doi:10.3191/thermalmed.35.41 · Cited by 18 · see citing works

The regulation of MDM2 oncogene and its impact on human cancers

YuHan, Zhao, Haiyang, Yu, Wenwei, & Hu (2014) · 生物化学与生物物理学报：英文版 · Cited by 1 · see citing works

Anticancer strategies by upregulating p53 through inhibition of its ubiquitination by MDM2

Anifowose, A., Agbowuro, A. A., Yang, X., & Wang, B. (2020) · Medicinal Chemistry Research · doi:10.1007/s00044-020-02574-9 · Cited by 25 · see citing works

Oncogenic c-Myc-induced lymphomagenesis is inhibited non-redundantly by the p19Arf–Mdm2–p53 and RP–Mdm2–p53 pathways

Meng, X., Zhang, Y., Dong, J., et al. (2020) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/7k14-b379 · Cited by 1 · see citing works

The Mdm2–p53 relationship evolves: Mdm2 swings both ways as an oncogene and a tumor suppressor

Manfredi, J. J. (2010) · Genes & Development · doi:10.1101/gad.1941710 · Cited by 344 · see citing works

Peptide Activators of the p53 Tumor Suppressor

Zhan, C., & Lu, W. (2011) · Current Pharmaceutical Design · doi:10.2174/138161211795222577 · Cited by 23 · see citing works