Cited by 654Cancer-related Molecular PathwaysCell death mechanisms and regulationHeat shock proteins research

The ARF/p53 pathway.

Sherr, Charles J, Weber, Jason D·2000·Current Opinion in Genetics & Development

Abstract

The ARF tumor suppressor connects pathways regulated by the retinoblastoma protein and p53. ARF inactivation reduces p53-dependent apoptosis induced by oncogenic signals. Nucleolar relocalization of Mdm2 by ARF connotes a novel mechanism for preventing p53 turnover and provides a framework for understanding how stress signals cooperate to regulate p53 function.

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Crossref · 10.1016/s0959-437x(99)00038-6

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49 of 49 references verified0 citation errors · 0 not checkable

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Authors
Sherr, C. J., & Weber, J. D.
Affiliations
St. Jude Children's Research Hospital (US)
Corresponding author
Sherr, Charles J
Venue
Current Opinion in Genetics & Development
Publisher
Elsevier BV
Published
2000-02
Volume
10
Issue
1
Pages
94-99
ISSN
0959-437X (ISSN-L)
OpenAlex
W1996834340
Cited by
654
References
49
Citations by year
2026: 7 · 2025: 6 · 2024: 6 · 2023: 1 · 2022: 7 · 2021: 10 · 2020: 11 · 2019: 11 · 2018: 19 · 2017: 13 · 2016: 5 · 2015: 10 · 2014: 13 · 2013: 28 · 2012: 17
FWCI
7.77
Type
journal article
Language
en
Open access
closed
Locations
  • Current Opinion in Genetics & Development (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Howard Hughes Medical Institute
  • American Lebanese Syrian Associated Charities
Topics
  • Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
Keywords
ARF tumor suppressor, p53, retinoblastoma protein, MDM2, p53-dependent apoptosis, stress signals, tumor suppression
MeSH terms
Animals, Carrier Proteins, Humans, Nuclear Proteins, Oncogenes, Proto-Oncogene Proteins, Genes, Tumor Suppressor, Tumor Suppressor Protein p53, Cyclin-Dependent Kinases, Cyclin-Dependent Kinase Inhibitor p16, ADP-Ribosylation Factors, Mice, Proto-Oncogene Proteins c-mdm2

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