The ARF/p53 pathway.
Abstract
The ARF tumor suppressor connects pathways regulated by the retinoblastoma protein and p53. ARF inactivation reduces p53-dependent apoptosis induced by oncogenic signals. Nucleolar relocalization of Mdm2 by ARF connotes a novel mechanism for preventing p53 turnover and provides a framework for understanding how stress signals cooperate to regulate p53 function.
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The biological action of Arf relies on the p53 pathway because Arf can directly bind to MDM2 and cause accumulation of p53 by segregating MDM2 from p53 and by inhibiting MDM2's E3 ubiquitin protein ligase activity for p53.
“In contrast, the biological action of Arf relies on the p53 pathway. This is because Arf can directly bind to mouse double minute 2 homolog (MDM2) and cause the accumulation of p53 by segregating MDM2 from p53 and by inhibiting MDM2’s E3 ubiquitin protein ligase activity for p53.10,11,14”
From Total body irradiation causes long-term mouse BM injury via induction of HSC premature senescence in an Ink4a- and Arf-independent manner (2014) · cites this paper as [14]
Activation of p53 by Arf can induce not only senescence but also apoptosis, depending on which gene downstream of p53 is induced after p53 activation.
“Therefore, activation of p53 by Arf can induce not only senescence but also apoptosis, depending on which gene downstream of p53 is induced after p53 activation.”
From Total body irradiation causes long-term mouse BM injury via induction of HSC premature senescence in an Ink4a- and Arf-independent manner (2014) · cites this paper as [14]
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- Authors
- Sherr, C. J., & Weber, J. D.
- Affiliations
- St. Jude Children's Research Hospital (US)
- Corresponding author
- Sherr, Charles J
- Venue
- Current Opinion in Genetics & Development
- Publisher
- Elsevier BV
- Published
- 2000-02
- Volume
- 10
- Issue
- 1
- Pages
- 94-99
- ISSN
- 0959-437X (ISSN-L)
- OpenAlex
- W1996834340
- Cited by
- 654
- References
- 49
- Citations by year
- 2026: 7 · 2025: 6 · 2024: 6 · 2023: 1 · 2022: 7 · 2021: 10 · 2020: 11 · 2019: 11 · 2018: 19 · 2017: 13 · 2016: 5 · 2015: 10 · 2014: 13 · 2013: 28 · 2012: 17
- FWCI
- 7.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Genetics & Development (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- American Lebanese Syrian Associated Charities
- Topics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
- Keywords
- ARF tumor suppressor, p53, retinoblastoma protein, MDM2, p53-dependent apoptosis, stress signals, tumor suppression
- MeSH terms
- Animals, Carrier Proteins, Humans, Nuclear Proteins, Oncogenes, Proto-Oncogene Proteins, Genes, Tumor Suppressor, Tumor Suppressor Protein p53, Cyclin-Dependent Kinases, Cyclin-Dependent Kinase Inhibitor p16, ADP-Ribosylation Factors, Mice, Proto-Oncogene Proteins c-mdm2
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Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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