Parks, John S.

LXR signaling couples sterol metabolism to proliferation in the acquired immune response

Bensinger, S. J., Bradley, M. N., Joseph, S. B., Zelcer, N., Janssen, E. M., Hausner, M. A., Shih, R., Parks, J. S., Edwards, P. A., Jamieson, B. D., et al. (2008) · Cell

Cholesterol and Lipid MetabolismCancer, Lipids, and Metabolism

Cited by 711

Targeted inactivation of hepatic Abca1 causes profound hypoalphalipoproteinemia and kidney hypercatabolism of apoA-I

Timmins, J. M., Lee, J.-Y., Boudyguina, E., Kluckman, K. D., Brunham, L. R., Mulya, A., Gebre, A. K., Coutinho, J. M., Colvin, P. L., Smith, T. L., et al. (2005) · Journal of Clinical Investigation

Cholesterol and Lipid MetabolismLipid metabolism and disorders

Cited by 447

Macrophage ABCA1 reduces MyD88-dependent Toll-like receptor trafficking to lipid rafts by reduction of lipid raft cholesterol

Zhu, X., Owen, J. S., Wilson, M. D., Li, H., Griffiths, G. L., Thomas, M. J., Hiltbold, E. M., Fessler, M. B., & Parks, J. S. (2010) · Journal of Lipid Research

Immune Response and InflammationCholesterol and Lipid Metabolism

Cited by 331

LXRs link metabolism to inflammation through Abca1-dependent regulation of membrane composition and TLR signaling

Ito, A., Hong, C., Rong, X., Zhu, X., Tarling, E. J., Hedde, P. N., Gratton, E., Parks, J., & Tontonoz, P. (2015) · eLife

Cholesterol and Lipid MetabolismImmune Response and Inflammation

Cited by 281

Impaired Cholesterol Efflux in Senescent Macrophages Promotes Age-Related Macular Degeneration

Sene, A., Khan, A. A., Cox, D., Nakamura, R. E. I., Santeford, A., Kim, B. M., Sidhu, R., Onken, M. D., Harbour, J. W., Hagbi-Levi, S., et al. (2013) · Cell Metabolism

Cholesterol and Lipid MetabolismAtherosclerosis and Cardiovascular Diseases

Cited by 277

The Nlrp3 inflammasome promotes age-related thymic demise and immunosenescence

Youm, Y.-H., Kanneganti, T.-D., Vandanmagsar, B., Zhu, X., Ravussin, A., Adijiang, A., Owen, J. S., Thomas, M. J., Francis, J., Parks, J. S., et al. (2012) · Cell Reports

Inflammasome and immune disordersT-cell and B-cell Immunology

Cited by 172

Pubertal Presentation of Congenital Δ5–-3β–Hydroxysteroid Dehydrogenase Deficiency*

ROSENFIELD, R. L., RICH, B. H., WOLFSDORF, J. I., CASSORLA, F., PARKS, J. S., BONGIOVANNI, A. M., WU, C. H., & SHACKLETON, C. H. L. (1980) · The Journal of Clinical Endocrinology & Metabolism

Sexual Differentiation and DisordersAdrenal Hormones and Disorders

Cited by 135

Tissue-Specific Induction of Intestinal ABCA1 Expression With a Liver X Receptor Agonist Raises Plasma HDL Cholesterol Levels

Brunham, L. R., Kruit, J. K., Pape, T. D., Parks, J. S., Kuipers, F., & Hayden, M. R. (2006) · Circulation Research

Cholesterol and Lipid MetabolismLipoproteins and Cardiovascular Health

Cited by 118

Δ-5 Fatty Acid Desaturase FADS1 Impacts Metabolic Disease by Balancing Proinflammatory and Proresolving Lipid Mediators

Gromovsky, A. D., Schugar, R. C., Brown, A. L., Helsley, R. N., Burrows, A. C., Ferguson, D., Zhang, R., Sansbury, B. E., Lee, R. G., Morton, R. E., et al. (2018) · Arteriosclerosis, Thrombosis, and Vascular Biology

Fatty Acid Research and HealthLipid metabolism and biosynthesis

Cited by 115

Deficiency of ATP-Binding Cassette Transporters A1 and G1 in Endothelial Cells Accelerates Atherosclerosis in Mice

Westerterp, M., Tsuchiya, K., Tattersall, I. W., Fotakis, P., Bochem, A. E., Molusky, M. M., Ntonga, V., Abramowicz, S., Parks, J. S., Welch, C. L., et al. (2016) · Arteriosclerosis, Thrombosis, and Vascular Biology

Cholesterol and Lipid MetabolismAtherosclerosis and Cardiovascular Diseases

Cited by 114

Tissue-Specific Roles of ABCA1 Influence Susceptibility to Atherosclerosis

Brunham, L. R., Singaraja, R. R., Duong, M., Timmins, J. M., Fievet, C., Bissada, N., Kang, M. H., Samra, A., Fruchart, J.-C., McManus, B., et al. (2009) · Arteriosclerosis, Thrombosis, and Vascular Biology

Cholesterol and Lipid MetabolismAtherosclerosis and Cardiovascular Diseases

Cited by 102

MicroRNA-33 regulates the innate immune response via ATP binding cassette transporter-mediated remodeling of membrane microdomains

Lai, L., Azzam, K. M., Lin, W.-C., Rai, P., Lowe, J. M., Gabor, K. A., Madenspacher, J. H., Aloor, J. J., Parks, J. S., Näär, A. M., et al. (2016) · Journal of Biological Chemistry

Immune Response and InflammationMicroRNA in disease regulation

Cited by 67

Hepatic ABCA1 and VLDL triglyceride production

Liu, M., Chung, S., Shelness, G. S., & Parks, J. S. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

Cholesterol and Lipid MetabolismLipid metabolism and disorders

Cited by 43

Hepatic ATP-Binding Cassette Transporter A1 Is a Key Molecule in High-Density Lipoprotein Cholesteryl Ester Metabolism in Mice

Singaraja, R. R., Stahmer, B., Brundert, M., Merkel, M., Heeren, J., Bissada, N., Kang, M., Timmins, J. M., Ramakrishnan, R., Parks, J. S., et al. (2006) · Arteriosclerosis, Thrombosis, and Vascular Biology

Cholesterol and Lipid MetabolismDrug Transport and Resistance Mechanisms

Cited by 33

Myeloid-specific genetic ablation of ATP-binding cassette transporter ABCA1 is protective against cancer

Zamanian-Daryoush, M., Lindner, D. J., DiDonato, J. A., Wagner, M., Buffa, J., Rayman, P., Parks, J. S., Westerterp, M., Tall, A. R., & Hazen, S. L. (2017) · Oncotarget

Cancer, Lipids, and MetabolismCholesterol and Lipid Metabolism

Cited by 32