Tissue-Specific Roles of ABCA1 Influence Susceptibility to Atherosclerosis
Abstract
Objective— The ATP-binding cassette transporter, subfamily A, member 1 ( ABCA1 ) plays a key role in HDL cholesterol metabolism. However, the role of ABCA1 in modulating susceptibility to atherosclerosis is controversial. Methods and Results— We investigated the role of ABCA1 in atherosclerosis using a combination of overexpression and selective deletion models. First, we examined the effect of transgenic overexpression of a full-length human ABCA1 -containing bacterial artificial chromosome (BAC) in the presence or absence of the endogenous mouse Abca1 gene. ABCA1 overexpression in the atherosclerosis-susceptible Ldlr −/− background significantly reduced the development of atherosclerosis in both the presence and absence of mouse Abca1 . Next, we used mice with tissue-specific inactivation of Abca1 to dissect the discrete roles of Abca1 in different tissues on susceptibility to atherosclerosis. On the Apoe −/− background, mice lacking hepatic Abca1 had significantly reduced HDL cholesterol and accelerated atherosclerosis, indicating that the liver is an important site at which Abca1 plays an antiatherogenic role. In contrast, mice with macrophage-specific inactivation of Abca1 on the Ldlr −/− background displayed no change in atherosclerotic lesion area. Conclusions— These data indicate that physiological expression of Abca1 modulates the susceptibility to atherosclerosis and establish hepatic Abca1 expression as an important site of atheroprotection. In contrast, we show that selective deletion of macrophage Abca1 does not significantly modulate atherogenesis.
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Cholesterol efflux from cells to apolipoprotein A-I (apoA-I) acceptors via the ATP-binding cassette transporters ABCA1 and ABCG1 is central in the antiatherogenic mechanism.
“Cholesterol efflux from cells to apolipoprotein A-I (apoA-I) acceptors via the ATP-binding cassette transporters ABCA1 and ABCG1 is thought to be central in the antiatherogenic mechanism.”
From MicroRNA‐33 Deficiency Reduces the Progression of Atherosclerotic Plaque in ApoE <sup>−/−</sup> Mice (2012) · cites this paper as [14]
Liver and macrophage ABCA1 both play roles in preventing atherosclerosis.
“Tissue-specific knockouts of the Abca1 locus were generated and revealed that liver and macrophage ABCA1 both play roles in preventing atherosclerosis.14”
From MicroRNA‐33 Deficiency Reduces the Progression of Atherosclerotic Plaque in ApoE <sup>−/−</sup> Mice (2012) · cites this paper as [14]
ABCA1-mediated cholesterol export is essential for the formation of HDL particles, because liver- and intestine-specific ABCA1 knockout mice show strong reductions in HDL levels.
“This process seems to be essential for the formation of HDL particles because liver-and intestine-specific knockout mice for ABCA1 show strong reductions in HDL levels (45)(46)(47).”
From Expression of miR-33 from an SREBP2 Intron Inhibits Cholesterol Export and Fatty Acid Oxidation* (2010) · cites this paper as [45]
Cites
Conditional gene targeting in macrophages and granulocytes using LysMcre mice
Clausen, B. E., Burkhardt, C., Reith, W., Renkawitz, R., & Förster, I. (1999) · Transgenic Research · doi:10.1023/a:1008942828960 · Cited by 2,143 · see citing works
Newly identified loci that influence lipid concentrations and risk of coronary artery disease
Willer, C. J., Sanna, S., Jackson, A. U., Scuteri, A., Bonnycastle, L. L., Clarke, R., Heath, S. C., Timpson, N. J., Najjar, S. S., Stringham, H. M., et al. (2008) · Nature Genetics · doi:10.1038/ng.76 · Cited by 1,585 · see citing works
Kathiresan, S., Melander, O., Guiducci, C., Surti, A., Burtt, N. P., Rieder, M. J., Cooper, G. M., Roos, C., Voight, B. F., Havulinna, A. S., et al. (2008) · Nature Genetics · doi:10.1038/ng.75 · Cited by 1,386 · see citing works
Polymorphisms Associated with Cholesterol and Risk of Cardiovascular Events
Kathiresan, S., Melander, O., Anevski, D., Guiducci, C., Burtt, N. P., Roos, C., Hirschhorn, J. N., Berglund, G., Hedblad, B., Groop, L., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0706728 · Cited by 696 · see citing works
Carr, T. P., Andresen, C. J., & Rudel, L. L. (1993) · Clinical Biochemistry · doi:10.1016/0009-9120(93)90015-x · Cited by 561 · see citing works
Yvan-Charvet, L., Ranalletta, M., Wang, N., Han, S., Terasaka, N., Li, R., Welch, C., & Tall, A. R. (2007) · Journal of Clinical Investigation · doi:10.1172/jci33372 · Cited by 536 · see citing works
Intestinal ABCA1 directly contributes to HDL biogenesis in vivo
Brunham, L. R. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27352 · Cited by 519 · see citing works
Self-citationTimmins, J. M., Lee, J.-Y., Boudyguina, E., Kluckman, K. D., Brunham, L. R., Mulya, A., Gebre, A. K., Coutinho, J. M., Colvin, P. L., Smith, T. L., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23915 · Cited by 447 · see citing works
Self-citationAlterations in Lipoprotein Metabolism in Peroxisome Proliferator-activated Receptor α-deficient Mice
Peters, J. M., Hennuyer, N., Staels, B., Fruchart, J., Fiévet, C., Gonzalez, F. J., & Auwerx, J. H. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.43.27307 · Cited by 429 · see citing works
Self-citationIncreased Atherosclerosis in Hyperlipidemic Mice With Inactivation of ABCA1 in Macrophages
Aiello, R. J., Brees, D., Bourassa, P.-A., Royer, L., Lindsey, S., Coskran, T., Haghpassand, M., & Francone, O. L. (2002) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000014804.35824.da · Cited by 390 · see citing works
Zhu, X., Lee, J., Timmins, J. M., Brown, J. M., Boudyguina, E. Y., Mulya, A., Gebre, A. K., Willingham, M. C., Hiltbold, E. M., Mishra, N., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801408200 · Cited by 350 · see citing works
Self-citationLeukocyte ABCA1 controls susceptibility to atherosclerosis and macrophage recruitment into tissues
Van Eck, M., Bos, I. S. T., Kaminski, W. E., Orsó, E., Rothe, G., Twisk, J., Böttcher, A., Van Amersfoort, E. S., Christiansen-Weber, T. A., Fung-Leung, W.-P., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.092327399 · Cited by 348 · see citing works
Clee, S. M., Kastelein, J. J. P., van Dam, M., Marcil, M., Roomp, K., Zwarts, K. Y., Collins, J. A., Roelants, R. J., Tamasawa, N., Štulc, T., et al. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10727 · Cited by 314 · see citing works
Self-citationWellington, C. L., Walker, E. K.-Y., Suarez, A., Kwok, A. Y. C., Bissada, N., Singaraja, R. R., Yang, Y., Zhang, L., James, E. R., Wilson, J. E., et al. (2002) · Laboratory Investigation · doi:10.1038/labinvest.3780421 · Cited by 296 · see citing works
Self-citationRole of endothelial dysfunction in insulin resistance
Hsueh, W. A., & Quiñones, M. J. (2003) · The American Journal of Cardiology · doi:10.1016/s0002-9149(03)00611-8 · Cited by 271 · see citing works
Joyce, C. W., Amar, M. J., Lambert, G. C., Vaisman, B. L., Paigen, B. J., Najib-Fruchart, J., Hoyt, R. F., Neufeld, E. D., Remaley, A. T., Fredrickson, D. S., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.012587699 · Cited by 269 · see citing works
Increased ABCA1 activity protects against atherosclerosis
Singaraja, R. R., Fievet, C., Castro, G., James, E. R., Hennuyer, N., Clee, S. M., Bissada, N., Choy, J. C., Fruchart, J.-C., McManus, B. M., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15748 · Cited by 250 · see citing works
Self-citationSingaraja, R. R., Brunham, L. R., Visscher, H., Kastelein, J. J. P., & Hayden, M. R. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000078520.89539.77 · Cited by 245 · see citing works
Self-citationVaisman, B. L., Lambert, G. C., Amar, M. J., Joyce, C. W., Ito, T., Shamburek, R. D., Cain, W. J., Fruchart‐Najib, J., Neufeld, E. D., Remaley, A. T., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci12517 · Cited by 240 · see citing works
Influence of Cardiovascular Risk Factors on Endothelial Progenitor Cells
Werner, N., & Nickenig, G. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000198239.41189.5d · Cited by 238 · see citing works
Basso, F., Freeman, L. A., Knapper, C. L., Remaley, A. T., Stonik, J. A., Neufeld, E. B., Tansey, T. R., Amar, M. J., Fruchart‐Najib, J., Duverger, N., et al. (2003) · Journal of Lipid Research · doi:10.1194/jlr.m200414-jlr200 · Cited by 228 · see citing works
Increased ABCA1 activity protects against atherosclerosis
Singaraja, R. R., Fiévet, C., Castro, G. R., James, E. R., Hennuyer, N., Clee, S. M., Bissada, N., Choy, J. C., Fruchart, J., McManus, B. M., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215748 · Cited by 220 · see citing works
Self-citationSantamarina-Fojo, S., Peterson, K. M., Knapper, C. L., Qiu, Y., Freeman, L. A., Cheng, J., Osorio, J., Remaley, A. T., Yang, X., Haudenschild, C., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.14.7987 · Cited by 206 · see citing works
van Dam, M., de Groot, E., Clee, S. M., Hovingh, G. K., Roelants, R. J., Brooks-Wilson, A., Zwinderman, A. H., Smit, A. J., Smelt, A. H. M., Groen, A. K., et al. (2002) · The Lancet · doi:10.1016/s0140-6736(02)07277-x · Cited by 196 · see citing works
Self-citationEck, M. V., Singaraja, R. R., Ye, D., Hildebrand, R. B., James, E. R., Hayden, M. R., & van Berkel, T. J. C. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000208364.22732.16 · Cited by 167 · see citing works
Self-citationLawn, R. M., Wade, D. P., Couse, T. L., & Wilcox, J. N. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.21.3.378 · Cited by 116 · see citing works
Alterations of plasma lipids in mice via adenoviral-mediated hepatic overexpression of human ABCA1
Wellington, C. L., Brunham, L. R., Zhou, S., Singaraja, R. R., Visscher, H., Gelfer, A., Ross, C. J., James, E. R., Liu, G., Huber, M. T., et al. (2003) · Journal of Lipid Research · doi:10.1194/jlr.m300110-jlr200 · Cited by 100 · see citing works
Self-citationSingaraja, R. R., Eck, M. V., Bissada, N., Zimetti, F., Collins, H. L., Hildebrand, R. B., Hayden, A., Brunham, L. R., Kang, M. H., Fruchart, J., et al. (2006) · Circulation · doi:10.1161/circulationaha.106.621433 · Cited by 84 · see citing works
Self-citationJoyce, C. W., Wagner, E. M., Basso, F., Amar, M. J., Freeman, L. A., Shamburek, R. D., Knapper, C. L., Syed, J., Wu, J., Vaisman, B. L., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m604526200 · Cited by 80 · see citing works
The ins and outs of reverse cholesterol transport
Groen, A. K., Elferink, R. P. J. O., Verkade, H. J., & Kuipers, F. (2004) · Annals of Medicine · doi:10.1080/07853890310020635 · Cited by 63 · see citing works
Brewer, H. B., & Santamarina-Fojo, S. (2003) · The American Journal of Cardiology · doi:10.1016/s0002-9149(03)00769-0 · Cited by 57 · see citing works
Cholesterol and apolipoprotein B metabolism in Tangier disease
Schaefer, E. J., Brousseau, M. E., Diffenderfer, M. R., Cohn, J. S., Welty, F. K., O'Connor, J., Dolnikowski, G. G., Wang, J., Hegele, R. A., & Jones, P. J. (2001) · Atherosclerosis · doi:10.1016/s0021-9150(01)00688-8 · Cited by 52 · see citing works
Furbee, J. W., & Parks, J. S. (2002) · Atherosclerosis · doi:10.1016/s0021-9150(02)00201-0 · Cited by 35 · see citing works
Self-citationZhou, X., He, W. S., Huang, Z., Gotto, A. M., Hajjar, D. P., & Han, J. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m706636200 · Cited by 35 · see citing works
Complete functional rescue of the ABCA1−/− mouse by human BAC transgenesis
Coutinho, J. M., Singaraja, R. R., Kang, M. H., Arenillas, D. J., Bertram, L. N., Bissada, N., Staels, B., Fruchart, J., Fiévet, C., Joseph‐George, A. M., et al. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m400506-jlr200 · Cited by 11 · see citing works
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Molecular Biology of Atherosclerosis
Hopkins, P. N. (2013) · Physiological Reviews · doi:10.1152/physrev.00004.2012 · Cited by 456 · see citing works
Expression of miR-33 from an SREBP2 Intron Inhibits Cholesterol Export and Fatty Acid Oxidation*
Gerin, I., Clerbaux, L.-A., Haumont, O., Lanthier, N., Das, A. K., Burant, C. F., Leclercq, I. A., MacDougald, O. A., & Bommer, G. T. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.152090 · Cited by 382 · see citing works
High-density lipoprotein heterogeneity and function in reverse cholesterol transport
Rothblat, G. H., & Phillips, M. C. (2010) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e328338472d · Cited by 341 · see citing works
Westerterp, M., Murphy, A. J., Wang, M., Pagler, T. A., Vengrenyuk, Y., Kappus, M. S., Gorman, D. J., Nagareddy, P. R., Zhu, X., Abramowicz, S., et al. (2013) · Circulation Research · doi:10.1161/circresaha.113.301086 · Cited by 311 · see citing works
Self-citationLüscher, T. F., Landmesser, U., von Eckardstein, A., & Fogelman, A. M. (2014) · Circulation Research · doi:10.1161/circresaha.114.300935 · Cited by 292 · see citing works
The Macrophage Cholesterol Exporter ABCA1 Functions as an Anti-inflammatory Receptor
Tang, C., Liu, Y., Kessler, P. S., Vaughan, A. M., & Oram, J. F. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.047472 · Cited by 284 · see citing works
ATP-Binding Cassette Transporters, Atherosclerosis, and Inflammation
Westerterp, M., Bochem, A. E., Yvan‐Charvet, L., Murphy, A. J., Wang, N., & Tall, A. R. (2014) · Circulation Research · doi:10.1161/circresaha.114.300738 · Cited by 257 · see citing works
Hepatic cholesterol transport and its role in non-alcoholic fatty liver disease and atherosclerosis
Li, H., Yu, X.-H., Ou, X., Ouyang, X.-P., & Tang, C. (2021) · Progress in Lipid Research · doi:10.1016/j.plipres.2021.101109 · Cited by 230 · see citing works
MicroRNA‐33 Deficiency Reduces the Progression of Atherosclerotic Plaque in ApoE <sup>−/−</sup> Mice
Horie, T., Baba, O., Kuwabara, Y., Chujo, Y., Watanabe, S., Kinoshita, M., Horiguchi, M., Nakamura, T., Chonabayashi, K., Hishizawa, M., et al. (2012) · Journal of the American Heart Association · doi:10.1161/jaha.112.003376 · Cited by 220 · see citing works
ABC transporters, atherosclerosis and inflammation
Fitzgerald, M. L., Mujawar, Z., & Tamehiro, N. (2010) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2010.01.011 · Cited by 190 · see citing works
Lipid homeostasis and the formation of macrophage-derived foam cells in atherosclerosis
Yuan, Y., Li, P., & Ye, J. (2012) · Protein & Cell · doi:10.1007/s13238-012-2025-6 · Cited by 181 · see citing works
Shao, B., Pennathur, S., & Heinecke, J. W. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.337345 · Cited by 170 · see citing works
Recent Highlights of ATVB Atherosclerosis
Lu, H. S., & Daugherty, A. (2015) · Arteriosclerosis, Thrombosis and Vascular Biology · doi:10.1161/atvbaha.115.305380 · Cited by 76 · see citing works
Bioactive Egg Components and Inflammation
Andersen, C. J. (2015) · Nutrients · doi:10.3390/nu7095372 · Cited by 150 · see citing works
ATP-binding cassette transporter A1: From metabolism to neurodegeneration
Koldamova, R., Fitz, N. F., & Lefterov, I. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.05.007 · Cited by 144 · see citing works
Liver X receptors at the intersection of lipid metabolism and atherogenesis
Lee, S. D., & Tontonoz, P. (2015) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.06.042 · Cited by 133 · see citing works
Adipocyte Modulation of High-Density Lipoprotein Cholesterol
Zhang, Y., McGillicuddy, F. C., Hinkle, C. C., O'Neill, S., Glick, J. M., Rothblat, G. H., & Reilly, M. P. (2010) · Circulation · doi:10.1161/circulationaha.109.897330 · Cited by 133 · see citing works
High Density Lipoprotein Biogenesis, Cholesterol Efflux, and Immune Cell Function
Sorci‐Thomas, M. G., & Thomas, M. J. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.300135 · Cited by 115 · see citing works
Westerterp, M., Tsuchiya, K., Tattersall, I. W., Fotakis, P., Bochem, A. E., Molusky, M. M., Ntonga, V., Abramowicz, S., Parks, J. S., Welch, C. L., et al. (2016) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.115.306670 · Cited by 114 · see citing works
Self-citationIslet cholesterol accumulation due to loss of ABCA1 leads to impaired exocytosis of insulin granules
Kruit, J. K., Wijesekara, N., Fox, J. E. M., Dai, X.-Q., Brunham, L. R., Searle, G. J., Morgan, G. P., Costin, A. J., Tang, R., Bhattacharjee, A., et al. (2011) · Diabetes · doi:10.2337/db11-0081 · Cited by 113 · see citing works
Self-citationDysfunctional HDL in diabetes mellitus and its role in the pathogenesis of cardiovascular disease
Srivastava, R. A. K. (2017) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-017-3165-z · Cited by 111 · see citing works
Regulation of Lipid Homeostasis by the Bifunctional SREBF2-miR33a Locus
Bommer, G. T., & MacDougald, O. A. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.02.004 · Cited by 92 · see citing works
Zhou, X., Yin, Z., Guo, X., Hajjar, D. P., & Han, J. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.073601 · Cited by 90 · see citing works
Ma, Z.-Q., Deng, C., Hu, W., Zhou, J., Fan, C., Di, S., Liu, D., Yang, Y., & Wang, D. (2017) · Current Issues in Molecular Biology · doi:10.21775/cimb.022.041 · Cited by 73 · see citing works
Macrophage Fatty-acid Synthase Deficiency Decreases Diet-induced Atherosclerosis
Schneider, J. G., YANG, Z. K., Chakravarthy, M. V., Lodhi, I. J., Wei, X., TURK, J. W., & Semenkovich, C. F. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.100321 · Cited by 74 · see citing works
Critical Role of the Human ATP-Binding Cassette G1 Transporter in Cardiometabolic Diseases
Hardy, L. M., Frisdal, É., & Goff, W. L. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18091892 · Cited by 68 · see citing works
Chung, S., Timmins, J., Duong, M., Degirolamo, C., Rong, S.-X., Sawyer, J., Singaraja, R., Hayden, M., Maeda, N., Rudel, L., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.096933 · Cited by 79 · see citing works
Self-citationFunction and regulation of ABCA1 – membrane meso‐domain organization and reorganization
Nagao, K., Tomioka, M., & Ueda, K. (2011) · FEBS Journal · doi:10.1111/j.1742-4658.2011.08170.x · Cited by 65 · see citing works
Stamatikos, A., Dronadula, N., Ng, P., Palmer, D. J., Knight, E., Wacker, B. K., Tang, C., Kim, F., & Dichek, D. A. (2018) · Human Gene Therapy · doi:10.1089/hum.2018.120 · Cited by 60 · see citing works
Ghosh, S. (2011) · Expert Review of Cardiovascular Therapy · doi:10.1586/erc.11.16 · Cited by 58 · see citing works
Role of ABCA1 in Cardiovascular Disease
Wang, J., Xiao, Q., Wang, L., Wang, Y., Wang, D. W., & Ding, H. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12061010 · Cited by 59 · see citing works
Machado, R. M., Nakandakare, E. R., Quintão, E. C. R., Cazita, P. M., Koike, M. K., Nunes, V. S., Ferreira, F. D., Afonso, M. S., Bombo, R. P. A., Machado‐Lima, A., et al. (2012) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2012.06.059 · Cited by 57 · see citing works
Stamatikos, A., Knight, E., Vojtech, L. N., Bi, L., Wacker, B. K., Tang, C., & Dichek, D. A. (2019) · Human Gene Therapy · doi:10.1089/hum.2019.245 · Cited by 54 · see citing works
Maïga, S. F., Kalopissis, A. D., & Chabert, M. (2013) · Biochimie · doi:10.1016/j.biochi.2013.08.027 · Cited by 49 · see citing works
LRP1 Controls cPLA2 Phosphorylation, ABCA1 Expression and Cellular Cholesterol Export
Zhou, L., Choi, H. Y., Li, W.-P., Xu, F., & Herz, J. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006853 · Cited by 45 · see citing works
ABCA1/ApoE/HDL Pathway Mediates GW3965-Induced Neurorestoration After Stroke
Cui, X., Chopp, M., Zhang, Z., Li, R., Zacharek, A., Landschoot‐Ward, J., Venkat, P., & Chen, J. (2016) · Stroke · doi:10.1161/strokeaha.116.015592 · Cited by 45 · see citing works
Dash, R., Ali, M. C., Rana, M. L., Munni, Y. A., Barua, L., Jahan, I., Haque, M. F., Hannan, M. A., & Moon, I. S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207606 · Cited by 42 · see citing works
Jia, Y., Li, Z., Zhang, H., Li, H., Liu, Y., & Li, X. (2010) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2010.08.033 · Cited by 41 · see citing works
Bi, X., Zhu, X., Duong, M., Boudyguina, E., Wilson, M. D., Gebre, A., & Parks, J. (2013) · Arteriosclerosis, Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.301110 · Cited by 42 · see citing works
Self-citationZhou, M., Learned, R. M., Rossi, S. J., Tian, H., DePaoli, A. M., & Ling, L. (2019) · Journal of Lipid Research · doi:10.1194/jlr.m089961 · Cited by 38 · see citing works
Sasaki, Y., Raza-Iqbal, S., Tanaka, T., Murakami, K., Anai, M., Osawa, T., Matsumura, Y., Sakai, J., & Kodama, T. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20225682 · Cited by 38 · see citing works
HDL, cholesterol efflux, and ABCA1: Free from good and evil dualism
Ogura, M. (2022) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2022.07.004 · Cited by 38 · see citing works
Devarajan, A., Grijalva, V. R., Bourquard, N., Meriwether, D., Imaizumi, S., Shin, B., Devaskar, S. U., & Reddy, S. T. (2012) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2012.06.020 · Cited by 37 · see citing works
Lipid efflux mechanisms, relation to disease and potential therapeutic aspects
Castaño, D., Rattanasopa, C., Monteiro-Cardoso, V. F., Corlianò, M., Liu, Y., Zhong, A., Rusu, M., Liehn, E. A., & Singaraja, R. R. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.04.013 · Cited by 37 · see citing works
Self-citationTofacitinib ameliorates atherosclerosis and reduces foam cell formation in apoE deficient mice
Wang, Z., Wang, S., Wang, Z., Yun, T., Wang, C., & Wang, H. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.06.020 · Cited by 35 · see citing works
van Eck, M. (2014) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000088 · Cited by 25 · see citing works
Bi, X., Zhu, X., Gao, C., Shewale, S. V., Cao, Q., Liu, M., Boudyguina, E. Y., Gebre, A. K., Wilson, M. D., Brown, A. L., et al. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.114.303791 · Cited by 31 · see citing works
Self-citationLee, S., Lee, M.-S., Chang, E., Lee, Y., Lee, J., Kim, J., Kim, C., Kim, I.-H., & Kim, Y. (2020) · Nutrients · doi:10.3390/nu12051499 · Cited by 31 · see citing works
HDL-C: clinical equipoise and vascular endothelial function
Campbell, S., & Genest, J. J. (2013) · Expert Review of Cardiovascular Therapy · doi:10.1586/erc.13.17 · Cited by 30 · see citing works
Andersen, C. J., Lee, J., Blesso, C. N., Carr, T. P., & Fernández, M. L. (2014) · Nutrients · doi:10.3390/nu6072650 · Cited by 30 · see citing works
Galle-Treger, L., Moreau, M., Ballaire, R., Poupel, L., Huby, T., Sasso, E., Troise, F., Potì, F., Lesnik, P., Goff, W. L., et al. (2019) · Cardiovascular Research · doi:10.1093/cvr/cvz138 · Cited by 31 · see citing works
Yakushiji, E., Ayaori, M., Nishida, T., Shiotani, K., Takiguchi, S., Nakaya, K., Uto‐Kondo, H., Ogura, M., Sasaki, M., Yogo, M., et al. (2016) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.115.306376 · Cited by 29 · see citing works
von Eckardstein, A. (2010) · Expert Review of Cardiovascular Therapy · doi:10.1586/erc.10.6 · Cited by 30 · see citing works
Biological role of MicroRNA-103 based on expression profile and target genes analysis in pigs
Li, G., Wu, Z., Li, X., Ning, X., Li, Y., & Yang, G. (2010) · Molecular Biology Reports · doi:10.1007/s11033-010-0615-z · Cited by 27 · see citing works
Jan, A., Karasinska, J. M., Kang, M. H., de Haan, W., Ruddle, P., Kaur, A., Connolly, C., Leavitt, B. R., Sorensen, P. H., & Hayden, M. R. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.05.007 · Cited by 28 · see citing works
Self-citationFawzy, M. S., Alhadramy, O., Hussein, M. H., Ismail, H. M., Ismail, N. M., Biomy, N. M., & Toraih, E. A. (2015) · Molecular Diagnosis & Therapy · doi:10.1007/s40291-015-0150-7 · Cited by 26 · see citing works
Feng, Y., Lievens, J., Jacobs, F., Hoekstra, M., Craeyveld, E. V., Gordts, S. C., Snoeys, J., & Geest, B. D. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq204 · Cited by 25 · see citing works
Lin, S., Zhou, C., Neufeld, E. B., Wang, Y., Xu, S., Lü, L., Wang, Y., Liu, Z., Li, D., Li, C., et al. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.300720 · Cited by 24 · see citing works
Marín, F. R., Soler‐Rivas, C., Martín‐Hernández, R., & Rodríguez‐Casado, A. (2014) · Cholesterol · doi:10.1155/2014/639751 · Cited by 23 · see citing works
Brunham, L. R., Kang, M. H., van Karnebeek, C., Sadananda, S. N., Collins, J. A., Zhang, L., Sayson, B., Miao, F., Stöckler, S., Frohlich, J. J., et al. (2014) · JIMD Reports · doi:10.1007/8904_2014_348 · Cited by 22 · see citing works
Self-citationLipid-free apoA-I structure - Origins of model diversity
Oda, M. N. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2016.11.010 · Cited by 23 · see citing works
Bai, Q., Lao, X., Pang, S., Zhao, Y., Liu, Y., Tian, X. Y., & Hao, J. (2025) · Advanced Materials · doi:10.1002/adma.202420189 · Cited by 21 · see citing works
Mouse Models of Disturbed HDL Metabolism
Hoekstra, M., & Eck, M. V. (2014) · Handbook of experimental pharmacology · doi:10.1007/978-3-319-09665-0_9 · Cited by 21 · see citing works
Hesse, D., Radloff, K., Jaschke, A., Lagerpusch, M., Chung, B., Tailleux, A., Staels, B., & Schürmann, A. (2013) · Journal of Lipid Research · doi:10.1194/jlr.m040089 · Cited by 20 · see citing works
Self-citationZhao, Y., Zhang, L., Liu, L., Zhou, X., Ding, F., Yang, Y., Du, S., Wang, H.-M., Eck, M. V., & Wang, J. (2022) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.122.318226 · Cited by 18 · see citing works
Wang, X., Wan, H., Wei, X., Zhang, Y., & Qu, P. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.5233 · Cited by 17 · see citing works
Tamehiro, N., Park, M. H., Hawxhurst, V., Nagpal, K., Adams, M. E., Zannis, V. I., Golenbock, D. T., & Fitzgerald, M. L. (2015) · Biochemistry · doi:10.1021/acs.biochem.5b00894 · Cited by 16 · see citing works
Kane, J., Jansen, M. F., Hendrix, S., Bosmans, L. A., Beckers, L., van Tiel, C. M., Gijbels, M. J., Zelcer, N., de Vries, C. J. M., von Hundelshausen, P., et al. (2021) · Thrombosis and Haemostasis · doi:10.1055/a-1711-1055 · Cited by 14 · see citing works
Versmissen, J., Oosterveer, D. M., Yazdanpanah, M., Mulder, M. T., Dehghan, A., Defesche, J. C., Kastelein, J. J. P., & Sijbrands, E. J. G. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehq208 · Cited by 13 · see citing works
Heo, S. H., Lee, E.-H., Park, H. H., Kim, B. J., Youn, H. C., Kim, Y. S., Kim, H. Y., Koh, S.-H., & Chang, D.-I. (2018) · Journal of Stroke · doi:10.5853/jos.2017.02390 · Cited by 12 · see citing works
Liu, G., Lai, P., Guo, J., Wang, Y.-H., & Xian, X. (2021) · Medical Review · doi:10.1515/mr-2021-0004 · Cited by 11 · see citing works
Utilizing the LoxP-Stop-LoxP System to Control Transgenic ABC-Transporter Expression In Vitro
Esobi, I. C., Oladosu, O., Echesabal-Chen, J., & Stamatikos, A. (2022) · Biomolecules · doi:10.3390/biom12050679 · Cited by 12 · see citing works
Demina, E. P., Мирошникова, В. В., Rodygina, T. I., Kurianov, P., Vinogradov, A. G., Denisenko, A. D., & Schwarzman, A. L. (2011) · Molecular Biology · doi:10.1134/s0026893310061019 · Cited by 12 · see citing works
Tang, C., Liu, Y., Yang, W., Storey, C., McMillen, T. S., Houston, B. A., Heinecke, J. W., & LeBoeuf, R. C. (2015) · Journal of Lipid Research · doi:10.1194/jlr.m064303 · Cited by 12 · see citing works
Sasaki, M., Komatsu, T., & Ikewaki, K. (2019) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.119.313016 · Cited by 12 · see citing works
Zhou, M., Li, R., Venkat, P., Yu, Q., Chopp, M., Zacharek, A., Landschoot‐Ward, J., Powell, B., Jiang, Q., & Cui, X. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.863934 · Cited by 10 · see citing works
Anamthathmakula, P., Jeyakumar, S. M., Giridharan, N. V., & Vajreswari, A. (2014) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.22186 · Cited by 9 · see citing works
Gene activation regresses atherosclerosis, promotes health, and enhances longevity
Luoma, P. V. (2010) · Lipids in Health and Disease · doi:10.1186/1476-511x-9-67 · Cited by 7 · see citing works
Tachometer for Reverse Cholesterol Transport?
von Eckardstein, A. (2012) · Journal of the American Heart Association · doi:10.1161/jaha.112.003723 · Cited by 8 · see citing works
ABCA1 and ABCG1 Expression in the Small Intestine of Type 2 Diabetic Rats
Lou, J., Zhou, H., Li, C., Hu, L., Lu, X., Li, J., Yao, H., Li, W., Zhang, X., & Xu, M. (2014) · Laboratory Medicine · doi:10.1309/lmo485spyxbqanxj · Cited by 7 · see citing works
ATP-Binding Cassette Transporter A1 in Lipoprotein Metabolism and Atherosclerosis
Eck, M. V., & van Berkel, T. J. C. (2013) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.113.301719 · Cited by 7 · see citing works
The Kinetics and Remodeling of HDL Particles: Lessons from Inborn Errors of Lipid Metabolism
Asztalos, B. F., & Brunzell, J. D. (2010) · Springer eBooks · doi:10.1007/978-1-4419-1059-2_4 · Cited by 6 · see citing works
Association of a Novel Homozygous Variant in ABCA1 Gene with Tangier Disease
Barbosa-Gouveia, S., Fernández-Crespo, S., Lázare-Iglesias, H., González-Quintela, A., Vázquez-Agra, N., & Hermida-Ameijeiras, Á. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12072596 · Cited by 4 · see citing works
Price, T. R., Emfinger, C. H., Schueler, K. L., King, S. M., Nicholson, R. J., Beck, T., Yandell, B. S., Summers, S. A., Holland, W. L., Krauss, R. M., et al. (2023) · Journal of Lipid Research · doi:10.1016/j.jlr.2023.100471 · Cited by 5 · see citing works
The Complexity of High-Density Lipoproteins
Asztalos, B. F., Tani, M., & Ishida, B. Y. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-407867-3.00003-2 · Cited by 5 · see citing works
Mukhamedova, N., D’Souza, W., Low, H., Kesani, R., Chimini, G., & Sviridov, D. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.07.113 · Cited by 4 · see citing works
Ouweneel, A. B., Zhao, Y., Calpe‐Berdiel, L., Lammers, B., Hoekstra, M., van Berkel, T. J. C., & Eck, M. V. (2021) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2021.01.001 · Cited by 4 · see citing works
Overview of the Measurement of Lipids and Lipoproteins in Mice
Tailleux, A., & Staels, B. (2011) · Current Protocols in Mouse Biology · doi:10.1002/9780470942390.mo110001 · Cited by 2 · see citing works
Self-citationShavva, V. S., Babina, A. V., Nekrasova, E. V., Lisunov, A. V., Dizhe, E. B., Oleinikova, G. N., & Orlov, S. (2022) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-022-01109-w · Cited by 2 · see citing works
Gemery, J. M., Forauer, A. R., & Hoffer, E. K. (2019) · Vascular Health and Risk Management · doi:10.2147/vhrm.s207161 · Cited by 2 · see citing works
Genetic Disorders of Lipoprotein Metabolism: Diagnosis and Management
Cupido, A. J., Stoekenbroek, R. M., & Kastelein, J. J. P. (2016) · Springer eBooks · doi:10.1007/978-3-319-44203-7_21 · Cited by 1 · see citing works
Vastrad, B. M., & Vastrad, C. M. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.02.22.529500 · Cited by 1 · see citing works
Genetic Disorders of the Lipoprotein Metabolism; Diagnosis and Management
Bakker, A. C., Jakulj, L., & Kastelein, J. J. P. (2010) · Springer eBooks · doi:10.1007/978-1-84996-471-5_20 · Cited by 1 · see citing works
Greco, D. (2013) · DSpaceUnipr (University of Parma)
tissue-specific role of ATP binding cassette transporter A1 in atherogenesis
Bi, X. (2013) · WakeSpace (Wake Forest University)
Genetic Disorders of Lipoprotein Metabolism: Diagnosis and Management
Cupido, A. J., Stoekenbroek, R. M., & Kastelein, J. J. P. (2020) · Springer eBooks · doi:10.1007/978-3-030-45457-9_23
Kontush, A., & Chapman, M. J. (2011) · doi:10.1002/9781118158678.ch4
Identification of genetic drivers of plasma lipoproteins in the Diversity Outbred mouse populationPreprint
Price, T. R., Emfinger, C. H., Schueler, K. L., King, S. M., Nicholson, R. J., Beck, T., Yandell, B. S., Summers, S. A., Holland, W. L., Krauss, R. M., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.08.26.554969
Wu, M. P., Yu, X.-H., & Zhang, B.-J. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4886570
- Authors
- Brunham, L. R., Singaraja, R. R., Duong, M., Timmins, J. M., Fievet, C., Bissada, N., Kang, M. H., Samra, A., Fruchart, J.-C., McManus, B., Staels, B., Parks, J. S., & Hayden, M. R.
- Affiliations
- Providence Health Care (CA)
- From the Centre for Molecular Medicine and Therapeutics and Child and Family Research Institute (L.R.B., R.R.S., N.B., M.H.K., M.R.H.), University of British Columbia, Vancouver, Canada; the Department of Pathology/Section on Lipid Sciences (M.D., J.M.T., J.S.P.), Wake Forest University Health Sciences, Winston-Salem, NC; Institut Pasteur de Lille, Inserm U545 (C.F., J.C.F., B.S.), Université de Lille, France; and the iCAPTURE Centre (A.S., B.M.), St Paul’s Hospital/Providence Health Care, University of British Columbia, Vancouver, Canada.
- ORCID
- Venue
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Published
- 2009-04
- Volume
- 29
- Issue
- 4
- Pages
- 548-554
- ISSN
- 1079-5642 (ISSN-L)
- 1524-4636
- OpenAlex
- W2160940635
- Cited by
- 102
- References
- 37
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 4 · 2022: 6 · 2021: 4 · 2020: 4 · 2019: 7 · 2018: 3 · 2017: 3 · 2016: 7 · 2015: 7 · 2014: 11 · 2013: 10 · 2012: 9
- FWCI
- 11.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Arteriosclerosis Thrombosis and Vascular Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL 49373, P01HL049373)
- Topics
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Keywords
- ABCA1, atherosclerosis susceptibility, HDL cholesterol metabolism, tissue-specific gene deletion, Ldlr-deficient mice, ApoE-deficient mice, atheroprotection
- MeSH terms
- Animals, Apolipoproteins E, Dietary Fats, Disease Models, Animal, Humans, Cholesterol, HDL, Cholesterol, LDL, Liver, Mice, Transgenic, Phenotype, Receptors, LDL, Cholesterol, VLDL, Macrophages, Peritoneal, Mice, Knockout, ATP-Binding Cassette Transporters, Genetic Predisposition to Disease, Chromosomes, Artificial, Bacterial, Atherosclerosis, Mice, ATP Binding Cassette Transporter 1
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