Δ-5 Fatty Acid Desaturase FADS1 Impacts Metabolic Disease by Balancing Proinflammatory and Proresolving Lipid Mediators

Biological, clinical and population relevance of 95 loci for blood lipids

Teslovich, T. M., Musunuru, K., Smith, A. V., Edmondson, A. C., Stylianou, I. M., Koseki, M., Pirruccello, J. P., Ripatti, S., Chasman, D. I., Willer, C. J., et al. (2010) · Nature · doi:10.1038/nature09270 · Cited by 3,487 · see citing works

Pro-resolving lipid mediators are leads for resolution physiology

Serhan, C. N. (2014) · Nature · doi:10.1038/nature13479 · Cited by 3,041 · see citing works

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

DIAGRAM Consortium, Dupuis, J., GIANT Consortium, Global BPgen Consortium, Anders Hamsten on behalf of Procardis Consortium, the MAGIC investigators, Langenberg, C., Prokopenko, I., Saxena, R., Soranzo, N., et al. (2010) · Nature Genetics · doi:10.1038/ng.520 · Cited by 2,166 · see citing works

An oxysterol signalling pathway mediated by the nuclear receptor LXRα

Janowski, B. A., Willy, P. J., Devi, T. R., Falck, J. R., & Mangelsdorf, D. J. (1996) · Nature · doi:10.1038/383728a0 · Cited by 1,754 · see citing works

Role of LXRs in control of lipogenesisPreprint

Schultz, J. R., Tu, H., Luk, A. Y., Repa, J. J., Medina, J. C., Li, L., Schwendner, S. W., Wang, S., Thoolen, M., Mangelsdorf, D. J., et al. (2000) · Genes & Development · doi:10.1101/gad.850400 · Cited by 1,673 · see citing works

Eicosanoid storm in infection and inflammation

Dennis, E. A., & Norris, P. C. (2015) · Nature Reviews Immunology · doi:10.1038/nri3859 · Cited by 1,517 · see citing works

Cholesterol and Bile Acid Metabolism Are Impaired in Mice Lacking the Nuclear Oxysterol Receptor LXRα

Peet, D. J., Turley, S. D., Ma, W., Janowski, B. A., Lobaccaro, J. A., Hammer, R. E., & Mangelsdorf, D. J. (1998) · Cell · doi:10.1016/s0092-8674(00)81432-4 · Cited by 1,428 · see citing works

Phospholipase A2Enzymes: Physical Structure, Biological Function, Disease Implication, Chemical Inhibition, and Therapeutic Intervention

Dennis, E. A., Cao, J., Hsu, Y., Magrioti, V., & Kokotos, G. (2011) · Chemical Reviews · doi:10.1021/cr200085w · Cited by 1,213 · see citing works

Reciprocal regulation of inflammation and lipid metabolism by liver X receptors

Joseph, S. B., Castrillo, A., Laffitte, B. A., Mangelsdorf, D. J., & Tontonoz, P. (2003) · Nature Medicine · doi:10.1038/nm820 · Cited by 1,158 · see citing works

Macrophage Phenotype and Function in Different Stages of Atherosclerosis

Tabas, I., & Bornfeldt, K. E. (2016) · Circulation Research · doi:10.1161/circresaha.115.306256 · Cited by 1,121 · see citing works

Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXRα

Venkateswaran, A., Laffitte, B. A., Joseph, S. B., Mak, P. A., Wilpitz, D. C., Edwards, P. A., & Tontonoz, P. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.200367697 · Cited by 1,005 · see citing works

Synthetic LXR ligand inhibits the development of atherosclerosis in mice

Joseph, S. B., McKilligin, E., Pei, L., Watson, M. A., Collins, A. R., Laffitte, B. A., Chen, M., Noh, G. J., Goodman, J., Hagger, G. N., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.112059299 · Cited by 950 · see citing works

Genome-wide association analysis of metabolic traits in a birth cohort from a founder population

Sabatti, C., Service, S. K., Hartikainen, A., Pouta, A. M., Ripatti, S., Brodsky, J. F., Jones, C. G., Zaitlen, N., Varilo, T., Kaakinen, M., et al. (2008) · Nature Genetics · doi:10.1038/ng.271 · Cited by 721 · see citing works

The resolution code of acute inflammation: Novel pro-resolving lipid mediators in resolution

Serhan, C. N., Chiang, N., & Dalli, J. (2015) · Seminars in Immunology · doi:10.1016/j.smim.2015.03.004 · Cited by 583 · see citing works

Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma

Chambers, J. C., Study, D. G. R. A. M.-A. (., Zhang, W., Sehmi, J., Li, X., Wass, M. N., van der Harst, P., Hólm, H., Sanna, S., Kavousi, M., et al. (2011) · Nature Genetics · doi:10.1038/ng.970 · Cited by 546 · see citing works

Resolvins, Specialized Proresolving Lipid Mediators, and Their Potential Roles in Metabolic Diseases

Spite, M., Clària, J., & Serhan, C. N. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2013.10.006 · Cited by 464 · see citing works

Polyunsaturated Fatty Acids Suppress Sterol Regulatory Element-binding Protein 1c Promoter Activity by Inhibition of Liver X Receptor (LXR) Binding to LXR Response Elements

Yoshikawa, T., Shimano, H., Yahagi, N., Ide, T., Amemiya-Kudo, M., Matsuzaka, T., Nakakuki, M., Tomita, S., Okazaki, H., Tamura, Y., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m105711200 · Cited by 426 · see citing works

Progress in antisense technology

Crooke, S. T. (2004) · Annual Review of Medicine · doi:10.1146/annurev.med.55.091902.104408 · Cited by 417 · see citing works

An imbalance between specialized pro-resolving lipid mediators and pro-inflammatory leukotrienes promotes instability of atherosclerotic plaques

Fredman, G., Hellmann, J., Proto, J. D., Kuriakose, G., Colas, R. A., Dorweiler, B., Connolly, E. S., Solomon, R., Jones, D. M., Heyer, E. J., et al. (2016) · Nature Communications · doi:10.1038/ncomms12859 · Cited by 411 · see citing works

Hepatic cholesterol metabolism and resistance to dietary cholesterol in LXRβ-deficient mice

Alberti, S., Schuster, G. U., Parini, P., Feltkamp, D., Diczfalusy, U., Rudling, M., Angelin, B., Björkhem, I., Pettersson, S., & Gustafsson, J.-Α. (2001) · Journal of Clinical Investigation · doi:10.1172/jci9794 · Cited by 367 · see citing works

FADS genotypes and desaturase activity estimated by the ratio of arachidonic acid to linoleic acid are associated with inflammation and coronary artery disease

Martinelli, N., Girelli, D., Malerba, G., Guarini, P., Illig, T., Trabetti, E., Sandri, M. F., Friso, S., Pizzolo, F., Schaeffer, L., et al. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/88.4.941 · Cited by 329 · see citing works

Omega-3 Fatty Acids, Hepatic Lipid Metabolism, and Nonalcoholic Fatty Liver Disease

Scorletti, E., & Byrne, C. D. (2013) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071812-161230 · Cited by 326 · see citing works

LXRs Regulate ER Stress and Inflammation through Dynamic Modulation of Membrane Phospholipid Composition

Rong, X., Albert, C. J., Hong, C., Duerr, M. A., Chamberlain, B. T., Tarling, E. J., Ito, A., Gao, J., Wang, B., Edwards, P. A., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.10.002 · Cited by 316 · see citing works

Genome-Wide Association Study of Coronary Heart Disease and Its Risk Factors in 8,090 African Americans: The NHLBI CARe Project

Lettre, G., Palmer, C. D., Young, T., Ejebe, K. G., Allayee, H., Benjamin, E. J., Bennett, F. I., Bowden, D. W., Chakravarti, A., Dreisbach, A., et al. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1001300 · Cited by 308 · see citing works

Fatty acids in cardiovascular health and disease: A comprehensive update

Baum, S. J., Kris‐Etherton, P. M., Willett, W. C., Lichtenstein, A. H., Rudel, L. L., Maki, K. C., Whelan, J., Ramsden, C. E., & Block, R. (2012) · Journal of clinical lipidology · doi:10.1016/j.jacl.2012.04.077 · Cited by 279 · see citing works

Genetic Adaptation of Fatty-Acid Metabolism: A Human-Specific Haplotype Increasing the Biosynthesis of Long-Chain Omega-3 and Omega-6 Fatty Acids

Ameur, A., Enroth, S., Johansson, Å., Zaboli, G., Igl, W., Johansson, A., Rivas, M. A., Daly, M. J., Schmitz, G., Hicks, A. A., et al. (2012) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2012.03.014 · Cited by 261 · see citing works

Detailed Physiologic Characterization Reveals Diverse Mechanisms for Novel Genetic Loci Regulating Glucose and Insulin Metabolism in Humans

Ingelsson, E., Langenberg, C., Hivert, M., Prokopenko, I., Lyssenko, V., Dupuis, J., Mägi, R., Sharp, S. J., Jackson, A., Assimes, T. L., et al. (2010) · Diabetes · doi:10.2337/db09-1568 · Cited by 254 · see citing works

Atherosclerosis – A matter of unresolved inflammation

Viola, J. R., & Soehnlein, O. (2015) · Seminars in Immunology · doi:10.1016/j.smim.2015.03.013 · Cited by 227 · see citing works

Lipoxin A4 Attenuates Obesity-Induced Adipose Inflammation and Associated Liver and Kidney Disease

Börgeson, E., Johnson, A. M. F., Lee, Y. S., Till, A., Syed, G. H., Shah, S. T. A., Guiry, P. J., Dalli, J., Colas, R. A., Serhan, C. N., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.05.003 · Cited by 225 · see citing works

Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations

Demirkan, A., van Duijn, C. M., Ugocsai, P., Isaacs, A., Pramstaller, P. P., Liebisch, G., Wilson, J. F., Johansson, Å., Rudan, I., Aulchenko, Y. S., et al. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002490 · Cited by 205 · see citing works

Dynamic Aspects of Macrophage Polarization during Atherosclerosis Progression and Regression

Peled, M., & Fisher, E. A. A. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00579 · Cited by 203 · see citing works

Polyunsaturated Lipids Regulate Membrane Domain Stability by Tuning Membrane Order

Levental, K. R., Lorent, J. H., Lin, X., Skinkle, A. D., Surma, M. A., Stockenbojer, E. A., Gorfe, A. A., & Levental, I. (2016) · Biophysical Journal · doi:10.1016/j.bpj.2016.03.012 · Cited by 196 · see citing works

Desaturase and elongase-limiting endogenous long-chain polyunsaturated fatty acid biosynthesis

Zhang, J. Y., Kothapalli, K. S. D., & Brenna, J. T. (2016) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000254 · Cited by 186 · see citing works

The Effect of n-3 Fatty Acids on Glucose Homeostasis and Insulin Sensitivity

Flachs, P., Rossmeisl, M., & Kopecký, J. (2014) · Physiological Research · doi:10.33549/physiolres.932715 · Cited by 183 · see citing works

How polyunsaturated fatty acids modify molecular organization in membranes: insight from NMR studies of model systems

Shaikh, S. R., Kinnun, J. J., Leng, X., Williams, J. A., & Wassall, S. R. (2015) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2014.04.020 · Cited by 179 · see citing works

Delta-5 and Delta-6 Desaturases: Crucial Enzymes in Polyunsaturated Fatty Acid-Related Pathways with Pleiotropic Influences in Health and Disease

Tosi, F., Sartori, F., Guarini, P., Olivieri, O., & Martinelli, N. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-07320-0_7 · Cited by 173 · see citing works

Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma

Chambers, J. C., Zhang, W., Sehmi, J., Li, X., Wass, M. N., van der Harst, P., Hólm, H., Sanna, S., Kavousi, M., Baumeister, S. E., et al. (2011) · Archive ouverte UNIGE (University of Geneva) · doi:10.5451/unibas-ep81762 · Cited by 169 · see citing works

Specialized proresolving lipid mediators in patients with coronary artery disease and their potential for clot remodeling

Elajami, T. K., Colas, R. A., Dalli, J., Chiang, N., Serhan, C. N., & Welty, F. K. (2016) · The FASEB Journal · doi:10.1096/fj.201500155r · Cited by 143 · see citing works

Genome-wide association analysis identifies multiple loci related to resting heart rate

Eijgelsheim, M., Newton‐Cheh, C., Sotoodehnia, N., de Bakker, P. I. W., Müller‐Nurasyid, M., Morrison, A. C., Smith, A. V., Isaacs, A. J., Sanna, S., Dörr, M., et al. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq303 · Cited by 141 · see citing works

Reducing LDL with PCSK9 Inhibitors — The Clinical Benefit of Lipid Drugs

Everett, B. M., Smith, R. J., & Hiatt, W. R. (2015) · New England Journal of Medicine · doi:10.1056/nejmp1508120 · Cited by 138 · see citing works

The Arachidonic Acid Metabolome Serves as a Conserved Regulator of Cholesterol Metabolism

Demetz, E., Schroll, A., Auer, K., Heim, C., Patsch, J. R., Eller, K., Theurl, M., Theurl, I., Theurl, M., Seifert, M., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.09.004 · Cited by 118 · see citing works

Lipoxin A 4 attenuates adipose inflammation

Börgeson, E., McGillicuddy, F. C., Harford, K. A., Corrigan, N., Higgins, D. F., MADERNA, P., Roche, H. M., & Godson, C. (2012) · The FASEB Journal · doi:10.1096/fj.12-208249 · Cited by 114 · see citing works

Fatty acid desaturase 1 gene polymorphisms control human hepatic lipid composition

Wang, L., Athinarayanan, S. J., Jiang, G., Chalasani, N., Zhang, M., & Liu, W. (2014) · Hepatology · doi:10.1002/hep.27373 · Cited by 86 · see citing works

Resolution of inflammation in obesity-induced liver disease

Rius, B., López‐Vicario, C., González‐Périz, A., Morán‐Salvador, E., García‐Alonso, V., Clària, J., & Titos, E. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00257 · Cited by 79 · see citing works

Characterization of an arachidonic acid-deficient (Fads1 knockout) mouse model

Fan, Y.-Y., Monk, J. M., Hou, T. Y., Callway, E., Vincent, L. L., Weeks, B. R., Yang, P., & Chapkin, R. S. (2012) · Journal of Lipid Research · doi:10.1194/jlr.m024216 · Cited by 77 · see citing works

ALOX5AP Overexpression in Adipose Tissue Leads to LXA4 Production and Protection Against Diet-Induced Obesity and Insulin Resistance

Elias, I., Ferré, T., Vilà, L., MUÑOZ, S. A., Casellas, A., García, M., Molas, M., Agudo, J., Roca, C., Ruberte, J., et al. (2016) · Diabetes · doi:10.2337/db16-0040 · Cited by 59 · see citing works

Fatty acid desaturase 1 knockout mice are lean with improved glycemic control and decreased development of atheromatous plaque

Powell, D. R., Gay, J. P., Smith, M. G., Wilganowski, N. L., Harris, A. L., Holland, A., Reyes, M., Kirkham, L., Kirkpatrick, L., Zambrowicz, B., et al. (2016) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s106653 · Cited by 40 · see citing works

Botanical oils enriched in n-6 and n-3 FADS2 products are equally effective in preventing atherosclerosis and fatty liver

Shewale, S. V., Boudyguina, E. Y., Zhu, X., Shen, L., Hutchins, P. M., Barkley, R. M., Murphy, R. C., & Parks, J. S. (2015) · Journal of Lipid Research · doi:10.1194/jlr.m059170 · Cited by 21 · see citing works

A New Model to Study the Role of Arachidonic Acid in Colon Cancer Pathophysiology

Fan, Y.-Y., Callaway, E. S., Monk, J. M., Goldsby, J. S., Yang, P., Vincent, L. L., & Chapkin, R. S. (2016) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-16-0060 · Cited by 9 · see citing works

Resolvins in inflammation: emergence of the pro-resolving superfamily of mediators

Serhan, C. N., & Levy, B. D. (2018) · Journal of Clinical Investigation · doi:10.1172/jci97943 · Cited by 1,344 · see citing works

Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities

Bäck, M., Yurdagul, A., Tabas, I., Öörni, K., & Kovanen, P. T. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0169-2 · Cited by 1,341 · see citing works

Bioactive Lipid Species and Metabolic Pathways in Progression and Resolution of Nonalcoholic Steatohepatitis

Musso, G., Cassader, M., Paschetta, E., & Gambino, R. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.06.031 · Cited by 332 · see citing works

Intake and metabolism of omega-3 and omega-6 polyunsaturated fatty acids: nutritional implications for cardiometabolic diseases

Schulze, M. B., Minihane, A. M., Saleh, R. N. M., & Risérus, U. (2020) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(20)30148-0 · Cited by 198 · see citing works

Fatty acid metabolism in the progression and resolution of CNS disorders

Bogie, J. F. J., Haidar, M., Kooij, G., & Hendriks, J. J. A. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.01.004 · Cited by 167 · see citing works

An Updated Review of Hypertrophic Scarring

Mony, M. P., Harmon, K. A., Hess, R., Dorafshar, A. H., & Shafikhani, S. H. (2023) · Cells · doi:10.3390/cells12050678 · Cited by 174 · see citing works

Obesity-linked suppression of membrane-bound O-acyltransferase 7 (MBOAT7) drives non-alcoholic fatty liver disease

Helsley, R. N., Varadharajan, V., Brown, A. L., Gromovsky, A. D., Schugar, R. C., Ramachandiran, I., Fung, K., Kabbany, M. N., Banerjee, R., Neumann, C. K. A., et al. (2019) · eLife · doi:10.7554/elife.49882 · Cited by 132 · see citing works

A Genome-wide Association Study Discovers 46 Loci of the Human Metabolome in the Hispanic Community Health Study/Study of Latinos

Feofanova, E. V., Chen, H., Dai, Y., Jia, P., Grove, M. L., Morrison, A. C., Qi, Q., Daviglus, M. L., Cai, J., North, K. E., et al. (2020) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2020.09.003 · Cited by 81 · see citing works

Multivariate genome-wide analysis of aging-related traits identifies novel loci and new drug targets for healthy aging

Rosoff, D. B., Mavromatis, L. A., Bell, A. S., Wagner, J., Jung, J., Marioni, R. E., Smith, G. D., Horvath, S., & Lohoff, F. W. (2023) · Nature Aging · doi:10.1038/s43587-023-00455-5 · Cited by 83 · see citing works

Metabolomic Investigation of Major Depressive Disorder Identifies a Potentially Causal Association With Polyunsaturated Fatty Acids

Davyson, E., Shen, X., Gadd, D. A., Bernabeu, E., Hillary, R. F., McCartney, D. L., Adams, M. J., Marioni, R. E., & McIntosh, A. M. (2023) · Biological Psychiatry · doi:10.1016/j.biopsych.2023.01.027 · Cited by 80 · see citing works

Gut microbe-targeted choline trimethylamine lyase inhibition improves obesity via rewiring of host circadian rhythms

Schugar, R. C., Gliniak, C. M., Osborn, L. J., Massey, W. J., Sangwan, N., Horak, A. J., Banerjee, R., Orabi, D., Helsley, R. N., Brown, A. L., et al. (2022) · eLife · doi:10.7554/elife.63998 · Cited by 73 · see citing works

Macrophage Responses to Environmental Stimuli During Homeostasis and Disease

Rasheed, A., & Rayner, K. J. (2021) · Endocrine Reviews · doi:10.1210/endrev/bnab004 · Cited by 79 · see citing works

Ageing: Is there a role for arachidonic acid and other bioactive lipids? A review

Das, U. N. (2018) · Journal of Advanced Research · doi:10.1016/j.jare.2018.02.004 · Cited by 71 · see citing works

Resolvin D1 and D2 reduce SARS‐CoV‐2‐induced inflammatory responses in cystic fibrosis macrophages

Recchiuti, A., Patruno, S., Mattoscio, D., Isopi, E., Pomilio, A., Lamolinara, A., Iezzi, M., Pecce, R., & Romano, M. (2021) · The FASEB Journal · doi:10.1096/fj.202001952r · Cited by 65 · see citing works

Lipidomics in pathogenesis, progression and treatment of nonalcoholic steatohepatitis (NASH): Recent advances

Musso, G., Saba, F., Cassader, M., & Gambino, R. (2023) · Progress in Lipid Research · doi:10.1016/j.plipres.2023.101238 · Cited by 67 · see citing works

Inflammatory response to dietary linoleic acid depends on FADS1 genotype

Lankinen, M. A., Fauland, A., Shimizu, B.-I., Ågren, J., Wheelock, C. E., Laakso, M., Schwab, U., & Pihlajamäki, J. (2018) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqy287 · Cited by 66 · see citing works

Macrophage fatty acid metabolism and atherosclerosis: The rise of PUFAs

Ménégaut, L., Jalil, A., Thomas, C., & Masson, D. (2019) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2019.10.002 · Cited by 64 · see citing works

Association between rosacea and cardiometabolic disease: A systematic review and meta-analysis

Chen, Q., Shi, X., Tang, Y., Wang, B., Xie, H., Shi, W., & Li, J. (2020) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2020.04.113 · Cited by 62 · see citing works

Cytochrome P450 Metabolism of Polyunsaturated Fatty Acids and Neurodegeneration

Sarparast, M., Dattmore, D. A., Alan, J. K., & Lee, K. S. S. (2020) · Nutrients · doi:10.3390/nu12113523 · Cited by 59 · see citing works

Severe consequences of a high-lipid diet include hydrogen sulfide dysfunction and enhanced aggression in glioblastoma

Silver, D. J., Roversi, G. A., Bithi, N., Wang, S. Z., Troike, K. M., Neumann, C. K. A., Ahuja, G. K., Reizes, O., Brown, J. M., Hine, C., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci138276 · Cited by 51 · see citing works

Fatty Acid Desaturase 1 Influences Hepatic Lipid Homeostasis by Modulating the PPARα‐FGF21 Axis

Athinarayanan, S. J., Fan, Y., Wang, X., Callaway, E. S., Cai, D., Chalasani, N., Chapkin, R. S., & Liu, W. (2020) · Hepatology Communications · doi:10.1002/hep4.1629 · Cited by 50 · see citing works

Coronary Artery Disease

Agrawal, H., Choy, H.-H., Liu, J., Auyoung, M., & Albert, M. A. (2020) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.313608 · Cited by 48 · see citing works

PUFA, genotypes and risk for cardiovascular disease

Panda, C., Varadharaj, S., & Voruganti, V. S. (2021) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2021.102377 · Cited by 46 · see citing works

Fucoxanthin alleviates palmitate-induced inflammation in RAW 264.7 cells through improving lipid metabolism and attenuating mitochondrial dysfunction

Li, S., Ren, X., Wang, Y., Hu, J., Wu, H., Song, S., & Yan, C. (2020) · Food & Function · doi:10.1039/d0fo00442a · Cited by 44 · see citing works

Association of genetic variants related to plasma fatty acids with type 2 diabetes mellitus and glycaemic traits: a Mendelian randomisation study

Yuan, S., & Larsson, S. C. (2019) · Diabetologia · doi:10.1007/s00125-019-05019-0 · Cited by 41 · see citing works

Huang-Qi San improves glucose and lipid metabolism and exerts protective effects against hepatic steatosis in high fat diet-fed rats

Li, Y., Wang, C., Jin, Y., Chen, H., Cao, M., Li, W., Luo, H., & Wu, Z. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109734 · Cited by 38 · see citing works

Mechanical stress protects against chondrocyte pyroptosis through lipoxin A4 via synovial macrophage M2 subtype polarization in an osteoarthritis model

Shen, P., Jia, S., Wang, Y., Zhou, X., Zhang, D., Jin, Z., Wang, Z., Liu, D., Bai, L., & Yang, Y. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113361 · Cited by 35 · see citing works

Omega-3 PUFA Responders and Non-Responders and the Prevention of Lipid Dysmetabolism and Related Diseases

Serini, S., & Calviello, G. (2020) · Nutrients · doi:10.3390/nu12051363 · Cited by 33 · see citing works

The FADS1 Genotype Modifies Metabolic Responses to the Linoleic Acid and Alpha‐linolenic Acid Containing Plant Oils–Genotype Based Randomized Trial FADSDIET2

Lankinen, M. A., de Mello, V. D., Meuronen, T., Sallinen, T., Ågren, J., Virtanen, K. A., Laakso, M., Pihlajamäki, J., & Schwab, U. (2021) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202001004 · Cited by 32 · see citing works

Chronic exposure to low-dose cadmium facilitated nonalcoholic steatohepatitis in mice by suppressing fatty acid desaturation

Zhu, Y., Zhao, Y., Chai, X., Jiang, Z., Shi, M., Zhao, Y., Tian, Y., Wang, X., Ying, T., Feng, Q., et al. (2022) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2022.113306 · Cited by 31 · see citing works

Dietary Choline Supplementation Attenuates High-Fat-Diet–Induced Hepatocellular Carcinoma in Mice

Brown, A. L., Conrad, K. A., Allende, D. S., Gromovsky, A. D., Zhang, R., Neumann, C. K. A., Owens, A. P., Tranter, M., & Helsley, R. N. (2019) · Journal of Nutrition · doi:10.1093/jn/nxz315 · Cited by 27 · see citing works

MBOAT7-driven phosphatidylinositol remodeling promotes the progression of clear cell renal carcinoma

Neumann, C. K. A., Silver, D. J., Varadharajan, V., Zhang, R., Traughber, C. A., Przybycin, C. G., Bayık, D., Smith, J. D., Lathia, J. D., Rini, B. I., et al. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2020.01.011 · Cited by 27 · see citing works

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Kim, Y., Gromovsky, A. D., Brown, J., & Chung, S. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.05.007 · Cited by 26 · see citing works

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Salazar, J. J., Pírela, D., Nava, M., Castro, A. V., Angarita, L., Parra, H., Durán‐Agüero, S., Rojas-Gómez, D. M., Galbán, N., Áñez, R., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063133 · Cited by 26 · see citing works

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Aravani, D., Kassi, E. N., Chatzigeorgiou, A., & Vakrou, S. (2020) · Thrombosis and Haemostasis · doi:10.1055/s-0040-1721388 · Cited by 24 · see citing works

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Vergara, D., Nigro, A., Romano, A., Domenico, S. D., D’Amato, M., Franck, J., Coricciati, C., Wisztorski, M., Cardon, T., Fournier, I., et al. (2019) · Cells · doi:10.3390/cells8060580 · Cited by 23 · see citing works

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Mihăilă, R. G. (2020) · Current Cardiology Reviews · doi:10.2174/1573403x15666190522100041 · Cited by 23 · see citing works

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Cui, J., Chen, H., Tang, X., Zhao, J., Zhang, H., Chen, Y. Q., & Chen, W. (2020) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-020-10958-5 · Cited by 22 · see citing works

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Huang, J., Shao, Y., Zong, X., Zhang, H., Zhang, X., Zhang, Z., & Shi, H. (2022) · Food & Function · doi:10.1039/d2fo00246a · Cited by 21 · see citing works

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Wu, C., Daugherty, A., & Lu, H. S. (2019) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.119.312001 · Cited by 21 · see citing works

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Khankari, N. K., Keaton, J. M., Walker, V. M., Lee, K. M., Shuey, M. M., Clarke, S. L., Heberer, K. R., Miller, D. R., Reaven, P. D., Lynch, J. A., et al. (2022) · EBioMedicine · doi:10.1016/j.ebiom.2022.104038 · Cited by 19 · see citing works

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Lacerda, J. T., Gomes, P. R. L., Zanetti, G., Mezzalira, N., Lima, O. G., de Assis, L. V. M., Güler, A. D., Castrucci, A. M. D. L., & Moraes, M. N. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23137014 · Cited by 19 · see citing works

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Massey, W. J., Varadharajan, V., Banerjee, R., Brown, A. L., Horak, A. J., Hohe, R. C., Jung, B. M., Qiu, Y., Chan, E. R., Pan, C., et al. (2023) · Journal of Lipid Research · doi:10.1016/j.jlr.2023.100349 · Cited by 19 · see citing works

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Bi, X., Kuwano, T., Lee, P. C., Millar, J. S., Li, L., Shen, Y., Soccio, R. E., Hand, N. J., & Rader, D. J. (2020) · Circulation Research · doi:10.1161/circresaha.120.317175 · Cited by 18 · see citing works

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Austin, G., Oqua, A. I., Eid, L. E., Zhu, M., Manchanda, Y., Peres, P., Coyle, H., Poliakova, Y., Balkhiyarova, Z., Bouzakri, K., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-66115-x · Cited by 17 · see citing works

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Das, U. N. (2021) · Archives of Medical Science · doi:10.5114/aoms/135703 · Cited by 15 · see citing works

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Suh, J. H., Zyba, S. J., Shigenaga, M. K., McDonald, C. M., & King, J. C. (2021) · Journal of Nutrition · doi:10.1093/jn/nxab425 · Cited by 15 · see citing works

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Giráldez, F. J., Santos, N., Santos, A., Valdés, C., López, S., & Andrés, S. (2021) · Animal Feed Science and Technology · doi:10.1016/j.anifeedsci.2021.114821 · Cited by 15 · see citing works

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Das, U. N. (2021) · Lipids in Health and Disease · doi:10.1186/s12944-021-01507-8 · Cited by 16 · see citing works

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Bessell, B., Loecker, J., Zhao, Z., Aghamiri, S. S., Mohanty, S., Amin, R., Helikar, T., & Puniya, B. L. (2023) · Briefings in Bioinformatics · doi:10.1093/bib/bbad387 · Cited by 14 · see citing works

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Pang, L., Shah, H., Xu, Y., & Qian, S. Y. (2021) · Translational Oncology · doi:10.1016/j.tranon.2021.101207 · Cited by 13 · see citing works

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Osborn, L. J., Orabi, D., Goudarzi, M., Sangwan, N., Banerjee, R., Brown, A. L., Kadam, A., Gromovsky, A. D., Linga, P., Cresci, G., et al. (2021) · Immunometabolism · doi:10.20900/immunometab20210029 · Cited by 14 · see citing works

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DeVito, L. M., Dennis, E. A., Kahn, B. B., Shulman, G. I., Witztum, J. L., Sadhu, S., Nickels, J. T., Spite, M. R., Smyth, S. S., & Spiegel, S. (2022) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14752 · Cited by 13 · see citing works

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Gong, Q., Li, H., Song, J., & Lin, C. (2023) · Journal of Cancer · doi:10.7150/jca.83466 · Cited by 13 · see citing works

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Lu, H. S., Schmidt, A. M., Hegele, R. A., Mackman, N., Rader, D. J., Weber, C., & Daugherty, A. (2019) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.119.313556 · Cited by 13 · see citing works

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Plunde, O., & Bäck, M. (2021) · Kardiologia Polska · doi:10.33963/kp.a2021.0003 · Cited by 12 · see citing works

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Aragón‐Herrera, A., Otero-Santiago, M., Anido‐Varela, L., Moraña‐Fernández, S., Campos‐Toimil, M., García‐Caballero, T., Barral, L., Tarazón, E., Roselló‐Lletí, E., Portolés, M., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.827033 · Cited by 12 · see citing works

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Lamantia, V., Bissonnette, S., Provost, V., Devaux, M., Cyr, Y., Daneault, C., Rosiers, C. D., & Faraj, M. (2018) · Journal of Nutrition · doi:10.1093/jn/nxy238 · Cited by 12 · see citing works

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Banaszak, M., Górna, I., & Drzymała-Czyż, S. (2025) · Metabolites · doi:10.3390/metabo15090595 · Cited by 11 · see citing works

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Cho, K., Ushiki, T., Ishiguro, H., Tamura, S., Araki, M., Suwabe, T., Katagiri, T., Watanabe, M., Fujimoto, Y., Ohashi, R., et al. (2021) · iScience · doi:10.1016/j.isci.2021.103117 · Cited by 11 · see citing works

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Skinner, C. M., Miousse, I. R., Ewing, L., Sridharan, V., Cao, M., Lin, H., Williams, D. K., Avula, B., Haider, S., Chittiboyina, A. G., et al. (2018) · Food and Chemical Toxicology · doi:10.1016/j.fct.2018.09.067 · Cited by 11 · see citing works

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Mandal, Š. (2019) · Health and Technology · doi:10.1007/s12553-019-00385-6 · Cited by 11 · see citing works

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Fairman, G., Robichaud, S., & Ouimet, M. I. (2020) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.119.312582 · Cited by 11 · see citing works

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Chen, Y., Wu, X., Li, J., Ren, Y., He, M., Zhai, X., Huang, C., & Chen, X. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1634724 · Cited by 10 · see citing works

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Žák, A., Jáchymová, M., Burda, M., Staňková, B., Zeman, M., Slaby, A., Vecka, M., & Šeda, O. (2022) · Metabolites · doi:10.3390/metabo12060568 · Cited by 10 · see citing works

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Aragón‐Herrera, A., Feijóo‐Bandín, S., Moraña‐Fernández, S., Anido‐Varela, L., Roselló‐Lletí, E., Portolés, M., Tarazón, E., Lage, R., Moscoso, I., Barral, L., et al. (2021) · The FASEB Journal · doi:10.1096/fj.202002620rr · Cited by 10 · see citing works

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Moriyama, K., Masuda, Y., Suzuki, N., Yamada, C., Kishimoto, N., Takashimizu, S., Akira, K. U. B. O., & Nishizaki, Y. (2022) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-021-00958-1 · Cited by 9 · see citing works

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Liu, Q., Liu, Z., Wu, D., & Wang, S. (2024) · Reviews in Cardiovascular Medicine · doi:10.31083/j.rcm2504142 · Cited by 8 · see citing works

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Lee, K., Kim, S., Park, S., Jang, H., Kim, M. J., Yang, H. J., Hur, H. J., Kim, J. H., & Kim, M. (2024) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202400201 · Cited by 8 · see citing works

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Wang, Y., Song, L., Ning, M., Hu, J., Cai, H., Song, W., Gong, D., Liu, L., Smith, J., Li, H., et al. (2023) · BMC Genomics · doi:10.1186/s12864-023-09160-4 · Cited by 8 · see citing works

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Kytikovа, O. Y., Novgorodtseva, T. P., Denisenko, Y., Antonyuk, M. V., & Gvozdenko, T. A. (2021) · Russian Open Medical Journal · doi:10.15275/rusomj.2021.0403 · Cited by 8 · see citing works

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Tang, J. T., Wang, L., Shi, M., Feng, S., Zhang, T., & Han, H. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.116780 · Cited by 8 · see citing works

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Kim, B. R., Kim, G., Jin, S., Choi, C. W., Kim, J.-H., & Park, H. (2025) · British Journal of Dermatology · doi:10.1093/bjd/ljaf052 · Cited by 7 · see citing works

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Cao, X., Li, F., Xie, X. S., Ling, G., Tang, X., He, W., Tian, J., & Ge, Y. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1498503 · Cited by 7 · see citing works

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Das, U. N. (2021) · European Journal of Clinical Nutrition · doi:10.1038/s41430-021-00925-2 · Cited by 7 · see citing works

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Péter, G., Lukić, J., Milla, S., Sándor, Z. J., Brlás-Molnár, Z., Ardó, L., Békefi, E., & Ljubobratović, U. (2023) · Fishes · doi:10.3390/fishes8050219 · Cited by 5 · see citing works

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Bae, S., & Moon, Y.-A. (2023) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.149292 · Cited by 5 · see citing works

Hepatocyte-Specific Fads1 Overexpression Attenuates Western Diet-Induced Metabolic Phenotypes in a Rat Model

Ghooray, D. T., Xu, M., Shi, H., McClain, C. J., & Song, M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25094836 · Cited by 5 · see citing works

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Li, N., Wu, S., Li, X., Yan, M., Ding, Y., Zhang, L., Brenner, D. A., Liu, X., & Kisseleva, T. (2025) · American Journal Of Pathology · doi:10.1016/j.ajpath.2025.06.012 · Cited by 4 · see citing works

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Huang, Z.-Y., Xu, H., Lin, H., & Zhou, Q. (2025) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2025239 · Cited by 4 · see citing works

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Baranowska‐Bosiacka, I., Olszowski, T., Gutowska, I., Korbecki, J., Rębacz‐Maron, E., Barczak, K., Lubkowska, A., & Chlubek, D. (2019) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2019.01.003 · Cited by 4 · see citing works

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Dron, J. S., Lazarte, J., & Hegele, R. A. (2018) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.118.311581 · Cited by 4 · see citing works

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Irvin, M. R., Montasser, M. E., Kind, T., Fan, S., Barupal, D. K., Patki, A., Tanner, R. M., Armstrong, N. D., Ryan, K. A., Claas, S. A., et al. (2021) · Nutrients · doi:10.3390/nu13114000 · Cited by 4 · see citing works

Fatty acid desaturases link cell metabolism pathways to promote proliferation of Epstein-Barr virus-infected B cells

Bonglack, E. N., Hill, K. K., Barry, A. P., Bartlett, A., Castellano‐Escuder, P., Hirschey, M. D., & Luftig, M. A. (2025) · PLoS Pathogens · doi:10.1371/journal.ppat.1012685 · Cited by 3 · see citing works

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Miladipour, A., Gholipour, M., Tamizkar, K. H., Abak, A., Oskooei, V. K., Taheri, M. N., & Ghafouri‐Fard, S. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.716151 · Cited by 3 · see citing works

Targeted Knockdown of Hepatic Δ-5 Fatty Acid Desaturase FADS1 Aggravates Atherosclerosis in ApoE-/- Mice

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FADS1 inhibition protects retinal pigment epithelium cells from ferroptosis in age related macular degeneration

Zhang, A., Wei, T., Tan, X., Tan, C., Zhuang, M., Xie, T., Cai, J., Yao, Y., & Zhu, L. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.177227 · Cited by 2 · see citing works

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Greenberg, Z., Oshins, R. A., Serban, K. A., Bazargani, S. F., Garrett, T. J., Casanova, N. G., Garcia, J. G. N., He, M., & Khodayari, N. (2025) · Extracellular Vesicle · doi:10.1016/j.vesic.2025.100093 · Cited by 2 · see citing works

Effect of atorvastatin on lipoxygenase pathway‐related gene expression in an in vitro model of lipid accumulation in hepatocytes

Miskiewicz, I. C. G., Cho, H. C., Lee, J. I., Lee, J., Lee, Y., Lee, Y. K., & Choi, S. H. (2023) · FEBS Open Bio · doi:10.1002/2211-5463.13552 · Cited by 2 · see citing works

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Murillo‐Saich, J., Coras, R., Ramírez, J., Quesada‐Masachs, E., Sala‐Climent, M., Eschelbach, K., Mahony, C. B., Celis, R., Armando, A. M., Quehenberger, O., et al. (2024) · Arthritis & Rheumatology · doi:10.1002/art.42848 · Cited by 2 · see citing works

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Yang, T., Sun, K., Peng, F., Hao, Y., Bai, Q., Yu, H., & Xia, Q. (2025) · Discover Oncology · doi:10.1007/s12672-025-02255-2 · Cited by 2 · see citing works

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Galmés, S., Palou, A., & Serra, F. A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241814152 · Cited by 2 · see citing works

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Morrow, N. M., & Huff, M. W. (2017) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.117.310382 · Cited by 2 · see citing works

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Fitzgerald, E., O’Toole, N., Pokhvisneva, I., Turecki, G., Nagy, C., & Meaney, M. J. (2023) · medRxiv · doi:10.1101/2023.03.16.23287352 · Cited by 2 · see citing works

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Liput, K. P., Lepczyński, A., Poławska, E., Ogłuszka, M., Starzyński, R. R., Urbański, P., Nawrocka, A., Jończy, A., Pierzchała, D., Pareek, C. S., et al. (2024) · Journal of Veterinary Research · doi:10.2478/jvetres-2024-0041 · Cited by 1 · see citing works

Association between red blood cell distribution width and genetic risk in patients with rheumatoid arthritis: a prospective cohort study and Mendelian randomization analysis

Chen, M., Lei, J., Liu, Z., Zhao, R., Jiang, Y., Xu, K., Zhang, T., Suo, C., & Chen, X. (2025) · BMC Rheumatology · doi:10.1186/s41927-024-00451-1 · Cited by 1 · see citing works

Abstract 227: The Role of Fatty Acid Desaturase 1 in Inflammation Initiation and Resolution in Atherosclerosis

Gromovsky, A. D., Schugar, R. C., Brown, A. L., Burrows, A. C., Ferguson, D., Sansbury, B. E., Graham, M. J., Crooke, R. M., Lee, R. G., Hazen, S. L., et al. (2016) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvb.36.suppl_1.227

Targeted Knockdown of Hepatic Δ-5 Fatty Acid Desaturase FADS1 Aggravates Atherosclerosis in ApoE-/- Mice

Liu, Q., Wang, P., Zhao, Y., Dai, Y., Ye, Z., & Wang, S. (2024) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2904131 · Cited by 2 · see citing works

The FADS1 genotypes modify the effect of linoleic acid-enriched diet on adipose tissue inflammation via pro-inflammatory eicosanoid metabolism

Vaittinen, M., Lankinen, M. A., Käkelä, P., Ågren, J., Wheelock, C. E., Laakso, M., Schwab, U., & Pihlajamäki, J. (2022) · European Journal of Nutrition · doi:10.1007/s00394-022-02922-y · Cited by 13 · see citing works

FADS genotypes and desaturase activity estimated by the ratio of arachidonic acid to linoleic acid are associated with inflammation and coronary artery disease

Martinelli, N., Girelli, D., Malerba, G., Guarini, P., Illig, T., Trabetti, E., Sandri, M. F., Friso, S., Pizzolo, F., Schaeffer, L., et al. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/88.4.941 · Cited by 329 · see citing works

FADS2 genotype regulates delta-6 desaturase activity and inflammation in human adipose tissue

Vaittinen, M., Walle, P., Kuosmanen, E., Männistö, V., Käkelä, P., Ågren, J., Schwab, U., & Pihlajamäki, J. (2015) · Journal of Lipid Research · doi:10.1194/jlr.m059113 · Cited by 63 · see citing works