Jang, Hyunbum

Allostery in Its Many Disguises: From Theory to Applications

Wodak, S. J., Paci, E., Dokholyan, N. V., Berezovsky, I. N., Horovitz, A., Li, J., Hilser, V. J., Bahar, I., Karanicolas, J., Stock, G., et al. (2019) · Structure

Protein Structure and DynamicsReceptor Mechanisms and Signaling

Cited by 404

Ras Conformational Ensembles, Allostery, and Signaling

Lu, S., Jang, H., Muratcioglu, S., Gursoy, A., Keskin, O., Nussinov, R., & Zhang, J. (2016) · Chemical Reviews

Protein Kinase Regulation and GTPase SignalingReceptor Mechanisms and Signaling

Cited by 355

The Structural Basis of Oncogenic Mutations G12, G13 and Q61 in Small GTPase K-Ras4B

Lu, S., Jang, H., Nussinov, R., & Zhang, J. (2016) · Scientific Reports

Protein Kinase Regulation and GTPase SignalingProtein Structure and Dynamics

Cited by 219

GTP-Dependent K-Ras Dimerization

Muratcioglu, S., Chavan, T. S., Freed, B. C., Jang, H., Khavrutskii, L., Freed, R. N., Dyba, M. A., Stefanisko, K., Tarasov, S. G., Gursoy, A., et al. (2015) · Structure

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 202

AlphaFold, Artificial Intelligence (AI), and Allostery

Nussinov, R., Zhang, M., Liu, Y., & Jang, H. (2022) · The Journal of Physical Chemistry B

Protein Structure and DynamicsComputational Drug Discovery Methods

Cited by 190

Drugging Ras GTPase: a comprehensive mechanistic and signaling structural view

Lu, S., Jang, H., Gu, S., Zhang, J., & Nussinov, R. (2016) · Chemical Society Reviews

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 188

AlphaFold, allosteric, and orthosteric drug discovery: Ways forward

Nussinov, R., Zhang, M., Liu, Y., & Jang, H. (2023) · Drug Discovery Today

Computational Drug Discovery MethodsProtein Structure and Dynamics

Cited by 96

High-affinity interaction of the K-Ras4B hypervariable region with the RAS active site

Chavan, T. S., Jang, H., Khavrutskii, L., Abraham, S. J., Banerjee, A., Freed, B. C., Johannessen, L., Tarasov, S. G., Gaponenko, V., Nussinov, R., et al. (2015) · Biophysical Journal

Protein Kinase Regulation and GTPase SignalingCellular transport and secretion

Cited by 79

Inhibitors of Ras–SOS Interactions

Lu, S., Jang, H., Zhang, J., & Nussinov, R. (2016) · ChemMedChem

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 72

Allostery: Allosteric Cancer Drivers and Innovative Allosteric Drugs

Nussinov, R., Zhang, M., Maloney, R., Liu, Y., Tsai, C.-J., & Jang, H. (2022) · Journal of Molecular Biology

Protein Degradation and InhibitorsProtein Kinase Regulation and GTPase Signaling

Cited by 66

Dynamic Protein Allosteric Regulation and Disease

Nussinov, R., Tsai, C.-J., & Jang, H. (2019) · Advances in Experimental Medicine and Biology

Protein Structure and DynamicsReceptor Mechanisms and Signaling

Cited by 18

mTOR Variants Activation Discovers PI3K-like Cryptic Pocket, Expanding Allosteric, Mutant-Selective Inhibitor Designs

Liu, Y., Zhang, W., Jang, H., & Nussinov, R. (2025) · Journal of Chemical Information and Modeling

PI3K/AKT/mTOR signaling in cancerComputational Drug Discovery Methods

Cited by 10