Cook, Stuart A.

Truncations of titin causing dilated cardiomyopathy

Herman, D. S., Lam, L., Taylor, M. R. G., Wang, L., Teekakirikul, P., Christodoulou, D., Conner, L., DePalma, S. R., McDonough, B., Sparks, E., et al. (2012) · New England Journal of Medicine

Cardiomyopathy and Myosin StudiesGenomics and Rare Diseases

Cited by 1,485

Anatomically constrained neural networks (ACNNS): application to cardiac image enhancement and segmentation

Oktay, O., Ferrante, E., Kamnitsas, K., Heinrich, M., Bai, W., Caballero, J., Cook, S. A., de Marvao, A., Dawes, T., O'Regan, D. P., et al. (2018) · IEEE Transactions on Medical Imaging

Medical Image Segmentation TechniquesAdvanced Neural Network Applications

Cited by 751

IL-11 is a crucial determinant of cardiovascular fibrosis

Schafer, S., Viswanathan, S., Widjaja, A. A., Lim, W.-W., Moreno-Moral, A., DeLaughter, D. M., Ng, B., Patone, G., Chow, K., Khin, E., et al. (2017) · Nature

Cardiac Fibrosis and RemodelingTGF-β signaling in diseases

Cited by 639

Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy

Hinson, J. T., Chopra, A., Nafissi, N., Polacheck, W. J., Benson, C. C., Swist, S., Gorham, J., Yang, L., Schafer, S., Sheng, C. C., et al. (2015) · Science

Cardiomyopathy and Myosin StudiesCardiac electrophysiology and arrhythmias

Cited by 638

Whole-genome sequencing of patients with rare diseases in a national health system

Turro, E., Astle, W. J., Megy, K., Gräf, S., Greene, D., Shamardina, O., Allen, H. L., Sanchis-Juan, A., Frontini, M., Thys, C., et al. (2020) · Nature

Genomics and Rare DiseasesGenetic Associations and Epidemiology

Cited by 554

Using high-resolution variant frequencies to empower clinical genome interpretation

Whiffin, N., Minikel, E., Walsh, R., O’Donnell-Luria, A. H., Karczewski, K., Ing, A. Y., Barton, P. J. R., Funke, B., Cook, S. A., MacArthur, D., et al. (2017) · Genetics in Medicine

Genomics and Rare DiseasesGenetic Associations and Epidemiology

Cited by 441

Interleukin-11 is a therapeutic target in idiopathic pulmonary fibrosis

Ng, B., Dong, J., D’Agostino, G., Viswanathan, S., Widjaja, A. A., Lim, W.-W., Ko, N. S. J., Tan, J., Chothani, S. P., Huang, B., et al. (2019) · Science Translational Medicine

Interstitial Lung Diseases and Idiopathic Pulmonary FibrosisPulmonary Hypertension Research and Treatments

Cited by 314

A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk

Cardiogenics Consortium, Heinig, M., Petretto, E., Wallace, C., Bottolo, L., Rotival, M., Lu, H., Li, Y., Sarwar, R., Langley, S. R., et al. (2010) · Nature

Diabetes and associated disordersGenetic Associations and Epidemiology

Cited by 283

Multi-input Cardiac Image Super-Resolution Using Convolutional Neural Networks

Oktay, O., Bai, W., Lee, M., Guerrero, R., Kamnitsas, K., Caballero, J., de Marvao, A., Cook, S., O’Regan, D., & Rueckert, D. (2016) · Lecture Notes in Computer Science

Advanced Image Processing TechniquesMedical Image Segmentation Techniques

Cited by 246

Inhibition of IL-11 signalling extends mammalian healthspan and lifespan

Widjaja, A. A., Lim, W.-W., Viswanathan, S., Chothani, S., Corden, B., Dasan, C. M., Goh, J. W. T., Lim, R., Singh, B. K., Tan, J., et al. (2024) · Nature

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 238

Myostatin Inhibits IGF-I-Induced Myotube Hypertrophy through Akt

Morissette, M. R., Cook, S. A., Buranasombati, C., Rosenberg, M. A., & Rosenzweig, A. (2009) · American Journal of Physiology-Cell Physiology

Muscle Physiology and DisordersMuscle metabolism and nutrition

Cited by 231

Transcriptional effects of chronic Akt activation in the heart

Cook, S. A., Matsui, T., Li, L., & Rosenzweig, A. (2002) · Journal of Biological Chemistry

Signaling Pathways in DiseaseCardiac Fibrosis and Remodeling

Cited by 199

Genetic Architecture of Acute Myocarditis and the Overlap With Inherited Cardiomyopathy

Lota, A. S., Hazebroek, M. R., Theotokis, P., Wassall, R., Salmi, S., Halliday, B. P., Tayal, U., Verdonschot, J., Meena, D., Owen, R., et al. (2022) · Circulation

Viral Infections and Immunology ResearchCardiomyopathy and Myosin Studies

Cited by 184

A bi-ventricular cardiac atlas built from 1000+ high resolution MR images of healthy subjects and an analysis of shape and motion

Bai, W., Shi, W., de Marvao, A., Dawes, T. J. W., O’Regan, D. P., Cook, S. A., & Rueckert, D. (2015) · Medical Image Analysis

Medical Image Segmentation TechniquesCardiac Imaging and Diagnostics

Cited by 171

Beyond fitness tracking: The use of consumer-grade wearable data from normal volunteers in cardiovascular and lipidomics research

Lim, W. K., Davila, S., Teo, J. X., Yang, C., Pua, C. J., Blöcker, C., Lim, J. Q., Ching, J., Yap, J. J. L., Tan, S. Y., et al. (2018) · PLOS Biology

Physical Activity and HealthContext-Aware Activity Recognition Systems

Cited by 70

IL11 stimulates ERK/P90RSK to inhibit LKB1/AMPK and activate mTOR initiating a mesenchymal program in stromal, epithelial, and cancer cells

Widjaja, A. A., Viswanathan, S., Wei Ting, J. G., Tan, J., Shekeran, S. G., Carling, D., Lim, W.-W., & Cook, S. A. (2022) · iScience

PI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and Cancer

Cited by 45

Midwall Fibrosis Is an Independent Predictor of Mortality in Patients With Aortic Stenosis

Dweck, M. R., Joshi, S., Murigu, T., Alpendurada, F., Jabbour, A., Melina, G., Banya, W., Gulati, A., Roussin, I., Raza, S., et al. (2011) · Journal of the American College of Cardiology

Cardiac Valve Diseases and TreatmentsCardiac Imaging and Diagnostics

Cited by 23

Genomic Analysis of Left Ventricular Remodeling

Sarwar, R., & Cook, S. A. (2009) · Circulation

Cardiac Fibrosis and RemodelingCardiomyopathy and Myosin Studies

Cited by 13