West, Andrew B.

Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

West, A. B., Moore, D. J., Biskup, S., Bugayenko, A., Smith, W. W., Ross, C. A., Dawson, V. L., & Dawson, T. M. (2005) · Proceedings of the National Academy of Sciences

Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and Signaling

Cited by 1,228

Transcriptome analysis reveals dysregulation of innate immune response genes and neuronal activity-dependent genes in autism

Gupta, S., Ellis, S. E., Ashar, F. N., Moes, A., Bader, J. S., Zhan, J., West, A. B., & Arking, D. E. (2014) · Nature Communications

Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental Disorders

Cited by 504

LRRK2 Inhibition Attenuates Microglial Inflammatory Responses

Moehle, M. S., Webber, P. J., Tse, T., Sukar, N., Standaert, D. G., DeSilva, T. M., Cowell, R. M., & West, A. B. (2012) · The Journal of Neuroscience

Neuroinflammation and Neurodegeneration MechanismsParkinson's Disease Mechanisms and Treatments

Cited by 463

Parkinson disease and the immune system - Associations, mechanisms and therapeutics

Tan, E.-K., Chao, Y.-X., West, A., Chan, L.-L., Poewe, W., & Jankovic, J. (2020) · Nature Reviews Neurology

Parkinson's Disease Mechanisms and TreatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 457

LRRK2 levels in immune cells are increased in Parkinson’s disease

Cook, D. A., Kannarkat, G. T., Cintron, A. F., Butkovich, L. M., Fraser, K. B., Chang, J., Grigoryan, N., Factor, S. A., West, A. B., Boss, J. M., et al. (2017) · npj Parkinson's Disease

Parkinson's Disease Mechanisms and TreatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 279

Anionic nanoplastic contaminants promote Parkinson’s disease–associated α-synuclein aggregation

Liu, Z., Sokratian, A., Duda, A. M., Xu, E., Stanhope, C., Fu, A., Strader, S., Li, H., Yuan, Y., Bobay, B. G., et al. (2023) · Science Advances

Parkinson's Disease Mechanisms and TreatmentsMicroplastics and Plastic Pollution

Cited by 262

Abrogation of α-synuclein–mediated dopaminergic neurodegeneration in LRRK2-deficient rats

Daher, J. P. L., Volpicelli-Daley, L. A., Blackburn, J. P., Moehle, M. S., & West, A. B. (2014) · Proceedings of the National Academy of Sciences

Parkinson's Disease Mechanisms and TreatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 223

Iduna protects the brain from glutamate excitotoxicity and stroke by interfering with poly(ADP-ribose) polymer-induced cell death

Andrabi, S. A., Kang, H. C., Haince, J.-F., Lee, Y.-I., Zhang, J., Chi, Z., West, A. B., Koehler, R. C., Poirier, G. G., Dawson, T. M., et al. (2011) · Nature Medicine

Cell death mechanisms and regulationPARP inhibition in cancer therapy

Cited by 216

α-Synuclein fibrils recruit peripheral immune cells in the rat brain prior to neurodegeneration

Harms, A. S., Delic, V., Thome, A. D., Bryant, N., Liu, Z., Chandra, S., Jurkuvenaite, A., & West, A. B. (2017) · Acta Neuropathologica Communications

Parkinson's Disease Mechanisms and TreatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 181

α-Synuclein fibril-induced inclusion spread in rats and mice correlates with dopaminergic Neurodegeneration

Abdelmotilib, H., Maltbie, T., Delic, V., Liu, Z., Hu, X., Fraser, K. B., Moehle, M. S., Stoyka, L., Anabtawi, N., Krendelchtchikova, V., et al. (2017) · Neurobiology of Disease

Parkinson's Disease Mechanisms and TreatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 172

Proteomic analysis of urinary extracellular vesicles reveal biomarkers for neurologic disease

Wang, S., Kojima, K., Mobley, J. A., & West, A. B. (2019) · EBioMedicine

Extracellular vesicles in diseaseAdvanced Proteomics Techniques and Applications

Cited by 145

To die or grow: Parkinson's disease and cancer

WEST, A., DAWSON, V, & DAWSON, T. (2005) · Trends in Neurosciences

Parkinson's Disease Mechanisms and TreatmentsCancer-related Molecular Pathways

Cited by 117

RAB32 Ser71Arg in autosomal dominant Parkinson's disease: linkage, association, and functional analyses

Gustavsson, E. K., Follett, J., Trinh, J., Barodia, S. K., Real, R., Liu, Z., Grant-Peters, M., Fox, J. D., Appel-Cresswell, S., Stoessl, A. J., et al. (2024) · The Lancet Neurology

Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and Signaling

Cited by 114

Sensitivity and specificity of phospho‐Ser129 α‐synuclein monoclonal antibodies

Delic, V., Chandra, S., Abdelmotilib, H., Maltbie, T., Wang, S., Kem, D., Scott, H. J., Underwood, R. N., Liu, Z., Volpicelli‐Daley, L. A., et al. (2018) · Journal of Comparative Neurology

Parkinson's Disease Mechanisms and TreatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 95

LRRK2 and Rab10 coordinate macropinocytosis to mediate immunological responses in phagocytes

Liu, Z., Xu, E., Zhao, H. T., Cole, T., & West, A. B. (2020) · The EMBO Journal

Cellular transport and secretionProtein Kinase Regulation and GTPase Signaling

Cited by 90

Transcriptome analysis of cortical tissue reveals shared sets of downregulated genes in autism and schizophrenia

Ellis, S. E., Panitch, R., West, A. B., & Arking, D. E. (2016) · Translational Psychiatry

Autism Spectrum Disorder ResearchSchizophrenia research and treatment

Cited by 48

Heterogeneity in α-synuclein fibril activity correlates to disease phenotypes in Lewy body dementia

Sokratian, A., Ziaee, J., Kelly, K., Chang, A., Bryant, N., Wang, S., Xu, E., Li, J. Y., Wang, S.-H., Ervin, J., et al. (2021) · Acta Neuropathologica

Parkinson's Disease Mechanisms and TreatmentsAlzheimer's disease research and treatments

Cited by 34

Mouse α-synuclein fibrils are structurally and functionally distinct from human fibrils associated with Lewy body diseases

Sokratian, A., Zhou, Y., Tatli, M., Burbidge, K. J., Xu, E., Viverette, E., Donzelli, S., Duda, A. M., Yuan, Y., Li, H., et al. (2024) · Science Advances

Parkinson's Disease Mechanisms and TreatmentsAlzheimer's disease research and treatments

Cited by 32

RNA-Seq optimization with eQTL gold standards

Ellis, S. E., Gupta, S., Ashar, F. N., Bader, J. S., West, A. B., & Arking, D. E. (2013) · BMC Genomics

Gene expression and cancer classificationGenomics and Phylogenetic Studies

Cited by 30