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Cited by 106

To die or grow: Parkinson's disease and cancer

WEST, A, DAWSON, V, DAWSON, T·2005·Trends in Neurosciences
DOI 10.1016/j.tins.2005.05.002
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Abstract

Epidemiological evidence suggests a reduced incidence of many common types of non-smoking-related cancers in individuals with Parkinson's disease (PD). Genes that underlie familial forms of PD are often abnormally expressed in cancer, owing to their differential regulation or mutation. Functional studies implicate these genes in maintenance of the cell cycle, in some cases through interaction in the ubiquitin-proteasome system. Variation in genes associated with familial-linked PD could therefore modify susceptibility to both cancer and PD, implying some degree of overlap in the underlying biochemical dysfunction. When considering the normal function of these PD-linked genes in the periphery and their potential role in cancer, further emphasis might be placed on protein handling relating to cell-cycle control in the etiology of PD.

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  • Failure of neurons to maintain the G0 phase is associated with neurodegenerative diseases such as Alzheimer's and Parkinson's disease.

    “Failure of neurons to maintain the G0 phase is associated with numerous neurodegenerative diseases, such as Alzheimer’s and Parkinson’s disease [8–10].”

    From MiR-338-3p regulates neuronal maturation and suppresses glioblastoma proliferation. (2017) · cites this paper as [8]

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Authors
WEST, A., DAWSON, V, & DAWSON, T.
Venue
Trends in Neurosciences
Publisher
Elsevier BV
Published
2005-07
Volume
28
Issue
7
Pages
348-352
ISSN
0166-2236
DOI
10.1016/j.tins.2005.05.002
Cited by
106
References
4
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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