Mouse α-synuclein fibrils are structurally and functionally distinct from human fibrils associated with Lewy body diseases

The intricate process of α-synuclein aggregation and fibrillization holds pivotal roles in Parkinson’s disease (PD) and multiple system atrophy (MSA). While mouse α-synuclein can fibrillize in vitro, whether these fibrils commonly used in research to induce this process or form can reproduce stru…