Tweardy, David J.

Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor- mediated cell growth In vitro.

Grandis, J. R., Drenning, S. D., Chakraborty, A., Zhou, M. Y., Zeng, Q., Pitt, A. S., & Tweardy, D. J. (1998) · Journal of Clinical Investigation

Cytokine Signaling Pathways and InteractionsHER2/EGFR in Cancer Research

Cited by 507

Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 To Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution

Bharadwaj, U., Kasembeli, M. M., Robinson, P., & Tweardy, D. J. (2020) · Pharmacological Reviews

Cytokine Signaling Pathways and InteractionsNF-κB Signaling Pathways

Cited by 314

Inhibition of Stat3 Activation Suppresses Caspase-3 and the Ubiquitin-Proteasome System, Leading to Preservation of Muscle Mass in Cancer Cachexia

Silva, K. A. S., Dong, J., Dong, Y., Dong, Y., Schor, N., Tweardy, D. J., Zhang, L., & Mitch, W. E. (2015) · Journal of Biological Chemistry

Muscle Physiology and DisordersNutrition and Health in Aging

Cited by 229

Contribution of STAT3 to inflammatory and fibrotic diseases and prospects for its targeting for treatment

Kasembeli, M. M., Bharadwaj, U., Robinson, P., & Tweardy, D. J. (2018) · International Journal of Molecular Sciences

Cytokine Signaling Pathways and InteractionsPsoriasis: Treatment and Pathogenesis

Cited by 199

STAT‐3 contributes to pulmonary fibrosis through epithelial injury and fibroblast‐myofibroblast differentiation

Pedroza, M., Le, T. T., Lewis, K., Karmouty‐Quintana, H., To, S., George, A. T., Blackburn, M. R., Tweardy, D. J., & Agarwal, S. K. (2016) · The FASEB Journal

Interstitial Lung Diseases and Idiopathic Pulmonary FibrosisTransplantation: Methods and Outcomes

Cited by 193

Essential role for IL-6 in postresuscitation inflammation in hemorrhagic shock

Meng, Z. H., Dyer, K., Billiar, T. R., & Tweardy, D. J. (2001) · American Journal of Physiology-Cell Physiology

Trauma, Hemostasis, Coagulopathy, ResuscitationSepsis Diagnosis and Treatment

Cited by 131

Multifunctional effects of a small-molecule STAT3 inhibitor on NASH and hepatocellular carcinoma in mice

Jung, K. H., Yoo, W., Stevenson, H. L., Deshpande, D., Shen, H., Gagea, M., Yoo, S.-Y., Wang, J., Eckols, T. K., Bharadwaj, U., et al. (2017) · Clinical Cancer Research

Cytokine Signaling Pathways and InteractionsHepatocellular Carcinoma Treatment and Prognosis

Cited by 124

STAT3 inhibition prevents lung inflammation, remodeling, and accumulation of Th2 and Th17 cells in a murine asthma model

Gavino, A. C., Nahmod, K., Bharadwaj, U., Makedonas, G., & Tweardy, D. J. (2016) · Allergy

Asthma and respiratory diseasesCytokine Signaling Pathways and Interactions

Cited by 114

Stat3 isoforms, α and β, demonstrate distinct intracellular dynamics with prolonged nuclear retention of Stat3β mapping to its unique C-terminal end

Huang, Y., Qiu, J., Dong, S., Redell, M. S., Poli, V., Mancini, M. A., & Tweardy, D. J. (2007) · Journal of Biological Chemistry

Cytokine Signaling Pathways and InteractionsNF-κB Signaling Pathways

Cited by 65

Diminution of signal transducer and activator of transcription 3 signaling inhibits vascular permeability and anaphylaxis

Hox, V., O'Connell, M. P., Lyons, J. J., Sackstein, P., Dimaggio, T., Jones, N., Nelson, C., Boehm, M., Holland, S. M., Freeman, A. F., et al. (2016) · Journal of Allergy and Clinical Immunology

Mast cells and histamineImmunodeficiency and Autoimmune Disorders

Cited by 64

Small-molecule targeting of signal transducer and activator of transcription (STAT) 3 to treat non-small cell lung cancer

Lewis, K. M., Bharadwaj, U., Eckols, T. K., Kolosov, M., Kasembeli, M. M., Fridley, C., Siller, R., & Tweardy, D. J. (2015) · Lung Cancer

Cytokine Signaling Pathways and InteractionsLung Cancer Treatments and Mutations

Cited by 63

Distinct effects of systemic infusion of G-CSF vs. IL-6 on lung and liver inflammation and injury in hemorrhagic shock

Meng, Z. H., Dyer, K., Billiar, T. R., & Tweardy, D. J. (2000) · Shock

Trauma, Hemostasis, Coagulopathy, ResuscitationSepsis Diagnosis and Treatment

Cited by 59

Structural requirements for signal transducer and activator of transcription 3 binding to phosphotyrosine ligands containing the YXXQ motif

Shao, H., Xu, X., Mastrangelo, M.-A. A., Jing, N., Cook, R. G., Legge, G. B., & Tweardy, D. J. (2004) · Journal of Biological Chemistry

Cytokine Signaling Pathways and InteractionsProtein Structure and Dynamics

Cited by 53

Identification and characterization of cis elements in the STAT3 gene regulating STAT3α and STAT3β messenger RNA splicing

Shao, H., Quintero, A. J., & Tweardy, D. J. (2001) · Blood

RNA Research and SplicingCytokine Signaling Pathways and Interactions

Cited by 43

Rhodium(II) proximity-labeling identifies a novel target site on STAT3 for inhibitors with potent anti-leukemia activity

Minus, M. B., Liu, W., Vohidov, F., Kasembeli, M. M., Long, X., Krueger, M. J., Stevens, A., Kolosov, M. I., Tweardy, D. J., Sison, E. A. R., et al. (2015) · Angewandte Chemie International Edition

Cytokine Signaling Pathways and InteractionsBiotin and Related Studies

Cited by 38

Protein stabilization improves STAT3 function in autosomal dominant hyper-IgE syndrome

Bocchini, C. E., Nahmod, K., Katsonis, P., Kim, S., Kasembeli, M. M., Freeman, A., Lichtarge, O., Makedonas, G., & Tweardy, D. J. (2016) · Blood

Immunodeficiency and Autoimmune DisordersCytokine Signaling Pathways and Interactions

Cited by 36

Successful ceftriaxone therapy of endocarditis due to penicillin non-susceptible viridans streptococci

Shelburne, S. A., Greenberg, S. B., Aslam, S., & Tweardy, D. J. (2007) · Journal of Infection

Infective Endocarditis Diagnosis and ManagementStreptococcal Infections and Treatments

Cited by 23

Prevention of trauma/hemorrhagic shock-induced lung apoptosis by IL-6-mediated activation of Stat3

Moran, A., Tsimelzon, A. I., Mastrangelo, M. A., Wu, Y., Yu, B., Hilsenbeck, S. G., Poli, V., & Tweardy, D. J. (2009) · Clinical and Translational Science

Cytokine Signaling Pathways and InteractionsTrauma, Hemostasis, Coagulopathy, Resuscitation

Cited by 22

Modulation of the unfolded protein response during hepatocyte and cardiomyocyte apoptosis in trauma/hemorrhagic shock

Thacker, S. A., Robinson, P., Abel, A., & Tweardy, D. J. (2013) · Scientific Reports

Endoplasmic Reticulum Stress and DiseaseTrauma, Hemostasis, Coagulopathy, Resuscitation

Cited by 19